Feature Channels: Autoimmune Diseases

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Released: 9-Mar-2023 3:05 PM EST
Molecule known to slow inflammation linked to scleroderma, could be treatment target
Michigan Medicine - University of Michigan

A molecule that was until recently known as a brake on inflammation has now been implicated in fibrosis in scleroderma patients.

Released: 9-Mar-2023 2:50 PM EST
Lupus: A frustrating diagnosis journey you don’t need to embark alone
Michigan Medicine - University of Michigan

Nicknamed the “invisible disease”, lupus is an autoimmune disorder that disproportionately affects women and even more specifically, Black women. It occurs when the immune system begins a pattern of attacking the body’s organs when immune cells are inappropriately activated in the body. It’s difficult to diagnose, and when it is, it’s accompanied by major lifestyle changes to help keep the condition under control.

Released: 9-Mar-2023 2:45 PM EST
For antiphospholipid syndrome patients, lab results don’t always paint the full picture
Michigan Medicine - University of Michigan

Antiphospholipid syndrome is an autoimmune disease that preferentially affects women. Patients with APS are typically given different medications to reduce their risk of blood clotting and help normalize lab values such as platelet count. Despite this, patients sometimes internally feel that they are not doing as well as the numbers are showing.

Released: 8-Mar-2023 12:40 PM EST
New Study: Abatacept Therapy Offers Promising Results Treating Juvenile Dermatomyositis
George Washington University

Juvenile dermatomyositis, a rare but often severe and chronic systemic autoimmune disease, includes a large number of patients who are treatment resistant, requiring long term immunosuppressive therapy. A small open-label study published in Arthritis and Rheumatology shows promise using a targeted biologic therapy called abatacept to treat such patients.

6-Mar-2023 10:45 AM EST
Genetic variation that protected against Black Death still helps against respiratory diseases today, but increases autoimmune disease risks
University of Bristol

The same genetics that helped some of our ancestors fight the plague is still likely to be at work in our bodies today, potentially providing some of the population with extra protection against respiratory diseases such as COVID-19. However, there is a trade-off, where this same variation is also linked to increased autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease.

Released: 3-Mar-2023 12:45 PM EST
Putting out “the fire in the brain”
Universität Leipzig

In autoimmune encephalitis, a rare but serious and sometimes life-threatening inflammation of the central nervous system, the body’s own defences are directed against the central nervous system.

Released: 28-Feb-2023 2:25 PM EST
First study to show childhood obesity is linked to increased risk of four of the five newly proposed subtypes of adult-onset diabetes
Diabetologia

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) is the first study to show that childhood obesity is associated with an increased risk of four of the five recently proposed subtypes of adult-onset diabetes.

Newswise: Mechanisms Underlying Autoimmunity in Down Syndrome Revealed
20-Feb-2023 9:55 AM EST
Mechanisms Underlying Autoimmunity in Down Syndrome Revealed
Mount Sinai Health System

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

Released: 21-Feb-2023 2:05 PM EST
A New Catalyst For Recycling Plastic, New Antioxidants Found In Meat, And Other Chemical Research News
Newswise

Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.

Newswise: Autoantibody linked to rare disorder that destroys fat, UT Southwestern researchers find
Released: 21-Feb-2023 1:00 PM EST
Autoantibody linked to rare disorder that destroys fat, UT Southwestern researchers find
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center have discovered the first molecular biomarker for acquired generalized lipodystrophy (AGL), a rare disorder in which fat deposits are destroyed, causing patients to have dangerously low body fat, signs of accelerated aging, and severe metabolic diseases including diabetes and fatty liver.

Newswise: UTSW study examines off-label drugs prescribed in addition to insulin for Type 1 diabetes
Released: 16-Feb-2023 1:00 PM EST
UTSW study examines off-label drugs prescribed in addition to insulin for Type 1 diabetes
UT Southwestern Medical Center

Two classes of drugs prescribed off-label for some patients with Type 1 diabetes can provide significant benefits but also come with health concerns, according to a study by UT Southwestern Medical Center researchers. The findings are published in The Journal of Clinical Endocrinology & Metabolism.

