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Medicine

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Myelodysplastic Syndrome, Genetics, Genetic Profiling, Dana-Farber Cancer Institute, Blood Cancers, Cancer Alternative Medicine Biology Breast Cancer Nutrition/Nutrients Public Health, MDs

Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study Finds

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A single blood test and basic information about a patient’s medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, according to new research by scientists at Dana-Farber Cancer Institute.

Medicine

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Miller-Dieker Syndrome , Organoids

Human Brain ‘Organoids’ Offer New Insight Into Rare Developmental Disease

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations

Medicine

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Osteomyelitis, MRSA, Mrsa Infections, MRSA strains, MRSA superbug, Stem Cell, stem cell activation, stem cell bio-manufacturing, Stem Cell Development, Scaffold, Scaffold Proteins, Scaffolding, Scaffolds, Bone Infections, Bone Regeneration, silver ions, Silver

A Silver Bullet Against MRSA: Silver Ion-Coated Medical Devices Could Fight MRSA While Creating New Bone

The rise of MRSA infections is limiting the treatment options for physicians and surgeons. Now, an international team of researchers, led by Elizabeth Loboa, dean of the University of Missouri College of Engineering, has used silver ion-coated scaffolds, or biomaterials that are created to hold stem cells, which slow the spread of or kill MRSA while regenerating new bone. Scientists feel that the biodegradable and biocompatible scaffolds could be the first step in the fight against MRSA in patients.

Medicine

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Anti-Inflammatory, Anti-Cell Death Agent a Potential Treatment for Vision Loss Associated with Multiple Sclerosis

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A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania and Noveome Biotherapeutics.

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Promising Epigenetic Drug Target for Diabetes

A research report published in Clinical Epigenetics, suggests that epigenetic mechanism based drugs could become one of the treatment armamentarium of future anti-diabetic agents.

Science

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Cancer, Tumor, DNA, ecDNA, Genomics, Tumor Cells, Bioinfomatics

New Ludwig Research Will Shift How Cancer Diversity and Resistance Are Understood and Studied

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Ludwig researchers discover that circular DNA, once thought to be rare in tumor cells, is actually very common and seems to play a fundamental role in tumor evolution

Medicine

Science

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Scientists' Computational Models Predict Mutations' Effect on Proteins

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According to new research, the key to a successful, long-term relationship is for each partner to adapt to the other’s changes over time.

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Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

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“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.

Medicine

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Breast Cancer, Dendritic Cells, Immune Cells, Clinical Cancer Research, breast cancer vaccines, Breast Cancer Risk

Mayo Clinic Researchers Quantify Immune Cells Associated with Future Breast Cancer Risk

Researchers from Mayo Clinic have quantified the numbers of various types of immune cells associated with the risk of developing breast cancer. The findings are published in a study in Clinical Cancer Research.

Medicine

Science

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Super Bug, MRSA, Mrsa Infections, Drug Development, Drug Discovery, Marine Organisms, Harbor Branch Oceanographic Institute

Compound from Deep-Water Marine Sponge Could Provide Antibacterial Solutions for MRSA

A compound extracted from a deep-water marine sponge collected near the Bahamas is showing potent antibacterial activity against the drug resistant bacteria methicillin-resistant Staphylococcus aureus (MRSA) also called the “super bug.”

Medicine

Science

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Biochemistry, Dna Repair, Nucleotide Excision Repair, Cancer

How Life Survives: UNC Researchers Confirm Basic Mechanism of DNA Repair

Day in and day out, the DNA in our cells is damaged for a variety of reasons, and thus DNA-repair systems are fundamental to the maintenance of life. Now UNC scientists have confirmed and clarified key molecular details of one of these repair systems, known as nucleotide excision repair.

Medicine

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Immune Cells, Mast Cells, Stress, Autoimmune Disease And Disorder, Allergies, Irritable Bowel Syndrome, Migraines, RNA, sex-specific associations , Gene Expression

Why Male Immune Cells Are From Mars and Female Cells Are From Venus

Michigan State University researchers are the first to uncover reasons why a specific type of immune cell acts very differently in females compared to males while under stress, resulting in women being more susceptible to certain diseases.

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CWRU Researchers Secure $2m NIH Grant to Test Portable Sickle Cell Monitor

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Researchers at Case Western Reserve University will use a $2 million grant from the National Institutes of Health to develop and test a small, portable blood-adhesion monitor for sickle cell disease patients. They hope to make the device as useful as at-home insulin monitors diabetes patients use to manage their disease.

Medicine

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drug, Aging, Cell Signaling, cell signaling pathways

UNM Cancer Center Researcher Discovers New Class of Drugs to Combat Aging Diseases

Eric Prossnitz, PhD and his team uncovered new details of the aging process. They discovered an altered balance between certain signaling molecules in the smooth muscle cells of blood vessels and the heart. The team also discovered a new class of drugs that combats an important part of the aging process.

Medicine

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Dna Barcoding, Nanoparticle, Gene Therapy

DNA “Barcoding” Allows Rapid Testing of Nanoparticles for Therapeutic Delivery

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Using tiny snippets of DNA as “barcodes,” researchers have developed a new technique for rapidly screening the ability of nanoparticles to selectively deliver therapeutic genes to specific organs of the body. The technique could accelerate the development and use of gene therapies for such killers as heart disease, cancer and Parkinson’s disease.

Medicine

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Organoids, Miller-Dieker Syndrome , Brain Development, Lissencephaly, Stem Cells

Human Brain ‘Organoids’ Offer New Insight into Rare Developmental Disease

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.

Science

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Evolution, Genome, Genome size

Genomes in Flux: New Study Reveals Hidden Dynamics of Bird and Mammal DNA Evolution

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Evolution is often thought of as a gradual remodeling of the genome, the genetic blueprints for building an organism. But in some instance it might be more appropriate to call it an overhaul. Over the past 100 million years, the human lineage has lost one-fifth of its DNA, while an even greater amount was added, report scientists at the University of Utah School of Medicine. Until now, the extent to which our genome has expanded and contracted had been underappreciated.

Medicine

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Scientists Catalogue “Parts List” of Brain Cell Types in a Major Appetite Center

Using Harvard-developed technology, scientists at Beth Israel Deaconess Medical Center (BIDMC) have catalogued more than 20,000 brain cells in one region of the mouse hypothalamus. The study, published in Nature Neuroscience, revealed some 50 distinct cell types, including a previously undescribed neuron type that may underlie some of the genetic risk of human obesity. This catalog of cell types marks the first time neuroscientists have established a comprehensive “parts list” for this area of the brain. The new information will allow researchers to establish which cells play what role in this region of the brain.

Medicine

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Cancer, immune therapy, Immunotherapy, Precision Medicine, Cells, Tumours, princess margaret cancer centre, University Health Network

Immune Therapy Scientists Discover Distinct Cells That Block Cancer-Fighting Immune Cells

Princess Margaret Cancer Centre scientists have discovered a distinct cell population in tumours that inhibits the body’s immune response to fight cancer.

Science

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Biological and Environmental Research, biological and environmental sciences, Mercury, Methylmercury, mercury in the environment, Applied and Environmental Microbiology, Microbiology, Microbes, microbes and cleanup, Oak Ridge National Laboratory, mercury science, Neurotoxins, neurotoxin, Genetics, microbial genetics, methylmercury production, Biology

Methylmercury Sleuths Armed with New Spotlight

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Researchers can now more quickly identify which microbes produce mercury toxins in the environment. These findings will enable a more realistic view of possible methylmercury production in a specific setting.







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