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Medicine

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Promising Epigenetic Drug Target for Diabetes

A research report published in Clinical Epigenetics, suggests that epigenetic mechanism based drugs could become one of the treatment armamentarium of future anti-diabetic agents.

Medicine

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Neonatology, pulmonary biology, Lungs, Antibiotics, Infection, Science Translational Medicine , Cincinnati Children's Hospital Medical Center, Gut Bacteria, Pediatrics, news release distribution

Excessive Antibiotic Use in Newborns Can Permanently Damage Lungs’ Defenses

Doctors have long understood that antibiotics that protect infants from infection also can disrupt the normal growth of their gut bacteria. However, a new study reveals that the consequences of routine antibiotic use may be deeper and longer lasting than expected. The study, published Feb. 8 in Science Translational Medicine, shows that short-term disruption of gut bacteria makes infant mice more likely to develop pneumonia. It also makes them more likely to die from it.

Medicine

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Cancer, Cancer Drug, UWM Research Foundation, Systems Oncology, Vitamin D, VDR

UWM Research Foundation Licenses a Novel Cancer Drug Compound to Systems Oncology

The compound employs a unique mechanism of action that has safely and effectively suppressed tumors in animal models.

Medicine

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Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

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“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.

Life

Education

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Binghamton University, Binghamton, SUNY Binghamton, pharmacy administration, School Absences, degree completion, Pharmaceutical Science, doctorate programs, College, Education, Higher Ed, Higher Education, Pharmacy, ACPE, Accreditation Council for Pharmacy Education , pharmacy education

Binghamton University Approved to Enroll Students in New Doctor of Pharmacy Program

Binghamton University’s School of Pharmacy and Pharmaceutical Sciences (SOPPS) has been granted Precandidate status for its Doctor of Pharmacy program from its accrediting body, the Accreditation Council for Pharmacy Education (ACPE), and can start enrolling students.

Medicine

Science

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Super Bug, MRSA, Mrsa Infections, Drug Development, Drug Discovery, Marine Organisms, Harbor Branch Oceanographic Institute

Compound from Deep-Water Marine Sponge Could Provide Antibacterial Solutions for MRSA

A compound extracted from a deep-water marine sponge collected near the Bahamas is showing potent antibacterial activity against the drug resistant bacteria methicillin-resistant Staphylococcus aureus (MRSA) also called the “super bug.”

Medicine

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drug, Aging, Cell Signaling, cell signaling pathways

UNM Cancer Center Researcher Discovers New Class of Drugs to Combat Aging Diseases

Eric Prossnitz, PhD and his team uncovered new details of the aging process. They discovered an altered balance between certain signaling molecules in the smooth muscle cells of blood vessels and the heart. The team also discovered a new class of drugs that combats an important part of the aging process.

Medicine

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Anesthesiology, Opioids, Elderly, Respiratory Health, Alcohol

Mixing Opioids and Alcohol May Increase Likelihood of Dangerous Respiratory Complication, Especially in the Elderly, Study Finds

Taking one oxycodone tablet together with even a modest amount of alcohol increases the risk of a potentially life-threatening side effect known as respiratory depression, which causes breathing to become extremely shallow or stop altogether, reports a study published in the Online First edition of Anesthesiology.

Medicine

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Fralin Life Science Institute, Virginia Tech Center for Drug Discovery, Malaria, malaria drug, Compound, Drug Resistance

Drug Discovery Researchers Awarded Grant to Refine Malaria Drug

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A research team from the Virginia Tech Center for Drug Discovery has received a $431,126 two-year grant from the National Institutes of Health to make improved versions of a promising compound called MMV008138, or 8138 for short.

Medicine

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TSRI Chemists Unveil Versatile New Method for Making Chiral Drug Molecules

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Chemists at The Scripps Research Institute (TSRI) have invented a new technique for constructing chiral drug molecules.

Medicine

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Medication Adherence, Drug Adherence, with acute lymphocytic leukemia

UAB Study Shows Children and Parents Over-Report Leukemia Medication Adherence

New research from UAB suggests that young patients with acute lymphocytic leukemia, or ALL — the most common type of pediatric cancer — and their parents are likely to report to their physician that they took more of their anti-cancer medication than they actually did.

