How bacteria live – whether as independent cells or in a communal biofilm – determines the course of their evolution, with implications for drug-resistant infections.
Having blood drawn by a courteous health care provider can really take the sting out of those procedures, suggests a study being presented at the ANESTHESIOLOGY® 2019 annual meeting.
New Precision Immunotherapy Therapy clinic at Moores Cancer Center at UC San Diego Health matches patients using genetic profiling to personalized cancer treatment plans.
Ludwig Cancer Research scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.
Breast cancer specialist Laura Esserman, MD, MBA, is being honored for excellence in the field of cancer research with an award from the University of Chicago Medicine Comprehensive Cancer Center.
In the October Special Issue of SLAS Technology, Guest Editors Soojung Claire Hur, Ph.D., and Deok-Ho Kim, Ph.D., (Johns Hopkins University; Baltimore, MD, USA) introduce a collection of articles and reviews focused on the advancement in technologies that are playing a major role in shifting healthcare closer to more predictive, preventative and personalized medicine.
The IU-led center is one of only two multi-institution teams in the nation selected as part of a new federal program intended to improve, diversify and reinvigorate the Alzheimer's disease drug development pipeline.
A nationally recognized Rutgers cardiologist recommends that aspirin be used as primary prevention for cardiovascular disease only with select patients, saying that the scientific evidence is too diverse to support a one-size-fits-all approach.
Research by the Weizmann Institute of Science's Prof. Yardena Samuels shows that heterogeneity in melanoma tumors prevents effective immune responses
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with specific mutations or patterns. However, this same personalized strategy has not translated to radiation therapy, and a one-size-fits-all approach for most patients is still common practice. Moffitt Cancer Center researchers hope to change this mindset for radiation treatment with the development of a genomically-based model that can optimize and personalize a radiation dose to match an individual patient’s needs.
The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.
On August 4, a special session at the 71st AACC Annual Scientific Meeting & Clinical Lab Expo will shed much-needed light on the nuances of direct-to-consumer genetic testing.
Building on a track record of developing adeno-associated viral (AAV) vectors as a groundbreaking clinical tool for gene therapy and gene editing, Children’s Hospital of Philadelphia (CHOP) researchers report a more sensitive method for capturing the footprint of AAV vectors—a broad range of sites where the vectors transfer genetic material.
High blood pressure among children is on the rise and a lack of research about how to treat it has left pediatricians trying to make their best guess. That’s until researchers released results of a pioneering study that used a series of personalized trials to identify a preferred therapy for kids – the first step in tackling the problem.
Imagine that you have a serious medical condition. Then imagine that when you visit a team of doctors, they could build an identical virtual ‘twin’ of the condition and simulate millions of ways to treat it until they develop an effective treatment. That is the vision of a team of scientists, led by Argonne National Laboratory.
Using an ultra-sensitive and high-throughput isolation technology, UCLA researchers were able to characterize and identify the neoantigens driving the antitumor responses in a patient treated with anti-PD-1 blockade and isolate the T cell receptors responsible for such effect.
Tulane University has named research scientist Tony Hu, PhD, a pioneer in developing advanced diagnostics for personalized medicine, as its second endowed presidential chair.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
Faced with a preteen boy who had painful swelling and respiratory distress from a severe, deteriorating rare condition, researchers at Children’s Hospital of Philadelphia identified the responsible gene mutation and harnessed that knowledge to develop a novel treatment that dramatically improved the problem.
A weakness in one common open source software for genomic analysis left DNA-based medical diagnostics vulnerable to cyberattacks. Researchers at Sandia National Laboratories identified the weakness and notified the software developers, who issued a patch to fix the problem. The issue has also been fixed in the latest release of the software.
Signaling its continued commitment to pioneering research, UC San Francisco has appointed Rohit Gupta as its inaugural Chief Biobank Officer (CBO). His appointment, which follows a national search, is effective June 19.
Collecting DNA samples for human genetic studies can be an expensive, lengthy process that has often made it difficult to include diverse populations in studies of medical and health data.
RB1 status has emerged not only as a key factor in cancer development and progression, but also as a crucial determinant of cell fate in response to various anticancer treatments
Machine learning has the potential to vastly advance medical imaging, particularly computerized tomography (CT) scanning, by reducing radiation exposure and improving image quality.
Scientists can't make a living copy of your brain outside your body. That's the stuff of science fiction. But in a new study, they recreated a critical brain component, the blood-brain barrier, that functioned as it would in the individual who provided the cells to make it.
