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National Institute Of Environmental Health Sciences, Niehs, Antidepressant, Amitriptyline, blood-brain barrier, central nervous system, P-glycoprotein, Rat study

Antidepressant May Enhance Drug Delivery to the Brain

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New research from the National Institutes of Health found that pairing the antidepressant amitriptyline with drugs designed to treat central nervous system diseases, enhances drug delivery to the brain by inhibiting the blood-brain barrier in rats. The blood-brain barrier serves as a natural, protective boundary, preventing most drugs from entering the brain. The research, performed in rats, appeared online April 27 in the Journal of Cerebral Blood Flow and Metabolism.

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Alan R. Cohen, Alan Cohen, Neurosurgery, Simulator, 3D, ETV, Hollywood

When Hollywood Met Neurosurgery

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A team of computer engineers and neurosurgeons, with an assist from Hollywood special effects experts, reports successful early tests of a novel, lifelike 3D simulator designed to teach surgeons to perform a delicate, minimally invasive brain operation.

Medicine

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Microbiome, Gut Bacteria, Salmonella, E. Coli, Mouse, Clostridium

Newborns Get Infection Protection, Not Just Digestion, From Gut Bacteria, New Study in Mice Shows

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Hundreds of thousands of babies worldwide die every year from infections that ravage their digestive systems. New research in mice offers evidence that the difference in survival may come from certain bacteria in their guts, called Clostridia, which appear to provide key protection against infection, in addition to helping digest food.

Medicine

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San Diego, Palm Beach, Neuroscience, Neurotransmission, Brain

Closer Look at Brain Circuits Reveals Important Role of Genetics

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Scientists at The Scripps Research Institute (TSRI) in La Jolla have revealed new clues to the wiring of the brain. A team led by Associate Professor Anton Maximov found that neurons in brain regions that store memory can form networks in the absence of synaptic activity.

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Pollution, Ramanathan, mice, Respitory, Sinuses, Breathing

Air Pollution May Directly Cause Those Year-Round Runny Noses, According to a Mouse Study

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Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant. Now, Johns Hopkins researchers report that experiments in mice continually exposed to dirty air have revealed that direct biological effect.

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heart attacks, Major Marathons, Cardiac Arrest, Death, Survival Rate, Races, Sporting events, Anupam Jena, Death Rates, Marathons, Health And Safety, Marathoners, Runners

People Suffering Heart Attacks Near Major Marathons Face Grimmer Survival Odds

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At a glance: People who suffer heart attacks and cardiac arrests in the vicinity of major marathons are more likely to die within a month. The bleaker survival odds are linked to delays in transportation to nearby hospitals. The delays are believed to stem from widespread road closures within the radius of the race. The study findings underscore the need for citywide strategies that ensure rapid transport for medical emergencies in the vicinity of major public events.

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Nanoparticles, Leukocyte, leukosome, protein corona formation, Cardiovascular Disease, Autoimmune Disease, Cancer Therapy, Regenerative Medicine

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

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A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface.

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HIV, Treatment, Prevention, Africa, World Health Organization

Study Finds UN Strategy for Eliminating HIV in Sub-Saharan Africa Is Unfeasible

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Statistical mapping technique shows widely dispersed population could pose challenges for initiative

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Paralysis, quadriplegia, Case Western Reserve University, Biotechnology, Cleveland FES Center, Biomedical Engineering

Man with Quadriplegia Employs Injury Bridging Technologies to Move Again—Just by Thinking

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Bill Kochevar, who was paralyzed below his shoulders in a bicycling accident, is believed to be the first person with quadriplegia in the world to have arm and hand movements restored with the help of two temporarily implanted technologies.

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Seth Margolis, Alzheimer’s, ephexin5 , Brain, Amyloid

Protein That Regulates Brain Cell Connections Could Be New Target for Treating Alzheimer's Disease

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In experiments with a protein called Ephexin5 that appears to be elevated in the brain cells of Alzheimer's disease patients and mouse models of the disease, Johns Hopkins researchers say removing it prevents animals from developing Alzheimer's characteristic memory losses. In a report on the studies, published online March 27 in The Journal of Clinical Investigation, the researchers say the findings could eventually advance development of drugs that target Ephexin5 to prevent or treat symptoms of the disorder.







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