Medicine

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Chikungunya virus, Arthritis

Drug Combination Effective Against Chikungunya Arthritis in Mice

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Chikungunya virus causes a painful, debilitating arthritis for which there is currently no treatment. A new study has found that combining a drug for rheumatoid arthritis with one that targets the chikungunya virus can eliminate the signs of arthritis in mice in the early stage of the disease.

Medicine

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Cancer, Genetics, Drug Development

Potential New Drug Class Hits Multiple Cancer Cell Targets, Boosting Efficacy and Safety

In a new paper published this week in PNAS, researchers at the University of California San Diego School of Medicine and Moores Cancer Center, in collaboration with colleagues at Rady Children’s Hospital-San Diego, the University of Colorado School of Medicine and SignalRx, a San Diego-based biopharmaceutical company, describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and safety.

Science

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HIV, Hiv 1, Hiv Aids, HIV and AIDS, Hiv Treatment, HIV drug, Antiviral, Antiviral Drugs, Antiviral Therapeutics, Antiviral Therapies, antiviral therapy, antiretrovials, Antiretroviral, antiretroviral drug therapy, Antiretroviral Drug Treatment, Antiretroviral Drugs, Antiretroviral Regimen, antiretroviral therapies , Antiretroviral Therapy, antiretroviral the

UNMC Research Team Discovers Novel Pharmaceutic Action for HIV/AIDS

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Using a process called LASER ART (long-acting slow effective release antiretroviral therapy), a research team has discovered an unexpected pathway to open cell storage areas for antiviral drugs. The discovery could revolutionize current treatments for HIV/AIDS by extending the actions of disease-combating medicines.

Medicine

Science

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sulfur bacterium, Microbe, Halorhodospira halophila, photo-active yellow protein (PYP), structural changes, Drug Development, Proteins, Marius Schmidt, University of Wisconsin‐Milwaukee, Structural Dynamics

How a Bacterial Protein’s Structure Aids Biomedical Studies

A light-sensing protein from a salt-loving, sulfur-forming microbe has proved key to developing methods essential to advanced drug discovery, understanding human vision and other biomedical applications. In a review published this week in Structural Dynamics, by AIP Publishing, physicist Marius Schmidt of the University of Wisconsin‐Milwaukee presents a history of decades of research of this microbe and the many new technologies that have enabled these applications.

Medicine

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drug, Drug Target, Drug Targets, Disease, Protein

Drugs, Diseases and Proteins: New Archive Helps Precision Medicine, Drug Development

Tudor Oprea, MD, PhD, at UNM Comprehensive Cancer Center and his collaborators from the UK-based European Bioinformatics Institute in Hinxton and from the Institute for Cancer Research in London have created the beginnings of an open archive that links a drug’s chemical structure, its molecular biology activity and the diseases it is used to treat.

Science

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Immunotherapy, immunome, immuno-oncology

Cancer Research Institute Awards Grant to Develop Powerful Genomic Data Resource for Cancer Immunotherapy Researchers

Three nonprofits partner to create powerful database that will aim to improve immunotherapy for many types of cancer.

Medicine

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COPD diagnosis, Chronic Obstructive Pulmonary Disease, COPD research, copd maintenance medications, GOLD

GOLD 2017 Report Released with New Recommendations on Assessing COPD, Drug Escalation Strategies, Non-Pharmacologic Treatments and Comorbidities

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The Global Initiative for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease (GOLD) has published its 2017 report online, ahead of print in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

Medicine

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Only FDA-Approved Device to Repair "Hole in the Heart" Condition Now Available at Baylor Heart and Vascular Services at Fort Worth

Baylor Heart and Vascular Services at Fort Worth on Tuesday, November 15, became the first program in Texas to implant the only FDA-approved device designed to prevent blood clots from entering the brain by sealing a hole in the heart. The device is designed to help reduce the risk of recurrent cryptogenic strokes in patients diagnosed with a patent foramen ovale (PFO) – a small opening between the upper chambers of the heart.

Medicine

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TSRI Scientists Find Brain Hormone That Triggers Fat Burning

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Biologists at The Scripps Research Institute (TSRI) have identified a brain hormone that appears to trigger fat burning in the gut. Their findings in animal models could have implications for future pharmaceutical development.







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