Johns Hopkins inHealth, Johns Hopkins Medicine’s precision medicine effort to tailor health care to the needs of individual patients, is convening nearly two dozen experts from across the nation for a one-day research symposium that will explore ways to improve patient care through precision medicine approaches.
University of California San Diego School of Medicine researchers found that treating patients with personalized precision medicine that combined therapies to target multiple alterations improved outcomes in patients with therapy resistant cancers.
Michael Snyder, PhD, of Stanford University is the recipient of the 2019 Genetics Society of America (GSA) George W. Beadle Award for developing and disseminating widely-used technology for the simultaneous analysis of thousands of genes, RNA molecules, and proteins. The Beadle Award recognizes significant, sustained service to the genetics community that goes beyond an exemplary individual research career.
Combining a wealth of information derived from previous studies with data from more than 500 patients, an international team led by researchers from Johns Hopkins has developed a computer-based set of rules that more accurately predicts when patients with a rare heart condition might benefit—or not—from lifesaving implanted defibrillators.
A global biobank analysis reveals nearly 70 percent of studied genomic data are derived from those of European descent
Findings published in the Journal of Clinical Oncology could help define strategies to more effectively treat colorectal cancer, the second leading cause of cancer death in the United States.
The University of Kansas Cancer Center is one of the latest major cancer research institutions to join The Leukemia & Lymphoma Society’s (LLS) Beat AML Master Clinical Trial, a paradigm-shifting collaboration to bring precision medicine to patients with acute myeloid leukemia.
Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy (DMD), according to a study that could have implications for optimizing gene therapies for other diseases.
researchers at Washington University School of Medicine in St. Louis have found a compound that may treat IBD without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice.
A new Johns Hopkins study offers promise towards someday being able to non-invasively examine changes in cancerous tumors to determine whether they’ll respond to radiation treatment, before treatment even begins.
High blood pressure is among the most common medical conditions in the United States. It’s also among the most treatable.
Researchers from the McKelvey School of Engineering and Washington University School of Medicine in St. Louis are one step closer to delivering precise amounts of medication to exact location, repurposing an existing imaging "painting" method.
Researchers at the University of New Mexico (UNM) recently solved a major gap in scientific literature by using mobile software technology to measure the real-time effects of actual cannabis-based products used by millions of people every day.
A new way to create proteins that can sneak through HIV’s protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.
By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic changeone in a gene involved in muscle formationin five of the tumors.
New preclinical findings from extensive cell and animal studies suggest that cysteamine bitartrate, a drug already used for a rare kidney disease, could benefit patients with some mitochondrial disorders. No proven effective treatments yet exist for these complex conditions with severe energy deficiency
A small, retrospective study has found that, in patients with particular pancreatic duct lesions, the presence of an inherited mutation in a pancreatic cancer susceptibility gene may increase the patients’ risk of developing pancreatic cancer. To verify these results and learn more about the development of this deadly cancer, the researchers recommend more genetic studies. Their hope—in line with the goals of precision medicine—is to eventually find a better way to guide patient care, dividing patients, for example, into those who need regular screening versus immediate surgery or other early interventions.
The Coriell Institute for Medical Research today announced it is expanding its leadership team by welcoming two skilled scientists to fill two new roles. Jaroslav Jelinek, M.D., Ph.D., will serve as the Institute’s new Chief Research Officer and Jozef Madzo, Ph.D., will join the Institute as its new Director of Bioinformatics. Both are scheduled to start on Feb. 28.
A new and novel outcome measure is being used to determine effectiveness of new scleroderma treatments. Learn how Michigan Medicine is leading the way.
UCLA researchers have identified for the first time the origin of an immune cell that plays a critical role in the formation of healthy heart valves. The findings could pave the way for new treatments for heart valve disorders, which can be caused by congenital defects, aging or disease. Their study, led by Dr. Atsushi “Austin” Nakano, a UCLA associate professor of molecular, cell and developmental biology and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, was published in the journal Developmental Cell.
An artificial intelligence technique that combs electronic medical records can identify trauma patients who misuse alcohol, a study has found. In 78 percent of cases, the technique was able to differentiate between patients who misused alcohol and those who did not.
The research, by the Genetic Investigation of ANthropometric Traits (GIANT) consortium, identifies genetic variants associated with obesity that are central to developing targeted interventions that can reduce the risks of chronic illnesses to which obesity contributes in significant ways.
The Next Generation Precision Oncology Symposium, a novel meeting of industry and academic leaders in cancer science and medicine, will be held February 21, 2019 at UC San Diego Moores Cancer Center.
Researchers have successfully identified two genetic markers for potentially effective treatment of Mesothelioma, an orphan disease most commonly associated with asbestos exposure, and for which few treatments exist.
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