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Science

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Bioethics, Genetics, Gene Editing, Genomics, NAS, NASEM

JHU EXPERT: HUMAN GENE EDITING INITIATIVE REPORT

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Medicine

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Diabetes, Genetics, Epigenetic, DNA regulation, Type 2 Diabetes, Transcription

Diabetes in Your DNA? Scientists Zero in on the Genetic Signature of Risk

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Many genetic mutations have been linked to Type 2 diabetes, but no clear genetic signature has emerged. Now, new results may explain how multiple genetic flaws can lead to the same disease: They seem to change the way certain cells in the pancreas “read” their genes.

Science

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Uniformed Services University Of The Health Sciences, Uniformed Services University, USU, Usuhs, Mastermind gene, Fusion Gene, pheochromocytomas , Paraganglioma, Cancer, Cancer Cell

New Study Links ‘Mastermind’ Gene to Rare Cancer-Causing Tumor

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Scientists have discovered a new “mastermind fusion gene” may be associated with a rare cancer-causing tumor – pheochromocytomas (“pheo”) and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes’ The Cancer Genome Atlas. This breakthrough discovery could lead to more precise treatment as well as a better understanding of cancer itself.

Science

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Bacteria, Protein, Antibiotic, Bioactive

New Protein Discovery May Lead to New, Natural Antibiotics

Scientists have discovered a new protein that likely will advance the search for new natural antibiotics, according to a study by Texas A&M AgriLife Research.

Medicine

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Heart-Shaped Cells, The Power of Aspirin, Stem Cells Transplants and More in the Cancer News Source

Click here to go directly to the Cancer News Source

Medicine

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Muscular Dystrophy, Genetics, Rare Diseases, Pediatrics, Pediatricians, Congenital Muscular Dystrophy, Intellectual Disability, Muscle Weakness, Short Stature, Cataracts, Genetic Mutation, The George Washington University, GW School of Medicine and Health Sciences, Dystroglycanopathies, Marinesco-Sjögren syndrome, Reproductive And Developmental Health, Mu

GW Researcher Finds Genetic Cause of New Type of Muscular Dystrophy

George Washington University & St. George's University of London research, published in The American Journal of Human Genetics, outlines a newly discovered genetic mutation associated with short stature, muscle weakness, intellectual disability, and cataracts, leading researchers to believe this is a new type of congenital muscular dystrophy.

Medicine

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Pediatrics, Cardiology, Genetics, Kawasaki Disease, whole genome sequencing, African American

Gene Variant Identified for Kawasaki Disease Susceptibility

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Researchers at University of California San Diego School of Medicine, with colleagues at Rady Children’s Institute for Genomic Medicine and in London and Singapore, have conducted novel whole genome sequencing of a family in which two of four children were affected by Kawasaki disease. They have identified plausible gene variants that predispose some children to developing the disease.

Medicine

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Stephen Desiderio, DNA, RAG-2, RAG, John Bettridge, Histone, Fragment

An 'Ignition Key' Revs Up DNA Shuffling To Make Antibodies

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Rearranging the genome is a risky endeavor, and human cells reserve it for special occasions, like making egg and sperm cells.

Medicine

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Myelodysplastic Syndrome, Genetics, Genetic Profiling, Dana-Farber Cancer Institute, Blood Cancers, Cancer Alternative Medicine Biology Breast Cancer Nutrition/Nutrients Public Health, MDs

Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study Finds

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A single blood test and basic information about a patient’s medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, according to new research by scientists at Dana-Farber Cancer Institute.

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Promising Epigenetic Drug Target for Diabetes

A research report published in Clinical Epigenetics, suggests that epigenetic mechanism based drugs could become one of the treatment armamentarium of future anti-diabetic agents.

Medicine

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Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

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“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.

Medicine

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Dna Barcoding, Nanoparticle, Gene Therapy

DNA “Barcoding” Allows Rapid Testing of Nanoparticles for Therapeutic Delivery

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Using tiny snippets of DNA as “barcodes,” researchers have developed a new technique for rapidly screening the ability of nanoparticles to selectively deliver therapeutic genes to specific organs of the body. The technique could accelerate the development and use of gene therapies for such killers as heart disease, cancer and Parkinson’s disease.

