A protective mineral coating identified by University of Wisconsin–Madison biomedical engineering researchers could allow powerful messenger RNA therapeutics like COVID-19 vaccines to be stored at room temperature, making them more accessible to lower-resourced communities across the world.In a new paper in the journal Acta Biomaterialia, Professor William Murphy and collaborators in his lab detail how using an optimized mineral coating composition can maintain mRNA activity for up to six months at room temperature.
New research from Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care System comparing the viruses that cause the flu and COVID-19 shows that people hospitalized with seasonal influenza also can suffer long-term, negative health effects, especially involving their lungs and airways. The study also found that in the 18 months after infection, patients hospitalized for either COVID-19 or seasonal influenza faced an increased risk of death, hospital readmission, and other health problems.
Expert on melanoma cancer vaccine currently in clinical trials, and showing promise
Findings published in the journal Nature by physician-scientists at Beth Israel Deaconess Medical Center (BIDMC) and colleagues suggest that it may be possible to improve protection against COVID-19 by delivering the vaccine directly to the respiratory tract— the primary site of entry in SARS-CoV-2 infection.
With virus cases rising and the holidays nigh, three expert from University of Michigan Health give their top 12 tips for avoiding or reducing the impact of COVID-19, flu, RSV, pneumonia and whooping cough in adults and kids.
The new study is among the first to quantify unmet demand for the vaccine — people who would be willing to be vaccinated if they had access.
According to new predictions by La Jolla Institute for Immunology (LJI) researchers, if the new SARS-CoV-2 Pirola variant wants to evade T cells, it isn't doing a very good job.
Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics.
Francesca Torriani, MD, infectious disease specialist at UC San Diego Health available to discuss importance of vaccination against influenza.
With the holiday season underway, and families and friends gathering to celebrate, a leading Cedars-Sinai Guerin Children’s pediatrician has one word of advice for parents: Vaccinate.
Darcy Dunn-Lawless, a doctoral student at the University of Oxford, is investigating the potential of a painless, needle-free vaccine delivery by ultrasound. The method uses cavitation, which is the formation and popping of bubbles in response to a sound wave. Though initial in vivo tests reported 700 times fewer vaccine molecules were delivered by the cavitation approach compared to conventional injection, the cavitation approach produced a higher immune response. The researchers theorize this could be due to the immune-rich skin the ultrasonic delivery targets. The result is a more efficient vaccine that could help reduce costs and increase efficacy.
In a paper published in The Journal of Infectious Diseases, Daniel Hoft, M.D., Ph.D., director of the Saint Louis University Center for Vaccine Development, and colleagues report a promising new approach to speed vaccine testing for TB.
Press conferences for Acoustics 2023 Sydney will be held virtually at 8:00 a.m. AEDT, Dec. 6 and Dec. 7. Topics will focus on a wide range of newsworthy sessions from the upcoming meeting, which runs Dec. 4-8 in Sydney, Australia.
During the first two years of the pandemic, a COVID-19 infection during pregnancy increased the risk of preterm birth and NICU hospitalizations.
Research sheds light on COVID in these child care settings
Clarivate calls these scientists "pioneers," noting that ranking on the Highly Cited Researchers list is a sign that a scientist has published significant findings and influenced their field of study.
Patients with autoimmune rheumatic diseases, which include rheumatoid arthritis and other chronic disorders that cause inflammation, are at increased risk of SARS-CoV-2 infection, as well as death due to severe COVID-19.
An international team has for the first time researched the longevity of neutralizing antibodies in HIV-1-infected people. Currently, it is assumed that an HIV-1 vaccine can only be effective if it produces these antibodies in vaccinated humans.
Despite the Centers for Disease Control and Prevention warning this year will be potentially dangerous for respiratory illnesses, a third of Americans are not concerned about the threat, according to a new national survey by The Ohio State University Wexner Medical Center.
Investigation raises concerns that the system is not operating as intended and signals are being missed
On World Pneumonia Day, Nov. 12, the Forum of International Respiratory Societies (FIRS), of which the American Thoracic Society is a founding member, is highlighting the urgent challenges in pneumonia prevention and treatment globally.
The most effective way to prevent cervical cancer is to give HPV vaccines to both boys and girls, reports a collaborative study involving researchers from Karolinska Institutet published in Cell, Host and Microbe. Beside personal immunity, such use of the vaccine also induces a herd immunity that will help to eradicate the carcinogenic virus types more quickly.
Asian malaria mosquito found to spread drug and diagnosis-resistant malaria in Africa.
The current flu season has started later and more gradually than last year, according to William Schaffner, MD, professor of Preventive Medicine at Vanderbilt University Medical Center (VUMC), although cases are expected to begin increasing in November before falling off in March.
Simon Fraser University researchers studying the evolutionary history of flu viruses have found that a new quantitative analysis of how they evolved may help predict future strains.
A report published today in the Association for Diagnostics & Laboratory Medicine’s (formerly AACC’s) The Journal of Applied Laboratory Medicine describes the strategies used by the National Basketball Association (NBA) to limit COVID-19 exposure among the individuals who participated in the 2019–2020 season. The success of the NBA’s approach demonstrates that strict adherence to certain protocols can be highly effective in preventing disease outbreaks in a self-contained environment and serves as a model for future pandemic management.
Johns Hopkins researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive.
Adults are more likely to follow government vaccination recommendations when they do not have to pay out of pocket for the vaccine, according to a new study by a University of Massachusetts Amherst researcher.
The explosive rise in tick-borne diseases in many parts of the United States over the last five decades represents a major public health threat that demands innovative solutions, warns a group of Yale scientists.
“What keeps you up at night?” It’s a question Anthony Fauci, MD, heard repeatedly over the course of his nearly four decades as director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. Today, as the COVID-19 pandemic wanes, Fauci describes a new nemesis – lack of “corporate memory.”
UC San Diego engineers have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. Its success lies in targeting a protein known to play a central role in cancer growth and spread, rather than targeting the primary tumor itself.
The United States’ respiratory virus season — which typically lasts from October to April — is making its annual return. The flu, COVID-19, respiratory syncytial virus (RSV) infection and other respiratory illnesses tend to circulate more in the fall and winter months, which can lead to a surge in hospitalizations.
A brief filed on behalf of 111 public health and health law and policy Deans and Scholars, the American Public Health Association, the Robert Wood Johnson Foundation, Trust for America’s Health, and ChangeLab Solutions highlights new findings on the preventive health gains at stake in Braidwood Management v Becerra.
CastleVax, a clinical stage vaccine platform company, has received a Project NexGen award valued at up to $338 million from the Biomedical Advanced Research and Development Authority (BARDA), to support the development of a next-generation, booster vaccine to protect against COVID-19 for years to come.
A UNLV-led team studied potentially fatal, diarrhea-causing Shigella bacteria, and demonstrated a possible way to prevent it from causing disease.
Dendritic cells are key orchestrators of the immune response, but most vaccination strategies don’t effectively target them. NIBIB-funded researchers have developed biodegradable nanoparticles that are designed to deliver mRNA cargo to dendritic cells in the spleen.
A guide to vaccines that adults - especially older adults and those with underlying health issues - should get to avoid serious illness this fall and winter, and beyond.
Hackensack Meridian Jersey Shore University Medical Center’s new four-year Anesthesiology Residency Program, launching spring 2024, recently earned accreditation from the Accreditation Council for Graduate Medical Education (ACGME).
A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.
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