The University of Chicago is one of three Illinois academic institutions that will work together to help launch President Obama’s Precision Medicine Initiative (PMI) Cohort Program to enroll 1 million or more participants in a national research effort designed to find better ways to prevent and treat disease based on lifestyle, environment and genetics.
Acupressure helped reduce persistent fatigue in women who had been treated for breast cancer, a new study finds.
A standard engineering project took on a deeper meaning when Wichita State engineering and physical therapy students watched 3-year-old Jocelyn McNeese drive around in a toy car they modified for her special needs.
On May 26, the National Institutes of Health (NIH) awarded Mayo Clinic $142 million over five years to serve as home for the 1-million-person Precision Medicine Initiative® (PMI) biobank.
Johns Hopkins University engineering students working to develop a better suit to protect health care workers in Ebola outbreaks have developed prototypes for a more comfortable hood and face mask that make breathing easier, and for a battery-powered system that curbs humidity in the suit.
VentureMed Group, Ltd., a medical device company based in northwest Ohio, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for the commercial distribution of a new surgical device for treating peripheral artery disease (PAD). It’s called the FLEX Scoring Catheter® and was developed by ProMedica Vascular Surgeon John Pigott, MD, as an alternative to balloon-based scoring with a one-size-fits-all platform technology.
A natural molecule shows benefit in a preliminary clinical trial for Parkinson’s Disease
Yesterday the American Medical Association’s House of Delegates approved a resolution introduced by the American College of Surgeons and other medical societies to train more professional first responders (i.e., police and firefighters) and civilians as immediate responders in the essential techniques of bleeding control and to place bleeding control kits (containing tourniquets, pressure bandages, hemostatic dressings, and gloves) with first responders.
Gary H. Lyman, MD, MPH, an internationally recognized oncologist and health economist at Fred Hutchinson Cancer Research Center and a member of a committee of the National Academies of Sciences, Engineering, and Medicine (NASEM), is available to discuss biomarker tests for molecularly targeted therapies. Earlier this month he co-authored a New England Journal of Medicine “Perspective” article summarizing the recommendations for biomarker tests, considered “the key to unlocking precision medicine.” These biomarker tests are very important as more and more tests become available to consumers, and both physicians and patients need to be sure the test they are taking is useful and of value specifically to them.
In the midst of an epidemic of prescription painkiller addiction and overdose deaths, a new Johns Hopkins Bloomberg School of Public Health survey suggests that more than half of patients prescribed opioids have leftover pills – and many save them to use later.
In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants.
A team of researchers from the National University of Singapore have found a way to make personalized medicine cheaper and easier - they have designed a new method of tablet fabrication that can make customizable pills that release drugs with any desired release profiles.
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Depressed Moms Not ‘in Sync’ with Their Kids, Children with ADHD Sleep Both Poorly and Less, Yeast Infection Linked to Mental Illness, and more in the Mental Health News Source
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Researchers at University of California San Diego School of Medicine have demonstrated that distinct types of glioblastoma, the most common form of brain cancer in adults, tend to develop in different regions of the brain. This finding provides an explanation for how the same cancer-causing mutation can give rise to different types of brain malignancies.
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Precision medicine’s public face is that of disease — and better treatments for that disease through targeted therapies. But precision medicine has an unsung partner that could affect the lives of many more people: Precision prevention — a reflection of the growing realization that preventing cancer and other diseases may not be one-size-fits-all.
Dr. Sunil Hingorani, a member of the Clinical Research and Public Health Sciences divisions at Fred Hutchinson Cancer Research Center, will present recent groundbreaking developments in treating pancreas cancer with engineered T-cells at the American Association for Cancer Research Annual Meeting 2016 in New Orleans on April 16.
The most common immune disorder, common variable immunodeficiency disorder (CVID), is notoriously difficult to diagnose early, before serious complications develop. Genetic analysis of six families from across the U.S. and Europe has revealed that mutations in IKAROS, known for its central role in immune cell development, define a new class of CVID. Published in the New England Journal of Medicine, the results open the door to personalized health care tailored to patients with this disorder.
In the journal Cell Reports, UNC Lineberger researchers reported they found markedly low levels of the protein NLRX1 in multiple laboratory models of colorectal cancer, and in samples of human tissue. Studies have shown that the protein is known to be involved in regulating immune system signals in order to prevent hyperactive inflammatory responses by the immune system, but UNC Lineberger researchers believe their finding also points to a role for the protein in preventing colorectal cancer growth. Based on their findings, they believe they’ve identified a potential treatment for colorectal cancer with low NLRX1.
The State of Cancer Care in America: 2016 report, to be released on March 15 by the American Society of Clinical Oncology (ASCO), chronicles the current realities of the cancer care delivery system in the United States and examines trends in the oncology workforce and practice environment that are affecting patient care and access.
