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Medicine

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Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, marker chromosome, human induced pluripotent stem cells, neural progenitor cell, Neural Progenitor Cells, Schizophrenia, Bipolar Disorder, bipolar disorder with psychosis, ISO, Mosaic

Some Genetic Variations May Be Particularly Difficult to Evaluate Using Current Stem Cell Modeling Techniques

Mount Sinai study on psychosis reveals the importance of clarifying the precise structure of any genetic mutation before moving forward with human-induced pluripotent stem cell studies

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Cancer, Oral Cancer, Oral Health, Head And Neck Cancer, Squamos Cell Carcinoma, Tumors, tumors mice, Cancer Stem Cells

Targeting Cancer Stem Cells Improves Treatment Effectiveness and Prevents Metastasis

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Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry. Head and neck squamous cell carcinoma is a highly invasive form of cancer and frequently spreads to the cervical lymph nodes.

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GABA, Photoreceptor, Vision, Zebrafish

NIH-Funded Study Helps Explain How Zebrafish Recover From Blinding Injuries

Researchers at Vanderbilt University in Nashville, Tennessee have discovered that in zebrafish, decreased levels of the neurotransmitter gamma-aminobutyric acid (GABA) cue the retina, the light-sensing tissue in the back of the eye, to produce stem cells. The finding sheds light on how the zebrafish regenerates its retina after injury and informs efforts to restore vision in people who are blind.

Medicine

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stem cell-regulating gene , John Yu, John S Yu , Brain Cancer, Brain Tumor, Glioma, ZEB1

Cedars-Sinai Neuroscientists Pinpoint Key Gene Controlling Tumor Growth in Brain Cancers

Cedars-Sinai investigators have identified a stem cell-regulating gene that affects tumor growth in patients with brain cancer and can strongly influence survival rates of patients. The findings, published in the online edition of Nature Scientific Reports, could move physicians closer to their goal of better predicting the prognosis of patients with brain tumors and developing more personalized treatments for them.

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World Kidney Day, Keck Medicine of USC, Kenneth Hallows, Andy McMahon, Obesity, Kidney Disease, kidney disease research, Stem Cell Research, USC

World Kidney Day: Keck Medicine of USC Experts Discuss Kidney Health and Research

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Medicine

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Transplanation, Lung Transplant, donor lungs, Biomedical Engineering, Tissue Engineering, Regenerative, Stem Cell

New Method Rescues Donor Organs to Save Lives

Researchers from Columbia Engineering and Columbia University Medical Center have—for the first time—maintained a fully functional lung outside the body for several days. They designed the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient over 36-56 hours, used the advanced support system to fully recover the functionality of lungs injured by ischemia and made them suitable for transplant. (Nature Biomedical Engineering 3/6)

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Cornea, eye, Blindness, Vision Loss, Stem Cell

Stem Cell Treatment May Restore Vision to Patients with Damaged Corneas

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Researchers have developed a new way to identify and sort stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient’s own eye tissue.

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Bone Marrow, Hematopoietic Stem Cells, Aging, Elderly, immune system cells, Cancer, Blood Cancers, Leukemia, Research, Experimental Treatment, EMBO, Cincinnati Children's Hospital Medical Center, press release, news, Media

Scientists Wage Fight Against Aging Bone Marrow Stem Cell Niche

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As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC’s form also ages, contributing to the problem. In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs are created.

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cancer stem cell, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia (All), Daunorubicin, Chemotherapy

Getting to the Root of the Problem by Targeting Cancer Stem Cells

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A research team comprised of members from The University of Kansas Cancer Center, Stowers Institute for Medical Research, and Children’s Mercy are looking at ways to target cancer stem cells to ensure that once a cancer patient goes into remission, they are not at risk of their cancer returning.

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