Feature Channels: Digestive Disorders

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Released: 15-Apr-2020 11:00 AM EDT
Ludwig MSK Study Reveals Bile Metabolite of Gut Microbes Boosts Immune Cells
Ludwig Cancer Research

A Ludwig Cancer Research study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells—immune cells that suppress autoimmune reactions and inflammation.

Released: 13-Apr-2020 6:05 PM EDT
$6M, 5-year NIH grant extends funding for collaborative Cleveland Digestive Diseases Research Core Center
Case Western Reserve University

A new $6 million, 5-year grant from the National Institutes of Health extends funding for the Silvio O. Conte Cleveland Digestive Diseases Research Core Center (DDRCC), a cross-institutional collaboration of digestive disease investigators.

Released: 9-Apr-2020 2:20 PM EDT
Researchers Reveal Important Genetic Mechanism Behind Inflammatory Bowel Disease
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target.

Released: 9-Apr-2020 1:05 PM EDT
Identical Mice, Different Gut Bacteria, Different Levels of Cancer
Michigan Medicine - University of Michigan

Some types of gut bacteria are better than others at stimulating certain immune cells, specifically CD8+ T cells. And while these CD8+ T cells normally help protect the body against cancer, overstimulating them may promote inflammation and exhaust the T cells — which can actually increase susceptibility to cancer, according to new mouse model study published in Cell Reports.

3-Apr-2020 1:50 PM EDT
Pancreatic cancer blocked by disrupting cellular pH balance
Sanford Burnham Prebys

Scientists at Sanford Burnham Prebys have found a new way to kill pancreatic cancer cells by disrupting their pH equilibrium. The study, published in Cancer Discovery, reports how depleting an ion transport protein lowers the pH to a point that compromises pancreatic cancer cell growth.

Released: 31-Mar-2020 4:10 PM EDT
Infants Introduced Early to Solid Foods Show Gut Bacteria Changes that May Portend Future Health Risks
Johns Hopkins Bloomberg School of Public Health

Infants who were started on solid foods at or before three months of age showed changes in the levels of gut bacteria and bacterial byproducts, called short-chain fatty acids, measured in their stool samples, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

Released: 31-Mar-2020 12:55 PM EDT
Digestive Symptoms Present in Mild COVID-19 Disease, Sometimes Without Fever
American Journal of Gastroenterology

A new study published in pre-print by The American Journal of Gastroenterology is the first analysis of gastrointestinal symptoms reported by COVID-19 patients with mild disease rather than those with moderate or critical illness and finds a unique sub-group with low severity disease marked by presence of digestive symptoms, most notably diarrhea. The authors from Union Hospital and Tongji Medical College in Wuhan, China report that among some of the patients included in the study, these digestive symptoms, particularly diarrhea, were the presentation of COVID-19, and were only later, or never, present with respiratory symptoms or fever.

Released: 30-Mar-2020 1:05 PM EDT
Crowdsourcing app aims to fill gaps in coronavirus data
Cornell University

A recent Cornell Tech alumnus is applying his health tech skills to a crowdsourcing app that allows users to share their COVID status, to better inform individuals and health authorities.

   
Released: 26-Mar-2020 1:25 PM EDT
Mount Sinai Researchers Unveil Mechanisms to Prevent Crohn’s Disease and First Study Linking Metals Exposure w/ IBD
Mount Sinai Health System

In a series of four studies published today in Gastroenterology, a journal of the American Gastroenterological Association, Mount Sinai inflammatory bowel disease (IBD) researchers, describe the identification of predictive tools and a new understanding of environmental factors that trigger IBD.

Released: 25-Mar-2020 9:55 AM EDT
Diet, Nutrition Have Profound Effects on Gut Microbiome
George Washington University

A new literature review from scientists at George Washington University and the National Institute of Standards and Technology suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Released: 19-Mar-2020 11:25 AM EDT
New COVID-19 info for gastroenterologists and patients
American Gastroenterological Association (AGA)

A paper published today in Clinical Gastroenterology and Hepatology by clinicians at Icahn School of Medicine at Mount Sinai outlines key information gastroenterologists and patients with chronic digestive conditions need to know about COVID-19, or coronavirus.

Released: 9-Mar-2020 9:00 AM EDT
March 2020 Issue of The American Journal of Gastroenterology Includes Complementary & Alternative Therapies for Functional GI Disorders
American College of Gastroenterology (ACG)

The March issue of The American Journal of Gastroenterology features evidence-based articles related to complementary and alternative medicine therapies for functional GI disorders, a new ACG Clinical Guideline for the diagnosis and management of Chronic Pancreatitis, opioid-related constipation, and more.

Released: 7-Mar-2020 8:50 AM EST
GI symptoms and potential fecal transmission in coronavirus patients
American Gastroenterological Association (AGA)

The world is bracing for the impact of the novel coronavirus, COVID-19, which has now spread to over 30 countries, infecting more than 80,000 people with over 2,600 deaths globally.

