Feature Channels: Dermatology

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The American Academy of Dermatology has announced the results of its annual election. The AAD’s new officers and board members will lead the world’s largest dermatologic society, representing more than 20,000 physicians who specialize in the diagnosis and medical, surgical and cosmetic treatment of skin, hair, and nail conditions. These officers and board members, all of whom are board-certified dermatologists, will also hold the same position for the American Academy of Dermatology Association, a sister organization to the AAD that focuses on government affairs, health policy and practice information.

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Board-certified dermatologist Kenneth J. Tomecki, MD, FAAD, has been elected to lead the American Academy of Dermatology. He will be installed as president-elect in March 2020 and will hold the office of president for one year beginning in March 2021.

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Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive outcomes are not long lasting, due to the development of drug resistance and tumor recurrence. Moffitt Cancer Center researchers have discovered a mechanism by which melanoma cells become resistant to the commonly used drugs that target the BRAF protein and its signaling pathway.

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The American Academy of Dermatology has honored Robert T. Brodell, MD, FAAD, for working with his colleagues to open a dermatology clinic in the Mississippi Delta — an area that previously did not have a dermatologist for nearly 100 miles.

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• The prevalence of moderate-to-extreme pruritus in patients with non-dialysis chronic kidney disease was 24% and was more likely in older patients, women, and in those with advanced kidney disease, among other health conditions. • More severe pruritus was associated with progressively poorer measures of quality of life and a higher likelihood of self-reported depression and restless sleep.

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Mount Sinai has received a $6 million donation from the Derfner Foundation to name the new Plastic and Reconstructive Surgery suite within the Department of Surgery

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Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” describes how inhibition of TDG, known for its role in cell repair and proliferation, may be used to trigger cell death of cancerous melanoma cells and halt tumor growth.

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As the days get warmer and more people head outdoors to garden or do yard work, dermatologists from the American Academy of Dermatology are reminding the public to take a few precautions. Although gardening can be an enjoyable activity for many, they say, it can take a turn for the worse if you injure yourself, come into contact with a poisonous plant or have an allergic reaction.

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A new study suggests that sunscreen protects the skin’s blood vessel function from harmful ultraviolet radiation (UVR) exposure by protecting dilation of the blood vessels. Perspiration on the skin may also provide protection to the skin’s blood vessels from sun damage. The findings will be presented today at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2019 in Orlando, Fla.

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Application of sun protection factor (SPF) moisturizers tends to miss more of the face, especially around the eyelid regions, compared with sunscreen application, according to a study published April 3 in the open-access journal PLOS ONE by Kevin Hamill of the University of Liverpool, and colleagues.

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Taking over-the-counter probiotic supplements was associated with a 70 percent lower chance of response to cancer immunotherapy treatment with anti-PD-1 checkpoint inhibitors in melanoma patients, according to a preliminary study from the Parker Institute for Cancer Immunotherapy (PICI) and The University of Texas MD Anderson Cancer Center. The results are being presented April 2 at the American Association for Cancer Research (AACR) 2019 Annual Meeting in Atlanta.

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A study from Sanford Burnham Prebys has demonstrated a causal link between the gut microbiome and the immune system’s ability to fight cancer. The researchers identified a cocktail of 11 bacterial strains that activated the immune system and slowed the growth of melanoma in mice. The study also points to the role of unfolded protein response (UPR), a cellular signaling pathway that maintains protein health (homeostasis). Reduced UPR was seen in melanoma patients who are responsive to immune checkpoint therapy, revealing potential markers for patient stratification. The study was published in Nature Communications.

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Hairlessness in dogs can be the result of deliberate breeding or, in certain breeds, a defect. A recent study completed at the University of Helsinki describes a gene variant in the SGK3 gene, which causes hairlessness in Scottish Deerhounds. The gene defect results in puppies born with thin fur that lose all of their hair in a few weeks. SGK3 is also a candidate for association with non-hormonal baldness in humans.

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Researchers at Binghamton University, State University of New York, have developed skin-inspired electronics to conform to the skin, allowing for long-term, high-performance, real-time wound monitoring in users.

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White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at the AACR Annual Meeting 2019 in Atlanta.

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A combination of two topical creams already shown to clear precancerous skin lesions from sun-damaged skin also lowers the risk that patients will later develop squamous cell carcinoma of the skin, according to a new study.

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Puberty is something we all go through and yet there is limited science to explain how it affects our physical and mental health. The answers to these questions may be found in our hair.

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Rosacea is a common skin condition that causes redness to form across the nose and cheeks. In addition to seeing a dermatologist for proper diagnosis and treatment, patients can help control their condition and prevent it from getting worse by identifying and avoiding the things that cause their rosacea to flare.

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Researchers at Binghamton University, State University of New York have developed a new device that could help minimize scarring during surgery. The device can ascertain the orientation of skin tension lines, which is important for wound-healing post-surgery.

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Researchers at Rutgers Cancer Institute of New Jersey and University of Virginia Center for Behavioral Health and Technology have found that a web-based intervention targeting sun protection behaviors and skin self-examinations in melanoma patients is effective in promoting short-term improvements in these activities.

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New research lays foundation for upcoming clinical trial for patients with epidermolysis bullosa

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Researchers at UC San Diego School of Medicine generated a new mouse model that mimics human acne for the first time, and used it to validate the concept of “good” and “bad” acne bacteria and introduce new possibilities for targeted treatments and vaccines.

