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Science

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Telomere, telomere length, Aging, Health, Diarrheal Disease, Infection, Public Health, Epidemiology, Population Studies, Correlation

'Protective' DNA Strands Are Shorter in Adults Who Had More Infections as Infants

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New research indicates that people who had more infections as babies harbor a key marker of cellular aging as young adults: the protective stretches of DNA which "cap" the ends of their chromosomes are shorter than in adults who were healthier as infants.

Medicine

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Newborn, Newborn Screening, Pediactrics, Child Health, Genetic Testing

New RTI International Program to Offer Free Elective Genetic Testing for North Carolina Newborns

A new program offering free elective genetic testing for newborns, developed at RTI International, will become available to North Carolina parents starting in 2018, thanks to a grant from the National Institutes of Health.

Medicine

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SBS, Short Bowel Syndrome, NEC, Necrotizing Enterocolitis, Gene Expression and Regulation, Bile Acid

Short Bowel Syndrome Results in Changes to Gene Expression

Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are markedly over or under expressed in SBS may assist scientists in developing future therapies for children and adults with this condition.

Science

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Paleontology, Evolution, Lizard, new species, Cretaceous Period, Paleoecology, Fossil

Prized Fossil Find — the Oldest, Most Complete Iguanian in the Americas — Illuminates the Lives of Lizards in the Age of Dinosaurs

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Paleontologists at the University of Washington, picking through a bounty of fossils from Montana, have discovered something unexpected — a new species of lizard from the late dinosaur era, whose closest relatives roamed in faraway Asia.

Science

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Genetics

Watching Gene Editing at Work to Develop Precision Therapies

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MADISON, Wis. — University of Wisconsin-Madison engineers have developed methods to observe gene editing in action, and they’re putting those capabilities to work to improve genetic engineering techniques.

Science

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fly genetics, Cancer Genetics, Neurodegenerative Disorders, Cancer, Kidney Cancer, Brain Cancer, Glioma, Acute Myelogenous Leukemia, Renal Cell Carcinoma, L-2-hydroxyglutaric aciduria, L-2-hydroxyglutarate, L-2HG, Drosphilia, oncometabolites

IU Study Finds Fly Growth Mimics Cancer Cells, Creating New Tool in Fight Against Disease

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Scientists who study a molecule known to play a role in certain types of cancers and neurodegenerative disorders have a powerful new tool to study this compound due to research conducted at Indiana University. The study was published Jan. 23 in the Proceedings of the National Academy of Sciences.

Medicine

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Cancer, Statin, Cancer Treatment, p53 gene

KU Researchers Find Statins May Hold Keys to Future Cancer Treatment

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Researchers at The University of Kansas Cancer Center have found that high doses of drugs commonly used to fight high cholesterol can destroy a rogue protein produced by a damaged gene that is associated with nearly half of all human cancers

Science

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TSRI Scientists Create First Stable Semisynthetic Organism

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Scientists at The Scripps Research Institute (TSRI) have announced the development of the first stable semisynthetic organism.

Science

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New Tools Will Drive Greater Understanding of Wheat Genes

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HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.

Science

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Choreographing the MicroRNA-Target Dance

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Molecular biologists at UT Southwestern Medical Center have uncovered a new mechanism that choreographs a complex molecular dance by applying the latest in gene editing technology combined with a traditional method of making a microRNA target produce a fluorescent green protein.

Medicine

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St. Jude Children's Research Hospital, AMKL, pediatric leukemia, next-generation sequencing, Acute Megakaryoblastic Leukemia, genetic alteration, therapy guidelines

Research Leads to New Treatment Recommendations for a High-Risk Pediatric Leukemia

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International researchers led by St. Jude Children’s Research Hospital have identified genetic alterations that can be used to guide treatment of pediatric acute megakaryoblastic leukemia, which has a dismal prognosis.

Science

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A Quark Like No Other, Biophysics Plays Key Role in Immune System Signaling and Response, ALMA Reveals Sun in New Light, and MORE in the Physics News Source Sponsored by AIP

Click here to go directly to the Physics News Source Sponsored by AIP.

Science

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hypomorphic mutants, Genetic Engineering, poly adenylation

New Genetic Engineering Technique Could Help Design, Study Biological Systems

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A new technique helps biologists tinker with genes, whether the goal is to turn cells into tiny factories churning out medicines or to study their effects on human health. The technique allows scientists to precisely regulate how much protein is produced from a particular gene.

Medicine

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Nyu Langone, Agnel Sfeir, Mitochondria, Genetics, common deletion, strand displacement, Pearson syndrome, Kearns-Sayre, ophthalmopl

Roots of Related Genetic Diseases Found in Cell Powerhouses

Scientists at NYU Langone Medical Center have discovered the mechanisms behind a genetic change known to cause a set of related diseases.

Medicine

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Research, Cancer, Pancreatic Cancer, Stomach Cancer, Colon Cancer

‘Collateral’ Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

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Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as “collateral lethality,” which may create new options for development of therapies for several cancers.

Science

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Fossils, Trilobites, cruziana , palaeozoic

Fossils Found Reveal Unseen ‘Footprint’ Maker

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Fossils found in Morocco from the long-extinct group of sea creatures called trilobites, including rarely seen soft-body parts, may be previously unseen animals that left distinctive fossil ‘footprints’ around the ancient supercontinent Gondwana.

Medicine

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Cancer, Melanoma, PD-1 blockade, Skin Cancer, Drug Resistance

Ludwig Study Reveals Why Cancer Cells Spread Within the Body

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Findings uncover an ancient mechanism that makes cancer cells invasive, explains melanoma’s resistance to therapy and opens the door to development of novel cancer therapies

Medicine

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Best Treatment Option Written in Cancer's Genetic Script

Acute myeloid leukaemia study finds personalised therapy is possible.

Medicine

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Andrew Feinberg, Pancreatic Cancer, Epigenetic, Metastases, Tumor

Potentially Reversible Changes in Gene Control 'Prime' Pancreatic Cancer Cells to Spread

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A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Science

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Genomics, Environment, Antarctic, Ocean, Diatoms, Evolution, Ecosystem, Genetics, Phytoplankton, Adaptation, Eukaryotes, eukaryotic biology, Population Genetics

Tracking Antarctic Adaptations in Diatoms

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An international team of researchers conducted a comparative genomic analysis to gain insights into the genome structure and evolution of the diatom Fragillariopsis cylindrus, as well as its role in the Southern Ocean.







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