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Medicine

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Stem Cells, Genomics, Genetics, induced pluripotent cells , iPSCORE

In Four Related Papers, Researchers Describe New and Improved Tools for Stem Cell Research

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In a new paper, a large team of researchers led by senior author Kelly Frazer, PhD, professor of pediatrics and director of the Institute for Genomic Medicine at University of California San Diego School of Medicine describe a new collection of 222 systematically derived and characterized iPSC lines generated as part of the National Heart, Lung and Blood Institute’s NextGen consortium.

Medicine

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DNA, DNA repair and cancer, Cancer, Yale Cancer Center, Cancer Research

Study Sheds Light on Role of DNA2 in DNA Repair

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A biochemical analysis study has discovered a new role for the DNA2 enzyme. The research, which was completed in the lab of Patrick Sung, professor of molecular biophysics and biochemistry at the Yale School of Medicine, looked at the way in which DNA2 repairs breaks in DNA that lead to the abnormalities that cause cancer.

Science

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New Hire, faculty appointment

New Investigator Anindya Bagchi Joins Sanford Burnham Prebys Medical Discovery Institute

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Anindya Bagchi, Ph.D., is joining the faculty of Sanford Burnham Prebys Medical Discovery Institute (SBP) as associate professor in the Tumor Initiation and Maintenance Program. Bagchi comes to SBP from the University of Minnesota.

Science

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Transgenic, GMO, Genetically engineered crops, Biofuel, grasses, Switchgrass, UW-Milwaukee , Plant Genetics, Green Energy

A 'Switch' for Switchgrass

A hardy perennial is a promising source of biofuel, and a UW-Milwaukee scientist is developing a technique to make a GMO version that cannot "infect" the genes of natural plants around it.

Medicine

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Depression, Stress, Serotonin, Genetics

Study Reverses Thinking on Genetic Links to Stress, Depression

For years, scientists have been trying to determine what effect a gene linked to the brain chemical serotonin may have on depression in people exposed to stress. But now, analyzing information from more than 40,000 people who have been studied over more than a decade, researchers led by a team at Washington University School of Medicine in St. Louis have found no evidence that the gene alters the impact stress has on depression.

Medicine

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Johns Hopkins University Society of Scholars, Society of Scholars, Eduardo Marban, Steven Piantadosi, cardiac stem cell infusion, cardiac stem cell research, cardiosphere-derived stem cells, CDCs

Pioneering Investigators in Experimental Heart Stem Cell and Cancer Therapies Recognized

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Two prominent Cedars-Sinai investigators — one leading the development of biological treatments for heart disease, the other spearheading the design and analysis of clinical trials for cancer research — were inducted April 3 into the Johns Hopkins University Society of Scholars. Eduardo Marbán, MD, PhD, and Steven Piantadosi, MD, PhD, are among a select group of medical researchers to receive the honor.

Medicine

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Drug Combination Shows Benefit in RAS-Driven Cancers

Dana-Farber Cancer Institute scientists report a number of patients in a small study with RAS-driven lung, ovarian, and thyroid cancers got long-term clinical benefit from a combination of two drugs that targeted molecular pathways controlled by the RAS gene.

Medicine

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Genetic Screening, Genome Sequence, whole genome, exome sequencing, Pediatric Cancer, BRCA, Leslie Robison, Life After Cancer Treatment, Jinghui Zhang, Childhood Cancer, cancer surveillance, Cancer Survivor

Study Finds More Childhood Cancer Survivors Would Likely Benefit From Genetic Screening

St. Jude Children’s Research Hospital has completed the first whole genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors carry mutations linked to an increased risk of cancer

Medicine

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Whitehead Institute, Piyush Gupta, Breast Cancer, genetics and cancer, Biomarker, Early Stage Breast Cancer, Metastasis, Aggressive Breast Cancer

Biomarker Identified for Likely Aggressive, Early Stage Breast Cancer

Whitehead Institute scientists have identified a gene that could help clinicians discern which patients have aggressive forms of early stage breast cancer, which could prevent hundreds of thousands of women from undergoing unnecessary treatment and save millions of dollars.

Medicine

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Icahn School of Medicine at Mount Sinai, the Mount Sinai Health System, Autism, Autism Genetics, Gene Sequencing, ASD, Autism and genetics, genetics and autism

Mount Sinai Researchers Receive Major NIH Award for Autism Genetics Research

$7 million grant extends Autism Sequencing Consortium through 2022 to collect genetic data of more than 50,000 individuals







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