Rutgers and other scientists have discovered how brown fat, also known as brown adipose tissue, may help protect against obesity and diabetes. Their study in the journal Nature adds to our knowledge about the role of brown fat in human health and could lead to new medications for treating obesity and type 2 diabetes.
The American Society of Nephrology (ASN) recently launched a new initiative aimed at saving lives of those who suffer from acute kidney injury (AKI). Made possible by a grant from Baxter Healthcare Corporation, the effort is called AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury.
Castleman Disease patients who do not respond to the only drug currently approved by the FDA may have another option that targets a specific pathway called PI3K/Akt/mTOR
AnaBios Corp. today announced it is providing validated human dorsal root ganglion (hDRG) to the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), for research collaborations to develop human cell-based screening platforms and novel drugs to treat pain and opioid use disorder.
Fluoride exposure may lead to a reduction in kidney and liver function among adolescents, according to a study published by Mount Sinai researchers in Environment International in August.
The internet can serve as a pathway to diagnosis and care for people who suspect they have a rare condition that has not been identified by their physicians, according to a study by researchers at Wake Forest School of Medicine, part of Wake Forest Baptist Health.
Mount Sinai researchers describe striking racial and ethnic disparities exist in the use of palliative care by hospitalized patients with end-stage kidney disease (ESKD) on dialysis, based on a a retrospective cohort study.
For transplant patients, organ rejection can be a serious complication. A new clinical trial at the UK Transplant Center seeks to change how the body reacts to a new organ by inducing tolerance to it through a special process prior to transplant.
• Brain aneurysms were detected by pre-symptomatic screening in 9% of patients with autosomal dominant polycystic kidney disease, more frequently in those with a history of hypertension and smoking. • Very few patients experienced aneurysmal ruptures, but the overall rupture rate was approximately 5 times higher than in the general population.
• The number of U.S. patients with kidney failure undergoing weight loss surgery increased 9-fold between 2006 and 2016. • The proportional use of sleeve gastrectomy in patients with kidney failure increased from less than 1% of weight loss surgeries in 2006 to 84% in 2016. • Complication rates for sleeve gastrectomy were similar between patients with and without kidney failure; however, patients with kidney failure had more hospital readmissions and slightly longer hospitals stays.
The American Society of Nephrology (ASN) is pleased to announce the launch of the Diabetic Kidney Disease Collaborative (DKD-C) in response to the recent development of new therapies for people with diabetic kidney disease (DKD). The Diabetic Kidney Disease Collaborative will work to increase coordination among primary care physicians, nephrologists, and other specialists to deliver appropriate therapies to people living with DKD.
• In an analysis of information on children with kidney failure who began dialysis in the United States between 1995 and 2015, the risk of death was 1.36 times higher among children with higher kidney function at dialysis initiation. • The risk of death was even greater for children with higher kidney function who initiated treatment with hemodialysis rather than peritoneal dialysis. • In more recent years, children have been started on dialysis with higher kidney function.
Among U.S. patients who started dialysis in 2005 to 2013, racial/ethnic differences in initiating home dialysis decreased over time, although in the most recent era, Blacks were still less likely to use home dialysis as the initial modality than other groups.
Washington, D.C. – July 11, 2019 – Today, the U.S. Department of Health and Human Services (HHS), American Society of Nephrology (ASN) and National Kidney Foundation (NKF) announced a new prize competition that seeks to identify ideas and solutions patients and care partners have developed to improve their daily life with kidney disease. The KidneyX Patient Innovator Challenge, funded by the National Kidney Foundation (NKF) invites individuals, communities, businesses, institutions, and not-for-profit organizations, among others, to submit ideas on how to improve therapeutic options and quality of life for people living with kidney disease.
•From 2006 to 2014, patients with chronic kidney disease (CKD) had a high prevalence of uncontrolled hypertension that did not decrease over time.