Released: 5-Mar-2020 1:10 PM EST
Better sleep? Prebiotics could help
University of Colorado Boulder

Dietary compounds called prebiotics, which are found in fibrous foods such as artichokes, onions, leeks and some whole grains, improve sleep and boost stress resilience, according to a new study

Released: 5-Mar-2020 8:05 AM EST
Colorectal Cancer Q&A: The Truth about Screening, Prevention, and More
Nuvance Health

A colonoscopy is the best way to screen for and prevent colorectal cancer (CRC) because it allows your doctor to find and remove precancerous growths called polyps before they have a chance to turn into cancer. The U.S. Preventive Services Task Force (USPSTF) recommends that most people have colonoscopy screenings starting at age 50. People who are at a higher risk for CRC due to family history or other factors should begin having screenings at a younger age based on their doctor’s recommendation.

Released: 3-Mar-2020 3:20 PM EST
March Is Colorectal Cancer Awareness Month: 5 Things You Should Know
Loyola Medicine

Colorectal cancer screening is highly effective in detecting and preventing colon and rectal cancers, the third leading cause of cancer death among men and women in the U.S., according to the U.S. Centers for Disease Control and Prevention (CDC). And yet, one-third of Americans, ages 50 and older, have not been screened.

Released: 3-Mar-2020 11:35 AM EST
Radiation therapy for colon cancer works better when specific protein blocked
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.

24-Feb-2020 4:50 PM EST
CHOP Researchers Develop Novel Approach to Capture Hard-to-View Portion of Colon in 3-D for the First Time
Children's Hospital of Philadelphia

In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon – in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited clinical information.

   
Released: 26-Feb-2020 11:05 AM EST
Potential New Heartburn Drug Studied at VUMC
Vanderbilt University Medical Center

An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests.

26-Feb-2020 10:00 AM EST
New bile discovery will rewrite textbooks
Michigan State University

Forget what you know about bile because that's about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature. Much of our knowledge about bile hasn’t changed in many decades. It’s produced in the liver, stored in our gall bladder and injected into our intestine when we eat, where it breaks down fats in our gut.

   
Released: 20-Feb-2020 3:55 PM EST
Gut Feelings
University of California, Irvine

The long, winding river that is the human digestive tract is prone to all manner of diseases, from the merely irritable to the decidedly deadly. All fall under the purview of the H.H. Chao Comprehensive Digestive Disease Center, an internationally lauded assemblage of doctors, pooled knowledge and technology devoted to gastrointestinal health gathered under one roof at the UCI Medical Center campus, in Orange.

19-Feb-2020 3:45 PM EST
A case of reverse development: Dana-Farber scientists solve long-debated puzzle of how the intestine heals itself
Dana-Farber Cancer Institute

Scientists find that normal intestinal cells “de-differentiate” en masse into stem cells that generate the cells needed for a healthy intestinal lining. New study establishes de-differentiation as the predominant mode of stem cell recover in the intestine

Released: 13-Feb-2020 3:35 PM EST
Loyola Medicine Study Explores Hypnotherapy for Gastrointestinal Issues
Loyola Medicine

Loyola Medicine is among the first to conduct a clinical study using hypnotherapy to treat functional dyspepsia, a gastrointestinal disorder affecting approximately 10 percent of the population.

11-Feb-2020 12:50 PM EST
New mouse model for celiac disease to speed research on treatments
University of Chicago Medical Center

Researchers at the University of Chicago have developed the first truly accurate mouse model of celiac disease. The animals have the same genetic and immune system characteristics as humans who develop celiac after eating gluten. This provides a vital research tool for developing and testing new treatments for the disease.

7-Feb-2020 1:50 PM EST
Human Gut-in-a-Dish Model Helps Define ‘Leaky Gut,’ and Outline a Pathway to Treatment
UC San Diego Health

UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin.

Released: 3-Feb-2020 8:05 AM EST
Diseases of the Colon and Rectum Journal February 2020 Video Abstracts and Editor Picks
Diseases of the Colon and Rectum Journal

Diseases of the Colon and Rectum Journal February 2020 Video Abstracts and Editor Picks

Released: 31-Jan-2020 1:05 PM EST
Diseases of the Colon and Rectum Journal January 2020 Video Abstracts and Editor Picks
Diseases of the Colon and Rectum Journal

Diseases of the Colon and Rectum Journal January 2020 Video Abstracts and Editor Picks

Released: 27-Jan-2020 8:45 AM EST
With High Fiber Diets, More Protein May Mean More Bloating
Johns Hopkins Bloomberg School of Public Health

People who eat high fiber diets are more likely to experience bloating if their high fiber diet is protein-rich as compared to carbohydrate-rich, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

Released: 27-Jan-2020 5:40 AM EST
Algae Shown to Improve Gastrointestinal Health
University of California San Diego

UC San Diego scientists have completed the first study in humans demonstrating that a common algae improves gastrointestinal issues related to irritable bowel syndrome. The green, single-celled organism called Chlamydomonas reinhardtii was found to help with diarrhea, gas and bloating.

