Feature Channels: Biotech

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Released: 9-Jun-2022 12:00 PM EDT
Hyaluronic acid biosynthesis promotes an invasive, stem-like cancer cell phenotype by broadly altering metabolism
Preprints

Adrian Adwait Shimpi, Matthew Lee Tan, Michael Vilkhovoy, David Dai, Ladeidra Monet Roberts, Joe Chin-Hun Kuo, Lingting Huang, Jeffrey Varner, Matthew J Paszek, Claudia Fischbach

Released: 9-Jun-2022 12:00 PM EDT
The Korean Undiagnosed Diseases Program Phase I: Expansion of the Nationwide Network and the Development of Long-term Infrastructures
Preprints

Soo Yeon Kim, Seungbok Lee, Hyewon Woo, Young Jun Ko, Youngkyu Shim, Soojin Park, Se Song Jang, Byung Chan Lim, Jung Min Ko, Ki Joong Kim, Anna Cho, Hunmin Kim, Hee Hwang, Ji Eun Choi, Man Jin Kim, Jangsup Moon, Moon-Woo Seong, Sung Sup Park, Sun Ah Choi, Ji Eun Lee, Young Se Kwon, Young Bae Sohn, Jon Soo Kim, Won Seop Kim, Yun Jeong Lee, Soonhak Kwon, Young Ok Kim, Hoon Kook, Yong Gon Cho, Chong Kun Cheon, Ki-Soo Kang, Mi-Ryoung Song, Hyuk-Jin Cha, Hee-Jung Choi, Yun Kee, Seung Tae Baek, Murim Choi, Jong-Hee Chae, Dong-Sung Ryu

Released: 9-Jun-2022 12:00 PM EDT
Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimer's Disease
Preprints

Yubing Liu, Bensun Cambell Fong, Richard A Harris, Marie-Michelle McNicoll, Amaal A Abdi, Jacob B Cuthbert, David P Cook, Daniel Figeys, Jing Wang, Barbara C Vanderhyden, Ruth S Slack

Newswise: First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting
Released: 9-Jun-2022 11:35 AM EDT
First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting
Cedars-Sinai

Investigators from Cedars-Sinai will present the latest novel stem cell and regenerative medicine research at the International Society for Stem Cell Research (ISSCR) Annual Meeting, which is being held in person and virtually June 15-19 in San Francisco.

Newswise: Robot skin heals
Released: 9-Jun-2022 11:30 AM EDT
Robot skin heals
University of Tokyo

A robotic finger with living skin tissue points to future manufacturing methods.

Released: 8-Jun-2022 2:05 AM EDT
Double Agents: How Stomach Stem Cells Change Allegiance Upon Injury
Institute of Molecular Biotechnology

The interest of scientists in adult stem cells resides in their ability to self-renew indefinitely and differentiate into all cell types making up the organ where they reside.

Released: 7-Jun-2022 1:05 PM EDT
Melanoma Researcher Covers All the Bases
University of California, Irvine

Dr. Anand Ganesan probably won’t be hanging from a ceiling `a la Tom Cruise in Mission Impossible, but the UCI Health dermatologist and School of Medicine professor of dermatology and biological sciences does compare part of what he does to a plot device in the 1996 action thriller. “You know where the guy opens the switch box, there are all these wires coming down, and he’s trying to figure out which wire to cut to stop something bad from happening? That’s kind of what we’re trying to do: Cut the right wire to short- circuit cancer,” says the co-director of the Biotechnology, Imaging & Drug Discovery program at the Chao Family Comprehensive Cancer Center.

Released: 7-Jun-2022 12:00 PM EDT
Effect of Electrical Stimulation on Spinal Cord Injury: In Vitro and In Vivo Analysis
Preprints

Woo-Seok Bang, Inbo Han, Seul-Ah Mun, Dae-Chul Cho, Sang-Woo Lee, Byoung-Joon Kim, Chi Heon Kim, Hyuk Choi, Kyoung-Tae Kim

Released: 6-Jun-2022 12:00 PM EDT
Expression of stem cell biomarkers Bmi1 and KLF4 in osteosarcoma and its clinical significance
Preprints

