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St. Jude Children's Research Hospital, T Cells, immune-checkpoint blockade , immune checkpoint blockade therapy, epigenitcs, T cell exhaustion, Chronic viral infection, HIV, epigenetic control, Immunology

Researchers Chart Pathway to ‘Rejuvenating’ Immune Cells to Fight Cancers and Infections

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St. Jude Children’s Research Hospital discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV

Medicine

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Anti-obesity Hormone, Leptin, Hormone Leptin, Protein, Obesity, Cell Metabolism, HMS, Harvard Medical School, Jeffrey Flier, Eleftheria Maratos-Flier, Starvation, Metabolism, obesity gene, Biology, Body Weight

Does the Emperor Have Clothes?

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Decades after the discovery of anti-obesity hormone, scant evidence that leptin keeps lean people lean, scientists caution

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Dna Damage, chilling stress, selective cell death, stem cell survival

NUS Study: Plants Sacrifice “Daughters” to Survive Chilly Weather

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A new study by a team of plant biologists from the National University of Singapore found that some plants may selectively kill part of their roots to survive under cold weather conditions.

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Biology, Biotechnology, Developmental Biology, Regenerative Medicine, gastrointestinal disease, Colon, Cell Biology, Genetics, human pluripotent stem cells, CELL STEM CELL, Cell Press , Science, Research, Cincinnati Children's Hospital Medical Center, National Institutes , Pediatrics, press release, press release distribution, Children

Lab Grown Human Colons Change Study of GI Disease

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Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.

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Cancer, Stem Cells

Researchers Find Way to Better Use Current Drugs to Target Cancer

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Researchers worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells can be killed.

Medicine

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Cancer, PD-1, Immunotherapy

Targeting Immune Cells That Help Tumors Stay Hidden Could Improve Immunotherapy

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Researchers have discovered a clue that could unlock the potential of immunotherapy drugs to successfully treat more cancers. The findings, published in Cell, were made in mice and showed that targeting a sub-population of immune cells called regulatory T cells could be an effective approach to treating cancers. The findings also point to what could be an important mechanism by which current immunotherapy drugs work, providing clues to making them more effective.

Medicine

Science

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Biochemistry, Cancer, Kidney Cancer, Set2, Epigenetics

Researchers Show How a Cancer Gene Protects Genome Organization

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UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme called Set2 found in virtually all organisms other than bacteria. The basic science finding may have implications for understanding cancer development and how to halt it.

Science

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Binge Eating, binge eating disorder, Eating Disorder, Overeating, Maternal Stress And Anxiety During Pregnancy, Maternal Stress, CHEN

Mice Exposed to Prenatal Stress Are Predisposed to Eating Disorders Later in Life

Researchers at the Weizmann Institute of Science have found that in utero exposure to stress, then experiencing stressors after birth, can lead to overeating disorders in females. However, the scientists were able to prevent the onset of the disorders through dietary intervention.

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Bread and Health: A Personal Matter

A new study at the Weizmann Institute of Science reveals that there is no difference between the health effects of “wholesome” and white bread – rather, one’s gut microbiome affects individual response.

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Sex Differences, Obesity, Diabetes & Endocrinology, Metabolic Diseases, Sex And Gender Differences, Tulane University

Does The Sex Of A Cell Matter In Research?

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A Tulane endocrinologist has co-authored a guide in the latest issue of Cell Metabolism to help scientists who study obesity, diabetes or other metabolic diseases better account for inherent sex differences in research.







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