Feature Channels: Stem Cells

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Released: 8-Nov-2022 12:00 PM EST
PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in rats
Preprints

Yunqi Yao, Lin Zhang, Fuyi Cheng, Qingyuan Jiang, Yixin Ye, Yushuang Ren, Yuting He, Dongsheng Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng

Released: 8-Nov-2022 12:00 PM EST
Exploiting Embryonic Niche Conditions to Grow Wilms Tumor Blastema in Culture
Preprints

Heather Wojcik, Harold N Lovvorn, Melinda Hollingshead, Janene Pierce, Howard Stotler, Andrew J Murphy, Suzanne Borgel, Hannah M Phelps, Hernan Correa, Alan O Perantoni

Released: 8-Nov-2022 12:00 PM EST
Endothelial cell-derived stem cell factor promotes lipogenesis through c-Kit-mediated upregulation of lipogenic enzymes in brown adipocytes
Preprints

Gou Young Koh, Hyuek Jong Lee, Young-Chan Kim, Jungmo Kim, Myung Jin Yang, Seon Pyo Hong, Jueun Lee, Geum-Sook Hwang

Released: 8-Nov-2022 12:00 PM EST
Induction of tissue-specific premature stem cell aging via Lef1 deficiency promotes senescence-like deterioration in remote organs
Preprints

Yasuaki Ikuno, Koichiro Watanabe, Yumi Kakeya, Shinsuke Ikeno, Toshimasa Nakabo, Ayano Narumoto, Yukie Kande, Tomoki Hayashi, Kahori Minami, Kasumi Nobuhiro, Yo Mabuchi, Shiho Nakamura, Hideyuki Okano, Dai Ihara,

Released: 8-Nov-2022 12:00 PM EST
Measures of genetic diversification in somatic tissues at bulk and single cell resolution
Preprints

Marius E. Moeller, Nathaniel V. Mon Pere, Benjamin Werner, Weini Huang

Released: 7-Nov-2022 12:00 PM EST
GDF3 simultaneously antagonizes BMP signaling and activates TGFβ receptor signaling
Preprints

Deepti Ramachandran, Nagasuryaprasad Kotikalapudi, David E Maridas, Anton Gulko, Linus T Tsai, Vicki Rosen, Alexander S Banks

Released: 7-Nov-2022 12:00 PM EST
Neural stem cell-derived exosomes protect spinal cord injury by the transfer of miR-31-5p
Preprints

Dongdong Jiang, Yongjun Luo, Xiaoshu Wu, Chenyu Huang, Qiaofeng Zhang, Chunzhi Jiang, Qingqiang Yao, Fei Jiang, Pengyu Tang

Released: 7-Nov-2022 12:00 PM EST
Engineering circuits of human iPSC-derived neurons and rat primary glia
Preprints

Sophie Girardin, Stephan Johannes Ihle, Arianna Menghini, Magdalena Krubner, Leonardo Tognola, Jens Duru, Tobias Ruff, Isabelle Fruh, Matthias Muller, János Vörös

Released: 7-Nov-2022 12:00 PM EST
Rescue of the increased susceptibility to Mild Chronic Oxidative Stress of iNeurons carrying the MAPT Chromosome 17q21.3 H1/H1 risk allele by FDA-approved compounds
Preprints

Eldem Sadikoglou, Daniel Domingo-Fernandez, Natalia Savytska, Noemia Fernandes, Patrizia Rizzu, Anastasia Illarionova, Tabea Strauss, Sigrid Schwarz, Alpha Kodamullil, Guenter Hoeglinger, Ashutosh Dhingra, Peter Heutink

Released: 6-Nov-2022 12:00 PM EST
Awakening adult neural stem cells: NOX signalling as a positive regulator of quiescence to proliferation transition in the Xenopus retina
Preprints

Alicia Donval, Cinthia Violeta Hernández Puente, Anaïs Lainé, Diana Roman, Romain Vessely, Julien Leclercq, Muriel Perron, Morgane Locker

Released: 4-Nov-2022 12:00 PM EDT
Assessment of the potential of cold plasma-pretreated beta-tricalcium phosphate in combination with periodontal ligament stem cells to enhance bone regeneration in vivo
Preprints

M Miletić, N Puač, N Škoro, B Brković, M Andrić, Bb Prokić, V Danilović, S Milutinović-Smiljanić, O Mitrović-Ajtić, S Mojsilović

