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Medicine

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Uniformed Services University Of The Health Sciences, Uniformed Services University, USU, Usuhs, National Institute Of Allergy And Infectious Diseases, National Institute for Alcohol Abuse and Alcoholism, Atopic Dermatitis, severe eczema

New Genetic Mutations Linked to Eczema

A genetic mutation could be the cause of severe eczema, according to new research published June 19 in Nature Genetics by researchers at the Uniformed Services University of the Health Sciences (USU). Researchers believe these new findings could influence new treatment strategies for the millions of individuals who struggle with this chronic condition.

Medicine

Science

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Human Genome

Firefly Gene Illuminates Ability of Optimized CRISPR-Cpf1 to Efficiently Edit Human Genome

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Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases. 

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DNA-Cutting Enzyme, Drug for High-Risk Leukemias, Infant Sun Protection, and More in the Children's Health News Source

Click here for the latest research and features on Children's Health.

Medicine

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Opthalmalogy, Wayne State University, Micrornas, Pseudomonas aeruginosa (PA)-induced keratitis

Wayne State Receives $1.9 M NIH Grant to Develop Novel Therapy for Corneal Bacterial Infection

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Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) — a newly recognized level of gene expression regulation — in bacterial keratitis – an infection of the cornea caused by bacteria — as well as to identify new therapeutic targets and alternative treatment strategies.

Science

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Developmental Biology And Molecular Biology, Whitehead Institute, Terry Orr-Weaver, Embryo Development, mRNA translation

Elegant Switch Controls Translation in Transition From Egg to Embryo

The transition from an egg to a developing embryo is one of life’s most remarkable transformations. Now Whitehead Institute researchers have used fruit flies to decipher how one aspect—control of the translation of messenger RNAs (mRNAs) into proteins—shifts as the egg becomes an the embryo. This type of switch could tell scientists more about how human cells work and embryos develop.

Medicine

Science

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Liver, Bioengineering, human pluripotent stem cells, Liver Disease, hepatic diseases, Tissue Engineering, Nature, Research, Transplant, Genetics, Genomics, Cincinnati Children's Hospital Medical Center, pediatrics disorders, news, press release, Bioengineered

Bioengineered Human Livers Mimic Natural Development

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An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ’s developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells. The scientists report online in Nature on June 14 that their bioengineered human liver tissues still need additional rounds of molecular fine tuning before they can be tested in clinical trials.

Science

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San Diego Supercomputer Center, Uc San Diego, National Science Foundation (NSF) , New York University Department of Biology, xsede, DNA, Gordon Supercomputer, Drug Design, Cancer Research

Shape and Size of DNA Lesions Caused by Toxic Agents Affects Repair of DNA

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A team led by New York University researchers has identified and described how a major player in the repair process, called nucleotide excision repair or NER, works to recognize certain lesions for subsequent removal by the NER machinery.

Medicine

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ALS, Dementia, RNA, FTD, Toxic Peptides, Proteins, genes, Harvard Medical School, HMS, Harvard Medical School Study, Splicing Errors, Amyothrophic Lateral Sclerosis, Frontotemporal Dementia, C9ORF72 gene, Robin Reed, Peptides, GR PR Peptides, U2 snRNP

Assembly Failure

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At a glance: Most frequent genetic cause of ALS and a form of dementia (FTD) is known to produce toxic peptides that interfere with RNA splicing—an intermediary step in generating functional proteins from genes. New Harvard Medical School study finds these toxic peptides block assembly of the cellular machinery responsible for RNA splicing. This blockage leads to splicing errors for genes that regulate the workings of mitochondria and neurons and the expression of other genes. Restoring normal splicing function may be a therapeutic strategy for averting or treating the development of ALS, FTD or both.

Science

Life

Law and Public Policy

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DNA, DHS, S&T, R&D, Rapid DNA, DNA results, BLOG, facebook town hall

S&T Tech Uses DNA to Uphold Laws, Reunite Families

A DHS Science and Technology Directorate technology aptly named Rapid DNA reduces the 8 to 10 hour processing time for DNA results to 90 minutes.

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International Study Identifies New Genetic Risk Factors for Testicular Cancer

Peter Kanetsky, Ph.D., M.P.H., chair of the Cancer Epidemiology Department at Moffitt Cancer Center, and colleagues from the International TEsticular CAncer Consortium (TECAC), launched a large analysis of five major testicular cancer studies to investigate genetic risk factors linked to TGCT. Their results, which uncovered eight new genetic markers associated with TGCT, were published in the June 12 issue of Nature Genetics.







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