Miji Yeo, Jung Won Yoon, Gyu Tae Park, Sung-Chan Shin, Young-Cheol Song, Yong-Il Cheon, Byung-Joo Lee, Geun Hyung Kim, Jae Ho Kim
BACKGROUNDSyringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain, paresthesia, and urination and defecation disorders, and in severe cases causes various paralyses. Curr
BACKGROUNDMesenchymal stem cells (MSC) effects on tissue regeneration are mainly mediated by their secreted substances (secretome), inducing their paracrine activity. This Conditioned medium (CM), including soluble factors (proteins, nucleic ac
… There was a statistically significant difference in the frequency of CD4+ CD95+, CD4+ CD95 Hi, and CD4+ CD95 low/med T stem cell memory (T SCM) cells between responder and nonresponder groups. However, the comparison of the …
… The child was pretreated with modified Bu/Cy plus ATG regimen for transplantation, and underwent haploid hematopoietic stem cell … , intravenous immunoglobulin (IVIG) transfusion, stem cell transfusion and other treatments, and …
Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem cells (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages …
… MSC, a pluripotent stem cell, has self-renewal capability and multidirectional differentiation potential, and it can be obtained from tissues, such as the umbilical cord, bone marrow and fat [24], [25]. Many experimental and clinical studies proved …
Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic …
… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …
… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …
… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …
… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …
Micropollutants in water often are hormones that accumulate in the environment and may have negative impacts on humans and animals. Researchers of Karlsruhe Institute of Technology (KIT) and Leibniz Institute of Surface Engineering (IOM) in Leipzig have now developed a process for the photocatalytic degradation of these pollutants when they flow through polymer membranes. It is presented in Nature Nanotechnology. Irradiation with light triggers a chemical reaction, as a result of which steroid hormones are degraded on the membranes coated with titanium dioxide. (DOI: 10.1038/s41565-022-01074-8)
… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …
… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …
… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …
… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …
The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …
… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …
… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …
In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …
… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …
Annika M Kisch, Karin Bergkvist, Sólveig Adalsteinsdóttir, Christel Wendt, Anette Alvariza, Jeanette Winterling
Sheerien Rajput, Khurram Minhas, Iqbal Azam, Usman Shaikh, El-Nasir Lalani
Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao
Hongkui Deng, Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, GaoFan Meng, Jialiang Zhu, Yanglu Wang, Shijia Liuyang, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen
Toshinobu Nakatake, Makoto Nabetani, Nanae Yutaka, Kaho Suzuki, Ryoichi Hazama, Satoshi Ohnishi, Takashi Hamazaki, Haruo Shintaku, Ran D Goldman
Tadeusz J. Kaczynski, Elizabeth D. Au, Michael H. Farkas
GuoYi Dong, Xiaojing Xu, Yue Li, Wenjie Ouyang, Weihua Zhao, Ying Gu, Jie Li, Tianbin Liu, Xinru Zeng, Huilin Zou, Shuguang Wang, Sixi Liu, Hai-Xi Sun, Chao Liu
Lenin D. Ochoa-De la Paz, Nadia Estefanía Gutiérrez-Castañeda, Jessica González-Corona, Ernesto Griego, Emilio J. Galván
Toru Okubo, Ryuhei Hayashi, Yuji Kudo, Yuki Ishikawa, Andrew J. Quantock
Yufeng Zhang, Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, YaoTing Ji
Marquita Camilleri, Georgios Bekris, Govundeep Sidhu, Caroline Buck, Esme Elsden, Orla McCourt, Jackie Horder, Fiona Newrick, Catherine Lecat, Jonathan Sive, Xenofon Papanikolaou, Rakesh Popat, Lydia Lee, Ke Xu, Charalampia Kyriakou, Neil Rabin, Kwee Yong, Abi Fisher
Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Kunal Goutam, Chanakya Nath Kundu
… stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
… cells remains eliciting the desired stem cell behavior once transplanted in the body. In their natural environment, stem cell fate is regulated by their … ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to …
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem cell proliferation control and …
… This article briefly introduced the regulatory framework development, the progress in stem cell clinical researches and clinical trials of commercially developed stem cell-based products, as well as the clinical review concerns of stem cell-based products in …
In this review, we will outline dimensions in which outcome of patients with myelofibrosis undergoing curative treatment can be optimized: patient selection, transplant procedure, and posttransplant prevention or treatment of relapse. For …
… of etoposide and cytarabine [8], or intensive chemotherapy followed by autologous stem cell transplantation (IC-ASCT) [9, 10]. Thiotepa-based myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) …
… Owing to the fact that MSC-derived exosomes can further control stem cell differentiation by carrying and transferring miRNAs, stem cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …
The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in unsuccessful or …
… Mesenchymal stem cell-derived EV have been shown to contain a diverse array of bioactive cargo, including proteins, nucleic acids, non-coding RNA and lipids. The lipid bilayer of the EV membrane protects the cargo from degradation and is often …
Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi Koivumäki, Jari Hyttinen
A pair of Rutgers researchers are teaming up to combat climate change and worldwide hunger at the same time. Yong Mao, associate research professor and lead biologist in the Laboratory for Biomaterials Science at Rutgers School of Arts and Sciences, and Joseph Freeman, professor, director of the Musculoskeletal Regeneration Laboratory, and graduate program director of biomedical engineering in Rutgers School of Engineering, will collaborate with Atelier Meats, a biotechnology company, to develop and produce lab-grown, structured meats.
Yeqing Yang, Junkai Zeng, Chong Jiang, Jiawen Chen, Ming Chen, Buling Wu
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