Feature Channels: Biotech

• share
• favorite_border

Dietary quantity and quality are key determinants for insect development from egg to adult.

• share
• favorite_border

The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies.

• share
• favorite_border

Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been demonstrated to be effective in the treatment of OA, but the precise target cells and response mechanisms are not well characterised.

• share
• favorite_border

Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration.

• share
• favorite_border

Bi-allelic loss-of-function mutations in TANGO2 (Transport and Golgi Organization protein 2) cause a rare multiorgan genetic disorder.

• share
• favorite_border

Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma stem cell (GSC) self-renewal, invasiveness and tumorigenicity.

• share
• favorite_border

Autism spectrum disorder (ASD) is a heterogenous, early-onset neurodevelopmental disorder with multifactorial aetiology. There are hundreds of genes that contribute to ASD.

• share
• favorite_border

Environmental obesogens are being studied for their potential role in the increasing prevalence of obesity globally.

• share
• favorite_border

It is difficult to capture the large numbers of steps and details that often characterize research in the biomedical sciences.

• share
• favorite_border

Drosophila ovarian Follicle Stem Cells (FSC) present an excellent paradigm for understanding how a community of active stem cells maintained by population asymmetry is regulated.

• share
• favorite_border

In a recent article, the authors provide a detailed summary of the characteristics and biological functions of mesenchymal stem cells (MSCs), as well as a discussion on the potential mechanisms of action of MSC-based therapies. They describe th

• share
• favorite_border

RNA-binding proteins FBF-1 and FBF-2 (FBFs) are required for germline stem cell maintenance in Caenorhabditis elegans and regulate the dynamics of progenitor cell proliferation and differentiation.

• share
• favorite_border

BACKGROUNDTreatments involving stem cell (SC) usage represent novel and potentially interesting alternatives in facial nerve reanimation. Current literature includes the use of SC in animal model studies to promote graft survival by enhancing n

• share
• favorite_border

Multiple sclerosis (MS) is an auto-immune inflammatory disorder affecting the central nervous system. The cause of the disease is unknown but both genetic and environmental factors are implicated in the pathogenesis. We derived cerebral organoids from induced pluripotent stem cells (iPSC) of healthy control subjects as well as from primary progressive MS (PPMS), secondary progressive MS (SPMS) and relapsing remitting MS (RRMS) patients to better understand the pathologic basis of the varied clinical phenotypic expressions of MS.

• share
• favorite_border

This letter focuses on a recently published article that provided an exceptional description of the effect of epigenetic modifications on gene expression patterns related to skeletal system remodeling. Specifically, it discusses a novel modalit

• share
• favorite_border

Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tis

• share
• favorite_border

Drosophila ovarian Follicle Stem Cells (FSCs) present a favorable paradigm for understanding how stem cell division and differentiation are balanced in communities where they can be regulated independently.

• share
• favorite_border

Artificial human blastoids investigate fundamentals of early embryo development using in vitro models and study the pregnancy failures and birth deficiencies, previously hindered by the need for human embryos.

• share
• favorite_border

Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tis

• share
• favorite_border

Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading to this defective activity and the impact on the disease severity are still elusive. Here, we explored through an unbiased approach the molecular signature leading to myogenic cell defects in DM1.

• share
• favorite_border

Cell-intrinsic response patterns control risks arising from genome-damaged cells, preventing malignant transformation. p53-dependent DNA damage responses halt the cell cycle and induce either repair, senescence or cell death. Cyclic-GMP-AMP synthase (cGAS) has emerged as a new principle detecting genome damage and activating complex response programs.

• share
• favorite_border

Neha Paranjape, Yu-Hsiu Tony Lin, Quetzal Flores-Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes, Arun P. Wiita

• share
• favorite_border

Human pluripotent stem cells (hPSCs) have become a powerful tool to generate various kinds of cell types comprising the human body. Recently, organoid technology emerged as a platform to build a physiologically relevant tissue-like structure from the PSCs, which provides a more relevant three-dimensional microenvironment to the actual human body than the conventional monolayer culture system for transplantation, disease modeling, and drug development.

• share
• favorite_border

Previous studies of the murine Ly49 and human KIR gene clusters have revealed a role for bidirectional promoters in the control of variegated gene expression. Whether or not competing promoters control other instances of cell fate determination remains an outstanding question.

• share
• favorite_border

The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best characterized stem cell systems in any cnidarian, providing valuable insight into cell type evolution and the origin of stemness in animals.

• share
• favorite_border

Canine renal ischemia-reperfusion (IR) causes severe acute kidney injury characterized by renal dysfunction and inflammatory disorder.

• share
• favorite_border

Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification of cardiac NCCs remain largely unknown.

• share
• favorite_border

Auxin plays pleiotropic roles in plant development via gene regulation upon perception by the receptors TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALING F-BOX (TIR1/AFBs). This nuclear auxin signaling (NAS) originated in the common ancestor of land plants.

• share
• favorite_border

Cell culture at liquid-liquid interfaces, for example at the surface of oil microdroplets, is an attractive strategy to scale up adherent cell manufacturing whilst replacing the use of microplastics.

• share
• favorite_border

Weimin Zhang, Ilona Golynker, Ran Brosh, Aleksandra M. Wudzinska, Yinan Zhu, Lucia Carrau, Payal Damani-Yokota, Camille Khairallah, Noor Chalhoub, Emily Huang, Hannah Ashe, Kamal M. Khanna, Matthew T. Maurano, Sang Yong Kim,

• share
• favorite_border

Relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HCT) still represents a major concern with poor outcomes.

• share
• favorite_border

Bone marrow (BM) stroma plays key roles in supporting hematopoietic stem cell (HSC) growth.

• share
• favorite_border

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and a leading cause of dementia.

• share
• favorite_border

This study aimed to investigate the effects and mechanisms of miRNA-140 in exosomes of hypoxic bone marrow mesenchymal stem cells on articular chondrocytes. Articular chondrocytes were stimulated with IL-1β (10 μg/ml) to give them an inflammatory state.

• share
• favorite_border

Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with varios metaplastic components.

• share
• favorite_border

Diabetic foot (DF) is one of the most common and serious complications of diabetes mellitus (DM), which brings great psychological and economic pressure to patients. This study aimed to evaluate the efficacy of stem cells in the treatment of diabetic foot.

• share
• favorite_border

Endogenous retroviruses (ERVs) have rewired host gene networks through co-option of their enhancers.

• share
• favorite_border

TANGO2-deficient disorder (TDD) is an autosomal recessive genetic disease caused by biallelic loss-of-function variants in TANGO2 gene.

• share
• favorite_border

RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism.

• share
• favorite_border

Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.

• share
• favorite_border

Matteo Togninalli, Andrew T.V. Ho, Christopher M Madl, Colin A. Holbrook, Yu Xin Wang, Klas E.G. Magnusson, Anna Kirillova, Andrew Chang, Helen Blau

• share
• favorite_border

Researchers at Ruhr-Universität Bochum have been studying the role of the two proteins tenascin C and tenascin R in multiple sclerosis. In this disease, cells of the immune system destroy the myelin sheaths, i.e. the sheaths of the nerve cells.

• share
• favorite_border

New wearable technology creates new possibilities for assessing the neurological development of young children. Early motor assessment is essential for supporting the early detection of neurodevelopmental problems and their therapeutic interventions.

• share
• favorite_border

Fabiana Faleiros, Deyse Braga, Soraia Dornelles Schoeller, Sílvia Helena Henriques, Naira Beatriz Favoretto Cunha, Lorena Gomes Neves Videira, Adriana Cordeiro Leandro Silva Grillo