Medicine

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Genetics, armc, Nature Communications, universite de montreal, mice study, Cushing's Syndrome

A New Immunologic and Endocrine Syndrome

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After 10 years of research, a team at Université de Montréal's research centre has succeeded in deleting the Armc5 gene in experimental mice, discovering that its loss gives rise to a heretofore unidentified syndrome.

Medicine

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Pediatrics, Genetics, genes, Molecular Biology, Jaundice, Newborns, Neonatology, OB GYN, Bilirubin, Hyperbilirubinemia

Severe Newborn Jaundice Could Be Preventable, Mouse Study Shows

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In a mouse study, researchers at University of California San Diego School of Medicine have identified a protein that inhibits the enzyme that breaks down bilirubin in newborns. Methods that block this inhibitor, and thus restore the enzyme’s activity, could provide a new therapeutic approach for preventing or treating severe newborn jaundice. The study is published February 6, 2017 by the Proceedings of the National Academy of Sciences.

Science

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Evolution, Genome, Genome size

Genomes in Flux: New Study Reveals Hidden Dynamics of Bird and Mammal DNA Evolution

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Evolution is often thought of as a gradual remodeling of the genome, the genetic blueprints for building an organism. But in some instance it might be more appropriate to call it an overhaul. Over the past 100 million years, the human lineage has lost one-fifth of its DNA, while an even greater amount was added, report scientists at the University of Utah School of Medicine. Until now, the extent to which our genome has expanded and contracted had been underappreciated.

Medicine

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Gene Therapy, Hearing Loss, Genetic Deafness, Usher Syndrome, vector drug delivery

Gene Therapy Restores Hearing in Deaf Mice… Down to a Whisper

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In the summer of 2015, a team at Boston Children’s Hospital and Harvard Medical School reported restoring rudimentary hearing in genetically deaf mice using gene therapy. Now the Boston Children’s research team reports restoring a much higher level of hearing — down to 25 decibels, the equivalent of a whisper — using an improved gene therapy vector developed at Massachusetts Eye and Ear. The new vector and the mouse studies are described in two back-to-back papers in Nature Biotechnology (published online February 6).

Medicine

Science

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Prostat cancer, lab research, CHD1, Cancer Biology, Nature, tumor suppresor, genetic

Researchers Identify ‘Synthetic Essentiality’ as Novel Approach for Locating Cancer Therapy Targets

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A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes. The process, which located a genetic site for the most common form of prostate cancer, has potential for developing precision therapy for other cancers, such as breast, brain and colorectal, say researchers at The University of Texas MD Anderson Cancer Center. Study results were published in the Feb. 6 online issue of Nature.

Science

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Biological and Environmental Research, biological and environmental sciences, Mercury, Methylmercury, mercury in the environment, Applied and Environmental Microbiology, Microbiology, Microbes, microbes and cleanup, Oak Ridge National Laboratory, mercury science, Neurotoxins, neurotoxin, Genetics, microbial genetics, methylmercury production, Biology

Methylmercury Sleuths Armed with New Spotlight

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Researchers can now more quickly identify which microbes produce mercury toxins in the environment. These findings will enable a more realistic view of possible methylmercury production in a specific setting.

Medicine

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Medical, Medicine, Health, Healthcare, AAP, Association of Academic Physiatrists, Nonprofit, Association, Las Vegas, Conference, Doctor, Physician, Physiatrist, Physiatry, Genetics, Reserach

Rotator Cuff Pain? Genetics Might Be to Blame

A new study presented this week at the Association of Academic Physiatrists Annual Meeting in Las Vegas shows rotator cuff disease might be a heritable trait. Rotator cuff disease is a common disorder that affects 30 to 50 percent of people over the age of 50. The disease often leads to shoulder pain and loss of function. While many think of this as a ‘tear’ due to an injury or sustained over/misuse, some studies suggest genetics might play a role.

Medicine

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Seattle Children’s Sets GUINNESS WORLD RECORDS™ title for DNA Experiment at Groundbreaking for New Research Building

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Seattle Children’s Research Institute succeeded in a GUINNESS WORLD RECORDS attempt for most people conducting a DNA isolation experiment simultaneously.







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