Released: 23-Jan-2020 1:45 PM EST
Liver Fibrosis 'Off Switch' Discovered in Mice
UC San Diego Health

UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.

Released: 22-Jan-2020 11:00 AM EST
Johns Hopkins Researchers: Climate Change Threatens to Unlock New Microbes and Increase Heat-Related Illness and Death
Johns Hopkins Medicine

The Journal of Clinical Investigation (JCI) recently published “Viewpoint” articles by Johns Hopkins University School of Medicine professors who warn that global climate change is likely to unlock dangerous new microbes, as well as threaten humans’ ability to regulate body temperature.

   
20-Jan-2020 9:00 AM EST
Gut Bacteria May be One Culprit for Increase of Colorectal Cancer in Younger People
Lombardi Comprehensive Cancer Center at Georgetown University

A bacteria typically linked to periodontal disease, Fusobacterium nucleatum (F. nuc), could play an important role in the rising incidence of colorectal cancer in people under the age of 45. Another type of bacteria, Moraxella osloensis, has been found in colorectal cancer tumors at a nearly four-fold higher rate in people over 75 than in those under 45 years of age, pointing out how differences in the bacteria that comprise what is known as the body’s microbiome could affect cancer outcomes to varying degrees. These are the preliminary findings of an ongoing study that will be presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium in San Francisco from January 23-25, 2020.

Released: 17-Jan-2020 4:55 PM EST
Scurvy is still a thing in Canada
McMaster University

McMaster University researchers surveyed the data of patients of Hamilton’s two hospital systems over nine years and found 52 with low Vitamin C levels. This included 13 patients who could be diagnosed as having scurvy, and an additional 39 who tested positive for scurvy but did not have documented symptoms. Among those with scurvy, some were related to alcohol use disorder or to bariatric surgery but the majority were related to other causes of malnutrition such as persistent vomiting, purposeful dietary restrictions, mental illness, social isolation and dependence on others for food.

Released: 17-Jan-2020 10:25 AM EST
Acid reflux drugs may have negative side effects for breast cancer survivors
Ohio State University

Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors’ memory and concentration.

Released: 16-Jan-2020 1:55 PM EST
John Theurer Cancer Center Participating in Early-Phase Study of Immunotherapy-Boosting Treatment
Hackensack Meridian Health

Investigators at John Theurer Cancer Center at Hackensack University Medical Center in New Jersey are participating in a first-in-patients clinical trial assessing VE800, a novel bacteria-containing therapy, in combination with the immunotherapy drug nivolumab. Laboratory research has suggested that VE800 may enhance the effectiveness of drugs like nivolumab.

13-Jan-2020 12:00 PM EST
More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows
Health Sciences at the University of Pittsburgh

A study involving tens of thousands of bariatric surgery patients found that gastric bypass patients were significantly more likely than gastric sleeve patients to end up back in the hospital in the years following surgery.

Released: 9-Jan-2020 2:25 PM EST
New Closed-Loop System Offers Promise as Novel Treatment for Post-Bariatric Hypoglycemia
Joslin Diabetes Center

Post-bariatric hypoglycemia is a profoundly life-altering condition for patients. Having unpredictable hypoglycemia that people can't detect is really an unsafe situation. Researchers at Joslin Diabetes Center and Harvard John A. Paulson School of Engineering and Applied Sciences have developed a closed-loop system that automatically provides patients with an appropriate, as-needed dose of liquid glucagon to treat this condition.

Released: 9-Jan-2020 8:05 AM EST
University of Colorado Cancer Center named National Pancreas Foundation Center of Excellence
University of Colorado Cancer Center

Due in part to advanced surgical techniques, more effective medicines, and a multidisciplinary approach to treating the disease, University of Colorado Cancer Center is able to operate on 30+ percent of pancreatic cancer patients, nearly double the national average.

Released: 8-Jan-2020 3:30 PM EST
Persistence of gut microbial strains in twins, living apart after cohabitating for decades
University of Alabama at Birmingham

Using a genomics strain-tracking bioinformatics tool, analyzed two metagenomic sequencing databases from pairs of twins — one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years.

Released: 8-Jan-2020 2:45 PM EST
Could pancreatitis be a stress hormone deficiency?
UT Southwestern Medical Center

UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.

Released: 7-Jan-2020 2:15 PM EST
Shedding light on pancreatic neuroendocrine tumors
University of Chicago Medical Center

The University of Chicago Medicine's Xavier Keutgen, MD, one of the few surgeons in the country with advanced expertise in extensive removal of neuroendocrine tumors, talks about this rare disease.

Released: 7-Jan-2020 1:45 PM EST
Mayo Clinic研究发现,许多较年轻的胃癌患者有独特的疾病特征
Mayo Clinic

Mayo Clinic的一项新研究发现,许多60岁以下的胃癌患者的疾病“在基因和临床上均具有独特性”。该研究发现,与年长患者所患有的胃癌相比,这种新的早发性胃癌,其生长和扩散速度通常更快,预后更差,并且对传统化疗的耐药性更高。该研究最近发表于《外科手术》(Surgery)期刊。



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