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Released: 10-Jul-2022 12:00 PM EDT
Stochastic modelling of cell differentiation networks from partially-observed clonal tracking data
Preprints

Motivation: Clarifying how hematopoietic stem cells differentiate into mature cell types is important for understanding how they attain specific functions and offers the potential for therapeutic manipulation.

Released: 10-Jul-2022 12:00 PM EDT
Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization
Preprints

Although model organisms have provided insight into the earliest stages of cardiac vascularization, we know very little about this process in humans.

Released: 10-Jul-2022 12:00 PM EDT
Bayesian Inference of RNA Velocity from Multi-Lineage Single-Cell Data
Preprints

Experimental approaches for measuring single-cell gene expression can observe each cell at only one time point, requiring computational approaches for reconstructing the dynamics of gene expression during cell fate transitions.

Released: 10-Jul-2022 12:00 PM EDT
Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis
Preprints

Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein (LTBP) or glycoprotein-A repetitions predominant (GARP) protein.

Released: 10-Jul-2022 12:00 PM EDT
Adult neural stem cells and neurogenesis are resilient to intermittent fasting
Preprints

Intermittent fasting (IF) is a promising non-pharmacological strategy to counteract ageing which has been shown to increase the number of adult-born neurons in the dentate gyrus of mice.

Newswise: A Major Step Forward for Organ Biofabrication
Released: 8-Jul-2022 3:35 PM EDT
A Major Step Forward for Organ Biofabrication
Harvard John A. Paulson School Of Engineering And Applied Sciences

Heart disease — the leading cause of death in the U.S. — is so deadly in part because the heart, unlike other organs, cannot repair itself after injury.

   
Released: 8-Jul-2022 3:15 PM EDT
Artificial intelligence folds RNA molecules
Ruhr-Universität Bochum

For the function of many biomolecules, their three-dimensional structure is crucial. Researchers are therefore not only interested in the sequence of the individual building blocks of biomolecules, but also in their spatial structure.

   
Released: 8-Jul-2022 12:00 AM EDT
Optimization of adeno-associated virus (AAV) gene delivery into human bone marrow stem cells (hBMSCs)
Preprints

Efficiently delivering nucleic acid into mammalian cells is essential to overexpress genes for assessing gene functions.

7-Jul-2022 11:25 AM EDT
Study: Making an Artificial Heart Fit for a Human — with Focused Rotary Jet Spinning, Not 3D
University of Pittsburgh

In a new study published in Science, a team of researchers from Harvard, University of Pittsburgh, University of California, Irvine and University of Zurich have come together to utilize a new, more advanced method to fabricate artificial tissues and organs. The researchers proposed the process of focused rotary jet spinning. This team included Qihan Liu, an assistant professor in the University of Pittsburgh Swanson School of Engineering.

   
Newswise: Smart Textiles Sense How Their Users Are Moving
Released: 7-Jul-2022 12:40 PM EDT
Smart Textiles Sense How Their Users Are Moving
Massachusetts Institute of Technology (MIT)

Using a novel fabrication process, MIT researchers have produced smart textiles that snugly conform to the body so they can sense the wearer’s posture and motions.

Released: 7-Jul-2022 12:00 PM EDT
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
Preprints

We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) scaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions.

Released: 7-Jul-2022 12:00 PM EDT
Hair growth and restoration by transcriptional control of tissue regeneration in cancer recovery process by Huaier
Preprints

In the process of caner recovery, Huaier simultaneously promotes significant hair growth and restoration as a typical evidence of its efficacy on induced tissue regeneration and repair function.

Released: 7-Jul-2022 12:00 PM EDT
Mesenchymal stem cells reverse the pathophysiology of cerebral malaria induced by Plasmodium berghei ANKA
Preprints

Cerebral malaria-associated over expression of pro-inflammatory cytokines and chemokines ultimately results in the up-regulation of adhesion molecules in the brain endothelium leading to sequestration of mature parasitized RBCs in the brain.

Newswise: ‘You Are What You Eat,’ and Now Researchers Know Exactly What You’re Eating
6-Jul-2022 1:55 PM EDT
‘You Are What You Eat,’ and Now Researchers Know Exactly What You’re Eating
UC San Diego Health

UC San Diego researchers describe a new method to identify all of the unidentified molecules derived from food, providing a direct way to link molecules in diet to health outcomes.

Newswise:Video Embedded scientists-develop-new-material-inspired-by-limpets-with-super-strength
VIDEO
6-Jul-2022 4:05 AM EDT
Scientists Develop New Material Inspired by Limpets with Super Strength
University of Portsmouth

An interdisciplinary team of biologists, chemists and engineers from the University of Portsmouth have become the first to successfully grow a limpet inspired biomaterial with extreme strength.

Released: 6-Jul-2022 4:50 PM EDT
A Potential Danger of CRISPR Gene Editing — and Why Base Editing May Be Safer
Boston Children's Hospital

Gene therapy using CRISPR/Cas9 gene editing is currently in clinical trials around the world for a variety of diseases.

