Antibiotics aren’t supposed to be effective against viruses. But new evidence in mice suggests antibiotics may help fight norovirus, a highly contagious gastrointestinal virus, report scientists at Washington University School of Medicine in St. Louis.
According to a new study led by researchers at Dana-Farber Cancer Institute, clinical trial patients with metastatic colorectal cancer who had high levels of vitamin D in their bloodstream prior to treatment with chemotherapy and targeted drugs, survived longer, on average, than patients with lower levels of the vitamin. Those findings were reported today at the 2015 American Society of Cancer Oncology (ASCO) Gastrointestinal Cancers Symposium in San Francisco.
A study of more than 2,000 patients by researchers at Mayo Clinic’s campus in Jacksonville, Florida, has dispelled the myth that cancer biopsies cause cancer to spread. In the Jan. 9 online issue of Gut, they show that patients who received a biopsy had a better outcome and longer survival than patients who did not have a biopsy.
A new study by researchers at Children’s Hospital Los Angeles has shown that tissue-engineered small intestine grown from human cells replicates key aspects of a functioning human intestine.
President Obama was recently diagnosed with acid reflux - a gastric condition caused by stomach acid entering the upper body. Holiday season is prime time for acid reflux as a Loyola gastroenterologist shares dos and don'ts.
The bacterium Helicobacter pylori is strongly associated with gastric ulcers and cancer. To combat the infection, researchers at University of California, San Diego School of Medicine and Jacobs School of Engineering developed LipoLLA, a therapeutic nanoparticle that contains linolenic acid, a component in vegetable oils. In mice, LipoLLA was safe and more effective against H. pylori infection than standard antibiotic treatments.
Sticking to a gluten-free diet over Thanksgiving may sound like no fun, but many people don’t have a choice.
Tufts University School of Engineering researchers and collaborators from Texas A&M University have published the first research to use computational modeling to predict and identify the metabolic products of gastrointestinal (GI) tract microorganisms. Understanding these metabolic products, or metabolites, could influence how clinicians diagnose and treat GI diseases, as well as many other metabolic and neurological diseases increasingly associated with compromised GI function.
In a randomized clinical trial, 72 percent of participants said that perineal self-acupressure, a simple technique involving the application of external pressure to the perineum — the area between the anus and genitals — helped relieve their constipation
Gluten proteins in wheat products might not be the only ones involved in celiac disease.
In a study published in the Nov. 1 issue of Neural Computation, researchers at the University of California, San Diego School of Medicine report that a high quality brand of coenzyme Q10 (CoQ10) – a compound commonly sold as a dietary supplement – provides health benefits to persons suffering from Gulf War illness symptoms.
Myasthenia gravis is a disorder than can be associated with abnormal function outside of skeletal muscle. Two studies presented at the annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) demonstrate that there is a significant proportion of myasthenia patients with arrhythmias and co-morbid inflammatory bowel disease (IBD).
A team of Children’s Hospital and Research Center Oakland (CHORI) researchers has found that a category of lipids known as sphingolipids may be an important link in the relationship between diet, inflammation and cancer. In a paper published online this week in the Journal of Clinical Investigation, Dr. Julie Saba, MD, PhD and her team provide evidence that a sphingolipid metabolite called sphingosine-1-phosphate (S1P) found in both mammalian food products and generated by normal human cells can contribute to inflammation of the colon, inflammatory bowel disease (IBD) and inflammation-associated colon cancer, whereas soy and plant-type sphingolipids called sphingadienes may protect against these conditions.
Promising new research in the area of hepatitis C (HCV) therapy that suggests more patients, including those with cirrhosis, will be cured from this common cause of potentially fatal viral liver disease; as well as a number of abstracts that advance understanding of the safety and effectiveness of fecal microbiota transplantation for Clostridium difficile, are among the highlights of ACG 2014, which will be held this week in Philadelphia.
In a series of virtual press briefings, renowned experts in the field of gastroenterology offer commentary and real word perspective on the key science presented this week at the American College of Gastroenterology's (ACG) 79th Annual Scientific Meeting in Philadelphia.
