A new review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions.
Nearly 1 percent of high school seniors report using Flakka, a highly potent and potentially dangerous synthetic drug, according to a study by researchers at NYU School of Medicine, the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health, and Columbia University Mailman School of Public Health.
Only a small fraction of people who had non-fatal opioid overdoses in West Virginia received treatment in the aftermath, a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests. The finding, the authors say, represents a missed opportunity to prevent future fatal overdoses in a state that leads the nation in these deaths.
A novel “Enhanced Recovery After Surgery” (ERAS) protocol developed by Penn Medicine for patients undergoing spinal and peripheral nerve surgery significantly reduced opioid use. The new study published in the Journal of Neurosurgery: Spine showed that when an ERAS protocol was employed fewer patients needed pain medications one month after surgery.
A study published today in the American Journal of Public Health estimates that 1,857 people injected drugs in the last six months in Cabell County, W.Va., a rural county with a population of 94,958. This estimate is based on an innovative survey technique that public health officials can now use in their own rural communities to address the opioid epidemic.
Researchers identified the brain circuits that form memories associating environmental cues with cocaine use and used optogenetics to specifically target those memories and reduce relapse-like behavior.
Recap of program featuring biotech startups building platforms in the fight against the opioid crisis.
Media advisory: To contact corresponding study author Scott E. Hadland, M.D., M.P.H., M.S., email Jenny Eriksen at [email protected]. The full study, invited commentary and a summary podcast are linked to this news release and a visual abstract is below.
New research from NYU School of Medicine and Boston Medical Center published online January 18 in JAMA Network Open shows that increased marketing of opioid products to physicians -- from consulting fees to free meals -- is associated with higher opioid prescribing rates and elevated overdose deaths in the U.S.
Opioid drugs prescribed to children for pain relief after a typical pediatric orthopaedic procedure may be significantly overprescribed, according to a new study by researchers at Children’s Hospital of Philadelphia. The patients used less than 25 percent of the drugs, suggesting a potential risk of opioid diversion.
A study finds a surprising response to cocaine in a novel strain of mutant mice – they failed to show hyperactivity seen in normal mice when given cocaine and didn’t run around. In other tests, they still found cocaine appealing, but displayed an inability to shake the memory of cocaine’s actions when the drug was no longer administered. The key change that blocks cocaine’s stimulant effects in these mice is serotonin, not dopamine, which is responsible for producing a high.
Despite the mounting death toll of America’s opioid crisis, only a minority of facilities that treat substance use disorders offer patients buprenorphine, naltrexone or methadone—the three FDA-approved medications for the long-term management of opioid use disorder, according to a new study from researchers at the Johns Hopkins Bloomberg School of Public Health.
English patients living in poorer areas are likely to be prescribed more opioids by their GPs, according to a study led by the University of Manchester and University of Nottingham researchers. The research also shows how smoking, obesity and depression are all associated with more prescribing of the drugs for problems such as lower back pain and arthritis.
A recent celebrity suicide and another celebrity's drug overdose point to differences in the way that toll-free helplines are publicized when such major news stories occur.
Researchers know that lesbian, gay and bisexual individuals are more likely than heterosexuals to use alcohol, tobacco or other drugs, but until now they didn't know to what degree.
Pain and substance use interact in a vicious cycle that can ultimately worsen and maintain both chronic pain and addiction, according to a research team including faculty at Binghamton University, State University of New York.
The increase in opioid prescriptions for people over the past decade may have been paralleled by an increase in opioid prescriptions for pets, according to a study from researchers at the University of Pennsylvania’s Perelman School of Medicine and the School of Veterinary Medicine. The findings, in this first-ever study of veterinary opioid prescriptions, suggest that there is also an increased demand for veterinary opioids, driven by complex procedures performed in veterinary medicine, as well as a heightened awareness of the importance of pain management. Given that opioid prescribing in veterinary medicine is not as heavily regulated as medical prescriptions for humans, it is possible that misused veterinary prescriptions could contribute to the ongoing opioid epidemic. The results are published today in JAMA Network Open.
UW researchers have developed a smartphone app that uses sonar to monitor someone's breathing rate and sense when an opioid overdose has occurred.
Suicides and drug overdoses kill American adults at twice the rate today as they did just 17 years ago, and opioids are a key contributor to that rise, according to a new review and analysis. Reversing this deadly double trend will take investment in programs that have been proven to prevent and treat opioid addiction, the researchers say.
