Feature Channels: Biotech

Filters close
Released: 4-May-2022 6:05 AM EDT
Massive periorbital edema following hematopoietic stem cell transplantation
American Journal of Ophthalmology Case Reports

… related to complications of hematopoietic stem cell transplantation. This highlights a non-… The most frequent ocular complication of autologous hematopoietic stem cell transplantation is … periorbital edema in a patient after hematopoietic stem cell …

Released: 4-May-2022 6:05 AM EDT
Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application
Journal of Personalized Medicine

… This article provides a review of the most frequently used CSCs and stem cell markers. … of stem cells, because they play a role in stem cell pluripotency and their interactions with various co-… Indeed, the functional role of stem cell factors in …

Released: 4-May-2022 6:05 AM EDT
Differentiation and Engineering of Human Stem Cells for Smooth Muscle Generation
Mary Ann Liebert Inc. Publishers

… the multitude of stem cell types (adipose derived, bone marrow derived, embryonic and induced pluripotent) and techniques employed to induce stem cell proliferation and differentiation … Here, we curate several studies on stem cell …

Released: 4-May-2022 6:05 AM EDT
Using stem cell models to explore the genetics underlying psychiatric disorders: linking risk variants, genes, and biology in brain disease
The American Journal of Psychiatry

… Instead, using stem cell models, it is possible to recapitulate neurodevelopment in vitro, essentially observing risk in a laboratory dish. We … The first human embryonic stem cell lines were grown in 1998, with the theoretical capability to …

Released: 4-May-2022 6:05 AM EDT
PO-660-03 Optical Control of Arrhythmia Morphology in Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Cell Sheets
Heart Rhythm

PO-660-03 OPTICAL CONTROL OF ARRHYTHMIA MORPHOLOGY IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED … To develop a method for the induction of morphologically and physiologically defined arrhythmias in human …

Released: 3-May-2022 12:00 PM EDT
Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation
Preprints

Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang

Released: 3-May-2022 12:00 PM EDT
The establishment of human embryonic stem cell lines demonstrated that chimeric embryos can self-correct
Preprints

Chuyu Li, Jiazi Xie, Juan Dong, Chao Gao, Meng Xia, Yuting Lin, Yugui Cui, Lianju Qin, Wei Wu

Released: 3-May-2022 12:00 PM EDT
Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport
Preprints

Yajuan Shi, Hyosung Kim, Catherine A Hamann, Elizabeth M Rhea, Jonathan M Brunger, Ethan S Lippmann

Newswise: Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids
Released: 2-May-2022 12:45 PM EDT
Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids
UC San Diego Health

UC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.

Released: 2-May-2022 12:00 PM EDT
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
Preprints

Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible for emergence of chemoresistant tumors.

Released: 2-May-2022 12:00 PM EDT
Hypoxia-induced reprogramming of glucose-dependent metabolic pathways maintains the stemness of human bone marrow-derived endothelial progenitor cells
Preprints

Dongni Lin, Kaihao Yan, Lingyun Chen, Junxiong Chen, Jianing Xu, Zhijing Xie, Zhujun Li, Shuo Lin, Jinghuan Li, Zhenzhou Chen

Newswise: Researchers Develop Smartphone-Powered Microchip for at-Home Medical Diagnostic Testing
Released: 2-May-2022 9:00 AM EDT
Researchers Develop Smartphone-Powered Microchip for at-Home Medical Diagnostic Testing
University of Minnesota College of Science and Engineering

A University of Minnesota Twin Cities research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.

Released: 2-May-2022 8:00 AM EDT
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient
Trends in Immunology

Much has been learned about the genes and pathways that contribute to a diverse array of hematopoietic malignancies and other hematopoietic diseases. However, for many of these diseases, an allogeneic hematopoietic stem cell (HSC) transplant …

Released: 2-May-2022 8:00 AM EDT
ILC1s control leukemia stem cell fate and limit development of AML
Nature Immunology

… Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus …

Released: 2-May-2022 8:00 AM EDT
Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway
Oncogenesis

… In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/… , which promotes stem cell-like characteristics [20, 21]. Thus, we aimed to determine …

Released: 2-May-2022 8:00 AM EDT
Function of epithelial stem cell in the repair of alveolar injury
Stem Cell Research & Therapy

