Feature Channels: Biotech

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Released: 12-Sep-2022 12:00 PM EDT
Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes
Preprints

Carlos Bernal-Mizrachi, Jisu Oh, Amy E Riek, Kevin T Bauerle, Adriana Dusso, Kyle McNerney, Ruteja Barve, Isra Darwech, Jennifer Sprague, Clare Moynihan, Rong M Zhang, Ting Wang, Xiaoyun Xing, Daofeng Li,

Newswise: Call for Papers – The International Halal Science and Technology Conference 2022 (IHSATEC): 15th Halal Science Industry and Business (HASIB)
Released: 12-Sep-2022 8:55 AM EDT
Call for Papers – The International Halal Science and Technology Conference 2022 (IHSATEC): 15th Halal Science Industry and Business (HASIB)
Chulalongkorn University

The Halal Science Center, Chulalongkorn University, and Research Synergy Foundation, invite all to attend “The International Halal Science and Technology Conference 2022 (IHSATEC): 15th Halal Science Industry and Business (HASIB)” and has opened up a call for papers. The conference sessions will be on December 15-16, 2022 at Chulalongkorn University, Bangkok, Thailand.

Newswise: Biologists Create Nanogold for Medicine and Agronomy
Released: 12-Sep-2022 3:05 AM EDT
Biologists Create Nanogold for Medicine and Agronomy
Scientific Project Lomonosov

RUDN biologists in collaboration with scientists from Iran have obtained gold nanoparticles using harmless fungi living on a peach tree. The resulting particles proved to be useful in the fight against a pathogenic fungus that infects rice and potatoes. Potentially, nanoparticles can be used in medicine.

Released: 10-Sep-2022 12:00 PM EDT
Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue
Preprints

Gregor Andelfinger, Andrew Song, Renata H.M. Sindeaux, Yuanyi Li, Hicham Affia, Tapan Agnihotri, Severine Leclerc, Patrick Piet van Vliet, Mathieu Colas, Jean-Victor Guimond, Natasha Patey, Jean-Sebastien Joyal, Elie Haddad, Luis Barreiro

Released: 9-Sep-2022 12:00 PM EDT
Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells
Preprints

Ross Burdis, Gabriela Soares Kronemberger, Daniel J Kelly

Released: 9-Sep-2022 12:00 PM EDT
Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators
Preprints

Saptarshi Mallick, Jayati Chakrabarti, Jennifer Eschbacher, Andreas G Moraitis, Andrew E Greenstein, Jared Churko, Kelvin W Pond, Antonia Livolsi, Curtis A Thorne, Andrew S Little, Kevin Cj Yuen, Yana Zavros

Released: 9-Sep-2022 12:00 PM EDT
Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway
Preprints

Hao Liu, Qiwei Zhang, Ranli Gu, Wei Li, Yunsong Liu, Yongsheng Zhou

Released: 9-Sep-2022 12:00 PM EDT
Macromolecular crowding facilitates rapid fabrication of intact, robust cell sheets
Preprints

Shuwen Guan, Shipeng Wu, Gang Li, Jiangwei Xiao, Botao Gao

Released: 9-Sep-2022 12:00 PM EDT
Unselfish traits and social decision-making patterns characterize six populations of real-world extraordinary altruists
Preprints

Shawn A Rhoads, Kruti Vekaria, Katherine O'Connell, Hannah S Elizabeth, David Gertler Rand, Megan Kozak Williams, Abigail Marsh

Released: 9-Sep-2022 12:00 PM EDT
Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy
Preprints

Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Joel Boutin, Junio Dort, Zakaria Orfi, Joris Michaud, Hugo Giguere, Alexandre Desroches, Francois Vezina, Sonia Bedard, Frederic Balg, Philippe Sarret,

Released: 9-Sep-2022 12:00 PM EDT
Impact of pretransplant donor-specific anti-HLA antibodies in HLA-mismatched peripheral blood stem cell transplantation
Preprints

Takeshi Hagino, Kazuhiro Ikegame, Hidenori Tanaka, Yoshinobu Kanda, Katsuji Kaida, Takahiro Fukuda, Yukio Kondo, Maho Sato, Noriko Doki, Hirohisa Nakamae, Ken-Ichi Matsuoka, Yasuo Mori, Hideki Sano, Tetsuya Eto,

