Curated News: Grant Funded News

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Researchers at the Icahn School of Medicine at Mount Sinai and others have identified a neurodevelopmental disorder, caused by mutations in a single gene, that affects tens of thousands of people worldwide. The work, published in the May 31 online issue of Nature Medicine [DOI: 10.1038/s41591-024-03085-5], was done in collaboration with colleagues at the University of Bristol, UK; KU Leuven, Belgium; and the NIHR BioResource, currently based at the University of Cambridge, UK. The findings will improve clinical diagnostic services for patients with neurodevelopmental disorders.

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A new University of Washington study, published May 21 in Developmental Science, is the first to compare the amount of music and speech that children hear in infancy. Results showed that infants hear more spoken language than music, with the gap widening as the babies get older.

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Researchers at Wake Forest University of School of Medicine have received a five-year, $1.5 million grant to study bone microarchitecture in patients following bariatric surgery.

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Wounds that are superficial for some can be life-threatening for others. With diabetic wounds, healing can be slow, particularly in the feet, increasing the tissue’s susceptibility to infection. Foot ulcers and other diabetic foot complications have similar mortality rates to some cancers, yet progress toward improved treatments has plateaued.

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University of Washington researchers worked with a group of 12 Seattle-area kids ages seven to 13 to explore how the kids’ creative processes interacted with AI tools.

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A new NSF-funded research center in the UWM College of Engineering & Applied Science will research high-performance concrete and greener methods of making concrete so that industry collaborators can bring discoveries into use.

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Changing how often a popular cancer therapy is delivered would reduce greenhouse gas emissions and improve environmental impact without decreasing cancer survival, according to a new analysis from researchers at the University of Michigan Health Rogel Cancer Center.

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PPPL scientists have developed a new theoretical model about the edge of a plasma, which can become unstable and potentially damage a fusion reactor. The model refines ideas about a critical obstacle on the path to harnessing clean energy from this fourth state of matter.

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Repeated vaccination and infection leads T cells and B cells to build an "immunity wall"

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Even slight cognitive changes can affect an older person’s decision to stop driving, according to a new study by researchers at Washington University School of Medicine in St. Louis. The findings suggest that routine cognitive testing — in particular, the kind of screening designed to pick up the earliest, most subtle decline — could help older adults and their physicians make decisions about driving that maximizes safety while preserving independence as long as possible.

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Engineers at the University of California San Diego have developed a wearable ultrasound patch that can offer continuous, non-invasive monitoring of blood flow in the brain. The soft and stretchy patch can be comfortably worn on the temple to provide three-dimensional data on cerebral blood flow—a first in wearable technology.

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A team of researchers from Wayne State University was awarded a $1.3 million, three-year grant from the U.S. Department of Defense to study “Advanced wireless augmented reality-enhanced exposure therapy for post-traumatic stress disorder.”

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New research from Binghamton University, State University of New York could revolutionize 3D printing and how engineers think about oxidation.

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Bolstered by years of generative cancer work, researchers at Cummings School of Veterinary Medicine are taking aim at hemangiosarcoma

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The idea of simplifying healthcare technology is a shared vision among Tufts faculty, who have recently introduced paper-based tests for monitoring personal health and environmental safety that eliminate the need for expensive laboratory equipment, and can be conducted by anyone, anywhere

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A novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to research from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy and Johns Hopkins Drug Discovery.

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Current methods to model or correct mutations in live cells are inefficient, especially when multiplexing — installing multiple point mutations simultaneously across the genome. Researchers from the UC San Diego have developed new, efficient genome editing tools called multiplexed orthogonal base editors (MOBEs) to install multiple point mutations at once.

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Researchers at Washington University School of Medicine in St. Louis have found that a strain of gut bacteria can boost immune responses and enhance cancer immunotherapy to fight sarcoma tumors in mice. Shown is a rendering of microbes in the intestine.

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A study by researchers at Washington University School of Medicine in St. Louis has found that repeat vaccination with updated versions of the COVID-19 vaccine promotes the development of antibodies that neutralize a wide range of variants of the virus that causes COVID-19, as well as related coronaviruses.

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The sweet taste receptor, expressed in taste bud cells, conveys sweetness from the mouth when it is activated. Monell researchers delved into how the sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. They team found that stimulation and inhibition of the receptor demonstrates that it helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.

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In a trial analyzing how messages were framed in an underserved population, offering colorectal cancer screening options resulted in the highest screening rate

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New research employs shutter speed analogies to validate 55-year-old theory about chemical reaction rates.

