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Ribosome, catalytic center, chloramphenicol, Linezolid

Two Antibiotics Fight Bacteria Differently Than Thought

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Two widely prescribed antibiotics — chloramphenicol and linezolid — may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found. Instead of indiscriminately stopping protein synthesis, the drugs put the brakes on the protein synthesis machinery only at specific locations in the gene.

Medicine

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HTA, voice of the patient, rare disease, Orphan Drugs

ISPOR 19th Annual European Congress Explores How HTA Bodies Can Consider the Voice of Patients with Rare Diseases

The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) led a session this afternoon entitled, "From Testimonials to Qualitative Research Embedded in Clinical Trials: How Do Health Technology Assessment Bodies Consider the Voice of Rare Disease Patients When Granting Access to Orphan Drugs?" The discussion took place at the Society’s 19th Annual European Congress—in Vienna, Austria.

Medicine

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Rna Interference, Rnai, Drug Development, RNA, RXi Pharmaceuticals, Geert Cauwenbergh, sd-rxRNA, RXI-109, connective tissue growth factor, CTGF, Fibrosis, scar formation, retinal scarring, age-related macular degeneration, AMD, hypertrophic scar

Expert: How Can ‘RNA Interference’ Enhance Drug Development?

Medicine

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Cancer, Brain Cancer, Pediatric Cancer, MEK inhibitors

Promise of Better Targeted Treatments Now Possible in Children’s Brain Cancer

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer. Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue. The research was conducted using a new zebrafish animal model system developed by the researchers, which closely resembles an aggressive subtype of pediatric brain tumors.

Medicine

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Anesthesia, Anesthesia And Critical Care, Alzheimer's Disease

Experimental Drug Shows Promise in Treating Alzheimer’s Disease

An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY® 2016 annual meeting.

Medicine

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Cancer, Breast Cancer, Precision Medicine, Cancer Recurrence

Precision Medicine Test Helps Guide Breast Cancer Patients’ Chemotherapy Decision

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One of the earliest widespread applications of precision medicine in cancer care is helping patients and physicians decide whether chemotherapy is needed, a new study finds.

Medicine

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Back Pain Research, Opioids, anesthesia and pain management, Anesthesiology and Critical Care

Many Back Pain Patients Get Limited Relief From Opioids and Worry About Taking Them, Survey Shows

Millions of people take opioids for chronic back pain, but many of them get limited relief while experiencing side effects and worrying about the stigma associated with taking them, suggests research presented at the ANESTHESIOLOGY® 2016 annual meeting.

Medicine

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Fibroids, Uterine Fibroids, Hysterectomy, Women's Health

Michigan Joins National, $20M Research Project to Improve Fibroid Treatment

The University of Michigan will join nine other clinical centers across the country working to compare the effectiveness of different treatment strategies for women with uterine fibroids.

Medicine

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Glioblastoma, Cancer, Neurology, Drug Development, Brain Cancer

Depriving Deadly Brain Tumors of Cholesterol May Be Their Achilles’ Heel

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Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

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Cancer, Cancer Research, Dr. Jann Sarkaria, Massachusetts Institute Of Technology, National Cancer Institute, news release, Physical Sciences-Oncology Centers

Mayo Clinic and Massachusetts Institute of Technology Receive Grant to Support Physical Sciences-Oncology Center

ROCHESTER, Minn. — Mayo Clinic and the Massachusetts Institute of Technology (MIT) have been awarded a five-year, $9.7 million grant from the National Cancer Institute (NCI) to support a Physical Sciences-Oncology Center (PS-OC). Researchers hope to learn more about the physical parameters that limit drug delivery into brain tumors and use this information to build models that will help physicians better predict how the body will distribute a particular drug to brain tumors and help them select the best drug to treat each patient based on their unique tumor.

Medicine

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Tuburculosis, Supplement, supplement risks , supplemental nutrition, Botancal, Treatment, Drug Treatment, Botanical Products, Botanical Research, Herbal, Herbal Medicine, Herbal Remedies, Medical Treatment, Tuberculosis, tuberculosis resistance, Tuberculosis treatment

Anti-Tuberculosis Drug Disrupted by Botanical Supplement, Can Lead to Development of Disease

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A new study from the University of Missouri in partnership with scientists in Africa has uncovered evidence that these supplements and their antioxidants may reduce the effectiveness of prescription medications. The researchers examined the effects of a widely used African botanical supplement, called Sutherlandia, and found that it may disrupt the effectiveness of a common anti-tuberculosis drug. This could lead to the development of active tuberculosis and perhaps drug resistant forms of the pathogen in some patients.

