Feature Channels: Stem Cells

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Newswise: UC San Diego Health among First in Nation to Perform Regenerative Brain Cell Procedure for Epilepsy
Released: 26-Jul-2023 4:05 PM EDT
UC San Diego Health among First in Nation to Perform Regenerative Brain Cell Procedure for Epilepsy
UC San Diego Health

UC San Diego Health is among the first in the nation to perform an experimental regenerative brain cell therapy for epilepsy aimed at eliminating seizures.

Released: 26-Jul-2023 12:00 PM EDT
Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche
World Journal of Stem Cells

BACKGROUNDScar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound healing. Previous studies have indicated that antler reserve mesenchyme (RM) cells and their conditioned medium improved regenerative w

Released: 26-Jul-2023 12:00 PM EDT
Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDZinc (Zn) is the second most abundant trace element after Fe, present in the human body. It is frequently reported in association with cell growth and proliferation, and its deficiency is considered to be a major disease contribut

Released: 26-Jul-2023 12:00 PM EDT
Generation of a human haploid neural stem cell line for genome-wide genetic screening
World Journal of Stem Cells

BACKGROUNDHaploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific

Released: 26-Jul-2023 12:00 PM EDT
Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing
World Journal of Stem Cells

BACKGROUNDCurrent evidence shows that human induced pluripotent stem cells (hiPSCs) can effectively differentiate into keratinocytes (KCs), but its effect on skin burn healing has not been reported. AIMTo observe the effects of hiPSCs-deri

Released: 26-Jul-2023 12:00 PM EDT
Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity
World Journal of Stem Cells

BACKGROUNDMesenchymal stromal cells (MSCs) are multipotent cell populations obtained from fetal and adult tissues. They share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic, chondrogeni

Released: 26-Jul-2023 12:00 PM EDT
Neural stem cells for Parkinson’s disease management: Challenges, nanobased support, and prospects
World Journal of Stem Cells

Parkinson’s disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neur

Released: 26-Jul-2023 12:00 PM EDT
Human retinal secretome: A cross-link between mesenchymal and retinal cells
World Journal of Stem Cells

In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectivel

Released: 26-Jul-2023 12:00 PM EDT
Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury?
World Journal of Stem Cells

Acute pancreatitis (AP) often leads to a high incidence of cardiac injury, posing significant challenges in the treatment of severe AP and contributing to increased mortality rates. Mesenchymal stem cells (MSCs) release bioactive molecules

Released: 24-Jul-2023 4:05 PM EDT
Researchers Identify the Cellular Mechanisms by Which Lactate Helps our Brains Develop
Tohoku University

Scientists at Tohoku University have discovered the critical role that lactate plays in helping neural stem cells develop into specialized neurons, a process dubbed neuronal differentiation.

Released: 21-Jul-2023 11:55 AM EDT
Oldest known molecule surprises researchers. It could lead to new important treatments
University of Copenhagen, Faculty of Health and Medical Sciences

The human body consists of numerous trillions of cells, and 60 percent of the energy used within a cell is dedicated to a specific molecular machine. That machine is responsible for producing proteins, which are fundamental building blocks of the body.

   
Newswise: UT Southwestern stem cell biologists develop embryo model
Released: 20-Jul-2023 2:30 PM EDT
UT Southwestern stem cell biologists develop embryo model
UT Southwestern Medical Center

UT Southwestern Medical Center biologists have developed a new stem cell-based embryo model for studying early human development, tissue formation, and differentiation, offering valuable contributions to the field of developmental biology and regenerative medicine.

Newswise: Powerhouse proteins protect heart cells from chemotherapy damage 
Released: 20-Jul-2023 2:05 PM EDT
Powerhouse proteins protect heart cells from chemotherapy damage 
University of Illinois Chicago

Researchers at the University of Illinois Chicago have identified a process by which enzymes can help prevent heart damage in chemotherapy patients

   
Released: 18-Jul-2023 12:00 PM EDT
Life on Earth didn’t arise as described in textbooks
University of Copenhagen, Faculty of Science

No, oxygen didn’t catalyze the swift blossoming of Earth’s first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago.

Released: 18-Jul-2023 11:45 AM EDT
A key function for tight junctions in embryo models
Gladstone Institutes

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide a single layer of embryonic stem cells to form three layers of distinct cell types that will later become different parts of the body.

   
Released: 13-Jul-2023 7:00 AM EDT
Artificially grown ‘mini-brains’ without animal components bring opportunities for neuroscience
Michigan Medicine - University of Michigan

Researchers at University of Michigan developed a method to produce artificially grown miniature brains — called human brain organoids — free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated. The work offers a solution to overcome Matrigel’s weaknesses.

