Feature Channels: Kidney Disease

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Relief™ Stent, a new urinary stent invented by Lee Ponsky, MD, in collaboration with Dean Secrest, secured FDA 510k clearance, which means it can be marketed in the U.S. for patients suffering from kidney stones and other issues causing difficulty with drainage of the kidney.

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In hospitalized patients with COVID-19, the SGLT2 inhibitor dapagliflozin was well tolerated regardless of kidney function, but did not significantly lower patients’ risk of organ failure, kidney problems, or death compared with placebo.

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The risk of major complications for people who donate a kidney via laparoscopic surgery is minimal. That is the conclusion of a 20-year Mayo Clinic study of more than 3,000 living kidney donors. Only 2.5% of patients in the study experienced major complications, and all recovered completely.

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What: Pediatric Academic Societies (PAS) 2022 Meeting When: April 21 to 25 Where: Colorado Convention Center (700 14th St., Denver, CO 80202)

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This Donate Life Month, the Nettleton and Conklin families are celebrating nearly 16 years of being family.

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Black kidney transplant recipients have a faster clearance rate of the immunosuppressive drug tacrolimus than white recipients, according to a new study led by the University at Buffalo. The study, published earlier this year in Pharmacotherapy, is one of the first to examine how both race and sex influence tacrolimus pharmacokinetics.

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About 5,000 children and teens in the United States are diagnosed with type 2 diabetes each year, and the rate is increasing about 5% annually, putting thousands of children at risk for diabetic kidney disease (DKD). While DKD is still considered relatively rare in children, Katherine Kutney, an assistant professor of pediatrics at Case Western Reserve University, expects cases to increase from pandemic-induced obesity—the lack of physical activity, more time spent stationary in front of computer screens. But DKD in children may be slowed with medication therapy if signs of the disease can be detected early and monitored—the goal of new research Kutney will pursue with a 2021 Hartwell Individual Biomedical Research Award.

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Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.

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While 2021 proved to be a record-breaking year for organ donation in the U.S., many people are still hesitant to register to become a donor. Nationwide, only about 48% of people are registered to be organ donors, according to LifeSource. That's despite surveys showing that 95% of people in the U.S. support organ donation.

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Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson.

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Loyola Medicine was recently named a Clinical Care Center for patients with von Hippel-Lindau disease by the VHL Alliance.

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Embargoed press materials are now available for the Experimental Biology (EB) 2022 meeting, featuring cutting-edge research from across the life sciences. EB 2022, to be held April 2–5 in Philadelphia, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.

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• Researchers have developed and validated a new instrument to measure CKD- and transplant-related knowledge in a racially, ethnically, and linguistically diverse group of patients with moderate to severe chronic kidney disease.

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Elizabeth Dravis was a medical field professional, a PhD student at UTHealth School of Public Health in Houston, an avid runner, and mother of two when she started to suffer from extreme fatigue at the beginning of the year. Dravis thought she just needed to rest after a busy holiday season until her symptoms progressively worsened and she passed out.

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Renowned robotic urologic oncology surgeon Dipen J. Parekh, M.D., was the first in the nation to test a new preoperative surgical rehearsal technology recently approved by the Food & Drug Administration for all genitourinary conditions. The kidney models, made by Lazarus 3D, provide an additional preparation tool for some surgical procedures.

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Today advocates of the American Society of Nephrology (ASN) and American Association of Kidney Patients (AAKP) will meet with their Congressional delegations to ask for new policies to improve kidney health for 37 million Americans living with kidney diseases.

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Kenneth Lieberman, M.D., chief of Pediatric Nephrology at Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, and professor of Pediatrics at Hackensack Meridian School of Medicine, has received the 2022 Excellence in Care Award from the National Kidney Foundation (NKF), a research and advocacy organization. He is the first New Jersey pediatric nephrologist to receive the honor.

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An innovative technique called burst wave lithotripsy (BWL) may provide an effective, more accessible alternative for noninvasive treatment of kidney stones, according to initial human studies reported in The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

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• There’s a push to transition dialysis care in the United States from in-center to home-based dialysis (including peritoneal dialysis), but a new review has identified several cost considerations that limit the use of peritoneal dialysis. • Addressing these barriers may help to incentivize a switch to peritoneal dialysis.

