Among the nation’s hospitals, those that serve high numbers of Black and Hispanic patients are far less likely to have advanced medical equipment and critical services that have been shown to boost the quality and effectiveness of cancer care, according to a study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center.
Investigators from the UCLA Health Jonsson Comprehensive Cancer Center have developed an artificial intelligence (AI) model based on epigenetic factors that is able to predict patient outcomes successfully across multiple cancer types.
New Jersey resident Andre LaPierre, 67, thought he had put cancer behind him. In 2019, he was diagnosed with prostate cancer and had, what he thought, a successful surgery to remove his cancerous prostate.
UCLA researchers have described a previously unknown step in the complex process by which dietary cholesterol is processed in the intestines before being released into the bloodstream – potentially revealing a new pathway to target in cholesterol treatment.
FINDINGS GPT-4 conversational artificial intelligence (AI) has the ability to diagnose and triage health conditions comparable to that provided by board certified physicians, and its performance does not vary by patient race and ethnicity. BACKGROUND While GPT-4, a conversational artificial intelligence, “learns” from information on the internet, the accuracy of this form of AI for diagnosis and triage, and whether AI’s recommendations include racial and ethnic biases possibly gleaned from that information, have not been investigated even as the technology’s use in health care settings has grown in recent years.
November marks Lung Cancer Awareness Month and UCLA Health lung cancer experts are working to spread the word about the importance of low-dose computed tomography (LDCT) of the chest. The annual scan is recommended for people with a long-term history of smoking, as well as other criteria, including age.
UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for “off-the-shelf” cell therapy to treat challenging cancers.
Researchers found that by restricting glucose in lung cancer cells, it caused the cells to lose their specialized features, making them more aggressive. This change was linked to alteration in certain molecules and how they modify DNA structure.
The National Institutes of Health (NIH) has granted $2.1 million to UCLA’s Center for HIV Identification, Prevention, and Treatment Services (CHIPTS) and the UCLA-CDU Center for AIDS Research (CFAR) to support four research projects and an implementation science consultation hub.
Two studies led by UCLA researchers offer new insights into the way neurons in the human brain represent time and space – the most basic ingredients of consciousness of human existence and the primary dimensions of experience that allow us to reconstruct the past and envision the future.
Treatment with datopotamab deruxtecan (Dato-DXd), a novel Trop-2 directed antibody-drug conjugate, was found to significantly improve progression-free survival in patients with metastatic non-small cell lung cancer, an improvement that was primarily driven by patients with non-squamous tumors.
A study led by UCLA researchers found that the children of parents who experienced adverse childhood experiences (ACEs)– such as abuse, neglect, violence in the home, or loss of a parent – are at increased risk of arrests and convictions by young adulthood.
In a new case report, researchers at UCLA Health describe promising results using repetitive transcranial magnetic stimulation (rTMS) in the management of post-stroke cerebellar ataxia, a debilitating condition marked by impaired coordination and balance.
A new study is gathering extensive data about people with bipolar disorder to improve diagnosis and treatment of this mental health condition that affects 40 million people worldwide, according to the World Health Organization.
New findings from researchers at UCLA Health suggest that measuring changes in how pupils react to light could help predict recovery from depression and personalize transcranial magnetic stimulation (TMS) treatment of major depressive disorder.
Herceptin has saved millions of women’s lives by targeting cancer at its genetic roots. In this interview, Dr. Slamon talks about the paradigm-shifting approach to cancer treatment and how the discovery has opened up an entirely new area of research.
A UCLA-led team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, possibly leading to new therapies for heart disease and cardiac damage.
A team of investigators from the UCLA Jonsson Comprehensive Cancer Center and the UCLA School of Dentistry received a five-year $4.6 million grant from the National Cancer Institute to develop and improve liquid biopsy technologies for the early detection of lung cancer — the leading cause of cancer death in both men and women in the U.S.
UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors.
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new role for a protein called extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that can trigger cells to self-destruct.
The eight companies selected to participate in UCLA Health’s second TechQuity Accelerator – launched in September – are creating innovative health care tools and services in harmony with the program’s special attention to equitable access for vulnerable populations.
A UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases chemical energy from fat metabolism as heat – a finding that could pave the way toward using it to treat obesity and related metabolic conditions.
Dr. Tanya Stoyanova, associate professor of molecular and medical pharmacology and urology at the David Geffen School of Medicine at UCLA, was awarded a $350,000 Idea Development Award from the Department of Defense.
People frequently exposed to racial or ethnic discrimination may be more susceptible to obesity and related health risks in part because of a stress response that changes biological processes and how we process food cues according to UCLA research.