Released: 10-Jul-2023 4:05 PM EDT
Hematopoietic stem cell culture technology for more effective and safer genome editing
University of Tsukuba

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

Newswise: New Insight into How Plant Cells Divide
6-Jul-2023 1:00 PM EDT
New Insight into How Plant Cells Divide
University of California San Diego

Plant and animal stem cells both rely on the cytoskeleton to divide properly, but a new study finds that they use them in opposite ways—while animal cells pull on the cytoskeleton, plant cells push it away. Harnessing that action could help scientists engineer more resilient plants.

Newswise: CRI’s Sean Morrison elected to European Molecular Biology Organization
Released: 5-Jul-2023 12:45 PM EDT
CRI’s Sean Morrison elected to European Molecular Biology Organization
UT Southwestern Medical Center

Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).

Newswise: Sylvester Research: Remnants of ancient retrovirus may drive aggressiveness and resilience of malignant brain cancers
26-Jun-2023 8:05 PM EDT
Sylvester Research: Remnants of ancient retrovirus may drive aggressiveness and resilience of malignant brain cancers
Sylvester Comprehensive Cancer Center

A new, EMBARGOED study suggests that reactivation of an ancient retrovirus from 6 million years ago may be at least partly to blame for the aggressiveness and treatment resistance of some glioblastomas.

Newswise: Base editing shows potential superiority for curing sickle cell disease
Released: 3-Jul-2023 11:00 AM EDT
Base editing shows potential superiority for curing sickle cell disease
St. Jude Children's Research Hospital

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.

Newswise: June Research Highlights
Released: 30-Jun-2023 2:45 PM EDT
June Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for June 2023.

Released: 27-Jun-2023 5:40 PM EDT
New model provides unprecedented window into human embryonic development
Yale University

Two to three weeks after conception, an embryo faces a critical point in its development. In the stage known as gastrulation, the transformation of embryonic cells into specialized cells begins.

Newswise: Human embryo-like models created from stem cells to understand earliest stages of human development
Released: 27-Jun-2023 11:50 AM EDT
Human embryo-like models created from stem cells to understand earliest stages of human development
University of Cambridge

Cambridge scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why and how pregnancies fail.

Released: 26-Jun-2023 12:00 PM EDT
Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis
World Journal of Stem Cells

Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive cartilage degeneration and bone destruction of subchondral bone. At present, clinical treatment is mainly for pain relief, and there are no effective

Released: 26-Jun-2023 12:00 PM EDT
Culture and identification of neonatal rat brain-derived neural stem cells
World Journal of Stem Cells

BACKGROUNDTiming of passaging, passage number, passaging approaches and methods for cell identification are critical factors influencing the quality of neural stem cells (NSCs) culture. How to effectively culture and identify NSCs is a cont

Released: 26-Jun-2023 12:00 PM EDT
Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis
World Journal of Stem Cells

BACKGROUNDBone marrow-derived mesenchymal stem cells (MSCs) show podocyte-protective effects in chronic kidney disease. Calycosin (CA), a phytoestrogen, is isolated from Astragalus membranaceus with a kidney-tonifying effect. CA preconditio

Released: 26-Jun-2023 12:00 PM EDT
Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment
World Journal of Stem Cells

The high incidence and disability rates of stroke pose a heavy burden on society. Inflammation is a significant pathological reaction that occurs after an ischemic stroke. Currently, therapeutic methods, except for intravenous thrombolysis

Released: 26-Jun-2023 12:00 PM EDT
Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip
World Journal of Stem Cells

BACKGROUNDInduced pluripotent stem cells (iPSCs) show great ability to differentiate into any tissue, making them attractive candidates for pathophysiological investigations. The rise of organ-on-a-chip technology in the past century has in

Released: 26-Jun-2023 12:00 PM EDT
Clinical relevance of stem cells in lung cancer
World Journal of Stem Cells

Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung ca

Released: 26-Jun-2023 12:00 PM EDT
Advances of nanotechnology applied to cancer stem cells
World Journal of Stem Cells

Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, prolif

Released: 26-Jun-2023 12:00 PM EDT
Adipokines regulate mesenchymal stem cell osteogenic differentiation
World Journal of Stem Cells

Mesenchymal stem cells (MSCs) can differentiate into various tissue cell types including bone, adipose, cartilage, and muscle. Among those, osteogenic differentiation of MSCs has been widely explored in many bone tissue engineering studies.

