Feature Channels: Blood

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Released: 8-Feb-2021 12:35 PM EST
COVID-stripping Blood Filters May Prove Effective Treatment for Sepsis, other Blood-borne Pathogens
Uniformed Services University of the Health Sciences (USU)

Two new blood filters, proven to safely and quickly remove a range of pathogens, including COVID-19, from blood during pre-clinical testing, will now be further evaluated to determine their efficacy in patients under a new cooperative agreement between the Uniformed Services University (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF).

Released: 5-Feb-2021 5:05 PM EST
Fred Hutch statement regarding the FDA approval of CD19 immunotherapy, lisocabtagene maraleucel
Fred Hutchinson Cancer Center

SEATTLE — Feb. 5, 2021 — Today the U.S. Food and Drug Administration approved the chimeric antigen receptor immunotherapy, Breyanzi (lisocabtagene maraleucel or liso-cel), for the treatment of adults with relapsed or refractory (R/R) large B-cell lymphoma after at least two prior therapies.The approval was granted to Bristol Myers Squibb, and development of the therapy was supported by physician-scientists at Fred Hutchinson Cancer Research Center.

Released: 5-Feb-2021 2:35 PM EST
Convalescent Plasma Improved Survival in COVID-19 Patients with Blood Cancers
Vanderbilt University Medical Center

Treatment with convalescent plasma vastly improved the survival rate of patients hospitalized for COVID-19 who also had hematologic malignances that compromise the immune system, according to new data released by the COVID-19 and Cancer Consortium (CCC19).

Released: 4-Feb-2021 3:10 PM EST
Making the ClotChip military ready
Case Western Reserve University

Case Western Reserve University researchers who developed a portable sensor to assess the clotting ability of a person’s blood are working with the U.S. Navy to develop a rugged version of the device to detect problems with blood coagulation in cases of traumatic injury and preserve critical blood supplies.

   
Released: 2-Feb-2021 10:20 AM EST
Moffitt Researchers Identify Why CAR T Therapy May Fail in Some Lymphoma Patients
Moffitt Cancer Center

In a new study published in Blood, the official journal of the American Society of Hematology, Moffitt researchers show that immune dysregulation can directly affect the efficacy of CAR T therapy in patients with diffuse large B-cell lymphoma.

1-Feb-2021 11:55 AM EST
Gene mutations linked to worse outcomes from leukemia in Hispanic and Latino children
Penn State College of Medicine

A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers.

29-Jan-2021 9:00 AM EST
Researchers Discover Mechanism to Overcome Drug-Resistance in B-Cell Acute Lymphoblastic Leukemia
Yale Cancer Center/Smilow Cancer Hospital

In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences.

Released: 1-Feb-2021 12:05 PM EST
Nutrition, companionship reduce pain in mice with sickle cell disease, UCI-led study finds
University of California, Irvine

Irvine, Calif., Feb. 1, 2021 — Researchers from the University of California, Irvine and the University of Minnesota have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin. They also discovered that duloxetine, an antidepressant that boosts serotonin levels, could be an alternative to opioids in treating chronic pain.

Released: 1-Feb-2021 8:35 AM EST
Subset of COVID-19 Patients Have Increased Bleeding Risk
Michigan Medicine - University of Michigan

A new potential biomarker raises concerns over the current standard for treating COVID-19 induced blood clots with high dose blood thinners.

Released: 29-Jan-2021 10:15 AM EST
Noninvasive blood test tracks organ injury from COVID-19
Cornell University

A Cornell-led collaboration has developed a noninvasive blood test that uses cell-free DNA to gauge the damage that COVID-19 inflicts on cells, tissues and organs, and could help aid in the development of new therapies.

Released: 28-Jan-2021 8:30 AM EST
NUS scientists discover a new pathway essential for blood formation
National University of Singapore (NUS)

Scientists from the National University of Singapore have discovered how a protein called Tip60 plays a vital role in the renewal of blood cells in the body. Without it, the stem cells that make new blood suffer catastrophic damage. This discovery could lead to better treatments for life-threatening blood-related diseases like leukemia.

