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Blood Disorders

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Medicine

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Dr. Vivek L. Patel, Dr. James B. Bussel , Platelet, Rituximab

Rituximab Promotes Long-Term Response for Patients with Immune Destruction of Platelets

A new analysis concludes that rituximab, a drug commonly used to treat blood cancers, leads to treatment responses lasting at least five years in approximately one quarter of patients with low platelet counts and a risk of bleeding due to chronic immune thrombocytopenic purpura (ITP). In study results published online today in Blood, the Journal of the American Society of Hematology (ASH), investigators at Weill Cornell Medical College provide the very first long-term outcome data for patients with chronic ITP treated with rituxamab.

Medicine

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Blood Clot, Blood Clot Prevention, Venous Thromboembolism, Infection, Older Americans, Older Adults

Infection Linked to Dangerous Blood Clots in Veins and Lungs

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Older adults at much greater risk for being hospitalized for a blood clot within three months of getting an infection.

Medicine

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Bone Marrow Transplant, Graft Vs. Host Disease, alpha-1 antitrypsin, Cancer

Natural Enzyme Provides Potential New Approach for Treating Graft-vs-Host-Disease

A natural enzyme derived from human blood plasma showed potential in significantly reducing the effects of graft-vs.-host disease, a common and deadly side effect of lifesaving bone marrow transplants.

Medicine

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Hemophilia A, Plasma, Albumin, Bleeding Disorder

Preventive Hemophilia A Treatment Reduces Annual Bleeding Events and Frequency of Infusions

A Rush University Medical Center led international research team has announced that a treatment to prevent bleeding episodes in children with hemophilia A also is effective for adolescents and adults.

Medicine

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Fixing Common Blood Disorder Would Make Kidney Transplants More Successful

Highlights • Correcting anemia in kidney transplant recipients slows the progression of kidney failure and improves the function of transplanted kidneys. • Transplant patients with completely corrected anemia experience a significant improvement in quality of life. • Anemia is a common complication of kidney transplantation, with a prevalence of 25% to 40% after the first year.

Medicine

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Gene Therapy, Hemophilia, Hemophilia B, Factor IX, Bleeding Disorder, Adeno-Associated Virus

Gene Therapy Achieves Early Success Against Hereditary Bleeding Disorder

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Symptoms improved significantly in adults with the bleeding disorder hemophilia B following a single treatment with gene therapy developed by researchers at St. Jude Children’s Research Hospital in Memphis and demonstrated to be safe in a clinical trial conducted at the University College London (UCL) in the U.K.

Science

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Sickle Cell Anemia, Cell Biology, Ipscs

Researchers Develop Safe Way to Repair Sickle Cell Disease Genes

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Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

Medicine

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Gene Therapy, Hemophilia A, Genetic Disease

Gene Therapy Shows Promise as Hemophilia Treatment in Animal Studies

For the first time, researchers have combined gene therapy and stem cell transplantation to successfully reverse the severe, crippling bleeding disorder hemophilia A in large animals, opening the door to the development of new therapies for human patients.

Medicine

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Sickle Cell Disease, Sickle Cell Anemia, Sickle Cell Treatment, protein modulation, Developmental Biology, hematology oncology, Hematological Disorders

Researchers Reveal Potential Treatment for Sickle Cell Disease

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Few options are availabe to prevent the painful episodes of sickle cell disease. But a University of Michigan Health System study reveals a protein trigger that could lead to a new treatment for sickle cell patients.

Medicine

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Cancer, Bone Marrow Transplant, Biomarker, Graft-versus-host disease

Biomarker Detects Graft-Versus-Host-Disease in Cancer Patients After Bone Marrow Transplant

A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in cancer patients after a bone marrow transplant.

Medicine

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Sickle Cell Disease, Blood Disorder, pluripotent , Stem Cells, IPS, Hemoglobin

Correcting Sickle Cell Disease with Stem Cells

Using a patient’s own stem cells, researchers at Johns Hopkins have corrected the genetic alteration that causes sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that then turned on a normal version of the gene.







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