Released: 26-Jun-2023 12:00 PM EDT
Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions of Cd271 in tooth development
World Journal of Stem Cells

BACKGROUNDAccumulating evidence suggests that the maxillary process, to which cranial crest cells migrate, is essential to tooth development. Emerging studies indicate that Cd271 plays an essential role in odontogenesis. However, the underl

Released: 26-Jun-2023 12:00 PM EDT
Neural lineage differentiation of human pluripotent stem cells: Advances in disease modeling
World Journal of Stem Cells

Brain diseases affect 1 in 6 people worldwide. These diseases range from acute neurological conditions such as stroke to chronic neurodegenerative disorders such as Alzheimer’s disease. Recent advancements in tissue-engineered brain disea

Newswise: Studying herpes encephalitis with mini-brains
Released: 22-Jun-2023 4:05 PM EDT
Studying herpes encephalitis with mini-brains
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in Nature Microbiology.

Newswise: Stem cell model of human brain development suggests embryonic origins of Alzheimer’s disease
Released: 22-Jun-2023 4:05 PM EDT
Stem cell model of human brain development suggests embryonic origins of Alzheimer’s disease
International Society for Stem Cell Research

Alzheimer's disease (AD) mainly affects the older population. Recent research found early disease signs in cell culture models of early human brain development, raising the possibility that the disease has its origins much earlier in life, possibly during embryogenesis – the formation and development of an embryo.

Newswise: Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Released: 22-Jun-2023 1:15 PM EDT
Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Johns Hopkins Medicine

Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study published in the New England Journal of Medicine. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard.

Released: 21-Jun-2023 4:25 PM EDT
Scientists discover mechanism affecting heart development in Down syndrome
University of Colorado Anschutz Medical Campus

Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects.

Newswise: Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
Released: 15-Jun-2023 5:10 PM EDT
Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
City of Hope

Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.

Released: 13-Jun-2023 7:40 PM EDT
Lung and heart stem cell research paves way for new COVID-19 treatments
Murdoch Childrens Research Institute

Researchers have used heart and lung stem cells infected with the virus that causes COVID-19 to better understand how the disease impacts different organs, paving the way for more targeted treatments.

Newswise: ISSCR 2023: Cedars-Sinai Scientists Who Sent Stem Cells Into Space Available for Interviews
Released: 12-Jun-2023 10:50 AM EDT
ISSCR 2023: Cedars-Sinai Scientists Who Sent Stem Cells Into Space Available for Interviews
Cedars-Sinai

Cedars-Sinai investigators studying the effects of space on stem cells will present their work at the International Society for Stem Cell Research (ISSCR) Annual Meeting June 14-17 in Boston, and are available for interviews throughout the conference.

7-Jun-2023 2:00 PM EDT
Novel Gene Therapy Shows Positive Initial Results in Sickle Cell Patients Treated in Clinical Trial at Cleveland Clinic Children’s
Cleveland Clinic

Researchers presenting preliminary data from a clinical trial aimed at discovering a cure for sickle cell disease reveal positive results among its first patients. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.

Released: 8-Jun-2023 9:30 AM EDT
Discovering Cell Identity: $6 Million NIH Grant Funds New Penn Medicine Research to Uncover Cardiac Cell Development
Perelman School of Medicine at the University of Pennsylvania

Historically, scientists have studied how cells develop and give rise to specialized cells, such as heart, liver, or skin cells, by examining specific proteins.

Newswise: Combining bioprinting techniques to pursue functional blood vessels
Released: 7-Jun-2023 1:05 PM EDT
Combining bioprinting techniques to pursue functional blood vessels
University Medical Center Utrecht

In this project volumetric bioprinting was for the first time successfully combined with melt electrowriting.

Released: 31-May-2023 2:55 PM EDT
Optimizing the Immune System to Beat Cancer
University of Kansas Cancer Center

Chimeric antigen receptor (CAR) T-cell therapy amplifies the immune system’s ability to recognize and kill cancer cells. The first CAR T-cell therapy was approved by the Food and Drug Administration (FDA) in 2017. Today, there are 6 FDA-approved CAR-based therapies to treat certain types of leukemia, lymphoma and myeloma, all of which are available at The University of Kansas Cancer Center.

Released: 26-May-2023 12:00 PM EDT
Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use
World Journal of Stem Cells

Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and have therefore been extensively investigated in preclinical studies of regenerative medicine. However, while MSCs have been shown to be safe as a cellul

Released: 26-May-2023 12:00 PM EDT
Advancements in adipose-derived stem cell therapy for skin fibrosis
World Journal of Stem Cells

Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation and ECM hyperplasia lead

Released: 26-May-2023 12:00 PM EDT
Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells
World Journal of Stem Cells

Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. It is usually considered that the differentiation process of MSCs depends on specialized



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