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Personalized Medicine

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Medicine

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Diagnostics, DNA, Genetics, Personalized Medicine

Personalized Medicine: U-M Forms New DNA Diagnostics Joint Venture

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As a key step toward providing patients with treatments based on their own DNA profiles, the University of Michigan and the International Genomics Consortium (IGC) have launched a new joint venture that will help usher in an age of personalized medicine.

Medicine

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Personalized Medicine, Genetic Breakthroughs, Health Care, Health & Medicine, technology and health care, Biomarkers & Prevention, Nonfiction, communicating science

Book Explores the Promise, Pitfalls of Personalized Medicine

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Personalized medicine has promised to radically change the way we look at health and disease. Talk of tailored drug therapies and early detection of cancer has captured the attention of scientists and lay people alike. So when will patients start to reap the benefits of this medical revolution? The transition to personalized medicine won’t be seamless or swift, says Lee Gutkind, who co-authored "An Immense New Power to Heal: The Promise of Personalized Medicine" (In Fact Books, May 2012) with novelist and science writer Pagan Kennedy.

Medicine

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estrogen receptor positive breast cancer, estrogen-lowering drugs, Advanced Breast Cancer, Aromatase Inhibitor Drugs, Genome Sequencing, Dna Sequencing, exome sequencing, cancer signatures

Decoding DNA Finds Breast Tumor Signatures That Predict Treatment Response

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Decoding the DNA of patients with advanced breast cancer has allowed scientists at Washington University School of Medicine in St. Louis to identify distinct cancer “signatures” that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment.

Medicine

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Parkinson's Disease, Parkinson, Biomarker, Biomarkers & Prevention, Israel, Silvia Mandel, Moussa Youdim, Neurodegenerative Disease, Neurodegenerative, Neurodegeneration

Researchers ID Cluster of Genes in Blood that Predict Parkinson's

Technion researchers have identified a biomarker shown to predict Parkinson's disease with high accuracy. It could ID at-risk individuals before symptoms develop, when prevention treatment efforts might have the greatest impact to slow disease progression.

Medicine

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Personalized Medicine, Health Care, Diagnostics, Prediction Models, Big Data

New Statistical Model Lets Patient’s Past Forecast Future Ailments

Analyzing medical records from thousands of patients, statisticians have devised a statistical model for predicting what other medical problems a patient might encounter.

Science

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AUF1, Cancer, Aging, Molecular Biology, Inflammation, Genetics

Key Gene Found Responsible for Chronic Inflammation, Accelerated Aging and Cancer

Researchers at NYU School of Medicine have, for the first time, identified a single gene that simultaneously controls inflammation, accelerated aging and cancer.

Science

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NGS, next generation sequencing, CPT, CPT Coding, AMA CPT, Molecular Diagnostics, Clinical Testing, NGS Technologies

AMP Developing a CPT® Coding Proposal for Next Generation Sequencing

The Association for Molecular Pathology (AMP) today announced that it is close to finalizing a framework proposal for CPT coding of Next Generation Sequencing (NGS) assays.

Medicine

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Cancer, Memorial Sloan-Kettering Cancer Center, Lung Cancer, Genetic Mutations, Targeted Cancer Therapies, Genetic Testing, Personalized Medicine

Testing for Mutations Identified in Squamous Cell Lung Cancer Tumors Helps Personalize Treatment

Researchers from Memorial Sloan-Kettering Cancer Center have begun testing for three new genetic targets and found that together they occur in approximately 50 percent of patients with squamous cell carcinomas of the lung, which affects 40,000 Americans each year. Initial findings of the research will be presented on June 4 at the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting.

Medicine

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patient app, mobile experience

Mayo Clinic Sets Industry Standard for Mobile Experience: Personal, Portable and Participatory

Mayo Clinic has created a comprehensive mobile health application; combining a custom mobile experience with unparalleled expertise and access. Empowering patients with information at their fingertips, this app sets a new standard for health care apps.

Medicine

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Personalized Medicine, Precision Medicine, Cancer Treatment, New Jersey, Trastuzumab, Genetic Profile, Cancer Diagnosis

Cancer Institute of New Jersey Aims to Advance Personalized Cancer Treatments Through ‘Precision Medicine’

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With recent advancements in technology and biomedical informatics, a more personalized approach to prescribing cancer treatment and developing these therapies is preferred over “one-size-fits-all” methods. The Cancer Institute of New Jersey has been on the cutting-edge of this movement and is now launching a more concrete effort that is poised to change the way that molecular and genetic information is being used to diagnose and treat cancer – an initiative known as “precision medicine” – also known to many as “personalized medicine.”

Medicine

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direct to consumer genetics tests, Genetic Testing, genetic testing kits

Patients See Benefits and Risks to Direct-to-Consumer Genetics Tests

Patients see potential benefits from direct-to-consumer genetic testing, but are also concerned about how test results will be used, and generally are unwilling to pay more than $10 or $20 for them.