… For example, in the repair phase after bacteria (Pseudomonas aeruginosa)-induced lung injury, 30–70% of the AT2s acquire the expression of a stem cell surface marker Sca-1 (stem cell antigen 1, or Ly6a) [15, 16]. The Sca-1 + AT2s are likely to …

Released: 2-May-2022 8:00 AM EDT
Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease
Stem Cell Reports

Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient …

Released: 2-May-2022 8:00 AM EDT
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
Nature Communications

… ASCL1 is required to establish the neuronal and stem cell-like lineage … To determine whether ASCL1 is required for the development of neuronal and stem cell-like phenotype… neuronal and stem cell differentiation and functions to bias the cell fate …

Released: 2-May-2022 8:00 AM EDT
Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation
Cancer and Metastasis Reviews

… of the gut microbiota correlate with superior outcomes after hematopoietic stem cell transplantation. Correlative data support the impact of … discuss data describing the key role of microbiota in hematopoietic stem cell transplantation for …

Released: 2-May-2022 8:00 AM EDT
ATR activity controls stem cell quiescence via the cyclin F–SCF complex
Proceedings of the National Academy of Sciences (PNAS)

… Stem cell quiescence is regulated by multiple factors including p53, Rb, cyclin-dependent kinase inhibitors, such as p21 and p27, and Notch signaling (5–10). How these pathways may integrate to maintain stem cell … Dysregulation or loss of quiescence …

Released: 2-May-2022 8:00 AM EDT
Biomaterials to enhance stem cell transplantation
Cell Stem Cell

… In this review, biomaterial-based advances to improve the physiological outcome of stem cell transplantation are described. The review does not aim to provide a comprehensive list of all biofunctional materials described in the literature but …

Released: 2-May-2022 8:00 AM EDT
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
Nature Biomedical Engineering

… Human induced pluripotent stem cell (hiPSC) technology can be used for disease … Culturing hiPSC-CM or human embryonic stem cell-derived cardiomyocytes (hESC-CM) within … sufficient to induce full maturation of pluripotent stem cell-derived …

Released: 29-Apr-2022 5:00 AM EDT
Adipose Mesenchymal Stem Cell-Derived Exosomes Promote Wound Healing Through the WNT/β-catenin Signaling Pathway in Dermal Fibroblasts
Stem Cell Reviews and Reports

… , movement, and morphology of cells, and it is also involved in mediating stem cell pluripotency [20]. β‐Catenin, a subunit of the cadherin … that whether ADMSC-Exos can also promote skin stem cell differentiation through the WNT signaling pathway …

Released: 29-Apr-2022 5:00 AM EDT
In vitro culture of hematopoietic stem cell niche using angiopoietin-1-coupled alginate hydrogel
International Journal of Biological Macromolecules

… stem cell niche. Here, we hypothesized that regulation of cell-cell interactions using a polymeric scaffold as synthetic extracellular matrix (ECM) could be critical in creating a hematopoietic stem cell … and cell-instructive characteristics for stem cell …

Released: 29-Apr-2022 5:00 AM EDT
Low-dose unfractionated heparin prophylaxis is a safe strategy for the prevention of hepatic sinusoidal obstruction syndrome after myeloablative adult allogenic stem cell transplant
Bone Marrow Transplantation

Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication after allogeneic stem cell transplantation (allo-HCT). However, there is no uniform consensus on the optimal strategy for SOS prevention. Ursodeoxycholic acid is the …

Released: 29-Apr-2022 5:00 AM EDT
Optimization of a PDMS-Based Cell Culture Substrate for High-Density Human-Induced Pluripotent Stem Cell Adhesion and Long-Term Differentiation into Cardiomyocytes under a Xeno-Free Condition
ACS Biomaterials Science & Engineering

… In this study, we found that the PDMS substrate coated with a combination of polydopamine (PDA) and laminin-511 E8 fragments (PDA + LME8-coated PDMS) can support human-induced pluripotent stem cell (hiPSC) attachment and growth for …

Released: 29-Apr-2022 5:00 AM EDT
Intrinsic role of chaperone-mediated autophagy in cancer stem cell maintenance
Autophagy