Released: 9-Sep-2022 12:00 PM EDT
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome induced ovarian insufficiency by modulating macrophage M2 polarization
Preprints

Dongmei Chen, Na Hu, Shasha Xing, Li Yang, Feiyan Zhang, Songlin Guo, Shudan Liu, Xiaona Ma, Xueyun Liang, Huiming Ma

Released: 9-Sep-2022 12:00 PM EDT
Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Preprints

Roman Thaler, Keigo Yoshizaki, Thai Nguyen, Satoshi Fukumoto, Pamela DenBesten, Daniel D Bikle, Yuko Oda

Released: 9-Sep-2022 12:00 PM EDT
Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages
Preprints

Wenyu Gou, Wei Hua, Lindsay Swaby, Wanxing Cui, Erica Green, Katherine Morgan, Charlie Strange, Hongjun Wang

Released: 9-Sep-2022 12:00 PM EDT
p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation
Preprints

Justine Creff, Ada Nowosad, Anne Prel, Anne Pizzocaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson

Released: 9-Sep-2022 12:00 PM EDT
Identification of the Metaphyseal Skeletal Stem Cell
Preprints

Guan Yang, Qi He, Xiaoxiao Guo, Rong-Yu Li, Jingting Lin, Wanyu Tao, Wenjia Liu, Huisang Lin, Mingchuan Tang, Shilai Xing, Yini Qi, Yanli Peng, Lei Dong, Jing-Dong J Han, Bin

Newswise: Ceramic material could improve MRIs by enabling faster times, better images
Released: 9-Sep-2022 9:30 AM EDT
Ceramic material could improve MRIs by enabling faster times, better images
Penn State Materials Research Institute

An academic/enterprise partnership that includes Penn State researchers is developing a new dielectric material to enable magnetic resonance imaging (MRI) machines with shorter scan times and higher image resolutions, good news for cutting the cost of MRI scans for the hospitals and for patients who struggle with MRI-related anxiety.

   
Released: 8-Sep-2022 12:00 PM EDT
A time and single-cell resolved model of hematopoiesis
Preprints

Iwo Kucinski, Joana Campos, Melania Barile, Francesco Severi, Natacha Bohin, Pedro N Moreira, Lewis Allen, Hannah Lawson, Myriam L R Haltalli, Sarah J Kinston, Dónal O'Carroll, Kamil R Kranc, Berthold Göttgens

Released: 7-Sep-2022 12:00 PM EDT
ESDR579 - Clinical grade human pluripotent stem cells derived engineered skin substitutes promote keratinocytes wound closure in vitro
Preprints

Sophie Domingues, Annabelle Darle, Yolande Masson, Manoubia Saidani, Emilie Lagoutte, Ana Bejanariu, Julien Coutier, Raif Eren Ayata, Marielle Bouschbacher, Marc Peschanski, Lemaitre Gilles, Christine Baldeschi

Released: 7-Sep-2022 9:00 AM EDT
MD Anderson and Virogin Biotech announce strategic collaboration to accelerate oncolytic virus research and development for treating advanced cancers
University of Texas MD Anderson Cancer Center

MD Anderson and Virogin Biotech today announced a strategic collaboration to accelerate the development of oncolytic virus therapies for advanced cancers.

Released: 6-Sep-2022 12:00 PM EDT
CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development
Preprints

Xiangling Meng, David Yao, Kevin W Kelley, Noah Reis, Mayuri V Thete, Shravanti Kulkarni, Michael C Bassik, Sergiu P Pasca

Released: 6-Sep-2022 12:00 PM EDT
Photoelectrochemical imaging of action potentials for single cardiomyocytes through contact force manipulation of organoids
Preprints

Rachel Jacques, Bo Zhou, Emilie Marhuenda, Jon Gorecki, Anirban Das, Thomas Iskratsch, Steffi Krause

Released: 6-Sep-2022 12:00 PM EDT
ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation
Preprints

Suyang Zhang, Yile Huang, Feng Yang, Liangqiang He, Yuying Li, Yi Ching Esther Wan, Yingzhe Ding, Kui Ming Chan, Ting Xie, Hao Sun, Huating Wang