Shiwei Chen, Taiyong Wu, Simin Ning, Zhuangzhuang Wu, Wenxuan Jin, Pengcui Li

Released: 6-Jun-2022 12:00 PM EDT
Continuous Indexing of Fibrosis (CIF): Improving the Assessment and Classification of MPN Patients
Preprints

Hosuk Ryou, Korsuk Sirinukunwattana, Alan Aberdeen, Gillian Grindstaff, Bernadett Stolz, Helen Byrne, Heather A. Harrington, Nikolaos Sousos, Anna L. Godfrey, Claire N. Harrison, Bethan Psaila, Adam J. Mead, Gabrielle Rees, Gareth D.H. Turner, Jens Rittscher, Daniel Royston

Released: 6-Jun-2022 12:00 PM EDT
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway
Preprints

Guoqing Wang, Xiangpeng Shen, Xiangkong Song, Ningfen Wang, Xuewen Wo, Yonglei Gao

Newswise: Fixing Spinal Cord Injuries With ‘Dancing Molecules’
Released: 6-Jun-2022 8:05 AM EDT
Fixing Spinal Cord Injuries With ‘Dancing Molecules’
Department of Energy, Office of Science

Researchers have created an injectable therapy for spinal cord injuries that uses specially engineered molecules that trigger a healing response in spinal cells. These molecules come together to form tiny fibers in a liquid solution. Scientists can control the motion of these fibers, allowing the fibers to connect more effectively with cells in the spine. The research may lead to a cure for spinal injuries in humans.

   
Released: 5-Jun-2022 12:00 PM EDT
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Preprints

Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun, Antje K Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Weslowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders Larsson, Patrick E MacDonald, Benjamin Davies, Marcel Den Hoed, Anna L Gloyn

Released: 5-Jun-2022 12:00 PM EDT
PRC2 clock: a universal biomarker of aging and rejuvenation
Preprints

Mahdi Moqri, Andrea Cipriano, Daniel Nachun, Tara Murty, Guilherme De Sena Brandine, Sajede Rasouli, Andrei Tarkhov, Karolina A Aberg, Edwin Jcg Van Den Oord, Wanding Zhou, Andrew D Smith, Crystal Mackall, Vadim N Gladyshev, Steve Horvath, Michael Snyder, Vittorio Sebastiano

Released: 5-Jun-2022 12:00 PM EDT
Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging
Preprints

Yue Wu, Bibo Zhu, Ruixuan Zhang, Nick P. Goplen, Xiaochen Gao, Harish Narasimhan, Ao Shi, Yin Chen, Ying Li, Haidong Dong, Thomas J. Braciale, Jie Sun

Released: 4-Jun-2022 12:00 PM EDT
Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss
Preprints

Jacqueline A Larouche, Emily C Wallace, Bonnie D Spence, Scott A Johnson, Mangesh Kulkarni, Eric Buras, Bryan N Brown, Stephen F Badylak, Carlos Andres Aguilar

Newswise: Bone, Heal Thyself: Toward Ceramics Tailored for Optimized Bone Self-Repair
Released: 3-Jun-2022 4:50 PM EDT
Bone, Heal Thyself: Toward Ceramics Tailored for Optimized Bone Self-Repair
Tokyo Medical and Dental University

Your chance of breaking a bone sometime within the next year is nearly 4%. If you're unlucky enough to need a bone replacement, it'll probably be based on a metal part. Unfortunately, metal parts are sometimes toxic over time, and will not help your original bone regrow.

   
Newswise: Novel Method for Early Disease Detection Using DNA Droplets
Released: 3-Jun-2022 3:05 PM EDT
Novel Method for Early Disease Detection Using DNA Droplets
Tokyo Institute of Technology

Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research.

Newswise: Recharging Cartilage After Knee Damage
Released: 3-Jun-2022 1:05 PM EDT
Recharging Cartilage After Knee Damage
National Institute of Biomedical Imaging and Bioengineering

Osteoarthritis – a painful condition that results from the deterioration of the cartilage in our joints – affects millions of people worldwide. To combat this issue, NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition.

