Feature Channels: Biotech

Filters close
Released: 19-Apr-2022 12:00 PM EDT
Effect of Fluid Shear Stress on Apoptosis and Osteogenesis of Mesenchymal Stem Cells
Preprints

Fei Jiao, Xiao Zhang, Chongyang Ye, Qing Sun, Yan Gao, Chenglin Liu, Bo Huo

Released: 19-Apr-2022 12:00 PM EDT
Nicotinamide mononucleotide enhances the efficacy and persistence of CD19 CAR-T cells via NAD + –Sirt1 axis
Preprints

Zhen Yu, Shuai Tong, Can Zhang, Yue Bai, Zhijing An, Chang Xu, Fang Wang, Yi Hu, Qinghui Zhuang, Xiaosong Zhong

Released: 19-Apr-2022 12:00 PM EDT
Regulation of stem cell dynamics through volume exclusion
Preprints

Rodrigo García-Tejera, Linus Schumacher, Ramon Grima

14-Apr-2022 1:05 PM EDT
Wearables can track COVID symptoms, other diseases
University of Michigan

If you become ill with COVID-19, your smartwatch can track the progression of your symptoms, and could even show how sick you become.

Released: 19-Apr-2022 10:00 AM EDT
MDS/AML with del5q: An acquired “laminopathy”?
Cell Stem Cell

In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o

Released: 19-Apr-2022 5:00 AM EDT
Androgens increase excitement in brain organoid research
Cell Stem Cell

Despite the surrounding controversy, quantitative sex-based differences exist in the human brain. In a recent issue of Nature, Kelava et al. shed light on the mechanisms underlying increased brain volume and neuron density in males, while highlighti

Released: 19-Apr-2022 5:00 AM EDT
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Cell Stem Cell

Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop

Released: 19-Apr-2022 5:00 AM EDT
Decoding the temporal and regional specification of microglia in the developing human brain
Cell Stem Cell

Our study comprehensively reveals the spatiotemporal dynamics of regional specification and state transition in the microglia of the developing human brain. By comparing microglia from mice and humans, we assess the conservation of state transitions

Released: 19-Apr-2022 5:00 AM EDT
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
Cell Stem Cell

Du et al. discover a chemical cocktail of five small molecules (5SM) promoting adult mammalian CM proliferation and heart regeneration after myocardial infarction. 5SM potentially targets α1 adrenergic receptor, JAK1, DYRKs, PTEN, and MCT1 and make

Released: 19-Apr-2022 5:00 AM EDT
Stem cell-derived β cells go in monkeys
Cell Stem Cell

Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the

Released: 19-Apr-2022 5:00 AM EDT
Capybara: A computational tool to measure cell identity and fate transitions
Cell Stem Cell

Kong et al. present Capybara, a computational pipeline to classify discrete cell identity and intermediate “hybrid” cell states. They apply Capybara to identify hybrid states in cardiac reprogramming, off-target neural identities in motor neuron

Released: 19-Apr-2022 5:00 AM EDT
Progress in multicellular human cardiac organoids for clinical applications
Cell Stem Cell

Recent advances and current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application are discussed.

Released: 19-Apr-2022 5:00 AM EDT
Successful organoid-mediated generation of iPSC-derived CAR-T cells
Cell Stem Cell

Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19+ CAR-T cells that mimi

Released: 19-Apr-2022 5:00 AM EDT
c-Maf: The magic wand that turns on LSEC fate
Cell Stem Cell

In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs,

Released: 19-Apr-2022 5:00 AM EDT
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
Cell Stem Cell

Abnormal nuclear morphology is a hallmark of cancerous cells. Here, Reilly et al. demonstrate that deletion of lamin B1, which is common in myeloid malignancies, causes acquired Pelger-Huët nuclear anomaly and links aberrant nuclear morphology with

Released: 19-Apr-2022 5:00 AM EDT
MDS/AML with del5q: An acquired “laminopathy”?
Cell Stem Cell

In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o

Released: 19-Apr-2022 5:00 AM EDT
An oncogenic enhancer encodes selective selenium dependency in AML
Cell Stem Cell

(Cell Stem Cell 29, 386–399.e1–e7; March 3, 2022)