Released: 27-Jan-2021 1:15 PM EST
Research finds blood pressure can be controlled without drugs after spinal cord injury
University of Calgary

Dr. Richi Gill, MD, is back at work, able to enjoy time with his family in the evening and get a good night's sleep, thanks to research.

Released: 26-Jan-2021 2:40 PM EST
Two Anti-viral Enzymes Transform Pre-Leukemia Stem Cells into Leukemia
UC San Diego Health

Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth.

Released: 25-Jan-2021 5:50 PM EST
Los niveles de anticuerpos en plasma convaleciente y el riesgo de muerte por COVID-19
Mayo Clinic

Investigadores y colaboradores de Mayo Clinic descubrieron una asociación entre la administración de plasma convaleciente con alta carga de anticuerpos y menores tasas de mortalidad en pacientes internados con COVID-19 sin respirador.

Released: 25-Jan-2021 8:05 AM EST
Aviso de un experto: Lo que se avista en el horizonte del mieloma múltiple y otros tipos de cáncer de la sangre
Mayo Clinic

El 4 de febrero de 2021 es el Día Mundial contra el Cáncer y sirve para resaltar cómo podemos todos ayudar a reducir el peso mundial del cáncer. En el año 2018, hubo 17 millones de casos nuevos de cáncer y 9,5 millones de muertes por cáncer en todo el mundo.

Released: 22-Jan-2021 3:30 PM EST
No more needles?
Washington University in St. Louis

Blood draws are no fun.They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too.Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.

   
Released: 22-Jan-2021 12:05 PM EST
Full-dose blood thinners decrease need for life support and improved outcomes in hospitalized COVID-19 patients in international trial
University of Manitoba

Clinical trial finds that full-dose treatment with blood thinner reduces need for vital organ support in ICUs in moderately ill hospitalized COVID-19 patients.

Released: 20-Jan-2021 4:55 PM EST
CRISPR technology to cure sickle cell disease at UIC
University of Illinois Chicago

University of Illinois Chicago is one of the U.S. sites participating in clinical trials to cure severe red blood congenital diseases such as sickle cell anemia or Thalassemia by safely modifying the DNA of patients’ blood cells.

   
19-Jan-2021 4:30 PM EST
Designer DNA Therapeutic Wipes Out Cancer Stem Cells, Treats Multiple Myeloma in Mice
UC San Diego Health

UC San Diego study supports launch of Phase I clinical trial to test a designer DNA agent — an antisense oligonucleotide that targets a gene called IRF4 — in patients with multiple myeloma.

Released: 19-Jan-2021 1:55 PM EST
Researchers discover long-sought mechanism behind most severe cases of a common blood disorder
SLAC National Accelerator Laboratory

G6PD deficiency affects about 400M people worldwide and can pose serious health risks. Uncovering the causes of the most severe cases could finally lead to treatments.

   
Released: 19-Jan-2021 11:00 AM EST
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.

Released: 19-Jan-2021 8:00 AM EST
New drug combination shows promise as powerful treatment for AML
Sanford Burnham Prebys

Scientists have identified two drugs that are potent against acute myeloid leukemia (AML) when combined, but only weakly effective when used alone. The researchers were able to significantly enhance cancer cell death by jointly administering the drugs that are only partially effective when used as single-agent therapies.

Released: 18-Jan-2021 12:05 PM EST
UCLA Researcher’s Team Finds Common Blood Pressure Medications do not Increase COVID-19 Risk
UCLA Fielding School of Public Health

Dr. Marc Suchard, of the UCLA Fielding School of Public Health, co-led international research team looking at two widely used types of blood pressure drugs.

Released: 15-Jan-2021 5:35 PM EST
Rapid blood test identifies COVID-19 patients at high risk of severe disease
Washington University in St. Louis

Scientists at Washington University School of Medicine in St. Louis have shown that a relatively simple and rapid blood test can predict which patients with COVID-19 are at highest risk of severe complications or death. The blood test measures levels of mitochondrial DNA, which normally resides inside the energy factories of cells. Mitochondrial DNA spilling out of cells and into the bloodstream is a sign that a particular type of violent cell death is taking place in the body.

