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Medicine

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Eye Fluctuations, Current Stimulation, New Gene Therapy, and More in the Vision News Source

The latest research and feature news on vision in the Vision News Source

Medicine

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bone grafts, Bone Fractures, bone-inducing gene , ultrasound-mediated gene delivery , nonhealing bone fractures

Injured Bones Reconstructed by Gene and Stem Cell Therapies

A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones.

Medicine

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blood-brain barrier, Allan-Herndon-Dudley syndrome, Clive Svendsen

Scientists Show How Defects in Blood-Brain Barrier Could Cause Neurological Disorder

Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome. The findings point to a path for treating this syndrome and hold promise for analyzing other neurological diseases.

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Stem Cells, Diseases, Pharmaceuticals, Brain, Neurological Deficits, Thyroid Hormone

Patient’s cells used to replicate dire developmental condition

A team of scientists from the University of Wisconsin-Madison and Cedars-Sinai in Los Angeles have used the cells of AHDS patients to recreate not only the disease, but a mimic of the patient’s blood-brain barrier in the laboratory dish using induced pluripotent stem cell technology.

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Bone Marrow Transplantation, B cell immune reconstitution, impairment of antibody immune reconstitution

New Finding Affecting Immune Reconstitution Related to B Cells

Researchers examined the mechanisms of B cell immune reconstitution in pediatric patients who had undergone bone marrow transplantation and discovered a disruption in the maturation of B cells – critical to the immune system – preventing the production of antibodies that fight infection.

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Stem Cell Trial for Stroke Patients Suffering Chronic Motor Deficits Begins at UTHealth

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A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).

Medicine

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Lymphoma, DHL, Stem Cell Transplant, Stem Cell Transplantation, Chemotherapy

Stem-Cell Transplants Show Limited Benefit for Double-Hit Lymphoma Patients in Remission

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Patients with double hit lymphoma (DHL) who undergo autologous stem-cell transplantation (autoSCT) after achieving remission are not more likely to remain in remission or live longer than patients who do not undergo autoSCT, according to a new analysis from the Perelman School of Medicine and the Abramson Cancer Center of the University of Pennsylvania.

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New Lung “Organoids” in a Dish Mimic Features of Full-Size Lung

New lung “organoids”—tiny 3-D structures that mimic features of a full-sized lung—have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

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T Cell, Stem Cell, Cancer, Lung Cancer, Cancer Vaccine

Stem Cell Vaccine Found to Increase Immune Responses, Inhibit Tumors in Animal Models

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Researchers at the University of Cincinnati (UC) have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.

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Leukemia, Lymphoma, multiple myelmoma

Twenty-Year Cancer Survivor Gives Back by Donating 20 Handmade Quilts

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Twenty years after undergoing a life-saving treatment at Loyola University Medical Center, cancer survivor Carolyn Gatenby returned to Loyola to donate 20 handmade quilts. “I wanted to give back,” Mrs. Gatenby said. “I’ve had 20 good years that I didn’t think I’d have.”







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