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Cutting the Ties That Bind

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The development of a new organism from the joining of two single cells is a carefully orchestrated endeavor. But even before sperm meets egg, an equally elaborate set of choreographed steps must occur to ensure successful sexual reproduction. Those steps, known as reproductive cell division or meiosis, split the original number of chromosomes in half so that offspring will inherit half their genetic material from one parent and half from the other.

Medicine

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Cancer, TCGA, Cancer Genome, Cancer Genomics, Thyroid Cancer, Cancer Genes, BRAF, Ras mutations

Thyroid Cancer Genome Analysis Finds Markers of Aggressive Tumors

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A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas Research Network has identified markers of aggressive tumors, which could allow for better targeting of appropriate treatments to individual patients.

Medicine

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Mitochondria, Mitochondrial Disease, heteroplasmy, Mitochondrial Dna, Genetics, Douglas C. Wallace, Center for Mitochondrial and Epigenomic Medicine, Neurodegenerative Diseases

Steadily Rising Increases in Mitochondrial DNA Mutations Cause Abrupt Shifts in Disease

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New work by a pioneering scientist details how subtle changes in mitochondrial function may cause a broad range of common metabolic and degenerative diseases.

Science

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Silencing the Speech Gene FOXP2 Causes Breast Cancer Cells to Metastasize

A research team led by investigators at Beth Israel Deaconess Medical Center has identified an unexpected link between a transcription factor known to regulate speech and language development and metastatic colonization of breast cancer.

Medicine

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Heart, Heart Attack, Genetics, Family History, Cardiology, Heart Research, intermountain healthcare, intermountain medical center

New Study Finds Heart Attacks Do Not Have as Strong of a Genetic Link As Previously Suspected

Heart attacks are not as connected to family history and genetics as may have been previously believed, according to a new study by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City.

Medicine

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Obese, Inhibitors, anti-obesity, FTO gene, FTO protein

NUS-Led Research Team Develops Novel Solutions to Fight the Obesity Gene

A research team led by scientists from the National University of Singapore (NUS) has identified several potent inhibitors that selectively target FTO, the common fat mass and obesity-associated gene.

Medicine

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rare genetic disorders, Dna Sequencing, Genome, Exome, Parents, Children, Pediatrics, prenatal testing

New Test Scans All Genes Simultaneously to Identify Single Mutation Causing Child’s Rare Genetic Disease

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A JAMA study found that sequencing the DNA of children with mystery genetic disorders produced a definitive diagnosis in 40 percent of UCLA’s most complex cases--a quantum leap from the field’s 5-percent success rate 20 years ago.

Medicine

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Mount Sinai Health System

Genetic Defect Links Rare Infections to Autoimmune Diseases

A team led by researchers at The Rockefeller University and the Icahn School of Medicine at Mount Sinai has explained the function of key immune protein and solved an international medical mystery, according to a letter published this week in the journal Nature.

Medicine

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Mayo Clinic, Duygu Selcen, Genetic Testing, Muscular Dystrophy

New Guideline in Genetic Testing for Certain Types of Muscular Dystrophy

Rochester, Minn. – The American Academy of Neurology (AAN) and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) offer a new guideline on how to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy. The guideline is published in the October 14, 2014, print issue of Neurology®, the medical journal of the AAN.

Science

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DNA, Replication, Genetics, Biology, Cell and Molecular Biology, Cancer

Key Moment Mapped in Assembly of DNA-Splitting Molecular Machine

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Scientists reveal crucial steps and surprising structures in the genesis of the enzyme that divides the DNA double helix during cell replication







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