A research volunteer with multiple sclerosis and another who had suffered stroke walked significantly better and faster with the aid of neural stimulation systems, potentially laying the foundation for implanted systems that restore some independence to people in these populations.
Chemists from Italy and Canada specializing in nanotechnology create a molecular
slingshot that could shoot drugs at precise locations in the human body once triggered by specific disease markers.
Some people who use so-called synthetic marijuana, known by names such as K2 and Spice, may be unable to metabolize the drug, leading them to experience its most harmful effects, a UAMS researcher said today at a national scientific meeting in Chicago.
New research from the National Institutes of Health found that pairing the antidepressant amitriptyline with drugs designed to treat central nervous system diseases, enhances drug delivery to the brain by inhibiting the blood-brain barrier in rats. The blood-brain barrier serves as a natural, protective boundary, preventing most drugs from entering the brain. The research, performed in rats, appeared online April 27 in the Journal of Cerebral Blood Flow and Metabolism.
Small trial uses chloroquine to nix the process of "autophagy" that some cancer cells use to resist treatment, resensitzing glioblastoma to targeted therapy
Cancer expert Antonio Giordano, MD, PhD, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, describes the recent progress and future possibilities of treating SCLC.
A team of engineers from Washington University in St. Louis has combined nanoparticles, aerosol science and locusts in new proof-of-concept research that could someday vastly improve drug delivery to the brain, making it as simple as a sniff.
Ryan’s Quest, Michael’s Cause and Pietro’s Fight are non-profits founded by families of boys with Duchenne muscular dystrophy who believe that their global collaboration is paramount to see potential therapies through the drug pipeline.
UAB physicians say prevention, not cure, may be the key to coping with the rising incidence of Alzheimer's disease. New imaging techniques, coupled with a better understanding of the disease, provide new hope.
Researchers published in Nature Medicine from the George Washington University, the University of Perugia, and the University of Rome have discovered a potential new drug to treat and stop the progression of cystic fibrosis. Thymosin α1 is a novel therapeutic single molecule-based therapy that not only corrects genetic and tissue defects, but also significantly reduces inflammation seen in cystic fibrosis patients.
A new study published in Nature provides clues that could enhance physicians’ ability to pinpoint, in real-time, which patients are not responding to therapy – and intervene with additional drugs to boost the chances of shrinking tumors.
The researchers report that low-dose penicillin taken late in pregnancy and in early life of mice offspring, changes behaviour and the balance of microbes in the gut. While these studies have been performed in mice, they point to popular increasing concerns about the long-term effects of antibiotics.
A natural, or bioidentical, combined estradiol-progesterone capsule (TX-001HR) significantly decreases the frequency and severity of moderate to severe hot flashes in postmenopausal women, the Replenish study finds. Results of this phase 3, randomized, placebo-controlled, multicenter trial will be presented Monday at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Fla.
Johns Hopkins researchers say that the findings they published in the current edition of The American Journal of Gastroenterology could have important implications for the field of personalized medicine.
Chemists have designed triple-threat cancer-fighting polymer capsules for guided drug delivery. They combine three traits: good imaging contrast with low-power ultrasound, stable packaging of the cancer drug doxorubicin, and ability to trigger drug release with low- or higher-power ultrasound.
Scientists from the Fred Hutchinson Cancer Research Center in Seattle are scheduled to present and discuss the latest developments in immunotherapy and proteomics at the American Association for Cancer Research Annual Meeting, Research Propelling Cancer Prevention and Cures, on April 1-5. What follows is a selection of the more than 30 Hutch presentations at the AACR gathering
Researchers at Baylor Scott & White Research Institute identified a new genetic biomarker for colon cancer that may lead to development of more targeted treatment of the disease
Collaborative study with Cleveland Clinic & SUNY Upstate Medical University shows that single high-dose SBRT treatment is as effective as three doses in patients with non-small cell lung cancer
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new drug delivery method that produces strong results in treating cancers in animal models, including some hard-to-treat solid and liquid tumors.
Proteins shake their bodies and wave their limbs — essentially dancing — all with the goal of optimizing their interaction with other molecules, including other proteins. A new study shows that, in biological courtship, dance moves matter. The findings help to lay a foundation for the development of drugs targeting molecular vibrations. Such pharmaceuticals would block proteins from carrying out tasks that contribute to disease.
In response to rising concern that many published scientific results may be false, the Reproducibility Project: Cancer Biology set out to replicate findings from the 50 most cited cancer studies from 2010–2012. A perspective in AACC’s Clinical Chemistry journal discusses the project’s preliminary results and suggests changes the research community can make to prevent reproducibility issues from inhibiting cancer care.
The patient ingests a capsule containing two miniature cameras on either end. As the capsule travels through the digestive tract, it captures images and wirelessly transmits them to a recorder the patient wears on a belt.