   
Released: 3-Jun-2022 12:00 PM EDT
A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry
Preprints

Austin B. Keeler, Amy L. Van Deusen, Irene Cheng, Corey M. Williams, Sarah M. Goggin, Ashley K. Hirt, Shayla A. Vradenburgh, Kristen I. Fread, Emily A. Puleo, Lucy Jin, O. Yipkin Calhan, Christopher D Deppmann, Eli R. Zunder

Released: 3-Jun-2022 12:00 PM EDT
Human hematopoietic stem cell vulnerability to ferroptosis
Preprints

Jiawei Zhao, Yuemeng Jia, Dilnar Mahmut, Amy Anderson Deik, Sarah Jeanfavre, Clary B. Clish, Vijay G. Sankaran

Released: 3-Jun-2022 12:00 PM EDT
Reconstituting human somitogenesis in vitro
Preprints

Yoshihiro Yamanaka, Kumiko Yoshioka-Kobayashi, Sofiane Hamidi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura, Cantas Alev

Released: 3-Jun-2022 12:00 PM EDT
Anatomical distribution of Cancer Stem Cells between Enhancing Nodule and FLAIR hyperintensity in supratentorial Glioblastoma: time to recalibrate the surgical target?
Preprints

Roberto Altieri, Giuseppe Broggi, Francesco Certo, Daniela Pacella, Giacomo Cammarata, Massimiliano Maione, Marco Garozzo, Davide Barbagallo, Michele Purrello, Rosario Caltabiano, Gaetano Magro, Giuseppe Barbagallo

Released: 3-Jun-2022 12:00 PM EDT
A genome-wide screen reveals new regulators of the 2-cell-like cell state
Preprints

Pierre-Antoine Defossez, Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Fumihito Miura, Laure Ferry, Olivier Kirsh, Anaelle Azogui, Kohsuke Yamaguchi, Marthe Laisné, Cécilia Domrane, Frédéric Bonhomme, Arpita Sarkar, Marine Delagrange, Bertrand Ducos, Gael Cristofari, Takashi Ito, Maxim Greenberg

Released: 3-Jun-2022 12:00 PM EDT
Expression Of CD44+/CD24-, RAD6 and DDB2 On Chemotherapy Response In Ovarian Cancer: A Prospective Flow Cytometry Study
Preprints

Unedo Hence Markus Sihombing, Andrijono Andrijono, Gatot Purwoto, Supriadi Gandamihardja, Alida R. Harahap, Primariadewi Rustamadji, Aria Kekalih, Retno Widyawati, Dzicky Rifqi Fuady

Released: 3-Jun-2022 12:00 PM EDT
Regulation of human trophoblast gene expression by endogenous retroviruses
Preprints

Miguel Branco, Jennifer Frost, Samuele Amante, Hiroaki Okae, Eleri Jones, Brogan Ashley, Rohan Lewis, Jane Cleal, Takahiro Arima, Tania Maffucci, Matthew Caley

Released: 3-Jun-2022 12:00 PM EDT
Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons
Preprints

Emiliano Hergenreder, Yana Zorina, Zeping Zhao, Hermany Munguba, Elizabeth L Calder, Arianna Baggiolini, Andrew P Minotti, Ryan M Walsh, Conor Liston, Joshua Levitz, Ralph Garippa, Shuibing Chen, Gabriele Ciceri, Lorenz Studer

Released: 3-Jun-2022 12:00 PM EDT
Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
Preprints

Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai, Haruhiko Akiyama

Released: 3-Jun-2022 12:00 PM EDT
An epigenetic barrier sets the timing of human neuronal maturation
Preprints

Gabriele Ciceri, Hyunwoo Cho, Meghana Kshirsagar, Arianna Baggiolini, Kelly A Aromolaran, Ryan M Walsh, Peter A Goldstein, Richard P Koche, Christina S Leslie, Lorenz Studer

Released: 2-Jun-2022 12:00 PM EDT
Improved conditionally replicative adenovirus delivery system against hepatocellular carcinoma by armed with bispecific T-cell engager
Preprints

Xiangfei Yuan, Yang Lu, Yuanyuan Yang, Wencong Tian, Dongmei Fan, Ruoqi Liu, Xiaomin Lei, Yafei Xia, Lei Yang, Shu Yan, Dongsheng Xiong

Released: 2-Jun-2022 12:00 PM EDT
Rapid and Live-cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry
Preprints

Smitha Surendran Thamarath, Ching Ann Tee, Shu Hui Neo, Dahou Yang, Rashida Binte Othman, Laurie Boyer, Jongyoon Han