13-Jan-2021 11:15 AM EST
Mount Sinai Finds That Transgender Women Can Safely Stay On Their Hormone Treatments During Gender Affirming Surgery, Without An Increase of Blood Clots
Mount Sinai Health System

This is the first study to demonstrate that there is no difference in blood clots when transgender women remain on estrogen hormone therapy for gender affirming surgery. Because both estrogen therapy and surgery can increase a person’s risk of blood clots, experts had long suggested that transgender women stop taking estrogen when undergoing gender affirming surgery. However, there was previously no published data on the blood clot risk specific to transgender women undergoing surgery.

Released: 13-Jan-2021 4:20 PM EST
The Medical Minute: How you can donate blood safely now
Penn State Health

You have the power to save lives today. January is National Blood Donation Month. Learn the benefits of donating—and how local organizations ensure donation is safe—in this week’s Penn State Health Medical Minute.

Released: 13-Jan-2021 2:10 PM EST
New Insights Into the Control of Inflammation
Wistar Institute

Wistar scientists discovered that EGR1 inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions.

Released: 13-Jan-2021 12:15 PM EST
New studies support blood test for early detection of Alzheimer's disease
University of Gothenburg

In three recent publications in Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer's disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials.

Released: 11-Jan-2021 2:45 PM EST
Study: Treatment-related complication for blood cancer patients could be reduced
Indiana University

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia.

Released: 31-Dec-2020 1:30 PM EST
Transfusions with higher red blood cell levels do not improve preterm baby outcomes
George Mason University

Very low birthweight infants are at a high risk for anemia and often need blood transfusions to survive.

Released: 29-Dec-2020 9:45 AM EST
An explanation for the lack of blood oxygenation detected in many COVID-19 patients
University of Seville

One of the physiopathological characteristics of COVID-19 that has most baffled the scientific and medical community is what is known as "silent hypoxemia" or "happy hypoxia".

Released: 28-Dec-2020 9:45 AM EST
The evolving role of platelet-rich plasma (PRP) in plastic surgery
Wolters Kluwer Health: Lippincott

Platelet-rich plasma (PRP) treatment, which involves injecting a small amount of a patient's own blood to release various growth factors from platelets, continues to increase in popularity. The American Society of Plastic Surgeons has tracked the procedure since 2015 and reports a 25 percent increase in cosmetic PRP use in the last four years.

Released: 23-Dec-2020 4:20 PM EST
New Wireless Wearable Sensors Monitor Brain Blood Flow and Oxygenation in Vulnerable Pediatric Patients
Ann and Robert H. Lurie Children's Hospital of Chicago

An interdisciplinary team from Northwestern University and Ann & Robert H. Lurie Children’s Hospital of Chicago developed and clinically tested soft, flexible, miniaturized sensors that gently adhere to the child’s forehead to wirelessly monitor changes in cerebral blood flow and oxygenation, to alert clinicians of potential need to intervene and restore equilibrium. Findings were published in the Proceedings of the National Academy of Sciences (PNAS).

Released: 22-Dec-2020 4:50 PM EST
Secondary Bloodstream Infections Associated with Severe COVID-19
Rutgers University-New Brunswick

People with severe COVID-19 and a secondary blood infection were significantly sicker upon hospital admission, had longer hospital stays and poorer outcomes, according to a Rutgers study.

22-Dec-2020 12:00 PM EST
International Trials of Blood Thinners in Critically Ill COVID-19 Patients Pause Due to Futility
University Health Network (UHN)

Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.

Released: 16-Dec-2020 11:50 AM EST
ALCEDIAG to announce game changing solutions in mental health diseases & diagnostic tools based on RNA-editing blood biomarkers
2020 AACC Annual Scientific Meeting Press Program

ALCEDIAG, one of 3 finalists for the “Disruptive Technology Award” at the annual AACC meeting 2020, will be holding a press conference to announce a game-changing technology and diagnostic tool for precision medicine in psychiatry: EDIT-BTM, the very first blood test for a high-performance differential diagnosis of unipolar depression and bipolar disorder.

