Feature Channels: Blood

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The Flow Cytometry Core at Sanford Burnham Prebys is getting a new piece of state-of-the-art research equipment, thanks to a grant from the National Institutes of Health.

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Memorial Sloan Kettering Cancer Center (MSK) announced today that the U.S. Food and Drug Administration (FDA) has approved the oral MEK inhibitor drug cobimetinib (Cotellic®) for the treatment of adult patients with the family of blood diseases known as histiocytic neoplasms (HN). These diseases include Erdheim-Chester disease, Rosai-Dorfman disease, and Langerhans cell histiocytosis. Cobimetinib is an oral inhibitor of MEK1 and MEK2, currently approved to treat melanoma.

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Hypertension control and management worsened during the early months of the COVID-19 pandemic, according to a new analysis conducted at three large health systems, led by Cedars-Sinai investigators.

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罗切斯特 ， 明尼苏达州 - 六十 前 ， ， 血液 骨髓 移植 只 种 尝试 救治血癌 试验性 疗法 ， 经过 年 发展 ， ， 如今 已然 种 重要 抗癌 手段。 当前 ， 医疗 医疗 医疗

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Nas seis décadas em que o transplante de sangue e medula tem sido usado para tratar pacientes com câncer no sangue, esse tratamento experimental tornou-se uma ferramenta vital de combate ao câncer. A Mayo Clinic, em Rochester, Minnesota, está celebrando a marca de 10 mil transplantes sanguíneos e de medula usados para o tratamento de cânceres sanguíneos e de doenças relacionadas.

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En las seis décadas posteriores a que se comience a utilizar el trasplante de médula para tratar a pacientes con distintos tipos de cáncer de la sangre, este tratamiento, que en un principio fue experimental, se ha vuelto una herramienta vital para la lucha contra el cáncer. Mayo Clinic de Rochester (Minnesota) celebra el trasplante de sangre y médula ósea número 10 000 utilizado en el tratamiento de distintos tipos de cáncer de la sangre y trastornos relacionados.

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The destruction of red blood cells, or mechanical hemolysis, is an inevitable complication of interventional devices, so scientists want to gain a better understanding of the phenomenon. In Physics of Fluids, researchers develop a red blood cell destruction model based on simulations of dissipative particle dynamics within a high shear flow. The team discovered that acceleration during shearing is a major factor in red blood cell destruction, beyond exposure time and shear stress. They recommend adding a flow buffer structure to the structural design of ventricular assist devices to reduce part of the hemolysis caused by shear acceleration.

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A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai

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RUDN doctors have found genetic factors that increase the risk of recurrent vascular stenosis after stent placement. The data obtained will help to adjust the treatment and choose an individual approach for patients with coronary heart disease.

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Physicists at McMaster University have identified a natural delivery system which can safely carry potent antibiotics throughout the body to selectively attack and kill bacteria by using red blood cells as a vehicle.

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Researchers at the Chan Zuckerberg Biohub (CZ Biohub), the Chan Zuckerberg Initiative (CZI), and UC San Francisco (UCSF) have developed a new diagnostic method that applies machine learning to advanced genomics data from both microbe and host – to identify and predict sepsis cases.

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Approximately 500 healthy volunteers with no history of cancer are being sought to contribute blood cells that may be used in the development of cancer clinical trials.

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The new study showed apixaban is superior to rivaroxaban against stroke or systemic embolism in patients with atrial fibrillation and valvular heart disease

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Currently, the U.S. leads western nations in infant mortality and cardiac birth defects are a leading cause. New research harnesses the power of AI to detect dangerous cardiac abnormalities prenatally. Resulting medical protocols implemented at birth in those at-risk could go a long way toward saving lives.

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Patients who have surgery to repair bone fractures typically receive a type of injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots, but a new clinical trial found that over-the-counter aspirin is just as effective.

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For the approximately 8.5 million people in the U.S. living with peripheral artery disease (PAD – pronounced P-A-D), which is narrowed or clogged arteries in the legs, treatment decisions and criteria for success should be led by their symptoms and self-reported quality of life, according to a new American Heart Association scientific statement published today in the Association’s flagship, peer-reviewed journal Circulation.

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In 2015, published findings from the landmark Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure management reduced cardiovascular disease and lowered the risk of death. In 2019, results of the SPRINT MIND trial showed that lowering blood pressure also reduced the risk of mild cognitive impairment in older adults. Now, researchers from Wake Forest University School of Medicine have shown that while intensive blood pressure control was beneficial to SPRINT participants’ health during the trial, the benefits for cardiovascular mortality went away after approximately two years when protocols for blood pressure management were no longer being followed.

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St. Jude Children’s Research Hospital scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias.

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Predicting the rupture of aneurysms is crucial for medical prevention and treatment. As aspect ratio and size ratio increase and an aneurysm expands, the stress applied against the aneurysm walls and the time blood spends within it increase. This leads the probability of rupture to rise. In Physics of Fluids, researchers develop a patient-specific mathematical model to examine what aneurysm parameters influence rupture risk prior to surgery. Computed tomography scans are fed into the model, which reconstructs the geometry and blood flow of the aneurysm. It then uses equations to describe the fluid flow, generating information about the blood vessel walls and blood flow patterns.

