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Medicine

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Alzheimer's, Drug Discovery, Jeff Conn, Craig Lindsley, academic drug discovery , Vanderbilt Center for Neuroscience Drug Discovery , William K. Warren Foundation, Schizophrenia, Paul Newhouse, Alzheimer’s Association, Alzheimer’s Drug Discovery Foundation

Investigational New Drug for Alzheimer’s Scheduled for First Study in Humans

Vanderbilt University scientists have received notification from the U.S. Food and Drug Administration (FDA) that testing in humans may proceed for an investigational new drug after more than 10 years of research by scientists at Vanderbilt University and Vanderbilt University Medical Center.

Medicine

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Head & Neck Cancer, Cetuximab, Chemotherapy, Radiation, personalized cancer care, Cancer, KRAS mutations, UCLA, UCLA Jonsson Comprehensive Cancer Center

UCLA-Led Study Provides Roadmap to More Personalized Cancer Treatment

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Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS-variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.

Medicine

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ASHP, Antibiotic Stewardship , Mentorship, American Society of Health-System Pharmacists, Antibiotic Administration, MQIIP, ASHP Mentored Quality Improvement Impact Program, Debra Goff, Serena Von Ruden, George Karam, St. Francis Hospital, ASHP InterSections, Antibiotic Resistance, The Ohio State University Wexner Medical Center , Pharmacy, Pharmacist, He

Interdisciplinary Teamwork Yields Improved Antibiotic Stewardship

A hospital engaged in a quality improvement program launched by ASHP (American Society of Health-System Pharmacists) has identified weaknesses in existing antibiotic stewardship initiatives and implemented workflow changes that resulted in faster antibiotic administration. St. Francis Hospital in Federal Way, Wash., was recently featured in ASHP’s InterSections, which highlights the hospital’s team approach to improving infection treatment with IV antibiotics.

Medicine

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Antibiotics, Burn Injury, burn injury infections, multidrug-resistant, Ut Southwestern

UT Southwestern Study Identifies a Way to Prevent Burn Injury Infection – Without Antibiotics

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A new way to fight multidrug-resistant bacteria by blinding them rather than killing them proved highly effective in a model of burn injuries, UT Southwestern Medical Center research shows.

Medicine

Science

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Cancer, Drug Design, Drug Development

Scripps Florida Scientists Discover New Natural Source of Potent Anti-Cancer Drugs

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Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

Medicine

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Latest Analysis From Clarity Science Opera Pain Study Confirms 45% Reduction of Opioid Usage by Using Transdermal Medication

/PRNewswire/ -- Clarity, a global international scientific research company, based in Austin, Texas, announces the latest results of its IRB-approved OPERA study. OPERA (Optimizing Patient Experience and Response to Topical Analgesics) evaluates patient perceptions of pain treatment with the use of FDA-approved topical/transdermal formulations alone or in combination with neuropathic supplements via a patient-reported survey.

Life

Social and Behavioral Sciences

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A Cure for Social Anxiety Disorders

A team of doctors and psychologists examined the effects of structured talk therapy and medication on patients with social anxiety disorders. In doing so they set a new world record in effectively treating social anxiety disorder.

Medicine

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Pediatric Cancer, Cancer, personalized medicine, digital health, Oral Health, UCLA, UCLA School of Dentistry, Artificial Intelligence, drug, drug dosing, Drug Therapy

‘Turbocharged Artificial Intelligence’ Could Personalize Combination Therapy in Pediatric Leukemia

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UCLA researchers show the potential of their digital health platform to help treat acute lymphoblastic leukemia by being able to personalize drug dosages and combinations

Medicine

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Lymphoma, Lymphoma Research, Lymphoma treatment, Diffuse large B-cell lymphoma, Clinical Trial, Clinical Trial participation, oral cancer drugs

UNMC Seeking Lymphoma Patients for Oral Two-Drug Study

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Most cancer treatments come in the form of chemotherapy given intravenously. This is unique because it uses a combination of two oral medications.

Medicine

Science

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Antibiotic Resistance, scientist profile, Profile, Microbiome, Drug Resistant Bacteria, Gut commensal microbiota

The Irresistible Resistome: How Infant Diapers Might Help Combat Antibiotic Resistance (Sort of)

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Biochemist Gautam Dantas inspects what’s deposited on infant diapers for clues about antibiotic resistance.