Kejin Hu, Ph.D., has found a robust reprogramming factor that increases the efficiency of creating human induced pluripotent stem cells (HiPSCs) from skin fibroblasts more than 20-fold, speeds the reprogramming time by several days and enhances the quality of reprogramming.
Atherosclerosis, a disease in which plaque builds up inside arteries, is a prolific and invisible killer, but it may soon lose its ability to hide in the body. Scientists have developed a nanoparticle that mimics high-density lipoprotein. It can simultaneously light up and treat atherosclerotic plaques that clog arteries, which could someday help prevent heart attacks and strokes. The researchers present their findings at the 251st National Meeting & Exposition of the American Chemical Society.
Get the latest news on heart disease, the leading cause of death for people of most ethnicities in the U.S., in the Newswise Heart Disease news source.
Understanding and integrating patients’ cultural beliefs into cancer treatment plans may help improve their acceptance of and adherence to treatment in multicultural settings. Researchers examined traditional Maya healers’ understanding of cancer and published their findings online today in the Journal of Global Oncology.
By utilizing a revolutionary method that allows mice to serve as “avatars” for patients, scientists at The Wistar Institute have shown that a previously ineffective targeted drug for melanoma may actually be quite potent in halting the progression of disease in certain patients.
NYU Langone Medical Center announced today the successful completion of the most extensive face transplant to date, setting new standards of care in this emerging field. Equally important, for the first time a face transplant has been performed on a first responder – a volunteer firefighter who suffered a full face and scalp burn in the line of duty.
Principal Investigator Takes Questions and Demonstrates Procedure with Video and Animation via Virtual Press Conference Tuesday, November 10th at 1:00 p.m. ET
A team of scientists, led by researchers at University of California, San Diego Moores Cancer Center and The University of Texas MD Anderson Cancer Center, report that a genetic biomarker called loss of heterozygosity or LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The findings, published in the November 5, 2015 online issue of Journal of the American Medical Association Oncology, present a new tool that could be used to identify patients most likely to benefit from chemoprevention — and may be applicable to preventing other types of cancer.
A 20-month-old girl suffering from a rare neurodegenerative disease was diagnosed by exome sequencing and successfully treated. The case, which exemplifies the potential of precision medicine, involved scientists at Columbia University Medical Center (CUMC) and Duke University.
Researchers at Baylor Research Institute have identified a small RNA molecule that appears to enable certain colorectal cancers to become especially aggressive, resistant to treatment and likely to migrate and invade normal tissue. Findings suggest that detecting high levels of the molecule could serve as a “biomarker” to help clinicians determine which patients might benefit from more aggressive therapy.
How is individualized medicine working? Let us count the ways.
Each of your kidneys wears a little yellow cap that helps keep blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high. Why this happens is still a mystery. But new findings could help figure out what's going on.
A new technology, improving the efficiency of the studies in epigenomics, is the subject of a Nature Methods journal article by Chang Lu and Zhenning Cao of Virginia Tech and Kai Tan, Changya Chen and Bing He of the University of Iowa. The research was funded by the National Institutes of Health, following a seed grant from Virginia Tech’s Institute for Critical Technology and Applied Science.
Patient satisfaction ratings after surgery for spinal degenerative disease—especially in terms of reduced pain and disability—are a good indicator of the procedure's effectiveness, reports a study in the August issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer.
After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at UC San Francisco.
Researchers at the University of Adelaide have discovered a new method for culturing stem cells which sees the highly therapeutic cells grow faster and stronger.
In the first study of its kind, researchers have shown how an anti-diabetic drug can have variable effects depending on small natural differences in DNA sequence between individuals. They aim to apply this knowledge to develop personalized approaches to treating diabetes and other metabolic disorders.
In a study published in Nature Medicine, UNC Lineberger Comprehensive Cancer Center researchers report their findings of just how a certain tumor-suppressing protein helps prevent colon cancer. With this discovery, researchers believe they’ve found a possible drug target for colon cancer patients who lack the tumor suppressor.
Metastatic colorectal cancer patients tend to live longer when they respond to the first line of chemotherapy their doctors recommend. To better predict how patients will respond to chemotherapy drugs before they begin treatment, researchers at University of California, San Diego School of Medicine conducted a proof-of-principle study with a small group of metastatic colorectal cancer patients. The results revealed two genes that could help physicians make more informed treatment decisions for patients with this disease.
Research will help inform the transition of healthcare to “precision medicine”, where individuals and physicians will routinely obtain and apply genomic information
A new report from UAB demonstrates that clinical and genetic factors affecting dose requirements for warfarin vary by race. The study, published online today in Blood, proposes race-specific equations to help clinicians better calculate warfarin dosage.
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