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Bandages infused with electricity can help heal wounds faster than typical bandages or antibiotics—but for years, researchers have not really understood why. A recent study by a team at The Ohio State University is offering new clues about the science behind those bandages, and researchers say the findings could help lead to better wound treatment.

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麻风病的历史跨越了数个世纪，触及过全球的社会群体。然而，这一疾病即便在现代依然是一个大问题。慢性传染性皮肤病的患者仍面临着社会歧视、医疗护理缺乏等问题，这些问题从疾病出现之初时就存在，并延续至今。尽管麻风病可治，世界卫生组织数据仍显示2016 年出现了 216,108 个病例，这其中的一些患者是在 Mayo Clinic 罗切斯特分院就医的。

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Laws that require landlords to disclose bed bug infestations help combat the spread of the insects and protect the health of potential tenants. According to a new study, these laws also lead to cost savings, on average, for landlords within five years. Researchers in the Perelman School of Medicine at the University of Pennsylvania published their findings today in Proceedings of the National Academy of Sciences (PNAS).

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The American Academy of Dermatology will install four new officers and four new members of its board of directors on Tuesday, March 5, at the conclusion of the 2019 AAD Annual Meeting in Washington.

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Board-certified dermatologist George J. Hruza, MD, MBA, FAAD, will begin his one-year term as president of the American Academy of Dermatology on Tuesday, March 5, at the conclusion of the 2019 AAD Annual Meeting in Washington.

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Research presented at the 2019 American Academy of Dermatology Annual Meeting in Washington indicates that people with hyperhidrosis are more likely than the general population to have anxiety, depression and attention deficit disorder.

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A growing body of evidence indicates that PRP treatment can provide effective therapy for hair loss.

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Data presented at the 2019 AAD Annual Meeting in Washington indicate that there is no significant difference in the frequency of depression between acne patients treated with isotretinoin and those who receive other types of therapy.

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As more frequent and intense flooding events have occurred in recent years, both disaster victims and relief workers have experienced significant dermatologic problems.

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Research indicates that 10 percent of people with tattoos experience some sort of complication; a board-certified dermatologist can help these individuals.

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While this technology has performed well in research settings, there is still a lot of work to be done before it is appropriate for real-world use.

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Los investigadores de Mayo Clinic identificaron un gen llamado UCP-1 que predice la aparición del cáncer pancreático en personas con diabetes tipo 2. Los resultados se publican en Gastroenterology.

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Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created such a mobile skin bioprinting system – the first of its kind – that allows bi-layered skin to be printed directly into a wound.

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New NCCN Guidelines for Patients: Squamous Cell Skin Cancer explains risk factors and treatment options for cancer type that impacts millions every year.

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A single dose of a PD-1 inhibitor before surgery for melanoma can put patients in remission.

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El historial de la lepra data de siglos atrás y muchas sociedades de todo el mundo se han visto afectadas por ella; pero la lepra continúa siendo un problema, aun en la era moderna.

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Because sunscreen is an important tool in the fight against skin cancer, the AADA supports any and all regulations to ensure that the public has access to safe and effective sunscreens.

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Leprosy has a history that has spanned centuries and societies across the globe. Yet, it continues to be a problem — even in the modern era. Sufferers from the chronic and infectious skin disease still face the social stigma and lack of medical care that people have endured since the origins of the disease itself. Although leprosy can be treated, the World Health Organization reported 216,108 cases in 2016, with some of these patients seeking treatment at Mayo Clinic's Rochester campus.

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Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system’s ability to fight melanoma in mice. The agents, dubbed s-DAB-IL-2 and s-DAB-IL-2(V6A), comprise a regulatory protein called human interleukin-2 fused to chemically modified portions of diphtheria toxin.

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The disease systemic lupus erythematosus (SLE) — marked by the attack on joints, skin, and kidneys by the body’s immune system — is linked to an abnormal mix of bacteria in the gut. This is according to a new study led by scientists at NYU School of Medicine.

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Collaborative research by The Wistar Institute and Moffitt Cancer Center has demonstrated that BRAF targeted therapies render resistant melanoma more sensitive to the attack of killer T cells.

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The American Academy of Dermatology and the National Psoriasis Foundation's two new psoriasis guidelines, which address comorbidities and biologics, were published online in the Journal of the American Academy of Dermatology on Feb. 13.

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Henry Ford Cancer Institute oral cancer patient Marlene Calverley, a minimally-invasive sentinel node biopsy meant having three instead of 30-60 lymph nodes removed, and a two-inch scar instead of a five-to-six-inch scar. It also meant no neck drains, no physical therapy, and a decreased risk of complications.

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In the spirit of Valentine’s Day, dermatologists from the American Academy of Dermatology are advising the public about a simple yet important self-care routine: nail grooming. Not only do short, well-manicured nails look great, they say, they are also less likely to harbor dirt and bacteria, which can lead to an infection. In addition, the right nail clipping technique can help prevent common issues like hangnails and ingrown toenails.

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New insights on circumventing a key obstacle on the road to anti-scarring treatment have been published by Maksim Plikus, an associate professor in development and cell biology at the UCI School of Biological Sciences and colleagues in Nature Communications. The research team discovered that the natural scar-free skin repair process relies partially on assistance from circulating blood cells. The results point the way toward possible treatments for scar-free wound healing that target the body’s own blood cells.

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Tungiasis, a tropical disease associated with poverty, is caused by the penetration of female sand fleas into a person’s skin, usually in their toes or feet. This week in PLOS Neglected Tropical Diseases, researchers report five cases of severe tungiasis to illustrate how the disease may develop into a life-threatening condition.

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