This year the College offers a series of pre-recorded virtual press briefings which feature the insights of leading gastroenterology experts on several key abstracts that will be unveiled at ACG 2014 in the areas related to hepatitis C
This year the College offers a series of pre-recorded virtual press briefings which feature the insights of leading gastroenterology experts on several key abstracts that will be unveiled at ACG 2014 in the areas related to inflammatory bowel disease.
This year the College offers a series of pre-recorded virtual press briefings which feature the insights of leading gastroenterology experts on several key abstracts that will be unveiled at ACG 2014 in the areas related to notable case reports related to protein shakes, chia seeds, and other supplementation where good health intentions go bad
This year the College offers a series of pre-recorded virtual press briefings which feature the insights of leading gastroenterology experts on several key abstracts that will be unveiled at ACG 2014 in the areas related to drug induced liver injury.
This year the College offers a series of pre-recorded virtual press briefings which feature the insights of leading gastroenterology experts on several key abstracts that will be unveiled at ACG 2014 in the areas related to fecal microbiota transplantation and C. difficile.
One of the few studies to examine gender differences among patients with irritable bowel syndrome (IBS) has found that males with the condition experience more interpersonal difficulties than do females with the condition.
Researchers at University of California, San Diego School of Medicine have discovered that T-cells – a type of white blood cell that learns to recognize and attack microbial pathogens – are activated by a pain receptor.
Proactive monitoring and dose adjustment of infliximab, a medication commonly used to treat inflammatory bowel disease (IBD), could improve a patient’s chances of having a long-term successful response to therapy, a pilot observational study at Beth Israel Deaconess Medical Center concludes.
Studies conducted by researchers at Children’s Hospital Los Angeles demonstrate that a protein called neuregulin-4 (NRG4)—present in breast milk, but absent from formula—may be protective against the intestinal destruction caused in necrotizing enterocolitis (NEC).
A new immunotoxin works by getting shuttled into cancer cells, selectively destroying colon cancer, thanks to a quirk of biology
UCLA researchers were part of a team that has discovered the interplay of several genetic factors that may be involved in the development of early-onset ulcerative colitis, a severe type of inflammatory bowel disease. The early research findings in mice suggest possible new targets for prevention and treatment strategies to address the inflammation generated by early-onset ulcerative colitis. The rare disease affects infants and young children and can lead to early development of colon cancer and an increased risk of liver damage.
A new study finds a wide range of epigenetic changes—alterations in DNA across the genome that may be related to key environmental exposures—in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.
University of Adelaide researchers have discovered that the immune system is defective in people suffering from irritable bowel syndrome, which is a major reason why sufferers have ongoing issues with pain.
A method of growing human cells from tissue removed from a patient’s gastrointestinal (GI) tract eventually may help scientists develop tailor-made therapies for inflammatory bowel disease and other GI conditions. Researchers at Washington University School of Medicine in St. Louis have made cell lines from individual patients in as little as two weeks. They said the cell lines can help them understand the underlying problems in the GI tracts of individual patients and be used to test new treatments.
The American College of Gastroenterology (ACG) published a new systematic review of evidence about the management of irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC) as a supplement to the August 2014 issue of The American Journal of Gastroenterology.
Enzyme supplements available without a prescription are becoming increasingly popular, but should everyone add them to their shopping list? Brent Bauer, M.D., director of the Mayo Clinic Complementary and Integrative Medicine Program, is co-author of a new paper in the medical journal Mayo Clinic Proceedings on the pros and cons of over-the-counter enzymes.
Scientists at Albert Einstein College of Medicine of Yeshiva University have found that bacteria that aid in digestion help keep the intestinal lining intact. The findings, reported online in the journal Immunity, could yield new therapies for inflammatory bowel disease (IBD) and a wide range of other disorders.
Learning the role of immune system cells in healthy digestive tracts and how they interact with neighboring nerve cells may lead to new treatments for irritable bowel syndrome (IBS).
University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn’s disease. The fundamental research points to a possible pathway for developing novel therapies for the inflammatory bowel disease.
