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Medicine

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Hepatitis C, Virus, Inhibitor, daclatasvir , Proteins, HCV, Kinetic, Modeling, Infection, Liver, Liver Disease, Liver Cancer, Hepatology, Genetics, Loyola, Cancer, Research

New Study On Hepatitis C Drug Treatment in vivo and in vitro

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Hepatitis C virus (HCV) infection affects 4 million in the US and is the prirmary cause of liver cirrhosis and liver cancer. New research shows that daclatasvir, an ant - HCV drug, has two modes of action and provides a more accurate estimate of the HCV half-life.

Science

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Platelet, Blood Clot, Thrombin, Fibrin, Injury, cellular signalling, Clotting, scar formation

Designer Blood Clots Could Improve Soldier Survival

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When it comes to healing the terrible wounds of war, success may hinge on the first blood clot – the one that begins forming on the battlefield right after an injury. Researchers believe the initial response to injury may control subsequent healing.

Medicine

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CLABSI, disinfection cap, infection prevention

Study Finds Use of Disinfection Cap Is Associated with Fewer Bloodstream Infections

Patients at NorthShore University HealthSystem are now better protected against potentially deadly infections, according to a newly published study.

Medicine

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blood transfusion threshold, Blood Transfusion, Red Blood Cell, JAMA, Clinical Evidence Synopsis, Journal of the American Medical Association, Hemoglobin, erythrocyte transfusion, Transfusion, transfusions for anemia

Lower Thresholds for Blood Transfusion Found to Have No Adverse Effects on Patients’ Health

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Today, in a new section called JAMA Clinical Evidence Synopsis, the Journal of the American Medical Association (JAMA), published a summary of the systematic review of the 19 clinical trials that compare higher versus lower hemoglobin thresholds in red blood cell transfusion. The comprehensive review concludes that there is no significant difference in patient outcomes with red blood cell transfusions using lower threshold levels.

Medicine

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Sepsis, Hematology, Immunology

Surviving Sepsis with LECT2

Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th.

Medicine

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Dana-Farber, American Society For Bariatric Surgery, bone and marrow clinical trials network, Graft Versus Host Disease, GVHD, Leukemia, Stem Cell Transplant

Experimental Graft-versus-Host Disease Treatment Equivalent to Standard Care in Phase 3 Trial

Dana-Farber researchers found an experimental drug combination for preventing graft-versus-host disease (GVHD) was not significantly better than the standard regimen of care, but that the new combination could provide an alternative that could be preferable in certain scenarios.

Medicine

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Dana-Farber, American Society Of Addiction Medicine, Hodgkin Lymphoma, galectin-1, sandwich ELISA

Blood Levels of Immune Protein Predict Risk in Hodgkin Disease

Dana-Farber researchers found levels galectin-1, an immunity-related protein, could be the basis of a test and potentially a targeted treatment for Hodgkin lymphoma.

Medicine

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Red Blood Cells, Sickle Cell Diseases, emergencey room, Medicaid, Health Care Costs, Pediatric Healthcare, Adult Healthcare

Into Adulthood, Sickle Cell Patients Rely on ER

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Patients with sickle cell disease rely more on the emergency room as they move from pediatric to adult health care, according to researchers at Washington University School of Medicine in St. Louis.

Medicine

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Graft Versus Host Disease, peripheral blood stem cell , Blood Stem Cell Transplant, Bone Marrow Transplant

Peripheral Blood Stem Cell Transplants from Unrelated Donors Associated with Higher Rates of Chronic Graft-Versus-Host-Disease

Claudio Anasetti, M.D., chair of the Department of Blood & Marrow Transplant at Moffitt Cancer Center, and colleagues from 47 research sites in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors. The goal was to determine whether graft source, peripheral blood stem cells or bone marrow, affects outcomes in unrelated donor transplants for patients with leukemia or other hematologic malignancies.