Nearly a fifth of the respondents in a recent study said they would reverse their opposition to compensating kidney donors if a form of non-cash payment led to a substantial increase in the supply of available organs for transplant.
President Donald J. Trump and Department of Health and Human Services Secretary Alex Azar, II, today unveiled the Advancing American Kidney Health initiative.
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients. Over 850 million people suffer from kidney diseases worldwide, a number which signifies epidemic proportions, yet these patients are still ignored by investigators and initiators of clinical trials in all medical fields – and are thus excluded from clinical trials. ASN, ERA-EDTA and ISN, collaboratively aim to bring about a paradigm change in medical research and have launched an information campaign to that end.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
• In older adults initiating dialysis at 17 centers in Netherlands, 40% experienced a decline in functional status, 34% remained stable, 18% improved, and 8% died within 6 months. • The risk of functional decline or death was higher in participants who were older and those who were frail. • The percentage of caregivers reporting a high burden of care increased from 23% to 38% after dialysis initiation.
A common metric for monitoring kidney health may not accurately represent that of Indian patients. Research into an improved method for this population is presented today at the American Physiological Society/American Society of Nephrology Conference, Control of Renal Function in Health and Disease.
• Among older living kidney donors, those with hypertension had higher risk of developing kidney failure through 15 years after donation; however, the absolute risk was small. • Hypertension was not linked with a higher risk of early death among older donors.
Researchers found a low dose of endotoxin prior to induction of acute kidney injury improved outcomes for male rats. Their study will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) Conference: Control of Renal Function in Health and Disease.
Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville, Va.
Early research suggests that the common pantry staple baking soda affects inflammation and insulin handling in type 2 diabetes. The findings will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease in Charlottesville, Va.
New treatments, exciting research and future trends in kidney health are the focus of discussion at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville, Va.
JASN maintains the highest impact ranking among kidney journals, according to a newly announced rating. Journal Citation Reports® (JCR) released its Impact Factor scores for 2018, and JASN earned a score of 8.5. This Impact Factor reflects the journal’s influence, based on the average annual number of citations in 2018 to articles published in a journal during 2016 and 2017. JASN was referenced more than any publication in the field.AMERICAN SOCIETY OF NEPHROLOGY JOURNALS MAINTAIN HIGH RANKING AND IMPACT AMONG KIDNEY JOURNALS Washington, DC (June 20, 2019)—JASN maintains the highest impact ranking among kidney journals, according to a newly announced rating. Journal Citation Reports® (JCR) released its Impact Factor scores for 2018, and JASN earned a score of 8.5. This Impact Factor reflects the journal’s influence, based on the average annual number of citations in 2018 to articles published in a journal during 2016 and 2017. JASN was referenced more than any publication in the f
Many elderly patients with metastatic renal cell carcinoma (RCC)—who are often underrepresented in clinical trials to treat the kidney cancer—are seeing overall survival benefits from treatment with targeted therapies, according to a new study from Penn Medicine researchers published this month in JAMA Network Open. Analyzing 13 years of data on Medicare patients, the study found that the patients who received targeted therapies were more medically complex than those who received the older, more toxic treatments that were available earlier in the study period, indicating that newer treatments are offering hope to more people.
The ASN Foundation for Kidney Research announced the 2019 recipients of research grants to advance new understandings of—and treatments for—kidney diseases. The Foundation will fund 46 leading researchers working to cure kidney diseases. These include 27 new projects, with 19 continuing from 2018. Established in 2012 by the American Society of Nephrology, the Foundation funds research that will help improve the health of approximately 40 million Americans burdened by kidney diseases, the 9th leading cause of death in the United States.
A new study performed in conjunction with the Harvey L. Neiman Health Policy Institute examines changing characteristics of utilization and potential disparities in US emergency department (ED) patients undergoing CT of the abdomen and pelvis (CTAP) for suspected urolithiasis.
A nephrologist at UAB who created a solution to help critically ill patients in the intensive care unit safely receive dialysis has created a fund to boost future inventions and products to help people living with kidney disease.