Released: 6-Sep-2022 12:00 PM EDT
3D Human Induced Pluripotent Stem Cell-derived Bioengineered Skeletal Muscles for Tissue, Disease and Therapy Modelling
Preprints

Luca Pinton, Moustafa Khedr, Valentina M. Lionello, Shilpita Sarcar, Sara M. Maffioletti, Sumitava Dastidar, Elisa Negroni, Sungwoo Choi, Noreen Khokhar, Anne Bigot, John R. Counsell, Andreia Sofia Bernardo, Peter S. Zammit, Francesco Saverio Tedesco

Newswise: Artificial Breathing System Reveals Alveoli Function in Lungs
31-Aug-2022 2:05 PM EDT
Artificial Breathing System Reveals Alveoli Function in Lungs
American Institute of Physics (AIP)

In Biomicrofluidics, scientists in China created a model alveolar system that mimics the breathing action of the human lung and allows visualization of flow patterns within the alveoli. The chip they designed includes tubes arranged like the structure of a bifurcation point in the bronchial network. The upper layer of the chip is made of a flexible polymer molded into small tubes that mimic the alveolar structure. The lower layer is glass, which allows the authors to visualize fluid flow through the tubes.

   
Newswise: Technology that simulates complex molecular interactions could lead to better treatments for diseases like cancer and COVID-19
5-Sep-2022 9:00 AM EDT
Technology that simulates complex molecular interactions could lead to better treatments for diseases like cancer and COVID-19
University of Minnesota College of Science and Engineering

A team led by University of Minnesota Twin Cities biomedical engineers has developed a universally accessible application that can simulate complex molecular interactions, which will allow researchers to design better treatments for diseases like cancer and COVID-19.

   
Released: 5-Sep-2022 12:00 PM EDT
Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion
Preprints

Fei Yang, Jingtao Pang, Guolong Liu, Yang Yang, Shenguang Qin, Ying Zhang, Yongrong Lai, Dan Liang, Yuxuan Wu

Released: 5-Sep-2022 12:00 PM EDT
Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer
Preprints

Zaoqu Liu, Siyuan Weng, Qin Dang, Hui Xu, Yuqing Ren, Chunguang Guo, Zhe Xing, Zhenqiang Sun, Xinwei Han

Released: 4-Sep-2022 12:00 PM EDT
PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling
Preprints

Jodie Hay, Anuradha Tarafdar, Ailsa Holroyd, Hothri A Moka, Karen M Dunn, Alzahra Alshayeb, Bryony H Lloyd, Jennifer Cassels, Natasha Malik, Ashfia F Khan, IengFong Sou, Jamie Lees, Hassan Nb Almuhanna, Nagesh Kalakonda,

Released: 4-Sep-2022 12:00 PM EDT
The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized mice
Preprints

Mathieu Amand, Philipp Adams, Rafaela Schober, Gilles Iserentant, Jean-Yves Servais, Michel Moutschen, Carole Seguin-Devaux

Released: 4-Sep-2022 12:00 PM EDT
Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition
Preprints

Yuki Sato, Mugiho Shigematsu, Maria Shibata-Kanno, Sho Maejima, Chie Tamura, Hirotaka Sakamoto

Released: 4-Sep-2022 12:00 PM EDT
A Beefy-R culture medium: replacing albumin with rapeseed protein isolates
Preprints

Andrew J. Stout, Miriam L. Rittenberg, Michelle Shub, Michael K. Saad, Addison B. Mirliani, David L. Kaplan

Released: 3-Sep-2022 12:00 PM EDT
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.
Preprints

James W McNamara, Ben L Parker, Holly K Voges, Neda Rahmani R Mehdiabadi, Francesca Bolk, Dylan D Chung, Natalie Charitakis, Jeff Molendijk, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L Pointer, Petros Syrris, Luis R Lope

Released: 3-Sep-2022 12:00 PM EDT
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to-mesenchymal transition
Preprints

Marko Marjanovic, Ana-Matea Mikecin Drazic, Marija Mioc, Filip Klicek, Mislav Novokmet, Gordan Lauc, Marijeta Kralj