Released: 19-Apr-2022 5:00 AM EDT
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment
Cell Stem Cell

Sun et al. discover that myogenic progenitors derived from hPSCs could engraft and mature to become local satellite cells in vivo after transplantation. These engrafted MPCs not only function as satellite cells in muscle regeneration but could also

Released: 19-Apr-2022 5:00 AM EDT
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction
Cell Stem Cell

Blood vessels adapt to the requirements of each organ. In the liver, this adaptation is a progressive specialized transition from fetal to postnatal development, which is facilitated by the transcription factor c-Maf. In vitro c-Maf induces a liver-

Released: 18-Apr-2022 12:00 PM EDT
Prevalence of Anti-HLA Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation in Pediatric Patients : A Single-Center Experience
Preprints

Muhammad Ameen, Sadia Khan, Ali Al-Ahmari, Muhab Ayas, Aya Kattih, Amani Alkofide, Mohamad Walid Ballourah, Muheeb Al-Awami

Released: 18-Apr-2022 12:00 PM EDT
Commensal Oral Microbiota Influences Ulcerative Oral Mucositis Clinical Course in Allogeneic Stem Cell Transplant Recipients
Preprints

Julia Bruno, Vitor Heidrich, Franciele H. Knebel, Vinícius Campos de Molla, Claudia Joffily Parahyba, Wanessa Miranda-Silva, Paula Fontes Asprino, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Eduardo Rodrigues Fregnani

Released: 16-Apr-2022 12:00 PM EDT
Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells.
Preprints

Thulaj Meharwade, Loick Joumier, Maxime Parisotto, Vivian Huynh, Edroaldo Lummertz da Rocha, Mohan Malleshaiah

Released: 16-Apr-2022 12:00 PM EDT
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Preprints

Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry

Released: 16-Apr-2022 12:00 PM EDT
Chromatin remodeler developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders
Preprints

Pauliina Auvinen, Jussi Vehviläinen, Heidi Marjonen, Vijayachitra Modhukur, Joonas Sokka, Essi Wallén, Karita Rämö, Laura Ahola, Andres Salumets, Timo Otonkoski, Heli Skottman, Miina Ollikainen, Ras Trokovic, Hanna Kahila, Nina Kaminen-Ahola

Released: 15-Apr-2022 12:00 PM EDT
Whole-embryonic identification of maternal microchimeric cell types in mouse using single-cell RNA sequencing
Preprints

Kana Fujimoto, Akira Nakajima, Shohei Hori, Yumiko Tanaka, Yoshitaka Shirasaki, Sotaro Uemura, Naoki Irie

Released: 14-Apr-2022 12:00 PM EDT
Predicting the risk of acute kidney injury after hematopoietic stem cell transplantation: development of a new predictive nomogram
Preprints

Zhaoping Gan, Liyi Chen, Meiqing Wu, Lianjin Liu, Lingling Shi, Qiaochuan Li, Zhongming Zhang, Yongrong Lai

Released: 14-Apr-2022 12:00 PM EDT
A congenital hydrocephalus causing mutation in Trim71 results in stem cell differentiation defects through inhibiting Lsd1 mRNA translation
Preprints

Qiuying Liu, Mariah K Novak, Rachel Pepin, Katharine Maschhoff, Xiaoli Chen, Shaojie Zhang, Wenqian Hu

Released: 14-Apr-2022 12:00 PM EDT
Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation
Preprints

Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee

Released: 14-Apr-2022 12:00 PM EDT
Identification of Protective, Metabolite-producing Bacterial and Viral Consortia in Allogeneic Stem Cell Transplantation Patients
Preprints

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Michael Gigl, Karin Kleigrewe, Julius Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Daniela Weber, Daniel Wolff, Matthias Edinger, Dirk Busch, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck

Released: 14-Apr-2022 12:00 PM EDT
Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of Pyroptosis Related Genes in Human Cancers
Preprints

Zhi-Na Wang, Hong-Ming Ma, Zi-Yi Chen, Jia-Wen Chen, Xu-Wen Yang, Nan Zhang, Fanjie Meng

Released: 14-Apr-2022 12:00 PM EDT
Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas based technology
Preprints

Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto

Released: 13-Apr-2022 12:00 PM EDT
Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes
Preprints

