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Organized Prescription Drug Collection Programs May Have Minimal Impact on Reducing Availability of Controlled Medications

More than 3.8 billion controlled medications, such as hydrocodone, oxycodone, Valium and Adderall, are dispensed by pharmacies annually in the United States. It has been estimated that only about 30 percent of these drugs are used by the people for whom they were prescribed. The remaining 70 percent represent a large surplus of controlled medications that could be abused or sold to others for abuse.

Medicine

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X-ray Crystallogaphy, Medicine, Solid State, Chemistry, Dosage, Cancer, rare disease, Antiviral Drugs, Global Health, pediatric diseases

AAPS Announces Dale E. Wurster Award in Pharmaceutics

The American Association of Pharmaceutical Scientists is pleased to announce the 2016 Dale E. Wurster recipient, Stephen R. Byrn, Ph.D., of Purdue University. Byrn is recognized for his work in the field of Solid State Chemistry of Drugs. Supported by the Dale E. Wurster Endowment, this award is given to individuals who have made significant contributions to the pharmaceutical sciences in the specific field of pharmaceutics.

Medicine

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Biologics, Personalized Medicine, polymyalgia rheumatica, Precision Medicine, Rheumatoid Arthritis, Sarcoidosis, Vasculitis

Mayo Clinic Research Sheds Light on Why Some Rheumatoid Arthritis Patients Respond Poorly to Biologics

A Mayo Clinic study is shedding light on why some rheumatoid arthritis patients respond poorly when treated with tumor necrosis factor inhibitors, part of a class of drugs called biologics.

Medicine

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CDC, Antibiotic, Antibiotic Resistant Infections, Resistant Bacteria, Drug Resistant Bacteria, Infection

Let’s “Get Smart About Antibiotics” Week

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The discovery of antibiotics remains one of the most important medical advances to date, but overuse and inappropriate use of antibiotics has led to many infections becoming resistant to treatment.

Medicine

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Celebrex, Celecoxib, Lexapro, Depression, inflammation and depression, Bipolar Disorder

Arthritis Drug Boosts Effectiveness of Antidepressant Medication

Giving severely depressed patients the arthritis drug celecoxib (Celebrex®) dramatically boosted the effectiveness of their antidepressant medication, a Loyola study has found.

Medicine

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genes, Genome, Health, Biochemistry, Personalized Medicine, DNA, Medicine

First Cellular Atlas of DNA-Binding Molecule Could Advance Precision Therapies

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Biochemists at the University of Wisconsin–Madison have created the first atlas that maps where molecular tools that can switch genes on and off will bind to the human genome. It is a development they say could enable these tools to be targeted to specific parts of an individual’s genome for use in precision medicine, developing therapies and treating disease.

Medicine

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interleukin 33, IL-33, Itch Gene, Antibodies, Poison Ivy Rash, Poison Ivy Treatment, Atopic Dermatitis, Psoriasis, Dermatologic Conditions, Duke Health, PNAS

Mouse Study Shows Antibody Can Soothe Raging, Nerve-Driven Poison Ivy Itch

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Scientists at Duke Health and Zhejiang Chinese Medical University have developed a strategy to stop the uncontrollable itch caused by urushiol, the oily sap common to poison ivy, poison sumac, poison oak and even mango trees. The team found that by blocking an immune system protein in the skin with an antibody, they could halt the processes that tell the brain the skin is itchy.

Medicine

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Sirna, Cancer, Ovarian Cancer, nanohydrogel, Targeted Drug Delivery, Cisplatin, Chemo Therapy, Kinase, EGF receptor, EGFR, EGFR inhibitor, Egfr Mutations, EGFR gene, Carcinoma, Tumor, epithelial cancer

Punching Cancer with RNA Knuckles

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Researchers achieved an unexpected eye-popping reduction of ovarian cancer during a successful test of targeted nanohydrogel delivery in vivo in mice. Adding cisplatin eliminated or starkly diminished tumors.

Medicine

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Ribosome, catalytic center, chloramphenicol, Linezolid

Two Antibiotics Fight Bacteria Differently Than Thought

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Two widely prescribed antibiotics — chloramphenicol and linezolid — may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found. Instead of indiscriminately stopping protein synthesis, the drugs put the brakes on the protein synthesis machinery only at specific locations in the gene.