Released: 16-Feb-2023 12:45 PM EST
Multiple sclerosis discovery could end disease’s chronic inflammation
University of Virginia Health System

UVA Health neuroscientists have discovered a potential way to disrupt the chronic inflammation responsible for multiple sclerosis.

Newswise: LLNL Biomedical Licensee Collaborating With Two Drug Companies To Advance Treatments For Autoimmune Diseases
Released: 16-Feb-2023 11:05 AM EST
LLNL Biomedical Licensee Collaborating With Two Drug Companies To Advance Treatments For Autoimmune Diseases
Lawrence Livermore National Laboratory

People afflicted with autoimmune diseases may someday receive help through treatments now under development by a Lawrence Livermore National Laboratory (LLNL) licensee and its’ collaborations with two major pharmaceutical companies.

Released: 15-Feb-2023 5:25 PM EST
UCLA receives $20 million to establish Goodman–Luskin Microbiome Center
University of California, Los Angeles (UCLA), Health Sciences

A $20 million gift from Andrea and Donald Goodman and Renee and Meyer Luskin will fund a new center at UCLA focused on the microbiome and its effect on health.

Newswise: HIV Treatment and Prevention in Zambian Prisons May be Model for Prisons Worldwide
Released: 15-Feb-2023 1:15 PM EST
HIV Treatment and Prevention in Zambian Prisons May be Model for Prisons Worldwide
Institute of Human Virology at the University of Maryland School of Medicine

A recent study performed in Zambia by University of Maryland School of Medicine’s (UMSOM) Institute of Human Virology researchers found that high uptake of HIV preventative medicine, known as pre-exposure prophylaxis (PrEP), is possible in prison populations with adequate resources and support from the criminal justice health system.

Newswise:Video Embedded new-17-million-grant-establishes-lji-as-global-hub-for-immunology-data-curation-and-analysis
VIDEO
Released: 14-Feb-2023 1:05 PM EST
New $17 million grant establishes LJI as global hub for immunology data curation and analysis
La Jolla Institute for Immunology

A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).

   
Released: 10-Feb-2023 8:10 PM EST
'Natural killer' immune cells can modify tissue inflammation: study
Monash University

Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells.

Released: 8-Feb-2023 9:00 AM EST
Harnessing good fats to relieve MS symptoms
American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers find that fish oil derivative reduces and delays disease–causing inflammation in mouse model of multiple sclerosis

   
Released: 7-Feb-2023 4:05 PM EST
New biomarker for disease progression in multiple sclerosis
University of Basel

The autoimmune disease multiple sclerosis can take a variety of courses.

Released: 31-Jan-2023 5:05 PM EST
The latest research news on surgery and transplants
Newswise

Below are some of the latest articles that have been added to the Surgery and the Transplantation channels on Newswise, a free source for journalists.

Newswise: A New Assay Screening Method Shows Therapeutic Promise for Treating Auto-Immune Disease
Released: 27-Jan-2023 2:00 PM EST
A New Assay Screening Method Shows Therapeutic Promise for Treating Auto-Immune Disease
SLAS

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

   
Newswise: Scientists find that microRNA affects inflammation in lupus disease
Released: 26-Jan-2023 2:15 PM EST
Scientists find that microRNA affects inflammation in lupus disease
Nagoya University

A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.

Newswise: Paving the way toward a cure? Study reports new insights into role of proteins in HIV latency
Released: 10-Jan-2023 5:50 PM EST
Paving the way toward a cure? Study reports new insights into role of proteins in HIV latency
University of Ottawa

Understanding HIV latency at the molecular level is crucial for efforts to eliminate the viral scourge that causes AIDS.

Newswise: Analysis: A Longer View on COVID-19 Antibodies
Released: 10-Jan-2023 3:00 PM EST
Analysis: A Longer View on COVID-19 Antibodies
Cedars-Sinai

A new analysis by Cedars-Sinai investigators is furthering the scientific community’s understanding of COVID-19 immunity by showing that similar levels of COVID-19 antibodies are reached over an extended period of time in different population groups.