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A collaborative NIH-funded team is using AI to mine common chest CT scans to predict mortality. Their research identified a collection of cardiac factors that were predictive of death in a large group of patients, potentially setting the stage for improved cardiac screening.

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Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease. Additionally, researchers observed sex-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of “old” oligodendrocytes to “old” neurons compared to the male cortex.

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Researchers at the Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) are using artificial intelligence to perfect the design of the vessels surrounding the super-hot plasma, optimize heating methods and maintain stable control of the reaction for increasingly long periods.

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An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study from the University of California San Diego.

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For people with autism, constipation, diarrhea, and abdominal pain often go along with the social struggles and repetitive behaviors that define the condition. This has prompted many to wonder whether gastrointestinal (GI) problems arise due to autism’s behavioral or sensory features, or whether they might instead contribute to them.

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Measuring heart rate or body temperature may sound easy, but retrieving the data from small animals with bulky traditional tech is difficult, especially during behavioral tests, which are critical for understanding brain disorders. Thanks to a recent study, the animal data is now in reach.

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New research from Penn Nursing’s Center for Health Outcomes and Policy Research (CHOPR) – recently published online in the journal Research in Nursing & Health – has successfully validated a new, streamlined version of the Practice Environment Scale of the Nursing Work Index (PES-NWI), originally authored in 2002 by Eileen T. Lake, PhD, RN, FAAN, Professor of Nursing, the Edith Clemmer Steinbright Professor in Gerontology, and Associate Director of CHOPR, who is also lead author on this publication.

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Fu-Shin Yu, Ph.D., professor of ophthalmology, visual and anatomical sciences in the Wayne State University School of Medicine, received an award from the National Eye Institute of the National Institutes of Health for his study aiming to reverse the adverse effects of diabetes on eyesight.

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The discovery opens doors to better stem cell therapies.

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A team led by Iowa State researchers is one of the first recipients of advanced computing support from the new National Artificial Intelligence Research Resource Pilot. The team will use one million "node hours" on a supercomputer to develop large, vision-based artificial intelligence tools to identify agricultural pests.

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Using his platform composed of carbon nanotubes and gold nanoparticles, Professor Alexander Star added antibodies to detect the opioid. His sensor can also distinguish fentanyl from several other common opioids.

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Bacterial Vaginosis (BV) affects about one-quarter of reproductive-age women and is linked to adverse health outcomes, such as increased HIV risk. Yet for decades, BV treatment in the United States has largely relied on antibiotics, and BV recurrence is common following antibiotic therapy.

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Charge-recharge cycling of lithium-superrich iron oxide, a cost-effective and high-capacity cathode for new-generation lithium-ion batteries, can be greatly improved by doping with readily available mineral elements.

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A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other cells within the lung and consist of a stratified outer layer of scale-like squamous cells that protect an underlying layer of rapidly expanding basal stem cells that are capable of restoring airway tissue after injury.

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For the first time, chemists in the University of Minnesota Twin Cities College of Science and Engineering have created a highly reactive chemical compound that has eluded scientists for more than 120 years. The discovery could lead to new drug treatments, safer agricultural products, and better electronics.

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Common household products containing nanoparticles – grains of engineered material so miniscule they are invisible to the eye – could be contributing to a new form of indoor air pollution, according to a Rutgers study. In a study published in the journal Science of the Total Environment, a team of Rutgers researchers found people walking through a space, where a consumer product containing nanoparticles was recently sprayed, stirred residual specks off carpet fibers and floor surfaces, projecting them some three to five feet in the air.

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A new type of bioplastic could help reduce the plastic industry’s environmental footprint. Researchers have developed a biodegradable form of thermoplastic polyurethane (TPU) filled with bacterial spores that, when exposed to nutrients present in compost, germinate and break down the material at the end of its life cycle.

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This method is a major leap forward for scientists investigating how proteins do their jobs in the immune system. “This method basically creates an entire new kind of world of experiments that people can do..."

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Scientists at Johns Hopkins Medicine say that an experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, and in some cases, to lengthen the animals’ lifespan.

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Spinocerebellar ataxia 4 is a devastating progressive movement disorder. A multinational study has now conclusively identified the genetic difference that causes the disease, bringing answers to families and opening the door to future treatments.

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Samples reveal evidence of changes experienced by the surface of asteroid Ryugu, some probably due to micrometeoroid bombardment.

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University of Minnesota Twin Cities researchers have constructed a robot that uses machine learning to fully automate a complicated microinjection process used in genetic research.