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The Donor Care Network has designated Loyola University Medical Center as a Center of Excellence. The Donor Care Network helps ensure living kidney donors are treated with the utmost courtesy and respect by implementing best practices and recognizing facilities that adhere to their guiding principles. The designation will help Loyola improve patient access to living kidney donor transplants through the National Kidney Registry.

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As we observe World Kidney Day 2022 and recognize all the incredible advances in our field, we must pause and remember members of the kidney community in war-torn countries. This year’s World Kidney Day theme, “Kidney Health for All,” underscores harsh inequities that currently exist around the world. Global attention is currently on the war in Ukraine; many other countries—such as Afghanistan, Cameroon, Ethiopia, Iraq, Libya, Sudan, Syria, and Yemen—are also in conflict.

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• Compared with individuals on dialysis who were not vaccinated against COVID-19, those who had received 2 mRNA vaccine doses were 69% and 83% less likely to become infected or experience severe disease, respectively. • There were no significant differences in vaccine effectiveness among age groups, mode of dialysis, or vaccine type.

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Don't miss these articles in our Staff Picks channel

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New studies show that higher body mass index—as well as low socioeconomic status—raise the risk for pediatric kidney stones. Urologists and nephrologists have long suspected that obesity increases the risk for kidney stones in children. This link is well-established in adults, but demonstrating it in children has been more challenging.

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Rutgers Cancer Institute expert shares what you need to know about kidney cancer.

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• In an observational study involving several New York City hospitals, palliative care was used more frequently for hospitalized patients with acute kidney injury (AKI) and COVID-19 than historically reported in AKI. • Despite high mortality associated with AKI, consultation for palliative care occurred late in the hospital course and was not associated with reduced initiation of life sustaining interventions.

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African Americans have an increased risk of kidney failure, and new research shows that some of this risk is related to variations in a gene called apolipoprotein L1 (APOL1). Scientists will address racial disparities in kidney transplant outcomes.

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Obesity may negatively affect kidney function in people with type 2 diabetes, particularly in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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The Latest Research News in Cardiovascular Health

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Dana-Farber Cancer Institute researchers will present important research studies during the 2022 ASCO Genitourinary (GU) Cancers Symposium. The Dana-Farber led research exemplifies innovative and multidisciplinary expertise in prostate, kidney, and bladder cancers, and includes studies examining quality of life and the impact of the COVID-19 pandemic specifically on GU malignancies.

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Hackensack Meridian Children's Health is the Only Pediatric Health Network in New Jersey Undertaking Study into New Kidney Medication

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One in four patients who developed a serious complication called acute kidney injury (AKI) in the hospital will die within one year, heightening the urgency for new treatment options to improve patients’ survival, according to a Henry Ford Health System study. The study, published this month in the Clinical Journal of the American Society of Nephrology, is the first to examine AKI associated mortality after one year using standard lab-based criteria instead of hospital billing codes, said Ryann Sohaney, D.O., a Henry Ford nephrologist and the study’s lead author.

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New Jersey Woman Gives the Gift of Life to Her Spouse this Valentine's Day

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• Results from a study from France suggest that both individual and herd vaccine-induced immunity protect against severe forms of COVID-19 in patients on dialysis. • A U.S. study found that antibody responses following COVID-19 vaccination wane over time across vaccine types in patients on dialysis.

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• Several factors not included in prior prediction models were important for atherosclerotic cardiovascular disease prediction among patients with chronic kidney disease. • Adding these factors could aid clinicians and patients with decisions related to heart disease prevention.

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The Johns Hopkins Health System will no longer use a long-standing clinical standard that factors a patient’s race into kidney function tests.

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While balancing the demands of the COVID-19 pandemic, the team at Baylor Scott & White Medical Center – Temple was able to successfully help nearly 200 patients receive a life-changing organ transplant last year. From January through December 2021, 191 abdominal transplant procedures were conducted, a new record for the hospital and a 25% increase from its previous record set in 2017.

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• Among veterans with acute kidney injury (AKI) at some point between 2008 to 2017, 6% died in-hospital and 28% died within 1 year. In contrast, in-hospital and one-year mortality was 0.8% and 14%, respectively, among non-AKI hospitalizations. • In veterans hospitalized with AKI, in-hospital and one-year mortality rates remained stable throughout the study period.

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• Interviews of adults with chronic kidney disease and their caregivers who had previously been involved in kidney disease–related research identified various factors that supported their involvement or created challenges to participation.