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Medicine

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Heart Valve Disease, Heart Disease, Rheumatoid Arthritis, Nashville, Vanderbilt, American Heart Association

Drug Developed for Arthritis Could Be First to Stop Heart Valve Calcification

About a quarter of Americans suffer hardening of the valves by age 65 and about half by 85. Without a suitable drug, the only treatment is surgical replacement.

Medicine

Life

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Education

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Pharmaceticals, Oncology, BRCA, Start Up, Big Data

University of Rhode Island Graduate Students Launch Pharmaceutical Company

The Ph.D. students say Alcinous Pharmaceuticals uses computational software available free on the Internet to sort through 40 million possible drug-binding targets.

Science

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Technology Unlocks Mold Genomes for New Drugs

Fungi are rich sources of natural molecules for drug discovery, but numerous challenges have pushed pharmaceutical companies away from tapping into this bounty. Now scientists at Northwestern University, the University of Wisconsin-Madison and the biotech company Intact Genomics have developed technology that uses genomics and data analytics to efficiently screen for molecules produced by molds to find new drug leads -- maybe even the next penicillin. From three diverse fungal species, the research team discovered 17 new natural products.

Medicine

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Health, Epidemiology

New Study Design Holds Promise for Drug Safety Research

As the pace of drug approvals accelerates and the U.S. Food and Drug Administration (FDA) faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use. The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval. Also first-in-class drugs may not have an applicable comparator drug, and traditional follow-up studies may give inaccurate results if those who take a new drug are different from those who took the comparator drug.

Medicine

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opioid addiction treatment, Cesearan

Study Shows Cesarean Patients Sent Home with More Narcotic Pain Medications Than Needed

Most women who undergo a cesarean childbirth are prescribed more opioid (narcotic) pain medications than needed upon release from the hospital, a Vanderbilt University Medical Center (VUMC) study shows.

Medicine

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Hepatitis C

Researchers Identify How Class of Drugs Blocks Hepatitis C Virus Replication

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For the first time, researchers at the University of North Carolina at Chapel Hill show how the antiviral class of drugs called NS5A inhibitors interacts with the hepatitis C virus, and these findings show a difference between strains of HCV. These results were published in PLOS Pathogens.

Medicine

Science

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Researching Radiosensitizers, a New Class of Drugs That Would Make Tumors More Vulnerable to Radiation Therapy

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Two out of three cancer patients are treated with radiation, but the therapy often fails to wipe out the tumor or slow its growth. Southern Research is working to develop a new class of drugs that will help the radiation deliver a more powerful punch to the disease.

Medicine

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Head And Neck Cancer, Bevacizumab, ASCO 2017, Yale Cancer Center

Expert to Speak on Bevacizumab in Advanced Head and Neck Cancer

Medicine

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digital medicine, Hypertension, Smart medical systems, Medication Adherence, Pharmaceucticals

Rush Begins Offering ‘Digital Medicine’ That Supports Medication Adherence

Rush University Medical Center has begun to offer “digital medicine.” Called Proteus Discover, it’s an FDA-approved medical “device” that pairs medication with an ingestible sensor the size of a grain of sand, which works together with a wearable sensor patch and mobile app.

Medicine

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Sleep Apnea, sleep 2017, Dronabinol

Anti-Nausea Drug Could Help Treat Sleep Apnea

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An old pharmaceutical product may be a new treatment for obstructive sleep apnea, according to new research presented today by University of Illinois at Chicago and Northwestern University scientists at the SLEEP 2017 annual meeting in Boston.







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