While it is well known that cannabis can cause the munchies, researchers have now revealed a mechanism in the brain that promotes appetite in a set of animal studies at Washington State University.
RUDN University scientists have discovered that in weightlessness the contractile activity of smooth muscles in the hollow organs of the gastrointestinal tract is disrupted. New data must be taken into account when planning long-term space missions.
Two teams from UNIL and EPFL have succeeded in demonstrating that the insect synthesizes nutrients for native gut microbes. A study published in Nature Microbiology.
The Environmental Molecular Sciences Laboratory a Department of Energy user facility, will hold a free webinar on Jan. 24 to showcase available imaging platforms for live cell microscopy.
A study of mutant models of fragile X syndrome (FXS), a genetic disorder related to autism and intellectual disability, shows that activation of the cerebellum mitigates aberrant responses in sensory processing areas of the brain and improves neurodevelopmental behaviors. The findings, published by UT Southwestern Medical Center researchers in Cell Reports, could offer an opportunity for developing new therapies for neurocognitive disorders.
Rice University scientists have developed a noninvasive way to monitor gene expression dynamics in the brain, making it easier to investigate brain development, cognitive function and neurological diseases, according to a study published in Nature Biotechnology.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include insights into the effects of the gut microbiome on remote tumors, a screening strategy for ovarian cancer early detection, a combination approach to overcome PARP inhibitor resistance, further understanding of ferroptosis resistance, a ferroptosis-based strategy for overcoming treatment resistance in acute myeloid leukemia (AML), potential targets for p53 mutations that lead to cancer progression, a signature for more accurately predicting risk in patients with AML given low-intensity treatments, and a prognostic tool to stratify patients with colorectal cancer.
Researchers at Dana-Farber Cancer Institute and the University of Trento, Italy, have developed a blood test, described in Cancer Discovery, that can reliably detect neuroendocrine prostate cancer and differentiate it from castration-resistant prostate cancer-adenocarcinoma.
RUDN University biologist described a green method for obtaining copper oxide nanoparticles from the noni plant (Morinda citrifolia), common in Asia. These nanoparticles have pronounced bactericidal and fungicidal properties.
While scientists have made significant progress in understanding the molecular mechanisms leading to melanoma development, it is still unclear how the PTEN protein regulates melanoma progression. In a new study published in Cancer Research, a journal of the American Association for Cancer Research, Moffitt Cancer Center researchers reveal how the antitumor activity of PTEN suppresses the cancer-promoting activity of the FRA1 transcription factor through the AKT signaling pathway.
The Environmental Molecular Sciences Laboratory, a Department of Energy user facility at Pacific Northwest National Laboratory, is accepting research proposals for four open calls.
For the first time ever in New Mexico, doctors at UNM Comprehensive Cancer Center have treated blood cancer patients by transplanting cells from a donor. Late last year, Matthew Fero, MD, FACP, and the Stem Cell and Bone Marrow Transplant team completed the first procedure, known as an allogeneic stem cell transplant.
The body’s immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by UTHealth Houston.
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency.
Unknown germs are a common occurrence in hospitals. Researchers at the University of Basel have spent many years collecting and analyzing them. They have identified many new species of bacteria, some of which are significant for clinical practice.
Mycelial fibers, the fibrous cells found in fruiting mushroom bodies, have gained momentum as a sustainable material for making leather and packaging owing to their excellent formability.
Thanks to technological advances, scientists have access to vast amounts of data, but in order to put it to work and draw conclusions, they need to be able to process it.
Cell replication in our bodies is triggered by a cascade of molecular signals transmitted between proteins. Compounds that block these signals show potential as cancer drugs. Recently, scientists uncovered the molecular mechanisms that underlie a step in the signal-transmission pathway that requires three proteins to link up. This points the way to new targets for drugs that fight certain types of cancer.
In a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind IKAROS, an essential protein for immune cell development and protection against pathogens and cancer.
Researchers at the University of Liège (ULiège) have identified microstructures in fossil cells that are 1.75 billion years old. These structures, called thylakoid membranes, are the oldest ever discovered.
Disease-causing bacteria of the genus Salmonella or Yersinia can use tiny injection apparatuses to inject harmful proteins into host cells, much to the discomfort of the infected person.
Hydrothermal vents are an unlikely environment for animals to flourish, characterized by rapid changes in temperature and a challenging chemistry: acidic pH, rich in sulfur and methane.
Like mail carriers who manage to deliver their parcels through snow, rain, heat and gloom, a critical group of mammalian proteins helps cells function properly even under less-than-ideal conditions.Using state-of-the-art cell imaging and genome editing technology, University of Wisconsin–Madison scientists have begun to unravel how this collection of proteins performs its essential service.