Embargoed research covered by CBS News
McMaster University researchers reviewed 96 clinical trials with more than 26,000 participants and found opioids provide only small improvements in pain, physical functioning and sleep quality compared to a placebo.
The introduction of plain tobacco packaging led to an increase in the price of leading products, according to new research from the University of Stirling.
Vanderbilt researchers have published findings indicating that regardless of whether a woman delivers a child by cesarean section or by vaginal birth, if they fill prescriptions for opioid pain medications early in the postpartum period, they are at increased risk of developing persistent opioid use.
States do not regulate the potency of recreational cannabis, even though THC levels have increased significantly. Now new research shows higher average potency cannabis at first use increases the risk for the first symptom of cannabis use disorder.
The number of hospitalizations and surgeries to treat drug-associated infective endocarditis have both increased more than tenfold in North Carolina, according to doctors at the University of North Carolina School of Medicine who published their research in the Annals of Internal Medicine.
While friends or family members may feel helpless if someone they know suffers from addiction, one UAB physician says hope can start at home.
Oregon State University College of Engineering researchers are developing novel lab-on-a-chip biosensors for testing food quality and safety as well as illicit drug use.
Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug –- now in its earliest stages -– that can treat certain types of chronic pain without the addictive consequences of opioids.
Bethesda, MD, December 4, 2018 – Human organoids are being hailed as a major development in biomedicine in a report issued by the American Society for Cell Biology (ASCB) to be released Monday, Dec. 10 at a session at the 2018 ASCB|EMBO Meeting in San Diego, CA.
Pain after surgery can be effectively managed with minimal or no opioids, according to research conducted at Roswell Park Comprehensive Cancer Center and published today in JAMA Network Open. A two-year study by a multidisciplinary team of surgeons and other cancer specialists shows that the amount of opioid medications prescribed after surgery can be drastically reduced without negatively affecting pain scores, postoperative complications or patient requests for additional
Vitamin C may reduce the harm done to lungs in infants born to mothers who smoke during their pregnancy, according to a randomized, controlled trial published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
Providing supervised access to medical-grade heroin to people whose use continues after trying multiple traditional treatments has been successful in other countries, and should be piloted and studied in the United States, according to a new RAND Corporation study.
Several presentations at the 2018 Society for Risk Analysis (SRA) Annual Meeting will explore novel approaches to monitoring real-time drug use in town and cities nationwide.
Fentanyl, a powerful synthetic opioid implicated in nearly 29,000 overdose deaths in the United States last year, most likely spread because of heroin and prescription pill shortages, and also because it was cheaper for drug wholesalers than heroin, according to a report on illicit US drug markets by researchers at UC San Francisco.
A Sandia National Laboratories employee started a Family and Friends of Addicts Support Group to give the workforce a place to talk where others "get it."
New study shows low use of telehealth services for substance use disorder. More than 20 million Americans have substance use disorders related to alcohol, opioids and other drugs. Less than one in five receive treatment for substance use disorder, in part because of lack of providers, especially in rural areas. Telehealth—which allows clinicians to evaluate and treat patients via video conferencing—could help fill this unmet need, but increasing use must overcome regulatory barriers and target rural areas.
Nursing and pharmacy researchers hope to find a replacement for prednisone with fewer and less-severe side effects.
New research from Cornell University suggests graphic warning labels on cigarette ads have the same anti-smoking effect as similar warning labels on cigarette packs.
Chicago adults identified drug abuse, obesity, and child abuse and neglect as the top three big health problems for children and adolescents in the city, according to results from a new survey developed by Ann & Robert H. Lurie Children’s Hospital of Chicago and the Chicago Department of Public Health (CDPH).
Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.
Opioid use in Mexico has been low, but national and international factors are converging and a threat of increased drug and addiction rates exists. Many of these factors may have originated in the U.S., making this a potential joint U.S.-Mexico epidemic.
Among pregnant women , amphetamine-affected births (mostly attributed to methamphetamine) doubled .
The Coriell Institute for Medical Research, Cooper University Health Care and Cooper Medical School of Rowan University (CMSRU) are launching the Camden Opioid Research Initiative (CORI), a first-of-its-kind undertaking to investigate the genetic and biological factors that contribute to the development of opioid use disorder (also referred to as opioid dependence or addiction). Opioid overdoses continue to climb in New Jersey and nationally and the opioid addiction epidemic is one of the most urgent public health concerns of our time. This year is the deadliest year of this epidemic in the Garden State.
Additional speakers are being announced today for the inaugural Bloomberg American Health Summit, which will be held November 29 and 30 at the Fairmont Hotel in Washington, D.C.
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