Released: 4-Nov-2022 12:00 PM EDT
Glycolytic metabolism and differentiation remodeling of hematopoietic stem cells in lung cancer
Preprints

Ziqi Guo, Shiming Pu, Liu Yang, Yaping Liu, Xin Li, Hongxia Zhao, Zuping Zhou, Cheng Yang

Released: 3-Nov-2022 12:00 PM EDT
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
Preprints

Dennis Kruk, Anna Yeung, Alen Faiz, Nick H.T. Ten Hacken, Wim Timens, Toin H. Kuppevelt, Willeke Daamen, Danique Hof, Martin C. Harmsen, Mauricio Rojas, Irene H. Heijink

Released: 3-Nov-2022 12:00 PM EDT
Preparation of Cell-Loaded Microbeads as Stable and Injectable Delivery Platforms for Tissue Engineering
Preprints

Mehmet Ali Karaca, Derya Dilek Kancagi, Ugur Ozbek, Ercument Ovali, Ozgul Gok

Released: 3-Nov-2022 12:00 PM EDT
Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations
Preprints

Yara Hussein, Utkarsh Tripathi, Ashwani Choudhary, Ritu Nayak, David Peles, Idan Rosh, Jose Djamus, Ronen Spiegel, Tali Garin-Shkolnik, Shani Stern

Released: 3-Nov-2022 12:00 PM EDT
HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures
Preprints

Oier Pastor-Alonso, Irene Dura, Sara Bernardo-Castro, Emilio Varea, Teresa Muro-Garcia, Soraya Martin-Suarez, Juan Manuel Encinas-Perez, Jose Ramon Pineda

Released: 3-Nov-2022 5:00 AM EDT
Glioblastoma Stem Cell HISTArionics
Cell Stem Cell

Glioblastomas are lethal malignancies that possess a rapidly evolving microenvironment containing necrotic/hypoxic areas, aberrant microvasculature, and glioblastoma stem cells (GSCs) that promote tumor growth, recurrence, and treatment resistance. C

Released: 3-Nov-2022 5:00 AM EDT
Reciprocal Regulation of Mesenchymal Stem Cells and Immune Responses
Cell Stem Cell

The reciprocal regulation between mesenchymal stem/stromal cells(MSCs)and immune responses is complex and critical for designing cell therapies. Wang et al. discuss the characteristics and functions of MSCs under different pathophysiological cond

Released: 3-Nov-2022 5:00 AM EDT
Uncovering the Emergence of HSCs in the Human Fetal Bone Marrow by Single-Cell RNA-Seq Analysis
Cell Stem Cell

Zheng et al. provide a transcriptomic landscape of hematopoietic stem and progenitor cells and microenvironment in human fetal bone marrow and spleen. They uncover the precise timepoint at which hematopoietic stem cells (HSCs) seed fetal bone marrow

Released: 3-Nov-2022 5:00 AM EDT
A Single-Cell Transcriptome Atlas of Glial Diversity in the Human Hippocampus Across the Postnatal Lifespan
Cell Stem Cell

Su et al. performed single-nucleus RNA-sequencing analysis to map diversity, molecular properties, disease relevance, and age-dependent dynamics of glial subpopulations in the human hippocampus across the postnatal lifespan. The resulting glial refe

Released: 3-Nov-2022 5:00 AM EDT
Functional Renal Collecting Ducts From Human PSCs
Cell Stem Cell

Collecting ducts in the kidney control the balance of water and electrolytes, as well as pH of the urine to maintain body homeostasis. Shi et al.1 recently reported in Nature Biotechnology a protocol to generate functional collecting duct cells from

Released: 3-Nov-2022 5:00 AM EDT
Vade-MECOM: How to Peel Back the Layers of Hematopoiesis
Cell Stem Cell

A recent study1 demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rar

Released: 2-Nov-2022 12:00 PM EDT
Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland
Preprints

Valeria Scagliotti, Maria Lillina Vignola, Thea L Willis, Mark Howard, Eugenia Marinelli, Carles Gaston-Massuet, Cynthia Lilian Andoniadou, Marika Charalambous

Released: 2-Nov-2022 12:00 PM EDT
AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion
Preprints

Anita E M Kneppers, Marine Theret, Sabrina Ben Larbi, Linda Gsaier, Audrey Saugues, Carole Dabadie, Arnaud Ferry, Kei Sakamoto, Rémi Mounier

Released: 2-Nov-2022 9:55 AM EDT
New 3D model shows how cadmium exposure may affect heart development
National Institute of Environmental Health Sciences (NIEHS)

Researchers have developed a three-dimensional model that shows how exposure to cadmium might lead to congenital heart disease.