Jie Huang, Haiyan Chen, Shujue Lan, Le Qin, Zixuan Xun, Shuai Han, Hongwei Zhao, Yunqing Ci, Chen Xu, Wenjia Zhu, Xinya Lu, Jiaxin Chen, Qiuyi Zheng, Ermin Li, Xinyun Chen, Chao Lu, Ruizhe Qian, Sifeng Chen, Xiaobo Li, Ning Sun

Released: 12-Apr-2022 12:00 PM EDT
Paeoniflorin drives immunomodulation of mesenchymal stem cells via regulating Th1/Th2 cytokines in oral lichen planus
Preprints

Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu

Released: 12-Apr-2022 12:00 PM EDT
Exploring Health Behaviors and the Feasibility of a Lifestyle Intervention for Patients with Multiple Myeloma
Preprints

Allen Hodge, Patricia Sheean, Paula O’Connor, Kiley Tyler, Abigail Kerschner, Alexis Williams, Kathleen Jensik, Alexis Visotcky, Anita D’Souza, Parameswaran Hari, Binod Dhakal, Saurabh Chhabra, Kathryn E. Flynn, Patrick Hagen, Melinda Stolley

Released: 11-Apr-2022 1:05 PM EDT
University of Rhode Island Sponsors National Workshop on Developing Bioenergy Crops
University of Rhode Island

KINGSTON, RI – April 11, 2022 – Albert Kausch, director of the Plant Biotechnology Laboratory at the University of Rhode Island, is welcoming 11 scientists from across the nation and Argentina to a 10-day National Science Foundation and Department of Energy sponsored workshop.The Cereal Crop Plant Transformation and Genome Editing Training Workshop, to be held at Kausch’s lab in West Kingston this week, will train participants to alter the DNA of sorghum to improve it as a bioenergy crop.

Newswise: Yongqin Jiao: Then and Now / 2011 Early Career Award Winner
Released: 11-Apr-2022 10:05 AM EDT
Yongqin Jiao: Then and Now / 2011 Early Career Award Winner
Department of Energy, Office of Science

Yongqin Jiao is a Group Leader in the Biosciences and Biotechnology Division at Lawrence Livermore National Lab. With her Early Career Research Program award, she investigated how the bacterium Caulobacter crescentus survives in high levels of uranium and its potential use for bioremediation.

Released: 23-Mar-2022 11:05 AM EDT
Sperm Research Spawns New Tests to Detect Stroke, Concussion
Cornell University

When reproductive biologist Alex Travis began investigating how sperm cells swim more than two decades ago, he had no idea the research would lead to a new way to diagnose stroke and other diseases. Now, Travis and his colleague Roy Cohen have co-founded a company, TETDiagnostics, to transform what they learned from sperm into a bio-inspired diagnostic technology.

   
Released: 22-Mar-2022 10:35 AM EDT
Fixing spinal cord injuries with ​‘dancing molecules’
Argonne National Laboratory

Research conducted at the Advanced Photon Source contributed to a groundbreaking new molecular therapy to treat paralysis. These new "dancing molecules" signaled cells to repair damaged spinal cord tissue, curing paralyzed mice.

Released: 22-Mar-2022 10:30 AM EDT
Biomed Valley Discoveries Announces Poster Presentations on Ulixertinib (BVD-523) at the AACR Annual Meeting 2022
BioMed Valley Discoveries

BioMed Valley Discoveries (BVD) announced today they will present four posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana.

Newswise: Engineering an “Invisible Cloak” for Bacteria to Deliver Drugs to Tumors
16-Mar-2022 11:55 AM EDT
Engineering an “Invisible Cloak” for Bacteria to Deliver Drugs to Tumors
Columbia University School of Engineering and Applied Science

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. By manipulating the microbes’ DNA, they programmed gene circuits that control the bacteria surface, building a molecular “cloak'' that encapsulates the bacteria.

Newswise: Argonne pioneers new processes to create materials for batteries, biofuels
Released: 17-Mar-2022 11:55 AM EDT
Argonne pioneers new processes to create materials for batteries, biofuels
Argonne National Laboratory

Argonne researchers have used a separations technique called capacitive deionization for battery recycling and to separate out fuels for sustainable aviation.



close
1.86662