A new study sheds light on the underlying mechanisms linking menopause to cognitive deficits and brain atrophy, revealing a crucial role for estrogen receptor beta (ERβ) in astrocytes.
Diabetes control can significantly improve for Latinos when a pharmacist implements an intervention that addresses these patients’ barriers to medication adherence.
Dr. Mina Sedrak, associate professor of medicine at the David Geffen School of Medicine at UCLA and director of the Cancer and Aging Program at the UCLA Health Jonsson Comprehensive Cancer Center, has received a five-year, $3.4 million grant from the National Institutes of Health to examine how exercise and certain drugs may be able to slow chemotherapy-related accelerated aging seen in breast cancer survivors.
Dr. Edward Garon, professor of medicine at the David Geffen School of Medicine at UCLA and director of the Signal Transduction and Therapeutics Program at the UCLA Jonsson Comprehensive Cancer Center, was awarded two grants totaling over $3.5 million from the National Institutes of Health to help improve outcomes for patients with early and advanced stages of non-small cell lung cancer.
Mice that consumed caffeine when awake slept more solidly and their overall amount of non-REM and REM sleep was not changed because they “slept in” later.
Below is a brief roundup of news and story ideas from the experts at UCLA Health. For more information on these stories or for help on other stories, please contact us at [email protected].
A new study finds poor quality of available foods, increased intake of calories from foods high in trans-fatty acids, and environments that do not foster physical activity, disrupt the flexibility of information processing in the brain that is involved in reward, emotion regulation, and cognition.
New UCLA-led research has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more than 50-fold since 2010, from 0.6% (235 deaths) in 2010 to 32.3% (34,429 deaths) in 2021. This rise in constitutes the ‘fourth wave’ in the US’s long-running opioid overdose crisis
A new grant will fund a multidisciplinary team to study the ability of the nervous system to prevent fatal arrhythmias.
In this interview, Dr. Salani, who is also a professor of obstetrics and gynecology in the David Geffen School of Medicine at UCLA, talks about the latest research advances for these cancers and how women can help reduce their risk and help with the early detection of the five main types of gynecologic cancers: cervical, ovarian, uterine, vaginal and vulvar.
FINDINGS UCLA-led research finds that among adult congenital heart disease (CHD) transplant recipients, single-ventricle physiology correlated with higher short-term mortality. But 10-year conditional survival was similar for biventricular and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
Even the best treatment approaches for Parkinson’s disease are inadequate if they do not address patients’ feelings of social rejection, isolation, loneliness and other psychosocial effects of stigma, according to a report from experts specializing in Parkinson’s and other movement disorders.
A multidisciplinary team of investigators from the UCLA Jonsson Comprehensive Cancer Center was awarded a $2.5 million Translational Team Science Award from the Department of Defense to develop a tailored treatment for glioblastoma, a deadly brain tumor with limited treatment options.
A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds new light on why tumors that have spread to the brain from other parts of the body respond to immunotherapy while glioblastoma, an aggressive cancer that originates in the brain, does not.
FINDINGS People from socioeconomically distressed communities who underwent heart transplantation between 2004 and 2018 faced a 10% greater relative risk of experiencing graft failure and dying within five years compared to people from non-distressed communities. In addition, following implementation of the 2018 UNOS Heart Allocation policy, transplant recipients between 2018 and 2022 faced an approximately 20% increase in relative risk of dying or experiencing graft failure within three years compared with the pre-policy period.
A UCLA-led study found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising prostate-specific antigen (PSA) levels after radiotherapy, commonly referred to as biochemical recurrence, do not necessarily improve a patient’s long-term overall survival.
In June 2021, Bob McCarrick and his wife Stacey headed out to Los Angeles to enroll in the MIRAGE trial and start radiation therapy.
This method produced enrollment rates many times higher than is typically seen for patient portal based recruitment – and unexpectedly increased racial and ethnic participation as well. So it could be a promising new tool to improve research recruitment and diversity in biomedical research.
Fertility specialist Mark Perloe, MD, dedicates a large portion of his time to meeting with patients in support groups and encourages men to screen for prostate cancer as well as to follow up on abnormal results.
E. Dale Abel, MD, PhD, chair of the Department of Medicine at the David Geffen School of Medicine at UCLA and executive medical director of the UCLA Health Department of Medicine has received the Endocrine Society Fred Conrad Koch Lifetime Achievement Award, the group’s highest honor, recognizing exceptional contributions to the field of endocrinology.
A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.
A brief roundup of news and story ideas from the experts at UCLA Health.
An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.
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