A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing
CAR-T therapy, a form of immunotherapy that revs up T-cells to recognize and destroy cancer cells, has revolutionized the treatment of blood cancers, including certain leukemias, lymphomas, and most recently, multiple myeloma. However, Black and Hispanic people were largely absent from the major clinical trials that led to the U.S. Food and Drug Administration approval of CAR-T cell therapies.
New research from NUI Galway and Boston University has identified a blood biomarker that could help identify people with the earliest signs of dementia, even before the onset of symptoms.
oswell Park Comprehensive Cancer Center specialists will share the latest advances and developments in the treatment of blood-related cancers at the 2022 Tandem Transplantation & Cellular Therapy Meetings of American Society for Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplant Research (CIBMTR) in Salt Lake City, Utah, from April 23 to 26.
Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Ira Braunschweig, MD, as chief, Section of Transplant and Cell Therapy at Rutgers Cancer Institute, chief of the Transplant and Cell Therapy Service of the RWJBarnabas Health Oncology Service Line, and director for Cell Therapy and Bone Marrow Transplantation at Robert Wood Johnson University Hospital, an RWJBarnabas facility.
Drug may safely boost platelet levels in patients with immune thrombocytopenia.
Actors from two popular medical TV dramas have joined efforts with the American College of Surgeons (ACS) to spread lifesaving STOP THE BLEED® information to the people of Ukraine through a new Public Service Announcement (PSA) released today.
去年早些时候，Veronica Ciudad-Real被诊断出患有多发性骨髓瘤，一种她从未听说过的血癌，这让她感到非常惊讶和困惑。她才40岁，比该疾病的大多数患者都要年轻。随后她又了解到，在她的祖国萨尔瓦多无法获得她所需的治疗。
عندما تم تشخيص فيرونيكا سيوداد ريال في أوائل العام الماضي بالورم النقوي المتعدد، وهو سرطان دم لم تسمع به من قبل، كان لديها أسئلة بلا إجابات. لقد كانت في الأربعين من عمرها، أي أصغر من معظم المصابين بالمرض.
Quando Veronica Ciudad-Real foi diagnosticada no começo do ano passado com mieloma múltiplo, um câncer do sangue do qual ela nunca tinha ouvido falar, ela teve mais perguntas do que respostas. Aos 40 anos, ela era mais jovem do que a maioria das pessoas com essa doença.
Cuando Verónica Ciudad-Real recibió a principios del año el diagnóstico de mieloma múltiple, cáncer de la sangre del cual ella nunca había escuchado hablar, tuvo muchas preguntas y pocas respuestas. A sus 40 años, era más joven que la mayoría de las personas que sufren de esta enfermedad.
Preventing the formation of a sticky, web-like substance that can form in blood vessels after a stroke could protect the brain and lead to better outcomes for patients, studies in mice suggest. The research was reported in the Journal of Clinical Investigation and led by scientists at University of Utah Health.
SEATTLE — April 6, 2022 — Below are summaries of recent Fred Hutchinson Cancer Research Center research findings and other news. If you’re covering the American Association of Cancer Research’s annual meeting, April 8-13, see our list of Fred Hutch highlights for AACR and contact [email protected] for help setting up interviews with experts.
Most immunocompromised people with a blood cancer called multiple myeloma benefited from a third dose of COVID-19 vaccines, a promising sign after it was shown that two doses tended to not be sufficient for them. However, some people with multiple myeloma still remained vulnerable and may need a fourth dose or antibody treatments as restrictions lift and new variants emerge, according to a fast-tracked study in Cancer Cell.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found that one of the subtypes can be used as a drug target for inflammatory diseases.
The Gairdner Foundation has announced that Stuart H. Orkin, MD, is one of the 2022 Canada Gairdner Award laureates for seminal discoveries and contributions to biomedical science.
A new type of anti-clotting drug caused fewer bleeding incidents among patients with atrial fibrillation than the commonly prescribed apixaban, according to results from a head-to-head comparison of the two.
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The drug tested, tranexamic acid (TXA), was given to patients at risk of bleeding or vascular complications. The study found that TXA did not increase deep vein clotting known as VTE, heart attack, non-hemorrhagic stroke, or other major vascular complication in the 30 days after surgery. In the study, half of 9,535 patients in 22 countries were randomly assigned TXA, half placebo. Patients were 45 years or older (average age 69 years); 44% of them were female.
A comprehensive look at all of the active clinical trials on new CRISPR-based genome editing therapies in 2022, and perspective on what is coming next.
In a new study from Vanderbilt University Medical Center, 10-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.
The researchers, who hope to continue developing the app, were undaunted by its lackluster performance. “That just means we need to work more on the app and try to improve it,” Collins says. “We’re working on another app that will be more sophisticated and will be compatible with Android and Mac iOS.”
The American College of Surgeons (ACS) STOP THE BLEED® Program is supporting efforts to help people in Ukraine learn the basics of the STOP THE BLEED® course.
Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet. Researchers at Penn Medicine have discovered that CAR-T cells directed to a tumor antigen, CDH17, a cell surface marker expressed on both NETs and GICs but also found on healthy tissues, eliminated GICs in several preclinical models without toxicity to normal tissues in multiple mouse organs, including the small intestine and colon. The results from this study, the first to target CDH17 in neuroendocrine tumors, suggest a new class of tumor associated antigens accessible to CAR-T cells in tumors but sequestered from CAR-T cells in healthy tissues.
A new study led by researchers at University of Utah Health details a novel mechanism that infectious bacteria use to quickly adjust to environmental stress. The discovery could help explain why certain types of common infections—such as urinary tract and bloodstream infections like sepsis—are hard to get rid of.
UCSF’s Division of Hematology-Oncology is welcoming Krishna Komanduri, MD, as division chief of Hematology-Oncology at UCSF Health. Komanduri is an international leader in the fields of hematology-oncology, transplantation, and cellular immunotherapy. He will start at UCSF on July 1.
Antiphospholipid syndrome (APS) is rare in children and known to cause inflammation and recurring, potentially fatal, blood clots. Researchers found that two-thirds of children with the autoimmune disease experienced additional symptoms not formally associated with APS, including low platelet counts, hemolytic anemia and livedo reticularis, a rash indicating abnormal blood flow to the skin. Investigators say the findings underscore the importance of creating pediatric-specific criteria for the diagnosis of APS.
The use of medications and exercise is more beneficial in preventing a second stroke in people with intracranial atherosclerosis than placing a stent in the blood vessel, according to a new practice advisory issued by the American Academy of Neurology (AAN). The practice advisory is published in the March 21, 2022, online issue of Neurology®, the medical journal of the AAN, and is endorsed by the American Heart Association/American Stroke Association, Neurocritical Care Society and Society of Vascular and Interventional Neurology.
Evidence-based clinical guidelines on the management of patients on common anticoagulant and antiplatelet therapies during gastrointestinal (GI) bleeding or undergoing elective endoscopy have been published jointly by the American College of Gastroenterology (ACG) and the Canadian Association of Gastroenterology (CAG).
New genetic research from UniSA shows that up to 19 per cent of childhood AML cases are linked to rare genetic changes that may be inherited through family blood lines.
New research from Mayo Clinic's Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia — an uncommon type of cancer of the bone marrow — have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia.
Scientists at Yale Cancer Center have discovered new consequences of specific gene mutations that play a role in the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
Stroke can have many causes. An atherothrombotic stroke is caused by a clot that forms from plaques that build up within blood vessels in the brain. A new study suggests that people who have this type of stroke who also have higher levels of triglycerides, a type of fat, in their blood may have a higher risk of having another stroke or other cardiovascular problems one year later, compared to people who had a stroke but have lower triglyceride levels. The research is published in the March 16, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study found an association even when people were taking statin drugs meant to lower triglycerides and protect against heart attack and stroke.
Iowa State University scientists are examining a genetic pathway triggered when cells undergo inflammation due to injury or infection that also plays an important role in the development of blood stem cells. The research could lead to the ability to treat blood diseases by regenerating a patient’s blood cells.
Blocking the protein UBE2N with novel small molecule kills AML cells, according to study in Science Translational Medicine.
McMaster researchers have been able to re-engineer red blood cells and use them as a promising new vehicle for vaccine delivery.
Adding the proteasome inhibitor bortezomib to chemotherapy significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma (T-LL), according to a Children’s Oncology Group (COG) study led by researchers at Children’s Hospital of Philadelphia (CHOP). This international phase 3 clinical trial also found that radiation could be eliminated in 90% of children with T-cell acute lymphoblastic leukemia (T-ALL) when the chemotherapy regimen was intensified.
Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and—when dysregulated by mutation—the emergence of blood cancers known as myeloproliferative neoplasms.
Don't miss these articles in our Staff Picks channel
The American College of Rheumatology (ACR), in partnership with the Vasculitis Foundation (VF), released a new guideline for the management of Kawasaki disease that addresses diagnostic issues relating to the disease, the treatment of high-risk patients, & the management of convalescent patients.
Black and Hispanic people with acute myeloid leukemia in greater Chicago were more likely to die from the disease than their non-Hispanic white counterparts, with a 59% and 25% greater risk, respectively, according to a new study led by University of Illinois Chicago researchers.
The Vasculitis Foundation (VF) is pleased to announce an exciting new initiative: Vasculitis-Building Outcomes, Leading Discoveries (V-BOLD), which combines three of the VF’s most critical programs: Fellowships, Vasculitis Centers, and Research.
An international team of scientists has found new biomarkers that can be used for diagnostic purposes and potentially as predictive tools of the risks associated with deep space flight.
Doing less exercise could deactivate a vital protein in the body, causing further inactivity and making exercise more difficult, new research suggests.
Chicago residents and visitors now have access to lifesaving STOP THE BLEED® kits as the city expands its Safe Chicago initiative.
Dr. Masi Shah of Rutgers Cancer Institute in partnership with RWJBarnabas Heath shares about Multiple Myeloma, a life changing disease with treatments to help control the disease.
Announcement of contents of the March 2022 issue of Neurosurgical Focus: Video
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