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Medicine

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Cystic Fibrosis, Mucus

The Mechanism of Mucus: Discovery Could Lead to Better Cystic Fibrosis Treatments

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University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.

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Early Infant Weight Gain, Preventing Vision Loss, Sesame Street's Julia, and More in the Children's Health News Source

Click here for the latest research and features on Children's Health.

Medicine

Life

Social and Behavioral Sciences

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Developmental Disabilities, Genetics, History Of Science, History of genetics

History Professor Earns NSF Grant to Look at Evolution of Attitudes Toward People with Developmental Disabilities

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Andrew Hogan, PhD, an assistant professor in the Creighton University Department of History, has earned a grant from the NSF’s Science, Technology and Society program to study the evolution of attitudes and narratives about people with developmental disabilities.

Science

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Metals, DNA, metal-containing drugs , Drugs, Cancer, Molecular Mechanisms, chemotherapeutic, Agents, Leticia González , University of Vienna, Jacinto Sá, Uppsala University , Interact

How Do Metals Interact with DNA?

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Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. The lack of knowledge about the underlying molecular mechanisms slows down the search for new and more efficient chemotherapeutic agents. An international team of scientists, led by Leticia González from the University of Vienna and Jacinto Sá from the Uppsala University, have developed a protocol that is able to detect how metal-based drugs interact with DNA.

Medicine

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Infectious Diseases, zika virus, Pregnancy, Obstetrics, Autism, Neurology, Virology

How Prenatal Maternal Infections May Affect Genetic Factors in Autism Spectrum Disorder

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In a new study, researchers at the University of California San Diego School of Medicine, University of Cyprus and Stanford University map the complex biological cascade caused by MIA: the expression of multiple genes involved in autism are turned up or down by MIA, affecting key aspects of prenatal brain development that may increase risk for atypical development later in life.

Medicine

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Alzheimber's Disease, Genetics, Neurology, Epidemiology, genetic assessment, polygenic hazard score

Genetic Assessment Developed to Determine Risk for Age-Associated Alzheimer’s Disease

An international team of scientists, led by researchers at University of California San Diego School of Medicine and University of California San Francisco, has developed a novel genetic score that allows individuals to calculate their age-specific risk of developing Alzheimer’s disease (AD), based upon genetic information.

Medicine

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New Software Tool Powers Up Genomic Research

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A group of computational biological researchers, led by Stony Brook University’s Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads. The research was published in the March 6 edition of Nature Methods. .

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Business

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Gene Editing, CRISPR-Cas9, UC Berkeley, UCSF, Jennifer Doudna, Fellowship Programs, Plant Pathology, Homologous Recombination, Genomics, Biotechnology

Bay Area’s Innovative Genomics Institute Announces Unique Entrepreneurial Fellowships

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The IGI has selected two scientists for its one-of-a-kind "Entrepreneurial Fellowship Program," pushing transformative scientific products to the market by supporting vital foundational research and professional networking for two years. Awardees are pursuing CRISPR genetic engineering applications.

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Globus Genomics Begins Its Second Chapter

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When Globus Genomics launched five years ago, biologists were just getting used to the idea of being a “big data” science. At that time, the rapidly falling costs of next-generation sequencing suddenly made large-scale genetics more accessible to life scientists. However, these new methods also brought new challenges, as researchers used to working with small datasets on their desktop computer were faced for the first time with the kind of hard-drive flooding data streams more commonly seen by physicists and astronomers.

Medicine

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Breast Cancer, Disparities in Breast Cancer, Yale Cancer Center

Racial Disparities in Genetic Testing of Women with Breast Cancer

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