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Released: 18-Jul-2022 12:00 PM EDT
Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma
Preprints

Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell,

Released: 18-Jul-2022 12:00 PM EDT
Osteocytes regulate organismal senescence of bone and bone marrow
Preprints

Peng Ding, Chuan Gao, Youshui Gao, Delin Liu, Hao Li, Jun Xu, Xiaoyi Chen, Yigang Huang, Changqing Zhang, Ming Hao Zheng, Junjie Gao

Released: 18-Jul-2022 12:00 PM EDT
Periodontal ligament stem cells inhibit THP-1 macrophage pyroptosis via modulating the NF-κB/NLRP3/GSDMD signaling axis
Preprints

Wenxuan Wang, Chun Fan, Xinbo Yu, Xu Qiu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Qiuxia Ji

Released: 18-Jul-2022 12:00 PM EDT
Palifermin Compared to Supersaturated Calcium Phosphate Rinse in Prevention of Severe Oral Mucositis after Stem Cell Transplantation
Preprints

Tarik Hadid, Ayad Al-Katib, Jose Binongo, Gina M. Berteotti, Salman Fazal, James M. Rossetti, John Lister

Released: 18-Jul-2022 8:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 18-Jul-2022 5:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 16-Jul-2022 12:00 PM EDT
Aberrant extracellular matrix and cardiac development in models lacking the PR-DUB component ASXL3
Preprints

Abstract: Background: Clinical and research based genetic testing has uncovered genes that encode chromatin modifying complex components required for organogenesis. Covalent histone modifications play a key role in establishing transcriptional plasticity during development, required for cell fate specification, and have been implicated as a developmental mechanism that accounts for autism spectrum disorder (ASD) and CHD co-occurrence. ASXL3 has been identified as a high confidence ASD gene. ASXL3 is a component of the Polycomb Repressive Deubiquitination (PR-DUB) complex, which deubiquitinates histone H2A. However, the role of ASXL3 in cardiac development remains unknown.

Released: 15-Jul-2022 5:05 PM EDT
Bacteria-based biohybrid microrobots on a mission to one day battle cancer
Max Planck Institute for Intelligent Systems

A team of scientists in the Physical Intelligence Department at the Max Planck Institute for Intelligent Systems have combined robotics with biology by equipping E. coli bacteria with artificial components to construct biohybrid microrobots.

   
Released: 15-Jul-2022 12:00 PM EDT
Umbilical cord mesenchymal stem cells and monosialotetrahexosy 1 ganglioside alleviate neuroinflammation in traumatic brain injury
Preprints

Neuroinflammation and activated microglia play important role in neuron damage in the traumatic brain injury (TBI). In this study, we determined the effect of human umbilical cord mesenchymal stem cells (UMSCs) combined with monosialotetrahexosy 1 ganglioside (GM1) on the neuroinflammation and polarization of microglia in a rat model of TBI, which was established in male rats using a fluid percussion brain injury device.

Released: 15-Jul-2022 10:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 15-Jul-2022 5:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 15-Jul-2022 12:00 AM EDT
Mouse and cellular models of KPTN-related disorder implicate mTOR signalling in cognitive and progressive overgrowth phenotypes
Preprints

KPTN-related disorder (KRD) is an autosomal recessive disorder associated with germline variants in KPTN (kaptin), a component of the mTOR regulatory complex KICSTOR.

Released: 15-Jul-2022 12:00 AM EDT
Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1
Preprints

Alternative splicing of neuronal genes is controlled in part by the coordinated action of the polypyrimidine tract binding proteins (PTBP1 and PTBP2).

Released: 15-Jul-2022 12:00 AM EDT
Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium
Preprints

Vascular cambium contains bifacial stem cells, which produce secondary xylem to one side and secondary phloem to the other.

Released: 14-Jul-2022 12:00 PM EDT
Impact of copper nanoparticles and copper ions on transcripts involved in neural repair mechanisms in rainbow trout olfactory mucosa
Preprints

Olfactory mucosa is well-known for its lifelong ability for regeneration. Regeneration of neurons and regrowth of severed axons are the most common neural repair mechanisms in olfactory mucosa.

Released: 14-Jul-2022 12:00 PM EDT
Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized Psychiatry
Preprints

The polygenic and multifactorial nature of many psychiatric disorders has hampered the personalized medicine approach implementation in clinical practice.

Released: 14-Jul-2022 12:00 PM EDT
Analysis of the differential expression and prognostic relationship of DEGs in AML based on TCGA database
Preprints

Acute myeloid leukemia (AML) is a common and lethal haematological malignant hyperplastic disease originating from hematopoietic stem cells.