Released: 3-Sep-2022 12:00 PM EDT
Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
Preprints

Xiaofei Li, Zaneta Andrusivova, Paulo Czarnewski, Christoffer Mattsson Langseth, Alma Andersson, Yang Liu, Daniel Gyllborg, Emelie Braun, Ludvig Larsson, Lijuan Hu, Zhanna Alekseenko, Hower Lee, Christophe Avenel, Helena Kopp Kallner

Released: 3-Sep-2022 12:00 PM EDT
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
Preprints

Yiming Chao, Yang Xiang, Jiashun Xiao, Shihui Zhang, Weizhong Zheng, Xiaomeng Wan, Zhuoxuan Li, Mingze Gao, Gefei Wang, Zhilin Chen, Mo Ebrahimkhani, Can Yang, Angela Ruohao Wu, Pentao Liu,

Released: 3-Sep-2022 12:00 PM EDT
MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia
Preprints

Arshad Ahmed Padhiar, Xiaohong Yang, Zhu Li, Jinqi Liao, İlyas Ali, Wei Shu, Arif Ali Chishti, Liangge He, Gulzar Alam, Abdullah Faqeer, Yan Zhou, Shuai Zhang, Ting Wang, Tao Liu,

Released: 2-Sep-2022 1:55 PM EDT
Water-based gel to be tested as dressing for diabetic wounds
Washington University in St. Louis

In early experiments, Jianjun Guan and his team found that after applying a single dose of their wound dressing into wounds in young diabetic mice, the wounds completely closed at day 14. Wounds that were treated only with the hydrogel or were untreated were reduced to roughly half of their original size.

Released: 2-Sep-2022 12:00 PM EDT
Exploration of HSPC aging mechanism based upon in vitro cell modeling and MDS clinical sampling
Preprints

Haiyan Hu, Xiangrong Song, Lin Zhao, Lanyue Hu, Chu Xu, Yanjuan Lin, Manying Zhou, Xiaolan Lian, Lina Zhang

Released: 2-Sep-2022 12:00 PM EDT
Computational Modeling of the Chlamydial Developmental Cycle Reveals a Potential Role for Asymmetric Division
Preprints

Travis J Cherelli, Nicole Grieshaber, Cody Appa, Scott S Grieshaber

Released: 2-Sep-2022 12:00 PM EDT
LGR5 targeting molecules as therapeutic agents for multiple cancer types
Preprints

Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise M O'Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger,

Released: 2-Sep-2022 12:00 PM EDT
Local induction of IAA5 and IAA29 promotes DNA damage-triggered stem cell death in Arabidopsis roots
Preprints

Naoki Takahashi, Nobuo Ogita, Toshiya Koike, Kohei Nishimura, Soichi Inagaki, Masaaki Umeda

Released: 1-Sep-2022 12:00 PM EDT
Nogo-A regulates the fate of human dental pulp stem cells towards osteogenic, adipogenic, and neurogenic differentiation
Preprints

Juliet Shen, Chai Foong Lai, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios Mitsiadis

Released: 1-Sep-2022 12:00 PM EDT
X chromosome dosage drives statin–induced dysglycemia and mitochondrial dysfunction
Preprints

Peixiang Zhang, Joseph J Munier, Laurent Vergnes, Carrie B Wiese, Jenny C Link, Fahim Abbasi, Emilio Ronquillo, Antonio Munoz, Yu-Lin Kuang, Meng Liu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul,

Released: 1-Sep-2022 12:00 PM EDT
Label-free imaging of 3D pluripotent stem cell differentiation dynamics on chip
Preprints

Scott Atwell, Dominik J. E. Waibel, Sayedali Shetab Boushehri, Carsten Marr, Matthias Meier

Released: 1-Sep-2022 12:00 PM EDT
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Protect Bone against Ovariectomy‑Induced Osteoporosis through ERK Signaling by Estrogen Receptor α
Preprints

Hui Qi, Enpu Shen, Beibei Li, Zhiwen Wu, Yongsheng Jie, Rui Zheng, Xiong Shu, Lei Chen, Danping Liu, Cheng'ai Wu



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