Newswise: Oncotarget | The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies
Released: 29-Dec-2022 1:05 PM EST
Oncotarget | The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies
Impact Journals LLC

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies.”

Newswise: Tissue-Specific Immunity May Be the Future, if We Can First Learn its Rules
Released: 28-Dec-2022 11:30 AM EST
Tissue-Specific Immunity May Be the Future, if We Can First Learn its Rules
University of California San Diego

UC San Diego study reveals critical insights into the complex biology of tissue-specific T cells, paving the way for a new branch of precision therapeutics in immunity, autoimmunity, and cancer.

Released: 21-Dec-2022 10:50 AM EST
4 things to know about stiff person syndrome
Michigan Medicine - University of Michigan

In a video posted to Instagram, Grammy-award-winning singer Celine Dion announced that she has a rare condition called stiff person syndrome. Here, a neuromuscular specialist shares helpful facts about symptoms, diagnosis and treatment.

Newswise: Immune surprise: recently evolved alarm molecule drives inflammation
Released: 19-Dec-2022 2:25 PM EST
Immune surprise: recently evolved alarm molecule drives inflammation
Trinity College Dublin

Scientists from Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated.

   
Released: 19-Dec-2022 1:35 PM EST
Paving the way for new drugs to treat a range of diseases
Argonne National Laboratory

Researchers from Boston Children’s Hospital and Harvard, using Argonne’s Advanced Photon Source, have characterized the structure of integrins, a type of cell surface receptor involved in the immune response.

Newswise: Neurologist explains autoimmune disease affecting Celine Dion
Released: 15-Dec-2022 2:00 PM EST
Neurologist explains autoimmune disease affecting Celine Dion
University of Miami

Dr. Kottil Rammohan, professor of clinical neurology at the Miller School of Medicine, addresses the autoimmune and neurological disorder that is affecting the Canadian singer and that impacts about one or two in a million people.

Newswise: Evidence of autoimmunity’s origins uncovered via new approach
6-Dec-2022 6:20 PM EST
Evidence of autoimmunity’s origins uncovered via new approach
Washington University in St. Louis

Autoimmune diseases are thought to be the result of mistaken identity. Immune cells on patrol, armed and ready to defend the body against invading pathogens, mistake normal human cells for infected cells and turn their weapons on their own healthy tissues.

   
Released: 5-Dec-2022 5:30 PM EST
Immunotherapy eliminates disease-causing cells in mice with MS-like disease
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have shown that the cancer therapy known as CAR-T can be applied to multiple sclerosis (MS), an autoimmune disease of the nervous system. The findings extend the powerful tool of immunotherapy to autoimmune diseases, a class of diseases that are often debilitating and difficult to treat.

   
Released: 2-Dec-2022 11:35 AM EST
Children with type 1 diabetes miss more school, study suggests
Cardiff University

Children living with type 1 diabetes miss an average of nine more sessions of school a year compared to children without the condition, a new study led by Cardiff University has found.

13-Nov-2022 10:00 AM EST
HSS Research Uncovers How UV Light Triggers Immune Activation and Disease Flares in Lupus
Hospital for Special Surgery

After sun exposure, people with systemic lupus erythematosus (SLE) frequently develop skin rashes, which often are accompanied by a flare of their overall disease. This connection between ultraviolet (UV) light and disease flares in lupus is well known, but the way in which UV exposure actually triggers the disease has been poorly understood.

12-Nov-2022 1:00 PM EST
Participation Doubles After Lupus Support Group at HSS Transitions to Virtual Format During Pandemic
Hospital for Special Surgery

A study at Hospital for Special Surgery (HSS) highlights the success of a lupus peer support and education group that transitioned to a virtual format during the pandemic. In addition to receiving high marks from group members, participation more than doubled after the meetings went remote.