Released: 14-Jul-2022 12:00 PM EDT
SOX10 Expression Levels may be a Critical Mediator of White Matter Deficits in Schizophrenia
Preprints

Abnormalities of brain connectivity are consistently observed in individuals with schizophrenias (SZ).

Released: 14-Jul-2022 12:00 PM EDT
Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells protect heart from myocardial infarction by modulating cardiomyocyte calcium homeostasis
Preprints

Human induced pluripotent stem cell–derived endothelial cells (hiPSC-ECs) exhibit potential in repairing the injured heart after myocardial infarction (MI) by promoting neovascularization and cardiomyocyte survival.

Released: 14-Jul-2022 12:00 PM EDT
A homozygous PIWIL2 frameshift variant affects the formation and maintenance of human induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell only-syndrome
Preprints

Background The most serious condition of male infertility is complete Sertoli cell-only syndrome (SCOS), referring to lack of all spermatogenic cells in testes.

Released: 14-Jul-2022 8:00 AM EDT
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
Cell Stem Cell

With human iPSC-based brain organoids and mouse chimeras, Jin and colleagues demonstrate that upregulated type-I-interferon (IFN-I) signaling in Down syndrome microglia causes elevated synaptic pruning during development and accelerated senescence, r

Released: 14-Jul-2022 8:00 AM EDT
Human Down syndrome microglia are up for a synaptic feast
Cell Stem Cell

In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling

Released: 14-Jul-2022 8:00 AM EDT
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
Cell Stem Cell

Li et al. demonstrate that amino acid catabolism and the GCN2-eIF2α axis control protein synthesis and energy production in hematopoietic stem cells for maintenance and proliferation. They also show that nicotinamide riboside increases amino acid c

Released: 14-Jul-2022 8:00 AM EDT
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero
Cell Stem Cell

Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

Released: 14-Jul-2022 8:00 AM EDT
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
Cell Stem Cell

The atypical chemokine receptor 1 (ACKR1) was discovered on erythrocytes as the Duffy blood group antigen (Cutbush et al., 1950), also called Duffy-antigen/receptor for chemokines, or DARC (Novitzky-Basso and Rot, 2012). Erythrocytes are terminally

Released: 14-Jul-2022 8:00 AM EDT
Mini kidney organoids deliver maximal drug screening impact
Cell Stem Cell

In this issue of Cell Stem Cell, Tran and colleagues develop a platform for differentiating thousands of miniature kidney organoids consisting of one or two nephron-like structures each. They use this platform to identify a potent new inhibitor of cy

Released: 14-Jul-2022 8:00 AM EDT
Cell competition and the regulative nature of early mammalian development
Cell Stem Cell

Cell competition is a fitness quality control that eliminates cells that are less fit than their neighbors. Nichols, Lima, and Rodríguez review the importance of cell competition in the early mammalian embryo for the elimination of abnormal cells, f

Released: 14-Jul-2022 8:00 AM EDT
Lymphatics act as a signaling hub to regulate intestinal stem cell activity
Cell Stem Cell

Niec et al. integrate spatial and single-cell transcriptomics data and develop computational approaches to finely map the cellular and transcriptional landscape of the intestinal crypt-villus axis. Combining these results with functional experiments

Released: 14-Jul-2022 8:00 AM EDT
A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1
Cell Stem Cell

Duffy antigen receptor for chemokines (DARC)/CD234, also known as atypical chemokine receptor 1 (ACKR1), is a seven-transmembrane domain protein expressed on erythrocytes, vascular endothelium, and a subset of epithelial cells (Peiper et al., 1995).

Released: 14-Jul-2022 8:00 AM EDT
Taming the transposon: H3K9me3 turns foe to friend in human development
Cell Stem Cell

In this issue of Cell Stem Cell, Xu et al. and Yu et al. use low-input epigenetic profiling techniques to map H3K9me3 deposition in early human development. They reveal stage-specific H3K9me3 deposition on retrotransposons, which may play crucial c

Released: 14-Jul-2022 8:00 AM EDT
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development
Cell Stem Cell

Wang and colleagues comprehensively compare the landscapes of H3K9me3 between human and mouse early embryos and reveal the roles of hominoid-specific retrotransposons in H3K9me3-dependent heterochromatin remodeling during early human development. The

Released: 14-Jul-2022 8:00 AM EDT
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos
Cell Stem Cell

Xu et al. profiled the genome-wide H3K9me3 distribution in human oocytes and early embryos. They found the function and mechanism of H3K9me3 modification on long terminal repeat (LTR) regulation and provide a detailed map of the sequential reprogram

Newswise: New Stem Cell Mechanism in Your Gut
Released: 13-Jul-2022 5:05 PM EDT
New Stem Cell Mechanism in Your Gut
Institute of Science and Technology Austria (IST Austria)

Your gut is a wondrous place. A special layer of cells that coats the insides of your small and large intestines takes in nutrients and water from what you ate while keeping anything bad out of your system.

