Using U.S. transplant registry data, clinical researchers at the University of Pittsburgh found that kidney transplants between identical twins have high success rates, but also surprisingly high rates of immunosuppressant use.
In patients taking immune checkpoint inhibitors as a treatment for cancer, 17% experienced acute kidney injury (AKI), 8% experienced sustained AKI, and 3% had potential immune checkpoint inhibitor–related AKI. • Use of proton pump inhibitors, which are commonly used to treat stomach ulcers or acid reflux, was associated with a higher risk of experiencing sustained AKI.
In what is believed to be the most comprehensive molecular characterization to date of the most common — and often treatment-resistant — form of kidney cancer, researchers at Johns Hopkins’ departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them. Their findings could inform overall patient survival and response to treatment.
A new report from the Johns Hopkins University School of Medicine and the American Society of Nephrology found graduating nephrologists perceived improvements in job markets close to their training institutes. An increasing majority of nephrology fellows would recommend the specialty. The report also points to gender imbalances in base starting salaries and levels of educational debt.
American Society of Nephrology President Mark E. Rosenberg, MD, FASN, has issued the following statement regarding the new Kidney Care Choices Model: “The American Society of Nephrology (ASN) welcomes the introduction of the voluntary Kidney Care Choices (KCC) Model, and its four kidney care payment options, addressing key aspects of the Executive Order on Advancing American Kidney Health (AAKH). This voluntary model will be a true game changer and brings desperately needed, sweeping changes to care for people with kidney diseases. ASN has long advocated for key elements of this model, and I thank HHS Secretary Azar and his entire team for putting forward such a visionary approach for the future of kidney care.
Highlights • Rates for all types of kidney replacement therapy in European countries were consistently higher in men than women from 1965 to 2015. • Male-to-female ratios increased with age, showing consistency over decades and for individual countries, despite changes in the causes of kidney disease. • The male-to-female ratio was higher for kidney transplantation in diabetic patients.
The US Food and Drug Administration (FDA) has awarded a contract to the Kidney Health Initiative (KHI) to study patient preferences for innovative renal replacement therapy (RRT) devices. The three-year project, “Building Capacity to Incorporate Patient Preferences into the Development of Innovative Alternatives to Renal Replacement Therapy” will capture patient preference and risk tolerance data from people with kidney failure to drive innovations in RRT.
Chronic kidney disease, which afflicts an estimated 6.4% of U.S. adults 45 and older, is associated with an increased risk of heart attack and other adverse cardiovascular outcomes, according to new research from Mayo Clinic.
The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.
A team at the Morgridge Institute for Research has characterized a natural chemical that paralyzes the parasite that causes schistosomiasis, offering a new pathway to fight the catastrophic neglected disease.
• In 2010-2016, many U.S. transplant centers commonly accepted deceased donor kidneys with less desirable characteristics. • The use of these organs varied widely across transplant centers, however, and differences were not fully explained by the size of waitlists or the availability of donor organs.
A multi-center randomized clinical trial evaluating a new artificial pancreas system — which automatically monitors and regulates blood glucose levels — has found that the new system was more effective than existing treatments at controlling blood glucose levels in people with type 1 diabetes.The study showed that the system improved participants’ blood glucose control throughout the day and overnight.
Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes
Dr. Josephine Briggs, the newly appointed Interim Executive Director for the Patient-Centered Outcomes Research Institute (PCORI) will keynote the PhRMA Foundation and the National Health Council conference, The Next Generation of Value Assessment: Including the Patient Voice, on November 12, 2019 in Washington, D.C.
The U.S. Department of Health and Human Services (HHS) Office of the Chief Technology Officer and the American Society of Nephrology (ASN) today introduced the members of the newly formed KidneyX Innovation Accelerator (KidneyX) steering committee. This diverse group of experts will play a critical role in advancing the KidneyX mission to improve the lives of the 850,000,000 people worldwide currently affected by kidney diseases by accelerating innovation in kidney disease prevention, diagnostics, and treatment.
UC San Diego Health has enrolled its first patient to evaluate a hand-held technology to fragment kidney stones. The clinical trial will assess the safety and effectiveness of breaking up kidney stones using acoustic energy.
Ceevra, Inc. today announced the publication of a study assessing the impact of using Ceevra’s 3D virtual reality models to plan for operations to remove kidney tumors. The study results, published in JAMA Network Open, showed substantial reductions in operating time, blood loss, ischemia time, and duration of hospital stay when the Ceevra models were used.
A common receptor may serve differentiated roles related to aging-associated cardiovascular disease in males and females. Jennifer DuPont, PhD, will present the findings of this first-of-its-kind study today at the American Physiological Society Aldosterone and ENaC Conference in Estes Park, Colo.
New research suggests that an individualized probiotic therapy regimen may improve symptoms of gout, gout-related kidney disease and other signs of metabolic syndrome. The study will be presented today at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.
• Compared with other pain medications, prescription opioids were linked with higher risks of death and hospitalization, particularly with higher doses. • The risk of death associated with opioids was highest among people with lower kidney function.