Researchers at Washington University School of Medicine in St. Louis have determined how Eastern equine encephalitis virus attaches to a receptor it uses to enter and infect cells. The findings laid the groundwork for a receptor decoy molecule that protects mice from encephalitis caused by the virus.
Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell. These subcellular structures carry out specific jobs within the cell, for example, mitochondria power the cell and lysosomes keep the cell tidy.
حدد الباحثون والمتعاونون في مايو كلينك بروتينًا تفرزه الخلايا المناعية والذي قد يقوم بدورٍ رئيسيٍ في ظهور مرضالتصلُّب الجانبي الضموري، المعروف أيضًا باسم مرض لو غيريغ. ووجد الفريق أيضًا أن العلاج التعديلي المناعي الذي يقوم بعملية إِحْصار للبروتين يمكنه استعادة الوظيفة الحركية في النماذج قبل السريرية. وتشير النتائج إلى أن البروتين، المعروف باسم أ5 إنتغرين (الذي يُنطق ألفا 5 إنتغرين)، هو مستهدف علاجي محتمل لعلاج مرض التصلُّب الجانبي الضموري.
Los investigadores y colaboradores de Mayo Clinic han identificado una proteína expresada en células inmunitarias que podría desempeñar un rol clave en el desarrollo de la esclerosis lateral amiotrófica (ELA), también conocida como enfermedad de Lou Gehrig. El equipo también descubrió que un tratamiento inmunomodulatorio que bloquea la proteína era capaz de restaurar la función motriz en modelos preclínicos. Los hallazgos indican que la proteína, conocida como integrina α5 (pronunciado integrina alfa 5), es un posible blanco terapéutico para la ELA.
Pesquisadores e colaboradores da Mayo Clinic identificaram uma proteína que é expressa por células imunológicas que pode desempenhar uma função importante no desenvolvimento daesclerose lateral amiotrófica (ELA), também conhecida como doença de Lou Gehrig. A equipe também descobriu que um tratamento imunomodulador que bloqueia a proteína conseguiu restaurar a função motora em modelos pré-clínicos. As descobertas sugerem que a proteína, conhecida como integrina α5 (pronunciada como integrina alfa 5), é um possível alvo terapêutico para ELA.
Researchers developed an artificial intelligence tool to quickly analyze gene activities in medical images and provide single-cell insight into diseases in tissues and tissue microenvironments.
The Matabele ants (Megaponera analis), which are widespread south of the Sahara, have a narrow diet: They only eat termites. Their hunting expeditions are dangerous because termite soldiers defend their conspecifics – and use their powerful mandibles to do so. It is therefore common for the ants to be injured while hunting.
Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2). Researchers at the Max-Planck-Institute for Terrestrial Microbiology have developed a synthetic biochemical cycle that directly converts CO2 into the central building block Acetyl-CoA.
Could healthy fats found in nuts and fish slow the progression of potentially deadly lung scarring known as pulmonary fibrosis and delay the need for lung transplants?
Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.
Zymo Research, a leading provider of innovative life science technologies, has been honored with the Top Workplaces USA 2023 and Culture Excellence 2023 awards
Food virologists from the National University of Singapore (NUS) have successfully propagated the human norovirus using zebrafish embryos, providing a valuable platform to assess the effectiveness of virus inactivation for the water treatment and food industries.
Patient-specific mutation-engineered mouse reveals how sensory neurons may trigger some allergy conditions but block others, suggesting more precise design of JAK inhibitors is necessary.
With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.
NEMO, a protein that is primarily associated with signaling processes in the immune system, prevents the deposition of protein aggregates that occur in Parkinson’s disease. For this purpose, it binds to certain protein chains that serve as markers for cellular waste removal, thus promoting the degradation of the harmful aggregates.
Researchers from Karlsruhe Institute of Technology (KIT) and partners all over Germany have developed a new system for X-ray imaging, which is suited for both living specimens and sensitive materials.
Cerebral organoids are three-dimensional, in vitro cultured brains that mimic the activities of the human brain. They have emerged as invaluable tools to comprehend evolution, disease pathogenesis, and neurodevelopmental processes. However, the development of these organoids is still in nascent stages with several limitations that hinder their broad applications. A major obstacle is the absence of a functional vasculature that can restrict the size of organoids, trigger cell death, and prevent cell differentiation in the organoids.
When plants are infected by pathogens, suffer from a lack of water or have to react to other external stimuli, the first thing they do is increase the proton and calcium concentration in the affected cells.