   
Newswise: Researchers Identify a Regulator of Breast Cancer Development
Released: 1-Nov-2022 3:00 PM EDT
Researchers Identify a Regulator of Breast Cancer Development
UT Southwestern Medical Center

UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.

Released: 1-Nov-2022 1:05 PM EDT
骨髓移植的五大关键进步
Mayo Clinic

罗切斯特 , 明尼苏达州 - 六十 前 , , 血液 骨髓 移植 只 种 尝试 救治血癌 试验性 疗法 , 经过 年 发展 , , 如今 已然 种 重要 抗癌 手段。 当前 , 医疗 医疗 医疗

Released: 1-Nov-2022 1:05 PM EDT
Cinco AvançOs Fundamentais Nos Transplantes De Medula óSsea
Mayo Clinic

Nas seis décadas em que o transplante de sangue e medula tem sido usado para tratar pacientes com câncer no sangue, esse tratamento experimental tornou-se uma ferramenta vital de combate ao câncer. A Mayo Clinic, em Rochester, Minnesota, está celebrando a marca de 10 mil transplantes sanguíneos e de medula usados para o tratamento de cânceres sanguíneos e de doenças relacionadas.

Released: 1-Nov-2022 1:00 PM EDT
خمسة تطورات رئيسية في عمليات زراعة نخاع العظم
Mayo Clinic

مدينة روتشستر، ولاية مينيسوتا. - على مدار الستة عقود الماضية منذ بداية استخدام عمليات زراعة الدم والنخاع لعلاج المرضى المصابين بسرطان الدم، أصبح هذا العلاج التجريبي أداة حيوية لمكافحة السرطان. تحتفل مايو كلينك في مدينة روتشستر بولاية مينيسوتا بإجراء 10,000 عملية زراعة دم ونخاع لعلاج سرطانات الدم والاضطرابات ذات الصلة.

Released: 1-Nov-2022 12:00 PM EDT
Cinco Avances Clave en Los Trasplantes De MéDula óSea
Mayo Clinic

En las seis décadas posteriores a que se comience a utilizar el trasplante de médula para tratar a pacientes con distintos tipos de cáncer de la sangre, este tratamiento, que en un principio fue experimental, se ha vuelto una herramienta vital para la lucha contra el cáncer. Mayo Clinic de Rochester (Minnesota) celebra el trasplante de sangre y médula ósea número 10 000 utilizado en el tratamiento de distintos tipos de cáncer de la sangre y trastornos relacionados.

Released: 1-Nov-2022 12:00 PM EDT
Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
Preprints

Yuka Sakata, Keren Cheng, Michinori Mayama, Yasunari Seita, Andrea J Detlefsen, Clementina A Mesaros, Trevor M Penning, Kyosuke Shishikura, Wenli Yang, Richard J Auchus, Jerome F Strauss, Kotaro Sasaki

Released: 1-Nov-2022 12:00 PM EDT
Axon guidance pathways modulate neurotoxicity of ALS-associated UBQLN2
Preprints

Sang Hwa Kim, Kye D Nichols, Eric N Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M. Smith, Udai Bhan Pandey, Randal S Tibbetts

Released: 1-Nov-2022 12:00 PM EDT
A TDP-43 acetylation-mimic mutation that disrupts RNA-binding drives FTLD-like neurodegeneration in a mouse model of sporadic TDP-43 proteinopathy
Preprints

Julie Necarsulmer, Jeremy Simon, Baggio Evangelista, YouJun Chen, Xu Tian, Sara Nafees, Ariana Marquez Gonzalez, Ping Wang, Deepa Ajit, Viktoriya Nikolova, Kathryn Harper, Jennifer Ezzell, Adriana Beltran, Sheryl Moy,

Released: 1-Nov-2022 12:00 PM EDT
Understanding the impact of bioactive coating materials for human mesenchymal stem cells and implications for manufacturing
Preprints

Pedro Silva Couto, Sam A. Molina, Denis O’Sullivan, Liam O'Neill, Alexander M. Lyness, Qasim Rafiq



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