The Global Outreach Symposium on Irritable Bowel Syndrome (IBS) is an educational conference and interactive webinar featuring Cedars-Sinai gastroenterology experts presenting the latest medical research and treatment options to educate and empower patients, families and healthcare providers on all aspects of IBS and Small Intestinal Bacterial Overgrowth (SIBO). The seminar will be simulcast on the Internet, drawing in participants from around the world.
Microparticles in crab, shrimp and lobster shells have anti-inflammatory mechanisims that that could lead to the development of novel preventive and therapeutic strategies for those who suffer from IBD. Since these shells are abundant and a major waste in the seafood industry, they may provide an alternative to costly drugs that don't always work.
New clinical guidelines on the diagnosis and management of idiosyncratic drug-induced liver injury (DILI) appear in the July issue of The American Journal of Gastroenterology. DILI is a rare adverse drug reaction, challenging to diagnose, and can lead to jaundice, liver failure and even death. The frequency of DILI incidence is increasing, as the use of herbal and dietary supplements has drastically increased over the last 10 years.
For World Digestive Health Day, the American College of Gastroenterology, along with World Gastroenterology Organisation (WGO), observes the 2014 focus on the human gut microbiome and its impact on health and disease.
A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study conducted by researchers at Rush University Medical Center.
Many Americans have heartburn at least weekly, and could be saving money on medicines to treat it. Survey shows doctors believe generics and name brands work the same for acid reflux and constipation, but they often recommend more expensive brand names.
Elafin, by interacting with the transglutaminase 2 enzyme, decreased the enzymatic reaction that increases the toxicity of peptides derived from gluten.
Is irritable bowel syndrome (IBS) caused by genetics, diet, past trauma, anxiety? All are thought to play a role, but now, for the first time, researchers have reported a defined genetic defect that causes a subset of IBS. The research was published in the journal Gastroenterology.
Social relationships, fatigue and other coexisting medical problems have a stronger effect on how patients with irritable bowel syndrome (IBS) rate their overall health than the severity of their gastrointestinal symptoms, a University at Buffalo study has found.
This research revealed that inflammation in the gut GM-CSF is produced in the normal gut in response to microbiota signals by specialized cells, requires sufficient GM-CSF to protect against gut inflammation. Deletion of GM-CSF gene in the mouse impaired gut regulatory function and compromised oral tolerance, and increased susceptibility to IBD.
Parents of children with short bowel syndrome measure their outcomes by the centimeters of intestine that remain after surgery. Many of these children live on intravenous nutrients and fluids, in combination with formula by a gastric tube in and a strict diet. All face daily challenges—infections, diarrhea and liver disease. Through a collaborative project with clinical researchers and a microbiologist in Canada, assistant professor Crystal Levesque of the South Dakota State University Animal Science Department hopes to help in finding a treatment that will help grow their intestines. Beginning its second year, the project has been supported by an annual $25,000 Maurice Shils Grant from the Nestlé Nutrition Institute awarded through the American Society for Parenteral and Enteral Nutrition Rhoads Research Foundation.
An innovative laparoscopic procedure that implants a ring of magnetic beads to help prevent acid reflux in patients who suffer from Gastroesophageal Reflux Disease (GERD) is the latest tool surgeons at Stony Brook University Hospital (SBUH) have to treat the disease.
The McMaster team found that segmentation motion occurs when not one but two sets of pacemakers interact with each other to create a specific rhythm. Then they work together with nerves and muscle to generate the movement that allows for nutrient absorption.The discovery is important as it gives direction for development of drugs or nutrients which will combat disorders when people have diarrhea, constipation, bloating or malabsorption of nutrients from food.
Adding quinoa to the gluten-free diet of patients with celiac disease is well-tolerated, and does not exacerbate the condition, according to new research published in The American Journal of Gastroenterology.
A newly-developed, “designer” dietary fiber with an added potential prebiotic effect may eliminate the side effects of current treatment for Irritable Bowel Syndrome (IBS) which affects 10-20 percent of the population, disproportionately women.
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