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National Institute Of Environmental Health Sciences, Niehs, Antidepressant, Amitriptyline, blood-brain barrier, central nervous system, P-glycoprotein, Rat study

Antidepressant May Enhance Drug Delivery to the Brain

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New research from the National Institutes of Health found that pairing the antidepressant amitriptyline with drugs designed to treat central nervous system diseases, enhances drug delivery to the brain by inhibiting the blood-brain barrier in rats. The blood-brain barrier serves as a natural, protective boundary, preventing most drugs from entering the brain. The research, performed in rats, appeared online April 27 in the Journal of Cerebral Blood Flow and Metabolism.

Medicine

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Cordant’s Drug Take-Back Service Helps Prevent Adolescent Opioid Misuse

Medication theft from the home is a leading cause of prescription drug overdose deaths, but nearly 70 percent of prescription opioid medications kept in homes with children are not stored safely, according to the Johns Hopkins Bloomberg School of Public Health. National Drug Take-Back Day is April 29. It is an important opportunity to appropriately dispose of unwanted prescription medications. In addition to a federal program, there is an easy-to-use, drug take-back program, sponsored by Cordant Health Solutions,

Medicine

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American Society for Investigative Pathology , Liver, Acetaminophen, Acetaminophen Overdose, acetaminophen induced liver injury, P53, Liver Failure

p53 Critical to Recovering from Acetaminophen Overdose

A new study shows that after an acetaminophen overdose, the p53 protein plays a key role in preventing the progression of liver damage and signaling the liver to repair itself. The findings could lead to new treatments for people who overdose on this popular pain reliever and fever reducer.

Medicine

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Immunotherapy, Maraba, non-small cell lung cancer

Hamilton Patient First to Receive Experimental Immunotherapy Combination for Cancer in Clinical Trial

Experts at Hamilton Health Sciences (HHS) and McMaster University, in partnership with The Ottawa Hospital, have begun a clinical trial to determine if the unique experimental immunotherapy combination may be able to treat non-small cell lung cancer. The experimental therapy combines two different viruses with an approved drug to stimulate the immune system to recognize and attack cancer cells.

Medicine

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Circadian Clock

“Cyclops” Algorithm Spots Daily Rhythms in Cells

Humans, like virtually all other complex organisms on Earth, have adapted to their planet’s 24-hour cycle of sunlight and darkness. That circadian rhythm is reflected in human behavior, of course, but also in the molecular workings of our cells. Now scientists have developed a powerful tool for detecting and characterizing those molecular rhythms -- a tool that could have many new medical applications, such as more accurate dosing for existing medications.

Medicine

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Anaesthesia, global anesthesia, Malawi, Patient Safety, Surgery, safe surgery, Anesthesia, Lifebox, pulse oximeter, anesthesia training

Study Reveals How Lifebox Pulse Oximeters Lead to Patient Safety Improvement

A new report published today in the journal Anaesthesia reveals the positive impact of the donation of Lifebox pulse oximeters and training to patient safety in Malawi.

Medicine

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Mortality, Opioid Use Disorder, General Healthcare System

'Alarmingly High' Risk of Death for People with Opioid Use Disorder in General Medical Care

Almost one-fifth of patients with opioid use disorder (OUD) in a large healthcare system died during a four-year follow-up period, reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published by Wolters Kluwer.

Medicine

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Anesthesiology, Surgery, Opioids, Methadone, Pain Medicine, Postoperative Pain

Methadone May Reduce Need for Opioids After Surgery

Patients undergoing spinal fusion surgery who are treated with methadone during the procedure require significantly less intravenous and oral opioids to manage postoperative pain, reports a new study published in the May issue of Anesthesiology.

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Preliminary Study Suggests Possible New Treatment for MS

A small, preliminary study may show promise of a new type of treatment for progressive multiple sclerosis (MS). Results from the first six people enrolled in the phase 1 study, a study designed to enroll 10 people, are being presented at the American Academy of Neurology’s 69th Annual Meeting in Boston, April 22 to 28, 2017.

Science

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Bladder Cancer, bladder cancer clinical trial, bladder cancer metastasis, bladder, bladder cancer treatment, atezolizumab, FDA Approval, FDA, FDA Cleared, bladder tumor, checkpoint inhibitors

NYU Langone Research Leads to Accelerated Approval of Bladder Cancer Immunotherapy Drug

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Findings from a clinical trial led by a researcher at NYU Langone’s Perlmutter Cancer Center helped pave the way for the recent, accelerated approval by the U.S. Food and Drug Administration (FDA) of a highly effective immunotherapy as first line treatment for patients with advanced bladder cancer who are not eligible for treatment with standard chemotherapy







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