… Its impact in any cancer stem cell (CSC) subtype remained elusive. In a recent study, we characterized the expression of LAMP2A and CMA activity in glioblastoma revealing its enrichment in a glioma stem cell (GSC) subpopulation. LAMP2A …

Released: 29-Apr-2022 5:00 AM EDT
4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1
Toxicology in Vitro

Benzophenones are widely used in industry and commonly added in many personal care products. However, the neurotoxicity, in particular neurodevelopmental toxicity, of benzophenone family chemicals and metabolites has not been fully elucidated …

Released: 29-Apr-2022 5:00 AM EDT
Human Umbilical Cord Mesenchymal Stem Cell–Based in vitro Model for Neurotoxicity Testing
Current Protocols

… Human neuronal models range from various neuroblastoma cell lines to stem cell–derived systems, including those derived from mesenchymal stem/stromal cells (hMSC). hMSCs exhibit numerous advantages, including the fact that they can be obtained in …

Released: 29-Apr-2022 5:00 AM EDT
Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment
Cell Proliferation

… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …

Newswise: High-Frequency Spinal Cord Stimulation Shows Improved Longer Lasting Pain Relief
Released: 28-Apr-2022 1:35 PM EDT
High-Frequency Spinal Cord Stimulation Shows Improved Longer Lasting Pain Relief
UC San Diego Health

Researchers at UC San Diego School of Medicine report that high-frequency spinal cord stimulation proved more effective at improving perceived pain reduction than low-frequency SCS in patients studied, and that there was some variation in PPR between male and female patients.

Released: 28-Apr-2022 12:00 PM EDT
Multi-Level Analysis of Adipose Tissue Reveals the Relevance of Perivascular Subpopulations and an Increased Endothelial Permeability in Early-Stage Lipedema
Preprints

Karin Strohmeier, Martina Hofmann, Jaroslaw Jacak, Marie-Sophie Narzt, Marlene Wahlmueller, Mario Mairhofer, Barbara Schaedl, Wolfgang Holnthoner, Martin Barsch, Matthias Sandhofer, Susanne Wolbank, Eleni Priglinger

Released: 28-Apr-2022 12:00 PM EDT
A human embryonic limb cell atlas resolved in space and time
Preprints

Bao Zhang, Peng He, John E Lawrence, Shuaiyu Wang, Elizabeth Tuck, Brian A Williams, Kenny Roberts, Vitalii Kleshchevnikov, Lira Mamanova, Liam Bolt, Krzysztof Polanski, Rasa Elmentaite, Eirini S Fasouli, Martin Prete, Xiaoling He, Nadav Yayon, Yixi Fu, Hao Yang, Chen Liang, Hui Zhang, David Fitzpatrick, Helen Firth, Andrew Dean, John Marioni, Roger A Barker, Mekayla A Storer, Barbara Wold, Hongbo Zhang, Sarah Teichmann

Released: 28-Apr-2022 12:00 PM EDT
Mitochondrial transfer to host cells from ex vivo expanded donor hematopoietic stem cells
Preprints

Hiroki Kawano, Yuko Kawano, Charles O. Smith, Mark W. LaMere, Matthew J. McArthur, Michael W. Becker, Scott W. Ballinger, Satoshi Gojo, Roman A. Eliseev, Laura M. Calvi

Released: 28-Apr-2022 12:00 PM EDT
Effects of Olfactory Mucosa Stem/Stromal Cell and Olfactory Ensheating Cells Secretome on Peripheral Nerve Regeneration
Preprints

Rui D. Alvites, Mariana Branquinho, Ana Catarina Sousa, Bruna Lopes, Patrícia Sousa, Justina Prada, Isabel Pires, Giulia Ronchi, Stefania Raimondo, Ana Lúcia Luís, Stefano Geuna, Artur S. P. Varejão, Ana Colette Maurício

27-Apr-2022 1:00 PM EDT
Researchers Share Insights about Mechanisms of Human Embryo and Create Method to Develop Transcriptionally Similar Cells in Tissue Culture
Mount Sinai Health System

Researchers share insights about the mechanisms of human embryo and create method to develop transcriptionally similar cells in tissue culture; latest discovery a step closer to finding alternative for bone marrow and other cancer treatments.