Newswise: Shapeshifting Microrobots Can Brush and Floss Teeth
Released: 6-Jul-2022 12:50 PM EDT
Shapeshifting Microrobots Can Brush and Floss Teeth
University of Pennsylvania

In a proof-of-concept study, researchers from the University of Pennsylvania showed that a hands-free system could effectively automate the treatment and removal of tooth-decay-causing bacteria and dental plaque.

Released: 6-Jul-2022 12:00 PM EDT
Knockdown of Musashi-1 enhances chemotherapeutic sensitivity and apoptosis in Group 3/4 medulloblastomas cells
Preprints

Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. The RNA-binding protein Musashi-1 (MSI1) is a neural stem cell marker, characterized as a gene translation regulator and associated with high oncogenicity in several human cancers.

Released: 6-Jul-2022 12:00 PM EDT
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
Preprints

TREM2 is an innate immune receptor expressed by microglia in the adult brain. Homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in NHD pathogenesis remains poorly understood.

Released: 6-Jul-2022 12:00 PM EDT
Screening Biophysical Sensors and Actuators that Influence Wound Healing in Human Induced Pluripotent Stem Cell-Derived Neurons
Preprints

All living cells maintain a charge distribution across their cell membrane (membrane potential) by carefully controlled ion fluxes. These bioelectric signals regulate cell behavior (such as migration, proliferation, differentiation) as well as higher-level tissue and organ patterning. Thus, voltage gradients represent an important parameter for diagnostics as well as a promising target for therapeutic interventions in birth defects, injury, and cancer. However, despite much progress in cell and molecular biology, little is known about bioelectric states in human stem cells.

Released: 6-Jul-2022 12:00 PM EDT
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption
Preprints

Lung adenocarcinoma is the most common and aggressive type of lung cancer with the highest incidence of bone metastasis. Epidermal growth factor‐like domain multiple 6 (EGFL6) is an exocrine protein, and the expression of EGFL6 is correlated with survival of patient with lung adenocarcinoma. However, the association between EGFL6 expression in lung adenocarcinoma and bone metastasis has not been investigated.

Newswise: Tabletop Magnetic Resonance Units to Revolutionize Diagnostics and Materials Analysis
Released: 6-Jul-2022 4:05 AM EDT
Tabletop Magnetic Resonance Units to Revolutionize Diagnostics and Materials Analysis
Karlsruhe Institute of Technology (KIT)

In the HyPERiON CRC coordinated by the Karlsruhe Institute of Technology (KIT), researchers from KIT and the universities of Kaiserslautern, Konstanz and Stuttgart are jointly developing technology for compact high-performance magnetic resonance units. In the future, the devices could be used in the chemical and pharmaceutical industries, in medical practices or at border checkpoints. The German Research Foundation is funding the interdisciplinary group with more than 10.6 million euros for four years starting on July 1, 2022.

Released: 5-Jul-2022 12:00 PM EDT
Human Adipose-Derived Stem Cells Can Optimize the Filling Material in Rats
Preprints

Introduction: Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. Human adipose-derived stem cells were added into filling materials.

Released: 5-Jul-2022 12:00 PM EDT
Abnormal Neural Differentiation in Response to Graphene Quantum Dots through Histone Modification Interference
Preprints

Background Graphene quantum dots (GQDs) have been broadly applied in biomedicine in recent years, and their environmental exposure and toxicological impacts have raised increasing concerns.

Newswise: Scientists Discover Cancer Trigger That Could Spur Targeted Drug Therapies
Released: 5-Jul-2022 11:00 AM EDT
Scientists Discover Cancer Trigger That Could Spur Targeted Drug Therapies
Oak Ridge National Laboratory

Researchers at the Department of Energy’s Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

   
Released: 4-Jul-2022 12:00 PM EDT
Graft of cardiac progenitors in a pig model of right ventricular failure triggers myocardial epimorphosis, regeneration and protection of function
Preprints

The failure of diseased adult heart to regenerate is a major burden to our societies. Besides patients with ischemia and left ventricular (LV) dysfunction, progress in pediatric surgery to repair cardiac malformations has led to a growing population of now adult congenital heart diseases (CHD) patients with right ventricular (RV) failure.

Released: 4-Jul-2022 12:00 PM EDT
Meta-Analysis Identifies Novel Common Genes Differently Altered in Cross-Species Models of Rett Syndrome
Preprints

Rett syndrome (RTT) is a rare disease and one of the most abundant causes for intellectual disa-bilities in females. Single mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2), are responsible for the disease.

Released: 4-Jul-2022 12:00 PM EDT
Stochastic Population Dynamics of Cancer Stemness and Adaptive Response to Therapies
Preprints

Intratumoral heterogeneity can exist along multiple axes: Cancer Stem Cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states and a spectrum of epithelial-hybrid-mesenchymal phenotypes.

Released: 4-Jul-2022 12:00 PM EDT
Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model
Preprints

WNT binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts have enabled us to shed light on WNT-FZD pharmacology in overexpressed HEK293 cell systems.