Released: 10-Nov-2022 11:25 AM EST
Immune system reboot in MS patients
University of Zurich

Every day, one person in Switzerland is diagnosed with multiple sclerosis. MS is an autoimmune disease in which the body’s own immune system attacks the myelin sheath of the nerve cells in the brain and spinal cord.

Released: 8-Nov-2022 12:20 PM EST
Study Links Lower Hydroxychloroquine Dose to More Hospitalizations for Systemic Lupus Erythematosus Flares
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual scientific meeting, found that the recommended weight-based or non-weight-based dose of hydroxychloroquine led to more hospitalizations for flares among patients with systemic lupus erythematosus

Released: 8-Nov-2022 11:55 AM EST
New Analysis Finds Belimumab Improves Cutaneous Lupus Erythematosus in Patients with or without SLE
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found that the B-cell inhibitor belimumab significantly improved cutaneous lupus erythematosus (CLE) whether or not patients also had systemic lupus erythematosus (SLE or lupus).

Released: 8-Nov-2022 11:50 AM EST
Study Finds Lower Risk of Severe Infection and Hospitalization with Belimumab Compared to Oral Immunosuppressants
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found that the biologic B-cell inhibitor belimumab was associated with a lower risk of severe infections and hospitalizations compared to nonbiologic immunosuppressants.

Released: 8-Nov-2022 11:20 AM EST
Holding Mycophenolate Mofetil for 10 Days or More May Improve COVID-19 Vaccine Response
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, demonstrated that withholding mycophenolate mofetil for 10 days significantly increased antibody response after 2 doses of COVID-19 vaccine, without a significant increase in flares.

Released: 8-Nov-2022 11:10 AM EST
Preterm Birth More Common in Unvaccinated Pregnant Patients with Rheumatic Disease and COVID-19
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found a greater number of preterm births in unvaccinated versus fully vaccinated pregnant patients with rheumatic disease and COVID-19.

Released: 8-Nov-2022 10:05 AM EST
Study Finds Half of Patients with Low-Grade Proteinuria Develop Treatable Lupus Nephritis within Two Years
American College of Rheumatology (ACR)

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found that 50% of people with low-grade proteinuria, which is protein in your urine, progress to clinical proteinuria within two years and show treatable lupus nephritis on biopsies.

Released: 7-Nov-2022 11:05 AM EST
Study Differentiating Function of Two Immune Cells Could Improve Vaccine Design
Rutgers University-New Brunswick

Rutgers researchers find that one type of tissue-resident memory cell fights reinfection better than another.

28-Oct-2022 3:15 PM EDT
Population-Level Study Provides Reassuring Data on the Risk of Kidney Disease Relapse After COVID-19 Vaccination
American Society of Nephrology (ASN)

• In a population-level study of 1,105 adults with stable glomerular disease (a type of autoimmune kidney disease), a first dose of a COVID-19 vaccine was not associated with relapse risk; however, receiving a subsequent vaccine dose was associated with a 2-fold higher relative risk of relapse. • Importantly, the increase in absolute risk associated with vaccination was low (1–5% depending on type of glomerular disease), and most vaccine-associated disease flares were mild.

3-Nov-2022 7:05 AM EDT
Study Finds That Patients with Cancer and a Suppressed Immune System Are at High Risk for Severe COVID if Treated with Systemic Drug Therapies
Dana-Farber Cancer Institute

Patients with cancer and a weakened immune system who are treated with immunotherapies tend to fare far worse from COVID-19 than those who haven't received such therapies in the three months before their COVID diagnosis, show findings in a new study by researchers at Dana-Farber Cancer Institute, and across the U.S., Canada, and Mexico. Researchers found worse outcomes in both the disease itself as well as the fierce immune response that sometimes accompanies it.

Released: 1-Nov-2022 5:55 PM EDT
Getting to the Heart of COVID-19 Vaccination and Its Cardiovascular Risks
Elsevier

A comprehensive review and meta-analysis of published research confirm that young adults (40 years old and younger) have a slightly elevated risk for myocarditis or pericarditis after mRNA COVID-19 vaccination.



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