Newswise: Johns Hopkins Students Create Lymphedema Early Detection Sensor
Released: 28-Apr-2022 7:05 AM EDT
Johns Hopkins Students Create Lymphedema Early Detection Sensor
 Johns Hopkins University

A sensor created by Johns Hopkins University graduate students to detect very early-stage lymphedema could spare thousands of patients a year, many women with breast cancer, from the painful, debilitating condition.

   
Newswise: Plug-and-Play Organ-on-a-Chip can be Customized to the Patient
26-Apr-2022 2:20 PM EDT
Plug-and-Play Organ-on-a-Chip can be Customized to the Patient
Columbia University School of Engineering and Applied Science

Researchers from Columbia Engineering and Columbia University Irving Medical Center have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. The researchers have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient.

   
Released: 27-Apr-2022 5:00 AM EDT
MDS/AML with del5q: An acquired “laminopathy”?
Cell Stem Cell

In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o

Released: 27-Apr-2022 5:00 AM EDT
Circulating endothelial cells and endothelial progenitor cells as potential predictors of acute GVHD after allogeneic hematopoietic stem cell transplantation
European Journal of Haematology

… stem cell transplantation. Endothelial cell damage may trigger the initiation of aGVHD. Methods: Endothelial damage and repair were evaluated by counting circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) in 17 …

Released: 27-Apr-2022 5:00 AM EDT
Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1
Cell Death Discovery

Exosomes are known to transmit microRNAs (miRNAs) to affect human cancer progression, and miR-17-5p has been manifested to exert facilitated effects on colorectal cancer (CRC) progression, while the role of tumor stem cells-derived …

Released: 27-Apr-2022 5:00 AM EDT
Reactive Oxygen Species in Modulating Intestinal Stem Cell Dynamics and Function
Stem Cell Reviews and Reports

… The levels of ROS in the gut influence stem cell renewal ROS itself however is further influenced by several other factors such as the microbiota concerning the gut and immune cells which in turn also influence one another by various cross-talk …

Released: 27-Apr-2022 5:00 AM EDT
E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR
Journal of Biological Chemistry

… Mesenchymal stem cells (MSCs) are adult stem cell populations and exhibit great potential in regenerative medicine and oncology. Platelet-derived growth factors (PDGFs) are well-known to regulate MSC biology through their chemotactic and mitogenic …

Released: 27-Apr-2022 5:00 AM EDT
Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia
Leukemia

Acute myeloid leukemia (AML) is characterized by poor clinical outcomes due to high rates of relapse following standard-of-care induction chemotherapy. While many pathogenic drivers have been described in AML, our understanding of the …

Released: 26-Apr-2022 12:05 PM EDT
New Collaboration Between RCSB Protein Data Bank and Amazon Web Services Provides Expanded Data Storage and Access to Researchers Worldwide
Rutgers University's Office for Research

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), headquartered at the Rutgers Institute for Quantitative Biomedicine, announces the expansion of its data storage capacity through the Amazon Web Services (AWS) Open Data Sponsorship Program. The AWS program is providing the RCSB PDB with more than 100 terabytes of storage for no-cost delivery of Protein Data Bank information to millions of scientists, educators, and students around the world working in fundamental biology, biomedicine, bioenergy, and bioengineering/biotechnology.

Released: 26-Apr-2022 12:00 AM EDT
Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients
World Journal of Stem Cells

Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell (CSC) population after 3 cycles of standard chemotherapy. The epigenetic response (miRNAs expression) and CSCs are also correlated in pa

Released: 26-Apr-2022 12:00 AM EDT
Skinny people serum factors promote the differentiation of multipotent stem cells into brown adipose tissue
World Journal of Stem Cells

The original study by Alessio et al reported that skinny people (SP) serum can promote the formation of brown adipocytes, but not the differentiation of white adipocytes. This finding may explain why SP do not often become obese, despite consum

Released: 26-Apr-2022 12:00 AM EDT
Acceleration of Esophageal Wound Healing by Anisotropically Aligned Smooth Muscle Cell-Laden Nanofibrous Patch
Preprints

Miji Yeo, Jung Won Yoon, Gyu Tae Park, Sung-Chan Shin, Young-Cheol Song, Yong-Il Cheon, Byung-Joo Lee, Geun Hyung Kim, Jae Ho Kim



close
1.51622