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Medicine

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Zinc in the Retina May Indicate A New Way to Protect and Regenerate the Optic Nerve in Glaucoma Patients

Connecting pieces of information by finding a common thread often takes glaucoma researchers in unexpected directions. Zinc is one such thread that joined together different experts at Boston Children’s Hospital and Harvard Medical School.

Medicine

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Pavlovian response, NEURON ACTIVITY, Alzheimer's Disease, Parkinson's Disease, Tourette Syndrome, Learning

Study Identifies Brain Cells Involved in Pavlovian Response

UCLA scientists have traced the Pavlovian response to a small cluster of brain cells -- the same neurons that go awry during Huntington’s disease, Parkinson’s disease and Tourette syndrome. The research could one day help scientists find new approaches to diagnosing and treating these neurological disorders.

Science

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Tree Of Life, Cornell University, Taxonomy, Ecology & Evolution, Ecology, Evolutionary Biology, Biodiversity

Cornell Evolutionary Biologist Explains How to 'Walk the Tree of Life'

Harry Greene, professor of ecology and evolutionary biology at Cornell University, and Cissy Ballen of the University of Minnesota have just published a paper in PLOS Biology, “Walking and Talking the Tree of Life: Why and How to Teach About Biodiversity,” discussing why the evolutionary TOL approach to biodiversity is best, to what extent the traditional taxonomy is still used and how to teach TOL using an active learning approach.

Science

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Membrane Fusion, Cell Biology, Snare, molecular biology of the cell, American Society For Cell Biology

New Cell Membrane Fusion Model Challenges Dogma

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Membrane fusion lies at the heart of many cell functions—from the secretion of antibodies to the release of neurotransmitters. For more than two decades, one view of the process by which membrane fusion occurs has been accepted as dogma; now recent studies indicate that fusion is more complex. These discoveries are being regarded by at least one leading cell biologist as “textbook changing” and could alter how we develop drugs that affect membrane fusion activities.

Science

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Metals, DNA, metal-containing drugs , Drugs, Cancer, Molecular Mechanisms, chemotherapeutic, Agents, Leticia González , University of Vienna, Jacinto Sá, Uppsala University , Interact

How Do Metals Interact with DNA?

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Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. The lack of knowledge about the underlying molecular mechanisms slows down the search for new and more efficient chemotherapeutic agents. An international team of scientists, led by Leticia González from the University of Vienna and Jacinto Sá from the Uppsala University, have developed a protocol that is able to detect how metal-based drugs interact with DNA.

Medicine

Science

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Tendon, Tendon Injury, stretch, Bioengineering, Engineering

Combating Wear and Tear

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University of Utah bioengineering researchers have discovered that damage to collagen, the main building block of all human tissue, can occur much earlier at a molecular level from too much physical stress. This could be helpful for some who want to know earlier if they are developing diseases such as arthritis or for athletes whose bodies are taking a toll.

Medicine

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New Software Tool Powers Up Genomic Research

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A group of computational biological researchers, led by Stony Brook University’s Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads. The research was published in the March 6 edition of Nature Methods. .

Medicine

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Brain Degenerative Disease, Degenerative Disease

Researchers Identify Potential Treatment for Type of Muscle and Brain Degenerative Disease

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UCLA researchers have discovered the molecular basis of an incurable disease known as inclusion body myopathy, Paget disease with frontotemporal dementia, or IBMPFD. Using both fruit flies and human cells the researchers discovered how IBMPFD mutations cause cellular damage, and identified two compounds that are able to reverse the mutations effects. The findings suggest potential strategies to combat IBMPFD and other diseases, including ALS.

Medicine

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CDA, Anemia, Stem Cell Transplant, Hematology

First Patient Cured of Rare Blood Disorder

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Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians at the University of Illinois Hospital & Health Sciences System have documented the first cure of an adult patient with congenital dyserythropoietic anemia.

Medicine

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Genomics, Appointment, Partnership, Pediatric Cancer

Sanford Burnham Prebys Scientist Joins Forces with Rady Children's for Genomic Medicine to Fight Childhood Brain Cancer

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Rady Children’s Institute for Genomic Medicine (RCIGM) announced that Robert Wechsler-Reya, Ph.D., has been named program director for the Joseph Clayes III Research Center for Neuro-Oncology and Genomics at RCIGM. Wechsler-Reya, a professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), will retain his position as director of the Tumor Initiation and Maintenance Program at SBP’s NCI-designated Cancer Center and will hold a joint appointment at RCIGM.







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