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New Lung “Organoids” in a Dish Mimic Features of Full-Size Lung

New lung “organoids”—tiny 3-D structures that mimic features of a full-sized lung—have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

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Dendritic Cell Vaccine Augments the Immune System in People with Non-Small Cell Lung Cancer

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UCLA scientists have discovered a dendritic cell vaccine that amplifies the response of the immune system in people with non-small cell lung cancer (NSCLC), the most common form of lung cancer. The study, which is the first to test the vaccine in humans, has important clinical implications as the method could boost the cancer-killing power of anti-PD-1 immunotherapies that are currently being evaluated in NSCLC and other advanced cancers, which are very difficult to treat successfully.

Medicine

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T Cell, Stem Cell, Cancer, Lung Cancer, Cancer Vaccine

Stem Cell Vaccine Found to Increase Immune Responses, Inhibit Tumors in Animal Models

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Researchers at the University of Cincinnati (UC) have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.

Medicine

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GABA neurotransmitter, Asthma, Inhaler, Asthma Inhaler, Inflammation, Lung Disease, asthma treatment, Pharmaceuticals, pill, Drug Discovery, Milwaukee Institute for Drug Discovery, UW-Milwaukee

Taming the Trouble with Inhalers: A New Way to Treat Asthma

What does asthma have in common with anxiety? New research shows that both can be treated with chemical compounds that exploit the calming effect of certain neurotransmitters. It could lead to fewer kids having to use an inhaler to take steroids.

Science

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Leigh syndrome, Hypoxia, Mitochondia, Proceedings Of The Natinal Academy Of Sciences, Brain Damage

Low Oxygen Reverses Mitochondrial Disease in Mice

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Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.

Medicine

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Tumor, Lung Cancer, Angiogenesis, Blood Vessels, Center for Molecular & Translational Medicine , Ming-Hui Zou, Endothelial Cells

Georgia State Researcher Gets $2.3 Million Grant to Study How to Reduce Tumor Growth in Lung Cancer

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Dr. Ming-Hui Zou, director of the Center for Molecular & Translational Medicine and a Georgia Research Alliance Eminent Scholar in Molecular Medicine, has received a five-year, $2.3 million federal grant to study how to reduce tumor growth in lung cancer.

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Penn Study Identifies New Target to Fight Prostate, Lung Cancer

A newly identified molecular chain of events in a mouse model of prostate cancer highlights novel targets to treat it and other cancers. A Penn team discovered that the overexpression of a protein called PKCε with the loss of the tumor suppressor Pten causes the progression of prostate cancer.

Medicine

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Robotic Surgery, Robotic Surgery for cancer, Robotic Lung Cancer Surgery, Lung Cancer, Esophageal Cancer Surgery, Esophageal Cancer, thoracic cancer, Thoracic Surgery

New Lung Cancer Center at NYU Langone Welcomes Renowned Thoracic Surgeon as Its Director

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Robert J. Cerfolio, MD – whose innovations in robotics have led to practice-changing advances in lung cancer surgery – will join NYU Langone as chief of clinical thoracic surgery. He also will become the first director of the Lung Cancer Center at NYU Langone’s Perlmutter Cancer Center.

Medicine

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Mount Sinai Health System, Lung Cancer, Immunotherapy, PD-1, PD-1 blockade, PD-L1 checkpoint inhibitors, Thoracic Surgery

Researchers Identify Immunotherapy Targets in Early-Stage Lung Cancer

Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance to take hold and offering a potential cure, according to a new Mount Sinai study published today in Cell.

Medicine

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artificial lungs , Pediatrics, Medical Technology, Medical Devices, Computer Simulation Research, Computer Simulation, Computational Biology, Medical Science, Pulmonary and Respiratory Medicine, pulmonary and critical care medicine, pulmonary biology, Pediatric Care Specialties, Supercomputing, Supercomputer Simulations, Supercomputing and high-performa

Engineering Researcher at MSU Helps Design Artificial Lung Device

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Children with chronic lung diseases often must wait months or even years for a transplant, while large, immobile hospital equipment that could help them breathe easier actually may worsen their condition by overtaxing already damaged lungs.







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