Medicine

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FLT3, AML, Myeloid Leukemia, Acute Myeloid Leukemia, Gene Sequencing, Leukemia

Scientists Identify FLT3 Gene as a Valid Therapeutic Target in Acute Myeloid Leukemia

Through a groundbreaking new gene sequencing technology, researchers have demonstrated that the gene FLT3 is a valid therapeutic target in Acute Myeloid Leukemia, AML, one of the most common types of leukemia. The technique, developed by Pacific Biosciences, allows for the rapid and comprehensive detection of gene mutations in patients with AML. The findings, published online April 15 in Nature, are a result of collaboration among scientists at the University of California, San Francisco, Pacific Biosciences and Mount Sinai School of Medicine. The discovery may help lead to the development of new drugs to treat AML.

Medicine

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Genetic Variations, Fracture Risk, genes, Osteoperosis, Bone Disease, Bone-mineral Density, BMD, Bone Biology, Nature Genetics, Bone Health, Endocrinologist, Genetic Factors of Osteoporosis, GEFOS, Clinical Research, National Instituate of Health, Women's Health Initiative, health diagnostics, Human Skeletal Health

Genetic Variants May Predict Those at Greatest Fracture Risk

An international consortium of researchers have identified a group of genes associated with the development of osteoporosis, a debilitating bone disease that cripples more than 10 million Americans a year and costs the U.S. healthcare system an estimated $17 billion annually. The study identified 56 genes associated with bone-mineral density (BMD), the measurement used to diagnose osteoporosis.

Medicine

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patient advocacy, Precision Medicine, Personalized Medicine, Disease Map, New Taxonomy

UCSF Chancellor Issues Call-To-Arms to Patient Advocates

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In November 2011, a National Academy of Sciences committee issued a report calling for the creation of a “Google Maps”-like data network intended to revolutionize medical discovery, diagnosis and treatment. Today, the co-chair of that committee, UCSF Chancellor Susan Desmond-Hellmann, MD, MPH, is issuing a call-to-arms to patient advocates to help make that idea a reality.

Medicine

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Cancer, Genome, Genome Sequencing, Personalized Cancer Treatment, Breast Cancer, Leukemia

DNA Sequencing Lays Foundation for Personalized Cancer Treatment

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Scientists at Washington University School of Medicine in St. Louis are using powerful DNA sequencing technology not only to identify mutations at the root of a patient’s tumor – considered key to personalizing cancer treatment – but to map the genetic evolution of disease and monitor response to treatment.

Science

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Cancer Genomics, Cancer cell lines, Personalized Cancer Therapy, Cancer Cell Line Encyclopedia, Computational Biology, Drug Development

Writing the Book of Cancer Knowledge

Scientists have published the first results from the Cancer Cell Line Encyclopedia, a freely available resource that marries deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments.

Medicine

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Liposome, Micropatterning, Nanoparticle, Drug Delivery, Dip-pen nanolithography, Microarray, Lab On A Chip, Nanotechnology, Chemistry, High Throughput Screening, Cancer, Pharmaceutical

Researcher on Verge of Breakthrough in Drug Creation Process

A Florida State University researcher is developing technologies to miniaturize the first phase of a process used by pharmaceutical companies to discover new drugs. A breakthrough could ultimately lead to personalized and therefore more effective medical treatments, as well as major health care savings.

Medicine

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Personalized Medicine, Autoimmune Diseases, Immunology

“Personalized Immune” Mouse Offers New Tool for Studying Autoimmune Diseases Model May Allow Development of Individualized Immunotherapies Against Cancer and Infection

Columbia University Medical Center (CUMC) scientists have developed a way to recreate an individual’s immune system in a mouse. The “personalized immune mouse” offers researchers an unprecedented tool for individualized analysis of abnormalities that contribute to type 1 diabetes and other autoimmune diseases, starting at the onset of disease. The findings were published today in the online edition of Science Translational Medicine.

Medicine

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Dr. mary charlson, Integrative Medicine, self-affirmation, positive affect

Taking Moments to Enjoy Life Helps Patients Make Better Health Decisions

The experience of daily positive affect -- a mild, happy feeling -- and self-affirmation helps some patients with chronic diseases, including coronary artery disease, high blood pressure and asthma, make better decisions about their health. These findings are detailed in three studies of 756 patients published online in the Jan. 23 edition of the Archives of Internal Medicine -- the first large, randomized controlled trials to show that people can use positive affect and self-affirmation to help them make and sustain behavior change.

Medicine

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Diabetes, Type 2 Diabetes, Personalized Medicine, Public Health, Obesity

Why Personalized Medicine Holds Promise for Preventing and Treating Diabetes

To address the prospects for personalized medicine in diabetes, investigators from Albert Einstein College of Medicine have surveyed the field for existing research and published their findings in the January issue of Health Affairs. The authors are Allen M. Spiegel, M.D., the Marilyn and Stanley M. Katz Dean and former director of the National Institute of Diabetes and Digestive and Kidney Diseases at the NIH, and Meredith Hawkins, M.D., director of Einstein’s Global Diabetes Initiative.







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