More than 87,000 chemicals are available commercially in the U.S., including analogues of bisphenol A (BPA), an industrial chemical that is used in consumer products. Frederick vom Saal, a University of Missouri endocrinologist and researcher, has studied BPA and other chemicals and their effects on humans and animals for more than 20 years. Now, vom Saal has released Integrative Environmental Medicine, a comprehensive book outlining practical resources and tools, such as websites and smartphone apps, to help health care practitioners promote healthier choices for themselves and their patients.
The press program for next week’s 2017 Multidisciplinary Thoracic Cancers Symposium features research advances in lung cancer including immunotherapy, proton therapy and liquid biopsy, among others.
A new intervention developed by Bar-Ilan University scientists to tamper with parasites' communication system may lead to the development of drugs to treat, and prevent the spread of, devastating diseases such as African sleeping sickness, leishmaniasis and Chagas' disease.
Mayo Clinic researchers have found that an experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma. The findings are published in Nature Medicine.
A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.
A preliminary study suggests that a new, wireless patch that you wear on your arm may help reduce migraine pain as well as drugs. The study is published in the March 1, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A new treatment for tuberculosis (TB) is set to be developed using compounds derived from bacteria that live in soil - according an international collaboration of researchers, including the University of Warwick.
Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego are running a Diabetes Intensive Medical Management (DIMM) “tune up” clinic for complex type 2 diabetes patients. In a study published in the March 2017 issue of the Journal of Managed Care & Specialty Pharmacy, the researchers report the clinic’s economic benefits, which include an estimated cost avoidance of $5,287 per DIMM clinic patient over three years.
Cedars-Sinai investigators are gearing up to study the most effective ways for doctors to discuss opioid use with chronic pain patients in an effort to reduce the impact of pain while curbing overuse of these addictive drugs. The research team has received $2 million from the Patient-Centered Outcomes Research Institute to conduct the study, which will launch in 2017.
Researchers have discovered unique amyloid fibers used by the highly drug resistant Staphylococcus aureus bacterium (which causes MRSA). The findings could lead to new types of antibiotics with a novel mechanism of action for attacking bacterial toxins.
/PRNewswire/ -- Science Exchange and Eurofins are excited to announce that Eurofins Central Laboratory is now a service provider listed on the Science Exchange marketplace for outsourced research services. This means that pharmaceutical and biotech companies around the world now have faster access to Eurofins's Clinical Testing portfolio, as well as its end-to-end analytical testing solutions from Drug Discovery to Product Testing.
Matthew Might, Ph.D., a renowned computer scientist and strategic leader appointed to the White House Precision Medicine Initiative by former President Barack Obama, has been named the inaugural director of the Hugh Kaul Personalized Medicine Institute at UAB.
Researchers at SUNY Downstate recently discovered that an inhibitory brain receptor triggers synaptic pruning in adolescence. Drugs that selectively target these receptors, when administered during adolescence, can alter synapse number, with possible implications for the treatment of autism and schizophrenia.
Only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.
In two recent studies, researchers at UC Davis have shown that placental tissue can provide critical information about the epigenetic landscape that influences fetal development.
Sandra Horning, MD, Chief Medical Officer and executive vice president of global development for Roche and Genentech, a member of the Roche Group, has been named the 2017 recipient of the Duane Roth Memorial Award, which will be presented February 16 at the annual Industry/Academia Translational Oncology Symposium at UC San Diego Moores Cancer Center.
People suffering from back pain should consider first trying chiropractic services and other non-drug therapies in light of a new research review that found common over-the-counter and prescription pain medications have limited effectiveness for back pain and raise the risk of side-effects, according to the American Chiropractic Association (ACA).
Though marijuana edibles are becoming increasingly common, scant information exists on how to test drivers for impairment following their consumption. For the first time, research published today in AACC’s Clinical Chemistry journal evaluates the performance of roadside saliva tests for tetrahydrocannabinol (THC) following consumption of edibles, showing that lower THC cutoff points are needed for these tests to effectively detect marijuana ingestion.
A team from The University of Texas MD Anderson Cancer Center describes this week in the journal Nature a series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models that point to potential treatments for patients with a rapidly-progressing and resistant subgroup of tumor cells.
“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.
Eric Prossnitz, PhD and his team uncovered new details of the aging process. They discovered an altered balance between certain signaling molecules in the smooth muscle cells of blood vessels and the heart. The team also discovered a new class of drugs that combats an important part of the aging process.
After 10 years of research, a team at Université de Montréal's research centre has succeeded in deleting the Armc5 gene in experimental mice, discovering that its loss gives rise to a heretofore unidentified syndrome.
A research team from the Virginia Tech Center for Drug Discovery has received a $431,126 two-year grant from the National Institutes of Health to make improved versions of a promising compound called MMV008138, or 8138 for short.