Released: 4-Jul-2022 12:00 PM EDT
Odd skipped-related 1 controls the pro-regenerative response of Fibro-Adipogenic Progenitors
Preprints

Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration.

Released: 4-Jul-2022 12:00 PM EDT
Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
Preprints

Nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional gene expression regulation mechanism in eukaryotic cells.

Released: 2-Jul-2022 12:00 PM EDT
Human cartilage progenitor cells from ear, nose, rib, and joint have a robust, stable phenotype for cartilage repair
Preprints

Cartilage progenitor cells (CPCs) are a small but highly proliferative cell population that resides within cartilage.

Released: 2-Jul-2022 12:00 AM EDT
Genetically corrected iPSC-derived Neural Stem Cell Grafts deliver NAGLU-IGFII fusion protein to affect CNS disease in Sanfilippo B Mice
Preprints

Sanfilippo syndrome type B (Mucopolysaccharidosis type IIIB or MPS IIIB) is a recessive genetic disorder that severely affects the brain due to a deficiency in the enzyme α-N-acetylglucosaminidase (NAGLU), leading to intralysosomal accumulation of partially degraded heparan sulfate.

Released: 1-Jul-2022 3:25 PM EDT
Dissolving implantable device relieves pain without drugs
Northwestern University

A Northwestern University-led team of researchers has developed a small, soft, flexible implant that relieves pain on demand and without the use of drugs.

Newswise: “Soft” CRISPR May Offer a New Fix for Genetic Defects
27-Jun-2022 3:30 PM EDT
“Soft” CRISPR May Offer a New Fix for Genetic Defects
University of California San Diego

Scientists have developed a CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new “soft” CRISPR system makes use of natural DNA repair machinery, providing a foundation for novel gene therapy strategies with the potential to cure genetic diseases.

   
Released: 1-Jul-2022 12:00 PM EDT
Altered contractility in mutation-specific hypertrophic cardiomyopathy: a mechano-energetic in silico study with pharmacological insights
Preprints

Mavacamten (MAVA), Blebbistatin (BLEB), and Omecamtiv mecarbil (OM) are promising drugs directly targeting sarcomere dynamics, with demonstrated efficacy against hypertrophic cardiomyopathy (HCM) in clinical trials.

Released: 1-Jul-2022 12:00 AM EDT
Fishing Cat Cell Biobanking for Conservation
Preprints

Woranop Sukparangsi, Ampika Thongphakdee, Santhita Karoon, Nattakorn Suban Na Ayuttaya, Intira Hengkhunthod, Rachapon Parkongkeaw, Rungnapa Bootsri, Wiewaree Sikaeo

Released: 1-Jul-2022 12:00 AM EDT
Metadichol® is a nano lipid emulsion that expresses all 48 nuclear receptors in stem and somatic cells
Preprints

Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes.

Released: 1-Jul-2022 12:00 AM EDT
Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Preprints

Clonal hematopoiesis resulting from enhanced fitness of mutant hematopoietic stem cells (HSCs) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear.

Released: 1-Jul-2022 12:00 AM EDT
Context-dependent transcriptional remodeling of TADs during differentiation
Preprints

Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute to the regulation of transcriptional programs.

Released: 1-Jul-2022 12:00 AM EDT
Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury
Preprints

Mesenchymal stem cell (MSC) transplantation was suggested as a promising approach to treat spinal cord injury (SCI).

Released: 1-Jul-2022 12:00 AM EDT
Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6
Preprints

The molecular mechanisms controlling the balance of quiescence and proliferation in adult neural stem cells (NSCs) are often deregulated in brain cancers such as glioblastoma (GBM).

Released: 1-Jul-2022 12:00 AM EDT
Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis
Preprints

Intramuscular fatty infiltration in muscle injuries and diseases, caused by aberrant adipogenesis of fibro-adipogenic progenitors, negatively impacts function.

Released: 1-Jul-2022 12:00 AM EDT
Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy
Preprints

Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML.

Released: 1-Jul-2022 12:00 AM EDT
Mitigation of gastrointestinal graft versus host disease with tocilizumab prophylaxis is accompanied by preservation of microbial diversity and attenuation of enterococcal domination
Preprints

A common feature in the gastrointestinal (GI) tract during allogeneic hematopoietic stem cell transplantation is the loss of microbial diversity and emergence of opportunistic pathogens that can adversely impact survival.

Released: 1-Jul-2022 12:00 AM EDT
Driving Osteocytogenesis from Mesenchymal Stem Cells in Osteon-like Biomimetic Nanofibrous Scaffolds
Preprints

The repair of critical-sized bone defects, resulting from tumor resection, skeletal trauma or infection, remains a significant clinical problem.

Released: 1-Jul-2022 12:00 AM EDT
H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements
Preprints

The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes.

Released: 1-Jul-2022 12:00 AM EDT
Impact of late larval nutritional stress on adult metabolic, gut and locomotor phenotypes in Drosophila melanogaster
Preprints

Dietary quantity and quality are key determinants for insect development from egg to adult.



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