Medicine

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Center for Individualized Medicine, Medical Research, Molecular Testing, Dna Sequencing, Pharmacogenomics, Precision Medicine, whole exome sequencing

4 Tips for Patients Seeking Individualized Medicine

The promise of precision medicine is becoming a reality as more doctors bring individualized therapies to the bedside.

Medicine

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Neuroscience, precision neuroscience, Personalized Medicine, Virginia Tech Carilion Research Institute, Virginia-Nordic Precision Neuroscience, Sunnaas Rehabilitation Hospital, University of Oslo, Roanoke

International Scientists Join Forces to Put ‘Precision’ Focus on Neuroscience

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For three days this week, Roanoke, Virginia, is the capital of the precision neuroscience world. The top minds of precision neuroscience are coming together in a think-tank setting to explore the challenges and promise of bringing personalized medicine to brain health.

Medicine

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Center for Individualized Medicine, Dna Sequencing, Medical Research, whole exome sequencing, Molecular Testing

4 Ways Individualized Medicine Can Be Applied Immediately to Patient Care

Individualized medicine is no longer the lore of science fiction. It is offering new hope for patients with cancer, heart disease, depression and rare diseases for which there historically have been no diagnosis or treatment. And that’s just the beginning.

Medicine

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Center for Individualized Medicine, Dna Sequencing, Medical Research, Minnesota News Releases, Molecular Testing, news releases, Pharmacogenomics, Precision Medicine

Mayo Clinic Patient: ‘Individualized Medicine Saved My Life’

What Karen Daggett didn’t know almost killed her. The medicine she relied on to control an irregular heartbeat wasn’t working and hadn’t for years and she didn’t understand why pain medication never seemed to make her feel better. She also had a history of not tolerating some over-the-counter medications. Silently, these drugs were building up in her system, causing harmful side effects until DNA testing at Mayo Clinic Center for Individualized Medicine showed some medications were incompatible with her genetic makeup.

Medicine

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Alzheimer's Disease, Georgetown University Medical Center, Howard Fillit, Nilotinib, repurposing cancer drugs, R. Scott Turner, Chronic Myeloid Leukemia, Cognitive Impairment, Neuroinflammation, misfiled proteins, atophagy, plaques and tangles, tau, beta-amyloid, Charbel Moussa, Georgetown Memory Disorders Program, anti-neurodegenerative drug, Georgetown U

New Clinical Trial Will Test Cancer Drug as Alzheimer’s Treatment

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The Alzheimer’s Drug Discovery Foundation (ADDF) announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna® for use as a cancer therapy) in patients with Alzheimer’s disease.

Medicine

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Hepatitis, Hepatitis B, Hepatitis B research, Hepatitis B Virus, hepatitis B virus (HBV), pharmacological research, Pharmacology, Pharmacologic, pharmacologic compound, pharmacology and therapeutics, Drug Research, Drug Research and Development

NIH Grants MU $3 Million to Develop New Hepatitis B Treatments

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Hepatitis B (HBV) is a viral infection that increases the likelihood of developing liver cancer or liver failure. According to the World Health Organization, an estimated 2 billion people currently are infected with HBV, which is more than 10 times the number of people who have human immunodeficiency virus (HIV). Currently, treatment for hepatitis B infections is limited to one class of drugs that targets the virus. Stefan Sarafianos, an investigator with the University of Missouri Bond Life Sciences Center (BLSC) recently was awarded $3 million from the National Institutes of Health to study the disease. Building on existing research, he and his team will work on the development of new drugs to treat HBV.

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Inside the Lab: Using Botox to Advance Science

Many know Botox as a trendy way to get rid of wrinkles, but the popular drug — made from botulinum neurotoxin (BoNT) — can do more than just fill lines.

Medicine

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drug deliver, Tumor, Cancer, magnetic bacteria

Swarms of Magnetic Bacteria Could Be Used to Deliver Drugs to Tumors

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Researchers have recently shown that magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs.

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Drug Restores Hair Growth in Patients with Alopecia Areata

Seventy-five percent of patients with an autoimmune disease that causes hair loss had significant hair regrowth after treatment with ruxolitinib, according to a study from Columbia University Medical Center.







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