Effect of Fluid Shear Stress on Apoptosis and Osteogenesis of Mesenchymal Stem Cells
PreprintsFei Jiao, Xiao Zhang, Chongyang Ye, Qing Sun, Yan Gao, Chenglin Liu, Bo Huo
Fei Jiao, Xiao Zhang, Chongyang Ye, Qing Sun, Yan Gao, Chenglin Liu, Bo Huo
Zhen Yu, Shuai Tong, Can Zhang, Yue Bai, Zhijing An, Chang Xu, Fang Wang, Yi Hu, Qinghui Zhuang, Xiaosong Zhong
Rodrigo García-Tejera, Linus Schumacher, Ramon Grima
If you become ill with COVID-19, your smartwatch can track the progression of your symptoms, and could even show how sick you become.
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o
(Cell Stem Cell 29, 515–527.e1–e8; April 7, 2022)
Despite the surrounding controversy, quantitative sex-based differences exist in the human brain. In a recent issue of Nature, Kelava et al. shed light on the mechanisms underlying increased brain volume and neuron density in males, while highlighti
Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop
Our study comprehensively reveals the spatiotemporal dynamics of regional specification and state transition in the microglia of the developing human brain. By comparing microglia from mice and humans, we assess the conservation of state transitions
Du et al. discover a chemical cocktail of five small molecules (5SM) promoting adult mammalian CM proliferation and heart regeneration after myocardial infarction. 5SM potentially targets α1 adrenergic receptor, JAK1, DYRKs, PTEN, and MCT1 and make
Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the
Kong et al. present Capybara, a computational pipeline to classify discrete cell identity and intermediate “hybrid” cell states. They apply Capybara to identify hybrid states in cardiac reprogramming, off-target neural identities in motor neuron
Recent advances and current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application are discussed.
Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19+ CAR-T cells that mimi
In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs,
Abnormal nuclear morphology is a hallmark of cancerous cells. Here, Reilly et al. demonstrate that deletion of lamin B1, which is common in myeloid malignancies, causes acquired Pelger-Huët nuclear anomaly and links aberrant nuclear morphology with
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o
(Cell Stem Cell 29, 386–399.e1–e7; March 3, 2022)
Sun et al. discover that myogenic progenitors derived from hPSCs could engraft and mature to become local satellite cells in vivo after transplantation. These engrafted MPCs not only function as satellite cells in muscle regeneration but could also
Blood vessels adapt to the requirements of each organ. In the liver, this adaptation is a progressive specialized transition from fetal to postnatal development, which is facilitated by the transcription factor c-Maf. In vitro c-Maf induces a liver-
Muhammad Ameen, Sadia Khan, Ali Al-Ahmari, Muhab Ayas, Aya Kattih, Amani Alkofide, Mohamad Walid Ballourah, Muheeb Al-Awami
Julia Bruno, Vitor Heidrich, Franciele H. Knebel, Vinícius Campos de Molla, Claudia Joffily Parahyba, Wanessa Miranda-Silva, Paula Fontes Asprino, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Eduardo Rodrigues Fregnani
Ji-Lin Chen, Na Li, Wen-Qiang Liu, Zhong-Fu Zuo, Ting-Hua Wang
Weisheng Hu, Yuan Jing, Qingqian Yu, Ning Huang
Mohammad Tolooei, Hassan Ehteram, Hamed Haddad Kashani
Thulaj Meharwade, Loick Joumier, Maxime Parisotto, Vivian Huynh, Edroaldo Lummertz da Rocha, Mohan Malleshaiah
Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry
Pauliina Auvinen, Jussi Vehviläinen, Heidi Marjonen, Vijayachitra Modhukur, Joonas Sokka, Essi Wallén, Karita Rämö, Laura Ahola, Andres Salumets, Timo Otonkoski, Heli Skottman, Miina Ollikainen, Ras Trokovic, Hanna Kahila, Nina Kaminen-Ahola
Kana Fujimoto, Akira Nakajima, Shohei Hori, Yumiko Tanaka, Yoshitaka Shirasaki, Sotaro Uemura, Naoki Irie
Zhaoping Gan, Liyi Chen, Meiqing Wu, Lianjin Liu, Lingling Shi, Qiaochuan Li, Zhongming Zhang, Yongrong Lai
Qiuying Liu, Mariah K Novak, Rachel Pepin, Katharine Maschhoff, Xiaoli Chen, Shaojie Zhang, Wenqian Hu
Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Michael Gigl, Karin Kleigrewe, Julius Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Daniela Weber, Daniel Wolff, Matthias Edinger, Dirk Busch, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Xian Wu, Hao Gou, Huijun Qiu, Hanmin Liu, Zhou Fu, Lina Chen
Zhi-Na Wang, Hong-Ming Ma, Zi-Yi Chen, Jia-Wen Chen, Xu-Wen Yang, Nan Zhang, Fanjie Meng
Chi Yang, Kai Shi, Jie Wang, Lianqi Yan
Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto
Haiting Ma, Rudolph Jaenisch
Yuxuan Li, Xiaofei Wang, Jing Lu
Jie Huang, Haiyan Chen, Shujue Lan, Le Qin, Zixuan Xun, Shuai Han, Hongwei Zhao, Yunqing Ci, Chen Xu, Wenjia Zhu, Xinya Lu, Jiaxin Chen, Qiuyi Zheng, Ermin Li, Xinyun Chen, Chao Lu, Ruizhe Qian, Sifeng Chen, Xiaobo Li, Ning Sun
Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu
Allen Hodge, Patricia Sheean, Paula O’Connor, Kiley Tyler, Abigail Kerschner, Alexis Williams, Kathleen Jensik, Alexis Visotcky, Anita D’Souza, Parameswaran Hari, Binod Dhakal, Saurabh Chhabra, Kathryn E. Flynn, Patrick Hagen, Melinda Stolley
KINGSTON, RI – April 11, 2022 – Albert Kausch, director of the Plant Biotechnology Laboratory at the University of Rhode Island, is welcoming 11 scientists from across the nation and Argentina to a 10-day National Science Foundation and Department of Energy sponsored workshop.The Cereal Crop Plant Transformation and Genome Editing Training Workshop, to be held at Kausch’s lab in West Kingston this week, will train participants to alter the DNA of sorghum to improve it as a bioenergy crop.
Yongqin Jiao is a Group Leader in the Biosciences and Biotechnology Division at Lawrence Livermore National Lab. With her Early Career Research Program award, she investigated how the bacterium Caulobacter crescentus survives in high levels of uranium and its potential use for bioremediation.
When reproductive biologist Alex Travis began investigating how sperm cells swim more than two decades ago, he had no idea the research would lead to a new way to diagnose stroke and other diseases. Now, Travis and his colleague Roy Cohen have co-founded a company, TETDiagnostics, to transform what they learned from sperm into a bio-inspired diagnostic technology.
Research conducted at the Advanced Photon Source contributed to a groundbreaking new molecular therapy to treat paralysis. These new "dancing molecules" signaled cells to repair damaged spinal cord tissue, curing paralyzed mice.
BioMed Valley Discoveries (BVD) announced today they will present four posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana.
Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. By manipulating the microbes’ DNA, they programmed gene circuits that control the bacteria surface, building a molecular “cloak'' that encapsulates the bacteria.
Argonne researchers have used a separations technique called capacitive deionization for battery recycling and to separate out fuels for sustainable aviation.