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Medicine

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Transplant, Medicine, Cells, Cell Biology, Biology, Immunology, Pharmacy, Surgery

When Rejection Comes From Within

new cellular structure responsible for previously unexplained rejection of organ transplants has been identified by researchers at the University of Montreal Hospital Research Centre (CRCHUM.) This discovery could one day revolutionize transplantation practice by modifying risk assessment of rejection in people who receive heart, lung, kidney, or liver transplants

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Species, Evolution, Biology

Study Finds People Transformed How Species Associated After 300 Million Years

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A study published today finds a surprising and very recent shift away from the steady relationship among species that prevailed for more than 300 million years. The study, published in the journal Nature, offers the first long-term view of how species associated with each other for half of the existence of multicellular life on Earth.

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Stem Cell Transplantation Does Not Provide Significant Improvement for Crohn Disease

Among adults with difficult to treat Crohn disease not amenable to surgery, hematopoietic stem cell transplantation, compared with conventional therapy, did not result in significant improvement in sustained disease remission at l year and was associated with significant toxicity, according to a study in the December 15 issue of JAMA.

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FAU Researchers Find New Mechanism Cells Use to Eat Each Other Before Becoming Toxic

In much the same way PAC-MAN gobbles through an intense maze of dots eating and destroying its aggressors, researchers have revealed for the first time how a similar mechanism in the eye lens does exactly the same thing. They have discovered that cells in close proximity to each other can sense when a cell is dying due to environmental stressors like UV light, smoke and other pollutants, and eat the cell before it becomes toxic.

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Beta Cells, Type 1 Diabetes, Diabetes, Insulin Resistance, T

Liver Protein Boosts Growth of Insulin-Producing Cells

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Now researchers at Joslin Diabetes Center have identified a key protein produced in the liver that aids in accelerating the growth of these cells.

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Multiple Sclerosis (MS), Brian Popko, University Of Chicago, Oligodendrocyte, Neurology

Brain Cell Death Is a Possible Trigger of Multiple Sclerosis

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Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model. This can be prevented through the application of specially developed nanoparticles, even after the loss of those brain cells.

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University of Arkanas for Medical Sciences, Nature, Senescent cells, Nature Medicine, cellular senescence, Radiation, Oxidative Stress, ABT-263, Daohong Zhou, University of Arkansas for Medical Sciences College of Pharmacy, UAMS College of Pharmacy, UAMS, Division of Radiation Health, Aging, Pharmacological, Bone Marrow, Irradiation

‘Toxic’ Cells Thought to Drive the Late Effects of Radiation and Diseases of Aging Can Be Cleared with a Drug

Researchers from the University of Arkansas for Medical Sciences (UAMS) and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells.

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Brain Cancer Self-Organizes into Streams, Swirls, and Spheres

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Brain cancer is not cellular anarchy, says Pedro Lowenstein and colleagues at the University of Michigan and University of Arizona, but highly organized—self-organized. At ASCB 2015, the researchers report that glioma cells build tumors by self-organizing into streams,10-20 cells wide, that obey a mathematically predicted pattern for autonomous agents flowing together. These streams drag along slower gliomas, may block entry of immune cells, and swirl around a central axis containing glioma stem cells that feed the tumor’s growth.

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Amoebas Reveals How Human Airway Cells Rally Against Cigarette Smoke Damage

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Chronic obstructive pulmonary disease (COPD )is the third leading cause of death in the US and cigarette smoking is the leading cause of COPD. Currently there is no cure, current treatments are largely palliative, and new treatment targets are scarce. Now Corrine Kliment and colleagues in Doug Robinson’s lab at Johns Hopkins University have found two new targets for blocking cigarette smoke-induced COPD in a surprising place—amoebas. Kliment presents the work at ASCB 2015.

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ASCB Celldance 2015 Premieres—Now Is the Golden Age of Cell Imaging

Driven by accelerating advances in super-resolution imaging, fluorescent tagging, and Big Data manipulation, we’re living in the Golden Age of Cell Movies. ASCB’s Celldance Studios today releases three new exciting examples of short (4-6 minute) videos, made by cell scientists themselves who tell their own cell research stories, featuring eye-popping live cell imaging.







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