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Medicine

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Dementia, Orthostatic Hypotension, Dizziness

Rapid Blood Pressure Drops in Middle Age Linked to Dementia in Old Age

Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.

Science

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Acute Myeloid Leukemia, AML

New Drug Combination Targets Aggressive Blood Cancer

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

Medicine

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lupus treatment, Lupus, Autoimmune Disease, Treatment Advances

Tackling Lupus and Its Renal Complications with Novel Small Molecule Drug Candidate

A new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.

Medicine

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Breast Cancer, triple negative breast cancer, Resistance, Chemotherapy, cobination therapy, Leflunomide

Newly Discovered Vulnerability in an Aggressive Breast Cancer Provides Therapeutic Target

• Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options. • BIDMC researchers discovered that TNBC cells increase production of pyrimidine nucleotides in response to traditional chemotherapy. • Discovery represents a vulnerability that can be exploited by blocking pyrimidine using an existing inhibitor in combination with chemotherapy.

Medicine

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Liver, Liver Enzymes, Blood Test, Pathology, Hepatology, Gastroenterology, Electronic Health Record

Too Many Patients Get Liver Tests They Don’t Need, Which Can Raise Fears and Costs, Research Shows

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Doctors are ordering too many liver-related blood tests at the same time, new research shows, which may lead to unneeded worry, biopsies and costs. Instead of “overtesting”, the researchers say, doctors should exclude common liver issues before testing for the uncommon ones, and healthcare computer systems should help.

Medicine

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Acute Lymphoblastic Leukemia, Leukemia, Phase III Clinical Trial, Clinical Trial, Monoclonal Antibody

Monoclonal Antibody Drug Superior to Chemotherapy for Advanced Acute Lymphoblastic Leukemia

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A Phase III clinical trial involving 101 centers in 21 countries revealed the monoclonal antibody blinatumomab to be more effective than standard chemotherapy for treatment of advanced acute lymphoblastic leukemia (ALL). Study findings were published in the March 1 online issue of the New England Journal of Medicine.

Medicine

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Acute Myeloid Leukemia (AML), Leukemia, Leukemia Research, Acetylation, Histone

MD Anderson Study Ties Protein ‘Reader’ ENL to Common Leukemia

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Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults.

Medicine

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bleeding control, American College Of Surgeons, Stop the Bleed, Hartford Consensus, Trauma, Capitol Hill, Congressional Briefing

Capitol Hill Lawmakers Participate in Bleeding Control Simulations

Leaders of the American College of Surgeons (ACS) and the Committee on Trauma (COT) hosted a Congressional Briefing to highlight the ACS and Hartford Consensus bleeding control program.

Medicine

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Gliobastoma, Brain Cancer, Blood Cancer, Targeted Therapy

Researchers Discover New Combination Therapy Strategy for Brain, Blood Cancers

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Researchers at the University of Cincinnati (UC) College of Medicine have discovered a new potential strategy to personalize therapy for brain and blood cancers.

Medicine

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Systolic Blood Pressure, H, High Blood Pressure

Intensive Lowering of Systolic Blood Pressure Would Prevent 107,500 Deaths Per Year

Intensive treatment to lower systolic (top number) blood pressure to below 120 would prevent 107,500 deaths per year in the United States, according to a study by researchers at Loyola University Chicago and other centers.







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