Released: 13-Jul-2022 12:00 PM EDT
Genetically Corrected RAG2-SCID Human Hematopoietic Stem Cells Restore V(D)J-Recombinase and Rescue Lymphoid Deficiency
Preprints

Recombination-activating genes (RAG1 and RAG2) are critical in lymphoid cell development and function for initiating the V(D)J-recombination process to generate polyclonal lymphocytes with broad antigen-specificity.

Released: 13-Jul-2022 12:00 PM EDT
Regulation of synaptic connectivity in schizophrenia by mutual neuron-microglia interaction
Preprints

The examination of post-mortem brain tissue suggests synaptic loss as a central pathological hallmark of schizophrenia.

Released: 13-Jul-2022 12:00 PM EDT
Nanoparticle mediated in vitro and in vivo CRISPR base correction of LCA16 causing nonsense mutation rescues Kir7.1 channel function
Preprints

Lebers Congenital Amaurosis (LCA16) is caused by point mutations in KCNJ13 gene, which encodes for an inward-rectifying potassium channel, Kir7.1.

Released: 13-Jul-2022 12:00 PM EDT
Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease
Preprints

Single nucleotide polymorphism rs6903956 has been identified as one of the genetic risk factors for coronary artery disease (CAD).

Released: 13-Jul-2022 12:00 PM EDT
Investigating the role of fluid shear stress in bone metastasis: the proliferation of co-cultured hMSCs/MDAPCa2b cells under dynamic culturing.
Preprints

We investigated the potential correlation between the fluid shear stress and the proliferation of bone prostate cancer cells on the surface of nanoclay-based scaffolds in a perfusion bioreactor.

Released: 13-Jul-2022 12:00 PM EDT
Stochastic and parameter analysis for an integrative cancer model
Preprints

In a previous work, we presented a model that integrates cancer cell differentiation and immunotherapy, analysing a particular therapy against cancer stem cells by cytotoxic cell vaccines.

Newswise: Turning White Blood Cells Into Medicinal Microrobots with Light
12-Jul-2022 12:10 PM EDT
Turning White Blood Cells Into Medicinal Microrobots with Light
American Chemical Society (ACS)

Researchers reporting in ACS Central Science have used lasers to precisely control neutrophils — a type of white blood cell — as a natural, biocompatible microrobot in living fish. The “neutrobots” performed multiple tasks, showing they could someday deliver drugs to precise locations in the body.

   
Released: 12-Jul-2022 12:00 PM EDT
Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation
Preprints

Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GVHD).

Released: 12-Jul-2022 12:00 PM EDT
Characterising Replisome Disassembly in Human Cells
Preprints

To ensure faultless duplication of the entire genome, eukaryotic replication initiates from thousands of replication origins.

Released: 12-Jul-2022 12:00 PM EDT
Particle-tracking-based estimation of shear stress on cell aggregates in shaking vessel with different shaking methods/speeds
Preprints

Suspension cultures are widely used for cell expansion in regenerative medicine and production.

Released: 12-Jul-2022 12:00 PM EDT
Efficient Human Germ Cell Specification from Stem Cells via Combinatorial Expression of Transcription Factors
Preprints

Germ cells are the vehicle of human reproduction, arising early in embryonic development and developing throughout adult life until menopause onset in women.

Newswise: Hidden Genes May Be Tapped for New Antibiotics
Released: 12-Jul-2022 2:05 AM EDT
Hidden Genes May Be Tapped for New Antibiotics
Rice University

Silents are potentially golden in the search for antibiotics to slow the ongoing crisis of resistance in the treatment of disease.

Released: 11-Jul-2022 3:05 PM EDT
Soft but tough: Biohybrid material performs like cartilage
Cornell University

Producing biomaterials that match the performance of cartilage and tendons has been an elusive goal for scientists, but a new material created at Cornell demonstrates a promising new approach to mimicking natural tissue.

   
Released: 11-Jul-2022 12:00 PM EDT
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity
Preprints

YES-associated protein (YAP) is a transcriptional cofactor with a key role in the regulation of several cellular processes, including proliferation, differentiation and epithelial-to-mesenchymal transition (EMT), by integrating multiple cell autonomous and microenvironmental cues.

Released: 11-Jul-2022 12:00 PM EDT
Recurrent Oral Aphtha, Diarrhea, Pneumonia, And Respiratory Distress Since Infancy: STAT1 GOF defect
Preprints

We report a case of 7-year old female patient. She had recurrent pneumonia since infancy and she was hospitalized several times. She had persistant lymphopenia with normal immunoglobulin levels and lymphocyte subsets.



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