Medicine

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Personaized Medicine, drug cocktails, Drug Combinations, Modeling, Cancer Treatment, Alon

How to Mix the Perfect (Drug) Cocktail

The fine art of mixing drug cocktails is incredibly complicated, with virtually infinite numbers of possible interactions and side effects. Now, a new model from the Weizmann Institute lab of Prof. Uri Alon lets scientists compare combinations of drugs to determine efficacy – a major step forward in personalized medicine.

Medicine

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Parkinson Disease, Parkinson Disease Treatment

Diabetes Drug Slows Experimental Parkinson’s Disease Progression, Human Trials to Begin Next Year

A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world’s first treatment to impede the progression of Parkinson’s disease following publication of research findings today in the journal Science Translational Medicine.

Medicine

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ASH Conference, Ash, American Society Of Hematology, Lymphoma, Acute Myeloid Leukemia, AML, hypomethylation, Yale Cancer Center

Alternative Option to Intensive Chemotherapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

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A Yale Cancer Center team has evaluated the use of hypomethylating agents in patients suffering from Acute Myeloid Leukemia (AML) who were resistant to treatment with intensive chemotherapy.

Science

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Gates Foundation, Grant Award, Taste, pharmaceutical compliance, Children, Bitter Taste Sensitivity, parasitic infections, Schistosomiasis, recurrent diarrhea, sensory science, taste cells, screening assays, develolping nations, Pharmaceuticals, Interdisciplinary Research, taste blockers

Monell Center Receives Funding to Develop Technologies to Improve Taste of Lifesaving Drugs

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The Monell Center announced today that it has received a $345,000 grant from the Bill & Melinda Gates Foundation. The grant supports an innovative global health research project titled, "Developing Novel Pediatric Formulation Technologies for Global Health: Human Taste Assays."

Medicine

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Chemotherapy, Taxane, Bevacizumab, Maintenance Therapy, Metastatic Breast Cancer, HER2 Negative, Survival Rate, progression-free survival

Treatment Combination to Improve Survival in HER2-Negative Metastatic Breast Cancer

The study, “A Real-World Multicentre Retrospective Observational Study of Paclitaxel-Bevacizumab and Maintenance Therapy as First-Line Treatment for HER2-Negative Metastatic Breast Cancer,” was recently published in the Journal of Cell Physiology.

Medicine

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Scripps Florida Scientists Create Innovative Drug Design Strategy to Improve Breast Cancer Treatment

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A new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) offers a novel structure-based drug design strategy aimed at altering the basic landscape of this type of breast cancer treatment.

Medicine

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Cancer, Precision Medicine, Personalized Medicine, molecular tumor board, Genetic Testing

Expanding Precision Medicine Options, UK Markey Cancer Center Launches Molecular Tumor Board

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The University of Kentucky Markey Cancer Center recently launched its own Molecular Tumor Board, an approach to cancer care that uses genetic analysis to help oncologists choose cancer therapies tailored to each patient's individual needs. The Molecular Tumor Board is the latest precision medicine initiative to come online at Markey.

Medicine

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Osteoporosis, NYU Dentistry, New York University College of Dentistry, National Institute of Diabetes and Digestive Kidney Diseases, Research Grant

NYU College of Dentistry’s Dr. Nicola Partridge Awarded $1.9 M to Further Osteoporosis Drug Research and Development

The federally funded grant will support bench research aimed at understanding how the protein hormone, parathyroid hormone-a related protein-and a drug analog that mimics the protein called abaloparatide, interact in the surface of a cell in bone and affect bone formation and breakdown.

Medicine

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Purdue Pharma, The University of Texas Health Science Center at Houston (UTHealth), Michael Blackburn, Bruce D. Butler, Drug Development

UTHealth, Purdue Pharma Enter Long-Term Research & Education Alliance

UTHealth and Purdue Pharma L.P. have entered into a specialized alliance to bring academic researchers and drug developers closer together with the common goals of accelerating the development of new drug therapies for patients while advancing the science and providing unique educational experiences for both.

Medicine

Channels:

Genome, Genome Sequence, Precision Medicine, Precision Medicine Initiative, Governor Brown, CHORI

UCSF Benioff Children’s Hospital Oakland Research Institute and Partners to Receive $1.2 Million Grant from California Initiative to Advance Precision Medicine

A team at the Oakland and San Francisco campuses of UCSF Benioff Children’s Hospitals, UCSF, and UC Berkeley have been awarded $1.2 million by California Initiative to Advance Precision Medicine (CIAPM) to help advance precision medicine in the state.







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