Released: 11-Dec-2020 3:10 PM EST
New analysis method for predicting the risks and effects of immunotherapy
Uppsala University

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphocytic leukaemia.

7-Dec-2020 12:05 PM EST
Pitt Scientists Identify Genetic Risks of Rare Inflammatory Disease
Health Sciences at the University of Pittsburgh

A group of international collaborators led by researchers from the University of Pittsburgh identified new genetic associations that can predict individual susceptibility to Takayasu arteritis.

Released: 10-Dec-2020 3:35 PM EST
Nova Blood Gas Analyzers Add Important New Test – Estimated Plasma Volume
2020 AACC Annual Scientific Meeting Press Program

The plasma volume status of a patient is one of the top priorities in evaluating and treating many different conditions including, shock, sepsis, congestive heart failure, acute or chronic kidney disease, chronic pulmonary disease, as well as general postoperative care.

Released: 10-Dec-2020 3:25 PM EST
Supercomputer Modeling Aids Sickle Cell Research Discovery
University of California San Diego

Researchers recently created detailed simulations showing how stiff red blood cells flow through blood vessels, deforming and colliding along the way.

   
Released: 10-Dec-2020 1:05 PM EST
New serological assay provides rapid, accurate testing for SARS-CoV-2 antibodies
University of California, Santa Cruz

Researchers at UC Santa Cruz have developed a novel serological assay for the detection of antibodies to SARS-CoV-2, the coronavirus that causes COVID-19.

3-Dec-2020 2:20 PM EST
Rutgers Research Identifies Safe and Effective Method of Delivering Medicines to the Lungs
Rutgers Cancer Institute of New Jersey

Investigators at Rutgers Cancer Institute of New Jersey and Rutgers New Jersey Medical School recently identified a new method for safe and effective delivery of medicines to the lungs that can be used for multiple clinical applications, potentially including aerosol vaccination.

Released: 9-Dec-2020 2:10 PM EST
Safely Donate Blood This Winter
Rutgers Cancer Institute of New Jersey

With the added concern of COVID-19 safety, there will be drop in the donation of critically needed blood throughout the United States, which is typically low during the winter months. Expert from Rutgers Cancer Institute of New Jersey urges giving the gift of life by donating blood.

4-Dec-2020 10:45 AM EST
Using light, red blood cells and a honey bee peptide to deliver therapeutic proteins
American Chemical Society (ACS)

Researchers reporting in ACS Central Science have engineered red blood cell (RBC) carriers that release therapeutic proteins when stimulated by light, with the help of a honey bee peptide.

8-Dec-2020 10:15 AM EST
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have found elevated levels of a biomarker related to blood vessel damage in children with SARS-CoV-2 infection, even if the children had minimal or no symptoms of COVID-19. They also found that a high proportion of children with SARS-CoV-2 infection met clinical and diagnostic criteria for thrombotic microangiopathy (TMA). TMA is a syndrome that involves clotting in the small blood vessels and has been identified as a potential cause for severe manifestations of COVID-19 in adults.

Released: 7-Dec-2020 11:55 AM EST
Yale Cancer Center Study Shows Caplacizumab Not Cost Effective for Rare Blood Disorder
Yale Cancer Center/Smilow Cancer Hospital

In a new study by Yale Cancer Center researchers, the drug caplacizumab is shown not to be cost-effective in treating thrombotic thrombocytopenic purpura (TTP) when added to the standard-of-care.

Released: 7-Dec-2020 10:35 AM EST
Novel antibody-drug conjugate shows promising early results in rare blood cancer
University of Texas MD Anderson Cancer Center

A phase I/II study led by researchers from The University of Texas MD Anderson Cancer Center found IMGN632, a novel CD123-targeting antibody-drug conjugate, was tolerable and resulted in a 29% overall response rate in patients with relapsed/refractory blastic plasmacytoid dendritic cell neoplasm.

3-Dec-2020 3:05 PM EST
Circulating tumor DNA indicates increased risk of relapse after stem cell transplant in patients with diffuse large B-cell lymphoma
Dana-Farber Cancer Institute

Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse.



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