With a $10-million donation, the University of Toronto is partnering with Princess Margaret Cancer Centre to launch the McCain Centre for Urological Innovation and Education.
The extract successfully restored the blood glucose levels, body weight, and normalized oxidative stress on renal function in a test group of Zucker diabetic fatty rats.
Top renal experts will discuss current and cutting-edge research on kidney function at the upcoming American Physiological Society (APS)/American Society of Nephrology (ASN) Conference: Control of Renal Function in Health and Disease in Charlottesville, Va.
Long-term hemodialysis is a lifesaver for approximately half a million patients in the United States with kidney failure (also known as end-stage renal disease, or ESRD) who are either waiting on or unsuitable for a kidney transplant. But before the external machinery can take over the function of the kidneys — filtering and cleansing wastes from the blood — a minor surgical procedure is needed to create a stable, functional and reusable access to the circulatory system, usually through blood vessels in the arm.
A clinical trial that followed more than 9,900 people in 24 countries has found that the drug dulaglutide reduced cardiovascular events and kidney problems in middle-aged and older people with Type 2 diabetes. During more than five years of follow-up, cardiovascular events like heart attacks and strokes were reduced by 12% in people taking dulaglutide compared to people taking a placebo. This effect was seen in both men and women with or without previous cardiovascular disease.
The faster fluid is removed using continuous dialysis from patients with failing kidneys, the higher the likelihood they will die in the next several months, according to a study published today in JAMA Network Open by University of Pittsburgh School of Medicine researchers.
• In a study of patients with chronic kidney disease who did or did not wear medical-alert bracelets or necklaces, the frequency of safety events—or unintended harm from medical therapy—reported at annual visits was not different in the 2 groups. • Wearing a medical-alert accessory was linked with a 62% lower risk of developing kidney failure, after adjustments. • There was no significant difference in rates of hospitalization or death in those who did and did not wear medical-alert accessories.
A new test to illuminate kidney cancers may identify patients who are most likely to benefit from immunotherapy.
A study from researchers at Washington University School of Medicine in St. Louis and Veterans Affairs St. Louis Health Care System has linked long-term use of drugs known as proton pump inhibitors (PPIs) to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. The researchers found that such risks increase with the duration of PPI use, even when taken at low doses.
Cancer patients previously excluded and underrepresented in immunotherapy clinical trials, such as African Americans and patients with HIV or viral hepatitis, actually benefit at the same rate as patients tested in the clinical trials, according to a Georgetown-led study to be presented at the 2019 ASCO Annual Meeting in Chicago.
BK polyomavirus is harbored in most humans; in kidney transplant patients, immune suppression drugs to help the kidney can reactivate the virus and instead cause kidney failure. Research shows a way to reduce BK polyomavirus levels in patients without reducing immunosuppressing drugs.
A new research study by Harvey L. Neiman Health Policy Institute found that utilization of invasive procedures on hemodialysis conduits—artificially constructed shuts used by many individuals who require dialysis—increased markedly from 2001 through 2015 for nephrologists and declined for radiologists. The study is published online in the Journal of Vascular and Interventional Radiology (JVIR).
In his lab, UdeM professor Alexis Vallée-Bélisle is busy perfecting a biosensor that patients with kidney disease, heart disease or other chronic illnesses can use without leaving home.
• Volume overload, or too much fluid in the body, is a frequent problem in patients with kidney failure initiating peritoneal dialysis. • Volume overload tends to improve over time after starting peritoneal dialysis, but is consistently higher in males vs. females and in patients with diabetes vs. those without. • Volume overload is associated with a higher risk of premature death.
An 84-year old becomes the oldest living kidney donor after donating to his 72-year old neighbor. Also, talks about how you are never too old to save someone's life.
Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have shown the feasibility of bioengineering vascularized functional renal tissues for kidney regeneration, developing a partial augmentation strategy that may be a more feasible and practical approach than creating whole organs.
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