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'DNA Is a Bully' That Hustles Transcribers to Targets

"DNA is a bully." That's how researcher Jeffrey Skolnick sums up the dominant power of DNA motion among the forces acting upon transcription factors as they move through DNA's winding thickets to their target sites. He and Edmond Chow have programmed a very large, unique simulation that tests and corroborates the hypothesis.

Science

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DOE Office of Science, Microbiology, DOE JGI, Genomics, Energy, Environment, Biotechnology, Biodiversity, Bacteria, Archaea, Biogeochemistry, Microbes, Biology

Uncovered: 1000 New Microbial Genomes

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Microbes play important roles in regulating Earth’s biogeochemical cycles and in Nature Biotechnology, U.S. Department of Energy Joint Genome Institute scientists report the release of 1,003 phylogenetically diverse bacterial and archaeal reference genomes—the single largest release to date.

Science

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Biotechnology, Cell Biology, Cell Division, Cell Division Regulation, cytokine abscission

Splitting Cells: How a Dynamic Protein Machinery Executes ‘the Final Cut’

Every day billions of cells die in our body and need to be replaced by newly dividing cells. Cell division is a beautifully orchestrated process that involves multiple critical steps. At the very end, “cellular abscission” splits the membrane and thereby gives birth to two daughter cells. Abscission is executed by a protein machinery named ESCRT-III. ESCRT-III consists of many subunits that form spiral-shaped filaments to constrict the membrane tube connecting the daughter cells until it splits. Insights into the function of ESCRT-III are also interesting for many other biological processes – as this machinery also pinches off viruses from the host cell membrane, and seals holes in cellular and nuclear membranes.

Science

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Technology Unlocks Mold Genomes for New Drugs

Fungi are rich sources of natural molecules for drug discovery, but numerous challenges have pushed pharmaceutical companies away from tapping into this bounty. Now scientists at Northwestern University, the University of Wisconsin-Madison and the biotech company Intact Genomics have developed technology that uses genomics and data analytics to efficiently screen for molecules produced by molds to find new drug leads -- maybe even the next penicillin. From three diverse fungal species, the research team discovered 17 new natural products.

Science

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Regeneration, Flatworms, Planaria, Space Travel, International Space Station, SpaceX, Bioengineering

Space-Traveling Flatworms Help Scientists Enhance Understanding of Regenerative Health

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Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration. The research has implications for human and animal space travelers and for regenerative and bioengineering science.

Science

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Binge Eating, binge eating disorder, Eating Disorder, Overeating, Maternal Stress And Anxiety During Pregnancy, Maternal Stress, CHEN

Mice Exposed to Prenatal Stress Are Predisposed to Eating Disorders Later in Life

Researchers at the Weizmann Institute of Science have found that in utero exposure to stress, then experiencing stressors after birth, can lead to overeating disorders in females. However, the scientists were able to prevent the onset of the disorders through dietary intervention.

Science

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maya schuldiner, EMBO Gold Medal Award, American Society For Cell Biology, ASCBEMBO meeting

2017 EMBO Gold Medal Awarded to ASCB Member Maya Schuldiner

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Maya Schuldiner of the Weizmann Institute of Science in Israel has won the prestigious EMBO Gold Medal for 2017. At a ceremony on December 4 at the 2017 ASCB/EMBO meeting in Philadelphia, Schuldiner will receive the medal and present her research at the EMBO Gold Metal Lecture.

Science

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Developmental Biology, Anatomy, Editor In Chief, Developmental Dynamics, Stowers Insitute, American Association of Anatomists, organismal biology

New Editor in Chief Appointed to Developmental Dynamics Journal

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American Association of Anatomists (AAA) is proud to announce the newest Editor-in-Chief of our leading developmental biology journal, Developmental Dynamics. Paul Trainor, Ph.D., Investigator at Stowers Institute for Medical Research was approved by the Board of Directors in April 2017, and will take over as Editor-in-Chief on January 1, 2018.

Science

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Acetylation, protein acetylation

Yeast Study Examines How Cells Respond and Adapt to Heat Stress

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A University of Arkansas biologist is studying heat-stress response in yeast to help determine the role of protein acetylation in cells

Medicine

Science

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Mining the Data Mother Lode

One of the newest entities with the Penn Institute for Biomedical Informatics, the Health Language Processing Lab combines social media content with other sources of health information in a unique way aimed at understanding how people use language to communicate health needs.







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