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Lou Gehrig's Disease, Genetics, ALS, SNP, Shuanglin Zhang

Mathematicians Identify Genes Linked to Lou Gehrig's Disease

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Their discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure. It can’t come any too soon. Lead researcher Shuanglin Zhang started showing symptoms of the disease himself four years ago.

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Genetics, Disparities, Health, Racial

Socio-cultural, Genetic Data Work Together to Reveal Health Disparities

How society sees people in terms of race might play a greater role than genetics when it comes to health disparities between different groups. The study by University of Florida researchers is the first to rigorously combine both socio-cultural and genetic data to simultaneously test the relative contributions of each to racial inequalities in health.

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Cystic Fibrosis, Cirrhosis Of The Liver, Cirrhosis, Liver Disease

Gene Variant Heightens Risk of Severe Liver Disease in Cystic Fibrosis

A UNC study, which appears in the Sept. 9 issue of the Journal of the American Medical Association (JAMA), could lead to earlier detection and diagnosis of cystic fibrosis liver disease and better treatment options for the patients affected by the disease.

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Alzheimer's Disease, Genetics, Genetics

Researchers Find Two More Genetic Risk Factors for Alzheimer's Disease

An international team of scientists has identified two more genetic risk factors for Alzheimer's disease. The group, led by investigators from the School of Medicine at Cardiff in the United Kingdom and including scientists from Washington University School of Medicine in St. Louis, completed the largest genome-wide association study ever involving patients with Alzheimer's disease. The study pooled DNA samples from more than 19,000 older European and U.S. residents. Seven thousand had Alzheimer's disease, and the others had no clinical symptoms of the disorder.

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Biology, Cell Biology, Mental Retardation, Dyslexia, Autism, Neurodevelopmental Disorders, Genetics

Researchers Identify Critical Gene for Brain Development, Mental Retardation

Researchers at the University of North Carolina at Chapel Hill School of Medicine have now discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia.

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Researchers Find Gene That Protects High-fat-diet Mice from Obesity

University of Michigan researchers have identified a gene that acts as a master switch to control obesity in mice. When the switch is turned off, even high-fat-diet mice remain thin.

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Parkinson’s disease

Researchers Find Gene That Contributes to Two Different and Common Neurological Movement Disorders

Researchers at the Mayo Clinic campus in Florida and their collaborators worldwide have discovered that a single gene promotes development of essential tremor in some patients and Parkinson’s disease in others. These are two common but distinct neurological disorders. Notably, patients with essential tremor shake when they move, and Parkinson’s disease patients shake when they are at rest.

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DNA, Cancer, Computer Software, Tumor, Mutation

Computational Process Zeroes in on Top Genetic Cancer Suspects

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Johns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer.

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Researchers Identify Protein–telomere Interactions That Could be Key in Treating Cancer, Other Diseases

A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres—a process that can protect aging cells and destabilize tumor cells—manipulating its expression may be useful in treating cancer and other diseases.

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Genetics, Gene Therapy, Parkinson's Disease, Neurological Diseases, Adeno Associated Virus, HIV, Cancer

Scientists Construct ‘Off Switch’ for Parkinson Therapy

Addressing safety concerns related to potential gene therapies for Parkinson's disease, UF McKnight Brain Institute researchers have tested a gene transfer therapy in rats that can be inhibited with a common antibiotic.

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NIH Awards Researcher $11.2 Million to Study Genome Instability as a Cause of Aging

The National Institutes of Health (NIH) has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $11.2 million grant to study the impact of damage to DNA on aging and disease.

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dog genetics, human diseases, dog coats fur

Why Obama's Dog Has Curly Hair

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University of Utah researchers used data from Portuguese water dogs – the breed of President Barack Obama’s dog Bo – to help find a gene that gives some dogs curly hair and others long, wavy hair.

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Scientists Identify Gene for Resistance to Parasitic 'Witchweed'

Scientists at the University of Virginia have identified a gene in cowpea (black-eyed pea) that confers resistance to attack from witchweed, a parasitic plant. This discovery will help researchers better understand how some plants can resist Striga, while others, such as corn and sorghum, are susceptible.

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Gene Variant Is 'Major Genetic Determinant of Psoriasis'

A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected.

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Genetic Variation Associated With Poorer Response, Cardiovascular Outcomes With Use of Clopidogrel

Patients with a certain genetic variation who received the antiplatelet drug clopidogrel had a decreased platelet response to treatment and among those who had percutaneous coronary intervention (procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) had an increased risk of having a cardiovascular event in the following year than patients who did not have this variant, according to a study in the August 26 issue of JAMA.

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Gene Therapy, Eureka, Nih Grant, Gene Silencing

Idaho Researchers Win Grant To Explore DNA Frontier

Three Idaho researchers are recipients of the National Science Foundation's EUREKA Award and the youngest participants in the program's history. They will explore new approaches to gene therapies by using locked nucleic acids or LNAs as invaders to target specific sections of chromosomes.

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Genetics, Computer, Computer Science, DNA, Privacy

Protecting Privacy in DNA Research

Dr. Eran Halperin of the International Computer Science Institute (ICSI) and Tel Aviv University, and colleagues at the University of California, Berkeley have developed software that protects the privacy of individuals in genome association studies.

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Researchers Find Target for Pulmonary Fibrosis

Researchers at the University of Michigan have discovered that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans.

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Gene Discovery Reveals Protein's Function in Hearing

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Discovery of a deafness-causing gene defect in mice has helped identify a protein that protects sensory cells in the ear. The mutated gene fails to produce normal claudin-9 protein, which normally maintains the proper distribution of potassium in the inner ear. Researchers are screening for the gene in people.

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Lesch Nyhan Disease, Parkinson Disease, Gene Thearpy, Stem Cells

Housekeeping Gene Study Impacts Lesch Nyhan & Parkinson's

A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain.







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