Rutgers Cancer Institute of New Jersey resident researcher was recently awarded a 2021 AACR-Bayer Innovation and Discovery Grant (21-80-44-HERR) from the American Association for Cancer Research (AACR) to further explore a novel mitochondrial uncoupling drug in the treatment of leukemia and a potential therapeutic strategy against T-ALL.
Mayo Clinic researchers and colleagues at Massachusetts Institute of Technology (MIT) have developed a rapid-sealing paste that can stop bleeding organs independent of clotting. The details are published in Nature Biomedical Engineering. The inspiration for this paste? Barnacles.
GRAND RAPIDS, Mich. (August 3, 2021) — The average American eats roughly 22 teaspoons of added sugar a day — more than three times the recommended amount for women and more than double the recommended amount for men.
The investigators discovered that in moderately ill patients full-dose heparin reduced the need for organ support compared to those who received lower-dose heparin.
A world-first study led by the University of South Australia has found that cancer patients receiving chemotherapy intravenously have more than double the risk of developing a blood clot or thrombosis if the vein is too small and the catheter occupies more than 45 per cent of the vein.
One in ten babies is born prematurely in the United States, but a blood test during a routine prenatal visit could reveal if a woman is at risk of a preterm delivery, according to a Michigan State University researcher. “Preterm births are common,” said Hanne Hoffmann, an assistant professor in the Department of Animal Science in the College of Agriculture and Natural Resources. “If we know the mother is at risk for a preterm birth, her doctor can monitor her more closely.”
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.
People living in the South, known as the Stroke Belt, are not only at a greater risk of having strokes, but the region is also associated with higher stroke mortality. The link between high blood pressure and stroke is well-known, and lowering blood pressure reduces stroke risk. But how can blood pressure be most effectively managed among stroke survivors, and is the use of telehealth the most effective strategy?
Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in The Lancet Oncology.
A collaboration led by St. Jude Children’s Research Hospital, Shanghai Children’s Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
After examining nearly the entire human genome for genetic changes that increase risk of aneurysm, researchers discovered a new change in the genetic code of a transcription factor.
University of Maryland School of Medicine and University of Vermont researchers have shown how the brain communicates to blood vessels when in need of energy, and how these blood vessels respond by relaxing or constricting to direct blood flow to specific brain regions.
Researchers revealed new insights into how acute myeloid leukemia (AML) develops and progresses, according to a study published in Molecular Cell on July 20, 2021. They describe a mechanism by which AML cells regulate a cancer-related protein, mutant IDH2, to increase the buildup of blood cancer cells—a distinguishing characteristic of the disease.
A potentially game-changing treatment for people with, or at risk of, blood clots has been found effective by an international team of researchers led by McMaster University. Results showed one abelacimab injection prevents blood clots for up to a month after surgery, reducing the risk by about 80%.
Lymphoma is a rare form of cancer that affects bone marrow, lymph nodes, the thymus gland and spleen, collectively known as the lymphatic system. To understand more about lymphoma, we spoke with the co-medical director of the Cancer Program at Mountainside Medical Center, Lori Leslie, M.D.
Findings from an international multicenter trials showed that while a full dose of heparin didn't statistically significantly lower incidence of the primary composite of death, mechanical ventilation or ICU admission compared with low-dose heparin, therapeutic heparin did reduce the odds of all-cause death by 78 percent.
The American College of Rheumatology (ACR), in partnership with the Vasculitis Foundation (VF), released three new guidelines for the treatment and management of systemic vasculitis.
The American College of Rheumatology (ACR), in partnership with the Vasculitis Foundation (VF), released three new guidelines for the treatment and management of systemic vasculitis.
A McMaster University team of researchers recently discovered how, exactly, the COVID-19 vaccines that use adenovirus vectors trigger a rare but sometimes fatal blood clotting reaction called vaccine-induced immune thrombotic thrombocytopenia or VITT.
In a new study on mice, Johns Hopkins Medicine researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington’s disease, a neurodegenerative disorder that attacks brain cells. The researchers say that by identifying and treating the mutation known to cause Huntington’s disease with this type of gene therapy, before a patient starts showing symptoms, it may slow progression of the disease.
Dr. Elizabeta Nemeth, professor of medicine and director of the Center for Iron Disorders at the David Geffen School of Medicine at UCLA, has been awarded the 2021 William Dameshek Prize by the American Society of Hematology (ASH) for her contributions to the field of hematology.
A Rutgers-led team of researchers has developed a microchip that can measure stress hormones in real time from a drop of blood.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include expanded use of a targeted therapy for a new group of patients with leukemia, molecular studies yielding novel cancer therapeutic targets, insights into radiation therapy resistance and a community intervention to reduce cervical cancer rates.
Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first time: Covid-19 significantly changes the size and stiffness of red and white blood cells - sometimes over months.
Four leading medical specialty societies released a new clinical practice guideline that includes recommendations for reducing blood loss during heart surgery and improving patient outcomes. The document is a multidisciplinary collaboration among The Society of Thoracic Surgeons, Society of Cardiovascular Anesthesiologists, American Society of ExtraCorporeal Technology, and Society for the Advancement of Patient Blood Management.
A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine.
Patients with a type of blood cancer called multiple myeloma had a widely variable response to COVID-19 vaccines—in some cases, no detectable response—pointing to the need for antibody testing and precautions for these patients after vaccination, according to a study published in Cancer Cell in June.
After a stroke, doctors can try to remove clots in blood vessels to keep blood flowing freely to the brain. But even though most of these procedures are successful, less than half of people have a successful recovery from the stroke. A new study published in the June 23, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology, sheds light on why that may be.
DALLAS – June 23, 2021 – UT Southwestern will lead a multicenter investigation into why children and young adults experience decreased physical activity and shortness of breath after experiencing blood clots, thanks to a four-year $2.97 million grant from the National Institutes of Health (NIH).
Irvine, Calif., June 21, 2021 — A large-scale meta-analysis led by University of California, Irvine researchers provides the strongest evidence yet of which blood pressure medications help slow memory loss in older adults: those that can travel out of blood vessels and directly into the brain. The findings, published in the American Heart Association journal Hypertension, will be of interest to the 91 million Americans whose blood pressure is high enough to warrant medication, as well as the doctors who treat them.
Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach.
A large, retrospective, multicenter study involving Washington University School of Medicine in St. Louis indicates that convalescent plasma from recovered COVID-19 patients can dramatically improve likelihood of survival among blood cancer patients hospitalized with the virus. The therapy involves transfusing plasma — the pale yellow liquid in blood that is rich in antibodies — from people who have recovered from COVID-19 into patients who have leukemia, lymphoma or other blood cancers and are hospitalized with the viral infection.
In a new paper published in the journal Circulation, researchers built a model to examine the potential impact of implementing similar blood pressure control programs at barbershops nationwide. Modeled off a 2018 randomized trial called the Los Angeles Barbershop Blood Pressure Study (LABBS), the team found that such programs could reach one in three Black men with uncontrolled blood pressure nationally.
The treatment’s effectiveness was described in a report describing three Canadian patients who received the AstraZeneca vaccine, and who subsequently developed VITT. Two suffered clotting in their legs and the third had clots blocking arteries and veins inside their brain.
New research by the Georgia Institute of Technology and Emory University published in the journal Biomaterials sheds new light on the mechanics and physics of blood clotting through modeling the dynamics at play during a still poorly understood phase of blood clotting called clot contraction. Understanding the physics of this clot contraction could potentially lead to new ways to treat bleeding problems and clotting problems.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers developed an approach that could produce more hemoglobin through a single vector. The results were published in Haematologica.
Cellphire Therapeutics, Inc., a biotechnology company developing next-generation platelet-based hemostatic therapeutics for application across multiple medical indications, announced today that the first patient has been dosed in the company's Phase 2 dose-ranging study of Thrombosomes®, a platelet-based freeze-dried hemostatic agent, in bleeding patients with thrombocytopenia. The study will evaluate the safety and efficacy of infusing multiple dose levels of Thrombosomes versus standard liquid stored platelets.
Antibodies aren’t the only immune cells needed to fight off COVID-19 — T cells are equally important and can step up to do the job when antibodies are depleted, suggests a new Penn Medicine study of blood cancer patients with COVID-19 published in Nature Medicine.
Along with a first-place winner, there are two honorable mentions in the Vasculitis Foundation’s (VFs) 2021 Recognizing Excellence in Diagnostics (V-RED) award program.
A rare syndrome has been observed in people following vaccination against Covid-19.
National STOP THE BLEED® Day provides a renewed opportunity to highlight why it’s important that everyone learn how to control serious bleeding.
Researchers at Rutgers Robert Wood Johnson Medical School are reporting the first instance of COVID-19 triggering a rare recurrence of potentially serious blood clots in people’s arms.
RNA-based drugs may change the standard of care for many diseases, making personalized medicine a reality. So far these cost-effective, easy-to-manufacture drugs haven’t been very useful in treating brain tumors and other brain disease. But a team of researchers at Georgia Tech and Emory University has shown that a combination of ultrasound and RNA-loaded nanoparticles can temporarily open the protective blood-brain barrier, allowing the delivery of potent medicine to brain tumors.
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