Science

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Sickle Cell, Sickle Cell Anemia, Sickle Cell Disease, Physics, Biophysics, Red Blood Cells, Hemoglobin

Physics Explains How Sickling Cells Make People Sick

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Researchers at Drexel University have identified the physical forces in red blood cells and blood vessels underlying the painful symptoms of sickle cell disease. Their experiment, the first to answer a scientific question about sickle cell disease using microfluidics engineering methods, may help future researchers better determine who is at greatest risk of harm from the disease.

Medicine

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Vigorous Physical Activity May Increase Risk of Bleeding for Children with Hemophilia

In children and adolescents with hemophilia, vigorous physical activity was associated with an elevated risk of bleeding, although it appears the absolute increase in risk may be small

Medicine

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CRBSI, catheter-related bloodstream infection, Occlusions, IV connector

Symposium at AVA Conference to Explore Bloodstream Infections

RyMed Technologies will host a breakfast symposium on the origin of catheter-related bloodstream infections (CRBSIs) and how to prevent them at the upcoming Annual Scientific Meeting of the Association for Vascular Access (AVA).

Medicine

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Leukemia, Graft-versus-host disease, GVHD, T-Cell, Interferon gamma receptor, Stem Cell Transplant, GUT, Gastrointestinal Tract

Deadly Complication of Stem Cell Transplants Reduced in Mice

Studying leukemia in mice, researchers at Washington University School of Medicine in St. Louis have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns.

Medicine

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Sickle Cell, Sickle Cell Disease, Sickle Cell Anemia, Transplant, Haploidentical Transplant

"Half-Match" Bone Marrow Transplants Wipe Out Sickle Cell Disease in Selected Patients

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In a preliminary clinical trial, investigators at Johns Hopkins have shown that even partially matched bone marrow transplants can eliminate sickle cell disease in some patients, ridding them of painful and debilitating symptoms and the need for a lifetime of pain medications and blood transfusions.

Medicine

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Tregs, T-regs, T regs, MDs, Myelodysplastic Syndromes

Researchers Find Novel Predictor for MDS Progression Risk

Researchers at Moffitt Cancer Center and colleagues have discovered that changes in the physical characteristics of the effector memory regulatory T cell can predict the progression risk of myelodysplastic syndromes (MDS) to acute myeloid leukemia. The finding could improve prognostication for patients with MDS and better inform therapeutic decision making.

Medicine

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double drug combo, abnormal blood vessel, VEGF, FDA, Dr. Timothy Hla, Pathology, Vascular Biology

Double Drug Combo Could Shut Down Abnormal Blood Vessel Growth that Feeds Disease

A new study by researchers at Weill Cornell Medical College shows combining two already-FDA approved drugs may offer a new and potent punch against diseases in which blood vessel growth is abnormal -- such as cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis.

Medicine

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Sickle Cell Disease, Sickle Cell Awareness Month, Child Life, Hematology, MRI, Blood Disorder, Sedation, Hemoglobin

Intervention Helps Children with Sickle Cell Disease Complete MRI Tests Without Sedation

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St. Jude Children’s Research Hospital reports success using a targeted educational approach to teach young sickle cell disease patients to remain motionless during MRI scans, making the process safer.

Science

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Hematology, Red Blood Cell Count, Red Blood Cells, Anemia, Cyclin, blood cell production

Protein Found to Regulate Red Blood Cell Size and Number

By examining the results of genome-wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells, researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Medicine

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September, New Jersey, Sickle Cell Disease, Blood Disorders, Blood Illness

September Is Sickle Cell Disease Awareness Month

September is Sickle Cell Disease Awareness Month. Sickle cell disease is a common inherited blood disorder, affecting an estimated 90,000 to 100,000 Americans. The Cancer Institute of New Jersey -- which has a comprehensive program for sickle cell patients -- is making experts available to comment on the condition as well as the latest options in treatment for sickle cell patients.

Medicine

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Lizhao Wu, New Jersey Medical School, Retinoblastoma, E2F, E2F8, Anemia, Red Blood Cells, Transcription Factor, Binding, Erythropoeitin

Keeping Up with Demand for Red Blood Cells

For the first time, researchers have established the ability of retinoblastoma (Rb) and E2F proteins to interact with each other without binding -- and found that an interaction between Rb and E2F8 promotes the formation of red blood cells.







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