Medicine

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HTA, voice of the patient, rare disease, Orphan Drugs

ISPOR 19th Annual European Congress Explores How HTA Bodies Can Consider the Voice of Patients with Rare Diseases

The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) led a session this afternoon entitled, "From Testimonials to Qualitative Research Embedded in Clinical Trials: How Do Health Technology Assessment Bodies Consider the Voice of Rare Disease Patients When Granting Access to Orphan Drugs?" The discussion took place at the Society’s 19th Annual European Congress—in Vienna, Austria.

Medicine

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Rna Interference, Rnai, Drug Development, RNA, RXi Pharmaceuticals, Geert Cauwenbergh, sd-rxRNA, RXI-109, connective tissue growth factor, CTGF, Fibrosis, scar formation, retinal scarring, age-related macular degeneration, AMD, hypertrophic scar

Expert: How Can ‘RNA Interference’ Enhance Drug Development?

Medicine

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Cancer, Brain Cancer, Pediatric Cancer, MEK inhibitors

Promise of Better Targeted Treatments Now Possible in Children’s Brain Cancer

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer. Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue. The research was conducted using a new zebrafish animal model system developed by the researchers, which closely resembles an aggressive subtype of pediatric brain tumors.

Medicine

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Anesthesia, Anesthesia And Critical Care, Alzheimer's Disease

Experimental Drug Shows Promise in Treating Alzheimer’s Disease

An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY® 2016 annual meeting.

Medicine

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Cancer, Breast Cancer, Precision Medicine, Cancer Recurrence

Precision Medicine Test Helps Guide Breast Cancer Patients’ Chemotherapy Decision

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One of the earliest widespread applications of precision medicine in cancer care is helping patients and physicians decide whether chemotherapy is needed, a new study finds.

Medicine

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Back Pain Research, Opioids, anesthesia and pain management, Anesthesiology and Critical Care

Many Back Pain Patients Get Limited Relief From Opioids and Worry About Taking Them, Survey Shows

Millions of people take opioids for chronic back pain, but many of them get limited relief while experiencing side effects and worrying about the stigma associated with taking them, suggests research presented at the ANESTHESIOLOGY® 2016 annual meeting.

Medicine

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Fibroids, Uterine Fibroids, Hysterectomy, Women's Health

Michigan Joins National, $20M Research Project to Improve Fibroid Treatment

The University of Michigan will join nine other clinical centers across the country working to compare the effectiveness of different treatment strategies for women with uterine fibroids.

Medicine

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Glioblastoma, Cancer, Neurology, Drug Development, Brain Cancer

Depriving Deadly Brain Tumors of Cholesterol May Be Their Achilles’ Heel

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Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

Medicine

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Cancer, Cancer Research, Dr. Jann Sarkaria, Massachusetts Institute Of Technology, National Cancer Institute, news release, Physical Sciences-Oncology Centers

Mayo Clinic and Massachusetts Institute of Technology Receive Grant to Support Physical Sciences-Oncology Center

ROCHESTER, Minn. — Mayo Clinic and the Massachusetts Institute of Technology (MIT) have been awarded a five-year, $9.7 million grant from the National Cancer Institute (NCI) to support a Physical Sciences-Oncology Center (PS-OC). Researchers hope to learn more about the physical parameters that limit drug delivery into brain tumors and use this information to build models that will help physicians better predict how the body will distribute a particular drug to brain tumors and help them select the best drug to treat each patient based on their unique tumor.

Medicine

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Tuburculosis, Supplement, supplement risks , supplemental nutrition, Botancal, Treatment, Drug Treatment, Botanical Products, Botanical Research, Herbal, Herbal Medicine, Herbal Remedies, Medical Treatment, Tuberculosis, tuberculosis resistance, Tuberculosis treatment

Anti-Tuberculosis Drug Disrupted by Botanical Supplement, Can Lead to Development of Disease

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A new study from the University of Missouri in partnership with scientists in Africa has uncovered evidence that these supplements and their antioxidants may reduce the effectiveness of prescription medications. The researchers examined the effects of a widely used African botanical supplement, called Sutherlandia, and found that it may disrupt the effectiveness of a common anti-tuberculosis drug. This could lead to the development of active tuberculosis and perhaps drug resistant forms of the pathogen in some patients.

Medicine

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Center for Individualized Medicine, Medical Research, Molecular Testing, Dna Sequencing, Pharmacogenomics, Precision Medicine, whole exome sequencing

4 Tips for Patients Seeking Individualized Medicine

The promise of precision medicine is becoming a reality as more doctors bring individualized therapies to the bedside.







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