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Science

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Biology, Genetics, Developmental Biology

Genetics Society of America Honors Jonathan Hodgkin with 2017 Novitski Prize

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The Genetics Society of America (GSA) is pleased to announce that Jonathan Hodgkin, PhD (Oxford University) is the 2017 recipient of the Edward Novitski Prize in recognition of his extraordinary creativity and intellectual ingenuity in solving significant problems in genetics research. Hodgkin uncovered the sex determination pathway in Caenorhabditis elegans, an important and widely used model for animal development and genetics. His innovations and contributions to genetic analysis, including the use of suppressor screens and epistasis analyses, helped advance the field in many ways. Hodgkin is a Professor in the Department of Biochemistry at the University of Oxford.

Medicine

Channels:

Bioinformatics, Genetics, Cancer, Pharmaceutical Science, Precision Medicine, CRISPR/Cas9

Gene Editing Technique Helps Find Cancer’s Weak Spots

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Genetic mutations that cause cancer also weaken cancer cells, allowing researchers to develop drugs that will selectively kill them. This is called “synthetic lethality” because the drug is only lethal to mutated (synthetic) cells. Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a method to search for synthetic-lethal gene combinations. The technique, published March 20 in Nature Methods, uncovered 120 new opportunities for cancer drug development.

Medicine

Channels:

Nephropathy, IgA Nephropathy, glomerulonephritis, Autoimmunity, genomewide-association study, O-glycosylation

Genetic Clues to Kidney Disease Uncovered

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Using international genomic studies backed by proof-of-concept cell experiments, researchers have identified two genes that contribute to the chronic kidney disease glomerulonephritis.

Medicine

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Heart Attack, Cardiovacular Disease, CVD prevention, CVD risk, Genetics

Why Heart Attacks Can Happen to Anyone

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A heart attack can happen even if to those who are relatively young and fit, and genetics can play a role.

Medicine

Channels:

Resistance, Genetics, Mutation, EGFR, Immunotherapy, Biopsy, Nsclc, non-small cell lung cancer, Lung Cancer, Thoracic, Radiation Therapy, Radiotherapy, Cancer, Astro, ASCO, sts, Multidisciplinary Thoracic Cancers Symposium

Genetic Profile of Treatment-Resistant Lung Cancer More Variable Than Previously Understood

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The genetic mutations underlying treatment resistance in non-small cell lung cancer (NSCLC) are more complex and dynamic than previously thought.

Medicine

Science

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Stem Cells, Schwann Cells, Neuron, Neurology, Parkinson Disease, Brain, neural crest cells, Chemical Engineering, biological engineering, smooth muscle cells, Melanocytes, Genetic Modification, genes, Genetics

From Skin to Brain: Stem Cells Without Genetic Modification

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A discovery, several years in the making, by University at Buffalo researchers proves that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain. The applications could be significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient’s own cells.

Medicine

Channels:

Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, marker chromosome, human induced pluripotent stem cells, neural progenitor cell, Neural Progenitor Cells, Schizophrenia, Bipolar Disorder, bipolar disorder with psychosis, ISO, Mosaic

Some Genetic Variations May Be Particularly Difficult to Evaluate Using Current Stem Cell Modeling Techniques

Mount Sinai study on psychosis reveals the importance of clarifying the precise structure of any genetic mutation before moving forward with human-induced pluripotent stem cell studies

Science

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Gene Editing

FSU Expert Explains Changing Attitudes Toward Embryonic Gene Editing

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Medicine

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CRISPR, Inflammation, Chronic Pain

Pain in the Neck

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Researchers led by University of Utah bioengineering assistant professor Robby Bowles have discovered a way to curb chronic pain by modulating genes that reduce tissue- and cell-damaging inflammation.

Science

Channels:

Biology, Genetics, Evolution

Genetics Society of America Honors David Kingsley with 2017 GSA Medal

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The Genetics Society of America (GSA) is pleased to announce that David Kingsley, PhD is the 2017 recipient of the GSA Medal for outstanding contributions to the field of genetics in the past 15 years. His experimental work has shifted paradigms about how the physical traits of vertebrate organisms evolve. Kingsley is a Professor and Howard Hughes Medical Institute Investigator in the Department of Developmental Biology at the Stanford University School of Medicine.







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