Released: 2-Jun-2022 12:00 PM EDT
Cultivated autologous limbal epithelial cells (CALEC): product development, manufacture, and initial evaluation of feasibility
Preprints

Ula Jurkunas, Jia Yin, Lynette Johns, Sanming Li, Helene Negre, Kit Shaw, Lassana Samarakoon, Allison Ayala, Ahmad Kheirkhah, Kishore Katikireddy, Alex Gauthier, Stephan Ong Tone, Stacey Ellender, Diego Hernandez Rodriguez, Heather Daley, Reza Dana, Jerome Ritz, Myriam Armant

Released: 2-Jun-2022 12:00 PM EDT
Genetic polymorphisms of rs12437118 in ESRRB locus associated with tuberculosis susceptibility in a Chinese Han population
Preprints

Wei Wang, Lingjuan Zhao, Yong Sun, Weicong Ren, Xuxia Zhang, Chuanyou Li, Mengqiu Gao

Released: 2-Jun-2022 12:00 PM EDT
Maternal Dendritic Cells Influence Fetal Allograft Response following Murine In-Utero Hematopoietic Stem Cell Transplantation
Preprints

Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Yeo Su Li, Li Zhihui, Koh Jiayu, Florent Ginhoux, Jerry Ky Chan, Mahesh A Choolani, Citra Nz Mattar

Newswise: A World First: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
Released: 1-Jun-2022 1:05 AM EDT
A World First: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
University of Zurich

The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.

Newswise: New Artificial Enzyme Breaks Down Tough, Woody Lignin
26-May-2022 1:20 PM EDT
New Artificial Enzyme Breaks Down Tough, Woody Lignin
Pacific Northwest National Laboratory

An innovative artificial enzyme has shown it can chew through woody lignin, an abundant carbon-based substance that stores tremendous potential for renewable energy and materials.

Released: 27-May-2022 12:00 AM EDT
Spinal Fusion Properties of Mechanically-Reinforced, Osteomodulatory Chitosan Hydrogels
Preprints

Blake T Darkow, Joseph P Herbert, Mark J Messler, Abigail Grisolano, August J Hemmerla, Austin D Kimes, Julien Lanza, Yisheng Sun, Julia R Crim, Derek Stensby, Caixia Wan, Don K Moore, Bret D Ulery

Released: 27-May-2022 12:00 AM EDT
A network of CLAVATA receptors buffers auxin-dependent meristem maintenance
Preprints

Amala John, Elizabeth Sarkel Smith, Daniel S Jones, Cara Soyars, Zachary L. Nimchuk

Released: 27-May-2022 12:00 AM EDT
Amsacrine combined with etoposide and methylprednisolone is a feasible and safe component in first-line intensified treatment of pediatric patients with high-risk acute lymphoblastic leukemia in CoALL-08-09 trial
Preprints

Gabi Escherich, Kerstin Mezger, Sabine Ebert, Hannah Muhle, Udo Zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Martin Zimmermann, Martin Horstmann

Released: 27-May-2022 12:00 AM EDT
Basal Forebrain Cholinergic Circuits Orchestrate Diverse Cell Types in the Adult Dentate Gyrus to Support Neural Stem Cell Function and Spatial Memory
Preprints

Luis Quintanilla, Juan Song, Jeremy Simon, Ya-Dong Li, Brent Asrican, Seth Tart, Yan-Jia Luo, Yijing Su, Hongjun Song, Ryan N. Sheehy, Guo-Li Ming

Released: 27-May-2022 12:00 AM EDT
CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage.
Preprints

Dongshu Liu, Suhe Dong, Cong Liu, Jicong Du, SiNian Wang, Huijie Yu, Wei Li, Zhongmin Chen, Renjun Peng, Qisheng Jiang, Mengying Zou, Fengsheng Li, Rong Zhang

Released: 27-May-2022 12:00 AM EDT
Stability and Biosafety of human epidermal stem cell for wound repair: Preclinical evaluation
Preprints

Xiaohong Zhao, Xue Li, Ying Wang, Yicheng Guo, Yong Huang, Dalun Lv, Mingxing Lei, Shicang Yu, Gaoxing Luo, Rixing Zhan



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