Aldosterone is a steroid hormone important to the regulation of salt, fluid and potassium in the body. Researchers at the “Metabolic and sex differences in aldosterone responses” symposium will explore the growing body of research that finds sex is a major determinant of how aldosterone acts on the body.
The University of Illinois at Chicago has received $2.8 million in funding from the National Institutes of Health to investigate non-opioid pain management strategies for people with kidney disease, which affects about 15% of adults in the U.S. With the funding, UIC will be one of eight clinical centers studying alternative pain management solutions for adults on maintenance dialysis
In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of death and kidney failure within a few months or years after surgery.
The complex interplay among the arteriovenous grafts, the vessels they connect, and the blood they transport has been difficult to simulate with computers, but one new method provides a way. Researchers report in Physics of Fluids on a series of simulations that reconstructed the fluid dynamics affected by the insertion of an AVG.
• The proportion of preemptive transplants—when a patient receives a kidney transplant before starting dialysis—increased after implementation of the 2014 Kidney Allocation System from 9.0% to 9.8% of all kidney transplants. • Increases in preemptive transplantation were not shared equally among all patient groups, however, and disparities were actually exacerbated for Black and Hispanic patients and for patients on Medicare.
Among the 30 million U.S. adults with Type 2 diabetes, 20% have impaired kidney function. In patients like this, metformin, the recommended first-line drug therapy for Type 2 diabetes, is associated in the new study with 20 percent decreased risk of major adverse cardiovascular events when compared to a class of common diabetes drugs called sulfonylureas.
• In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease. • A healthy dietary pattern was also linked with a 23% lower incidence of albuminuria, an early indicator of kidney damage
A study largely validates that immunoglobulin IgG is a crucial part of the pathogenic immunodeposits in kidneys of patients with IgA nephropathy. The routine clinical test that identifies the presence of IgA in all cases of IgA nephropathy fails to show IgG in 50 to 80 percent of biopsies.
• Kidney donation was linked with a 19% higher risk of developing hypertension, and this association did not vary by race. • Kidney function tended to improve after donation and then plateau if they developed hypertension.
• Researchers have uncovered 16 genetic regions linked to diabetic kidney disease. • The findings point to potential targets for prevention and treatment.
A UCLA-led study has found that using three-dimensional virtual reality models to prepare for kidney tumor surgeries resulted in substantial improvements, including shorter operating times, less blood loss during surgery and a shorter stay in the hospital afterward.
Kidneys from donors who were infected with the Hepatitis C virus (HCV) function just as well as uninfected kidneys throughout the first year following transplantation, according to a new Penn Medicine study.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many U.S. centers, and they are functioning well one year after transplantation.
A potential treatment for polycystic kidney disease – a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure – has shown promising results in animal testing.
UAB has successfully completed more than 14,000 transplants since doctors performed Alabama’s first kidney transplant in 1968.
On July 10, the Department of Health and Human Services (HHS) announced they were aiming to reduce the number of Americans developing end-stage renal disease by 25% by 2030. But, the results of a focus group study done by Johns Hopkins researchers of more than 30 veteran primary care physicians across the United States
A new method that automates the classification of progressive diabetic kidney disease, reducing variability and boosting precision, has been developed by researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
• In two different studies, researchers used machine learning algorithms to classify kidney biopsy samples and found substantial agreement with standard classification by pathologists • The methods may augment traditional diagnostics of kidney disease.
Using a novel approach and a machine designed to remove fluid from adults with heart failure, an article published in the Clinical Journal of the American Society of Nephrology (CJASN) reports higher survival rates and lower complications than previous studies.
The Kidney Health Initiative (KHI), today announced the availability of two new resources to advance the global pursuit of an artificial kidney for use in humans. The US Department of Health and Human (HHS)’s Advancing American Kidney Health initiative made developing an artificial kidney a national priority through KidneyX and its Redesign Dialysis prize competition. KHI’s Technology Roadmap for Innovative Alternatives to Renal Replacement Therapy (RRT Technology Roadmap) established the foundational strategy for KidneyX and details the basic science requirements of an artificial kidney.
Most patients who died or were removed from the kidney transplant waitlist before getting a transplant received multiple offers for a donor kidney.
Patients with advanced chronic kidney disease who died in Department of Veterans Affairs’ facilities often received intensive patterns of end-of-life care that appeared to be primarily directed at life extension.
Legend states that after the Greek army defeated the invading Persian forces near the city of Marathon in 490 B.C.E., the courier Pheidippides ran to Athens to report the victory and then immediately dropped dead.
For the first time in Southern California, surgeons at UC San Diego Health have transplanted the kidney of a deceased donor with HIV into a recipient with a pre-existing HIV infection. The procedure is part of an unprecedented multi-site national clinical trial.
French organ transplant centers are far more likely to accept “lower-rated” kidneys, like those from older organ donors, than centers in the United States, according to a study published today in JAMA Internal Medicine.
• Between 1996 and 2013, approximately 27% of adults, 21% of elderly adults, and 16% of children with kidney failure in the United States were hospitalized with a psychiatric diagnosis in the first year of kidney failure. • The prevalence of hospitalizations with psychiatric diagnoses increased over time across age groups, mostly due to secondary diagnoses.
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