Using a genomics strain-tracking bioinformatics tool, analyzed two metagenomic sequencing databases from pairs of twins — one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years.
UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.
The University of Chicago Medicine's Xavier Keutgen, MD, one of the few surgeons in the country with advanced expertise in extensive removal of neuroendocrine tumors, talks about this rare disease.
Mayo Clinic的一项新研究发现，许多60岁以下的胃癌患者的疾病“在基因和临床上均具有独特性”。该研究发现，与年长患者所患有的胃癌相比，这种新的早发性胃癌，其生长和扩散速度通常更快，预后更差，并且对传统化疗的耐药性更高。该研究最近发表于《外科手术》(Surgery)期刊。
A review article from the George Washington University highlights the correlation between highly processed foods and increased prevalence of obesity in the United States.
Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and inflammation? The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.
Viele Menschen unter 60 Jahren, die an Magenkrebs erkranken, weisen eine genetisch und klinisch besondere Form der Krankheit auf, wie neue Forschungsergebnisse von Mayo Clinic belegen.
De nombreuses personnes de moins de 60 ans, qui développent un cancer de l’estomac souffrent d'une maladie « génétiquement et cliniquement distincte », selon les nouvelles découvertes de recherches menées par la Mayo Clinic.
Uma nova pesquisa feita pela Mayo Clinic descobriu que várias pessoas com menos de 60 anos que desenvolvem câncer de estômago têm uma doença diferenciada do ponto de vista “genético e clínico”. O estudo descobriu que, em comparação ao câncer de estômago em adultos mais velhos, essa forma mais nova e de início precoce frequentemente cresce e se espalha mais rapidamente, tem um prognóstico pior e é mais resistente aos tratamentos quimioterápicos tradicionais.
هناك العديد من الأشخاص تحت سن 60 عامًا ممن أُصيبوا بمرض سرطان المعدة لديهم "مرض ملحوظ وراثيًا وسريريًا،" كما اكتشف بحث كانت Mayo Clinic قد أعدته. وغالبًا ما ينمو هذا الشكل الجديد والمُبكر من ظهور المرض وينتشر بسرعة أكبر مقارنة بسرطان المعدة لدى البالغين الأكبر سنًا، كما أنه ينطوي على تنبؤات أسوأ بخصوص سير المرض ويكون أكثر مقاومة لطرق العلاج التقليدية بالمعالجة الكيميائية، حسبما وجدت الدراسة. وتجدر الإشارة إلى أن البحث نُشر مؤخرًا في مجلة الجراحة.
Scientists studied how the bacteria transport electrons across their cell wall. The bacteria use a method that’s different from other, known electricity-producing bacteria. They also found that hundreds of other bacterial species use this same process.
Muchas personas menores de 60 años con cáncer de estómago tienen una enfermedad “diferenciada genética y clínicamente”, descubrió un nuevo estudio de Mayo Clinic. Comparado con el cáncer de estómago en adultos de más edad, este nuevo tipo de aparición temprana suele desarrollarse y diseminarse con mayor rapidez, tiene peor pronóstico y es más resistente a la quimioterapia tradicional.
Many people under 60 who develop stomach cancer have a "genetically and clinically distinct" disease, new Mayo Clinic research has discovered. Compared to stomach cancer in older adults, this new, early onset form often grows and spreads more quickly, has a worse prognosis, and is more resistant to traditional chemotherapy treatments.
if you’re traveling over the river and through the woods for the holiday, here are tips from Ritu Verma, MD, medical director of the University of Chicago Medicine Celiac Disease Center, to help keep your child who is living with celiac disease healthy and in the holiday spirit.
Gastroesophageal reflux disease (GERD), a digestive disorder that causes hearburn and other uncomfortable symptoms, may affect nearly a third of U.S. adults each week, and most of those who take certain popular medications for it still have symptoms, according to a new Cedars-Sinai study.
Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it can drive cell proliferation. Inhibiting this transport step could block the growth of most colorectal cancers caused by elevated βcatenin levels.
Researchers from Queen’s University Belfast have questioned the World Health Organisation’s blanket classification of processed meat as carcinogenic after finding significant evidence gaps between processed meat treated with nitrites and nitrite-free processed meat.
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).
Munmun Chattopadhyay, Ph.D., M.Sc., an assistant professor at Texas Tech University Health Sciences Center El Paso’s Graduate School of Biomedical Sciences, has been awarded a $100,429 grant from the Edward N. and Margaret G. Marsh Foundation for her research project, “Gastroparesis, a Mysterious Stomach Disorder and its Prevalence in Women.”
Edith Cowan University researchers have found that a chronic disease affecting up to 80 per cent of overweight people may be causing an iron deficiency that simply leaves them too tired to get off the couch.
Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.
Study in mice shows the nervous system not only detects the presence of Salmonella in the gut but actively stops the organism from infecting the body Nerves in the gut prevent Salmonella infection by shutting the cellular gates that allow bacteria to invade the intestine and spread beyond it As a second line of defense, gut neurons help avert Salmonella invasion by maintaining the levels of key protective microbes in the gut Findings reveal prominent role for nervous system in infection protection and regulation of immunity
The International Society of Gastrointestinal Oncology (ISGIO), a not-for-profit global educational organization committed to GI oncology, announces that Weijing Sun, MD, FACP, has been elected the society’s next leader.
Research from doctors at The Ohio State University Wexner Medical Center finds a new “virtual biopsy” allows them to definitively diagnose cysts in the pancreas with unprecedented accuracy. This means they can eliminate precancerous cysts and potentially save lives.
University of Utah Health scientists say they have detected new genetic clues about hibernation that could lead to better understanding and treatment of obesity and metabolic disorders that afflict millions of people worldwide.
The highly contagious norovirus causes diarrhea and vomiting and is notorious for spreading rapidly through densely populated spaces, such as cruise ships, nursing homes, schools and day care centers. There are no treatments for this intestinal virus. A new study led by scientists at Washington University School of Medicine in St. Louis has shown that gut microbes can tamp down or boost the severity of norovirus infection based on where along the intestine the virus takes hold.
Experts from the University of Chicago Medicine Center for Esophageal Diseases share their tips on how to celebrate Thanksgiving without feeling the sting of acid reflux.
Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study. The study, published in the journal Gastroenterology, describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.
Every day, more than 1200 people worldwide are told they have pancreatic cancer. Within 12 months, 80 per cent of them will have succumbed to the disease.
A UC Davis study found that Lactobacillus plantarum bacteria rapidly repaired damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus. It linked chronically inflamed leaky gut to the loss of PPARα signaling and damage to mitochondria.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)–approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.
Heliobacter pylori infection, quite common around the world, is linked to gastric cancer. Now, a Penn study shows that successfully wiping out the infection lowers the cancer risk.
A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero. These findings are being presented this week at the 2019 ACR/ARP Annual Meeting (Abstract #1901).
Proton Pump Inhibitors (PPIs) — such as Prilosec, Protonix and Nexium, have long been one of the most prescribed medications in the country to aid in the reduction of stomach acid. f
A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.
Pancreatitis causes more than 360,000 hospitalizations each year. Sajan Nagpal, MD, a medical pancreatologist at the University of Chicago Medicine, answers common questions about this painful condition.
New information published by scientists at Wake Forest Baptist Health suggests that gut bacteria and its interactions with immune cells and metabolic organs, including fat tissue, play a key role in childhood obesity.
November is national Pancreatic Cancer Awareness month. This year alone, more than 56,000 Americans will be diagnosed with pancreatic cancer. Pancreatic tumors are particularly aggressive and hard to treat "due to a mutational profile that makes it resistant to therapies that work better for other tumor types," explains Angela Alistar, MD, medical director of GI oncology at Morristown Medical Center. Dr. Alistar, an internationally known expert on pancreatic cancer, is now enrolling patients in five clinical trials aimed at pancreatic cancer.
Cleveland Clinic has successfully performed the Midwest’s first purely laparoscopic living donor surgery for liver transplantation in an adult recipient. The advanced procedure is available at only a few hospitals worldwide, and Cleveland Clinic is the second U.S. academic medical center to offer this approach for living donor liver transplantation.
What began as a 51-year-old mystery comes down to a single gene, as researchers from the University of Chicago and University of California, San Francisco discovered the cause of a new inherited form of pancreatitis.
Mayo Clinic physicians will present findings at the American College of Gastroenterologists Annual Scientific Meeting, Oct. 25–30 in San Antonio.
The American College of Gastroenterology Annual Scientific Meeting features innovative clinical gastroenterology research with implications for patients with digestive and liver diseases. ACG's Public Relations Committee has picked Noteworthy Abstracts and invited investigators to offer Author Insights.
Gastro Girl, Inc. in partnership with the American College of Gastroenterology announces a joint venture to bring GI OnDEMAND to market as gastroenterology’s virtual care and support platform. Telehealth capabilities will enable providers to get reimbursed for out-of-office patient support.
Dr. Mark B. Pochapin, a gastroenterologist at NYU School of Medicine/NYU Langone Health, was elected President of the American College of Gastroenterology. Dr. Pochapin's clinical and research interests include prevention, early detection, and treatment of gastrointestinal cancers and quality in endoscopy.
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