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In the six decades since blood and marrow transplantation was used to treat patients with blood cancers, this once experimental treatment has become a vital cancer-fighting tool. Mayo Clinic in Rochester, Minnesota, is celebrating the 10,000th blood and marrow transplant used in the treatment of blood cancers and related disorders.

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In a long-term prospective study of more than 600 older participants, Johns Hopkins Medicine researchers say they have evidence that higher levels of cell-free DNA circulating in the blood may signal increased risk of chronic inflammation associated with early signs of frailty and dementia.

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Researchers have discovered a novel, non-invasive way to measure blood flow to the brains of newborn children at the bedside – a method that has the potential to enhance diagnosis and treatment across medicine, a Michigan Medicine study suggests.

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Researchers from Hokkaido University and Toppan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

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New data validate the benefits of the BVA-100 diagnostic blood volume measurement test in reducing hospital length of stay (LOS) for heart failure (HF) patients. Data were presented at the Heart Failure Society of America (HFSA) Annual Scientific Meeting (ASM) 2022 – which brought together the world’s leading experts in heart failure.

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New data validate the benefits of the BVA-100 blood volume measurement test for Medicare heart failure patients. Data were presented at the Heart Failure Society of America (HFSA) Annual Scientific Meeting (ASM) 2022 – which brought together the world’s leading experts in heart failure.

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A nanoparticle therapy developed by investigators at University Hospitals (UH) and Case Western Reserve University targets overactive neutrophils, a specific kind of white blood cell, to prevent almost all types of blood clots while causing no increased risk for bleeding. The preclinical findings, published in Science Translational Medicine, may lead to safer ways to care for patients impacted by blood clots. According to the Centers for Disease Control and Prevention (CDC), roughly 900,000 people in the U.S. suffer from life-threatening blood clots each year.

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The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include an investigation into the efficacy of dexamethasone for dyspnea relief, a combination therapy for hairy cell leukemia, an analysis of RAS mutations and their prognostic value in acute myeloid leukemia (AML), a possible new combination therapy for basal-like breast cancer, and swallowing exercises to improve the quality of life for patients with head and neck cancer undergoing radiotherapy.

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RUDN neurosurgeons have developed a method for more accurate diagnosis of vertebrobasilar insufficiency. This will help to take into account the individual characteristics of the patient and choose the right method of surgical intervention.

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Using live imaging and cellular barcoding, researchers in the Stem Cell Program at Boston Children’s Hospital have glimpsed how new stem cells — in this case, blood stem cells — are vetted for quality soon after they’re born.

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Dr. Eiring previously studied the proteins that contribute to disease progression and drug resistance in AML and identified that Hispanic patients from El Paso had higher incidence rates and worse overall survival compared to AML patients elsewhere in Texas. While many AML patients initially respond to therapy, the five-year survival rate is bleak. Less than 25% survive due to drug resistance and relapse.

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A national authority in hematology will soon lead Hematology and Hematological Malignancies at Huntsman Cancer Institute and University of Utah Health. Dr. Ramiro Garzon’s focus is patients with leukemia and researching the molecular mechanisms of these cancers. Garzon’s major focuses include developing new treatment for cancers that begin in blood forming tissue such as the bone marrow or in the cells of the immune system. He explains his research and clinical goals.

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The 2022 NCCN Annual Congress on Hematologic Malignancies™ (#NCCNhem22) is taking place Friday, October 14–Saturday, October 15, 2022 in New York City. All live sessions will also stream remotely through a virtual event platform.

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Australian researchers will use new technology to improve the diagnosis and treatment of blood cancers, which affect 1.24 million people globally, including 720,000 who die from leukemia, lymphoma or myeloma each year.

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St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.

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COVID-19 infection increases the risk of potentially life-threatening blood clots for at least 49 weeks, according to a new study of health records of 48 million unvaccinated adults from the first wave of the pandemic.

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When patients who are on a commonly prescribed blood thinner stop taking aspirin, their risk of bleeding complications drops significantly (more than 30%), a new study finds. Researchers say aspirin should only be taken under the direction of a physician to review if the expected benefit outweighs the risk.

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Conditions like asthma or COVID-19 make it harder for bodies to absorb oxygen from the lungs. In a proof-of-principle study, University of Washington and University of California San Diego researchers have shown that smartphones are capable of detecting blood oxygen saturation levels down to 70%. This is the lowest value that pulse oximeters should be able to measure, as recommended by the U.S. Food and Drug Administration.

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A genomic test being developed by a Charlottesville, Va., company can predict a patient’s risk of developing severe COVID-19, new research from UVA Health suggests.

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It isn’t a result of smoking, obesity or heredity. This vascular illness affects even young athletes, and it’s often misdiagnosed. Two Penn State Heart and Vascular Institute surgeons discuss thoracic outlet syndrome.

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Rutgers Cancer Institute expert shares evidence-based cancer information with this population and steps that can be taken now to prevent and reduce risk of disease.

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Bloodstream levels of a protein fragment called endotrophin can be used to predict outcomes in patients with a common form of heart failure, according to a study co-led by researchers at the Perelman School of Medicine at the University of Pennsylvania.