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Released: 6-Nov-2017 11:05 AM EST
Trained T-Cells to Target Toxic Viruses in Pediatric Patients
Children's Hospital Los Angeles

Children’s Hospital Los Angeles has been awarded $4.8 million by the California Institute for Regenerative Medicine (CIRM) to study the use of a new T-cell therapy to help fight active viral infections in children with severe immune deficiencies.

Released: 6-Nov-2017 11:05 AM EST
FDA Announces First Approval of Targeted Therapy Based on Basket Study
Memorial Sloan Kettering Cancer Center

The US Food and Drug Administration (FDA) has announced that it has approved the drug vemurafenib for the treatment of patients with BRAF V600-mutant Erdheim-Chester disease (ECD). This is the first approval of a targeted therapy based on a basket study and the first-ever drug approved for ECD, a rare blood disorder. This landmark approval came as a direct result of research at Memorial Sloan Kettering Cancer Center (MSK).

30-Oct-2017 9:00 AM EDT
In Hypertensive Patients, Greater Blood Pressure Drops May Harm the Kidneys
American Society of Nephrology (ASN)

• In patients treated for hypertension, greater reductions in mean blood pressure were linked with reduced kidney function. • Results from the analysis will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

30-Oct-2017 9:00 AM EDT
NightTime Blood Pressure May Predict Risk of Kidney Failure in Children with Kidney Disease
American Society of Nephrology (ASN)

• Among children with impaired kidney function, those with high blood pressure at night experienced a faster time to kidney failure than children with normal blood pressure. This decline was even more pronounced in patients with high blood pressure during both day and night when compared with children with normal blood pressure. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

27-Oct-2017 1:05 PM EDT
Inflammation in Middle Age May Be Tied to Brain Shrinkage Decades Later
American Academy of Neurology (AAN)

People who have biomarkers tied to inflammation in their blood in their 40s and 50s may have more brain shrinkage decades later than people without the biomarkers, according to a study published in the November 1, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 1-Nov-2017 3:05 PM EDT
Sepsis: The Unknown Medical Emergency
University of Alabama at Birmingham

Little-known sepsis is a medical emergency, a life-threatening condition caused by an overwhelming response by the body to infection. It's a leading cause of in-hospital death, and one of the most expensive conditions for U.S. hospitals. Forty percent of patients diagnosed with severe sepsis die, and half of the survivors suffer from a debilitating condition known as post-sepsis syndrome. Sepsis has also been named the most expensive in-patient cost in American hospitals, according to a study published by the Agency of Healthcare Research Policy. Costs to hospitals in 2014 reached nearly $24 billion.

1-Nov-2017 2:00 PM EDT
New Tissue-Engineered Blood Vessel Replacements One Step Closer to Human Trials
University of Minnesota College of Science and Engineering

Researchers at the University of Minnesota have created a new lab-grown, first-of-its-kind nonsynthetic, decellularized graft that becomes repopulated with cells by the recipient’s own cells when implanted.

Released: 31-Oct-2017 3:45 PM EDT
Sickle Cell Conference to Focus on Causes and Pathways to a Cure
American Physiological Society (APS)

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society (APS), will explore SCD—the world’s most prevalent single-gene mutation disease—and new research on preventing and reversing its deadly consequences.

Released: 31-Oct-2017 2:05 PM EDT
Radon on the Radar
University of North Dakota

Researchers have known for decades that exposure to radon may cause lung cancer, and that North Dakota and Iowa have some of the highest radon rates in the country. Could radon potentially cause other cancers? Researchers from the geography department and the School of Medicine & Health Sciences teamed up to explore that possibility. Along with a high incidence of radon, North Dakota also has the highest rate in the nation of chronic lymphocytic leukemia, or CLL. No one knows what causes this cancer, which usually is found in people over age 70. It is not curable but is treatable for some patients. Could there be a correlation?

Released: 31-Oct-2017 11:00 AM EDT
Mayo Clinic to Offer CAR T-Cell Therapy for Relapsed Non-Hodgkin Lymphoma
Mayo Clinic

Mayo Clinic announced today that its Rochester campus is one of 16 cancer centers nationally selected to provide chimeric antigen receptor T-cell therapy (CAR T-cell therapy) for adults with B-cell non-Hodgkin lymphoma who have not responded to, or have relapsed, after two or more lines of treatment.

Released: 31-Oct-2017 8:05 AM EDT
How an Interest in Bipolar Disorder Drugs Led to a Better Understanding of Leukemia
American Society for Biochemistry and Molecular Biology (ASBMB)

A research project that began 20 years ago with an interest in how lithium treats mood disorders has yielded insights into the progression of blood cancers such as leukemia. The research, which centers on a protein called GSK-3, will be published in the Nov. 3 issue of the Journal of Biological Chemistry.

   
Released: 30-Oct-2017 10:05 AM EDT
Umbilical Cord Blood Improves Motor Skills in Some Children With Cerebral Palsy
Duke Health

An infusion of cells from a child’s own umbilical cord blood appears to improve brain connectivity and motor function in children with spastic cerebral palsy, according to a randomized clinical trial published this week by Stem Cells Translational Medicine.

Released: 26-Oct-2017 10:05 AM EDT
Stars Come Out for AARDA
Autoimmune Association

Actors, singer-songwriters, musicians and others lend their talents to help end autoimmune disease

Released: 26-Oct-2017 9:05 AM EDT
Hypertension in Women: Review Calls for More Data to Improve Treatment
American Physiological Society (APS)

Women account for half of all cases of high blood pressure (hypertension) in the U.S., yet the majority of hypertension research focuses on men. A review of more than 80 studies highlights sex differences in hypertension-related kidney (renal) disease and explores possible reasons why women respond differently than men. The article, published in the American Journal of Physiology—Renal Physiology, emphasizes the need for more hypertension research in females.

Released: 25-Oct-2017 10:05 AM EDT
Insights From a Rare Genetic Disease May Help Treat Multiple Myeloma
American Chemical Society (ACS)

A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. Now scientists, reporting in ACS Central Science, have found that insights into a rare genetic disease known as NGLY1 deficiency could help scientists understand how that resistance works — and potentially how drugs can outsmart it.

Released: 23-Oct-2017 11:05 AM EDT
Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers
Perelman School of Medicine at the University of Pennsylvania

Researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways. Myc is a critical gene in governing cell proliferation and survival.

18-Oct-2017 12:00 AM EDT
Screening for Hepatitis C Improves Opioid Abuse Treatment Outcomes
American Association for the Study of Liver Diseases (AASLD)

Research presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – shows people in treatment for opioid substance abuse significantly lowered their non‐prescribed opioid use after testing positive for hepatitis C virus.

18-Oct-2017 12:00 AM EDT
Direct‐Acting Antiviral Therapy Cuts Liver Cancer Risk By 71%
American Association for the Study of Liver Diseases (AASLD)

A new study presented this week at The Liver Meeting® — held by the American Association for the Study of Liver Diseases — found that eradication of the hepatitis C virus induced by direct‐acting antiviral medications is associated with a 71 percent reduction in the risk of liver cancer.

Released: 19-Oct-2017 5:05 PM EDT
Dana-Farber and Brigham and Women’s researchers laud FDA approval of CAR T-cell therapy for non-Hodgkin Lymphoma
Dana-Farber Cancer Institute

Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women’s Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. Dana-Farber/Brigham and Women’s Cancer Center, the only facility in the northeast to be part of the clinical trial, is one of a few locations certified to offer this new therapy nationwide.

Released: 19-Oct-2017 11:05 AM EDT
New Gene-Altering Treatment Offered for Certain Blood Cancers
Washington University in St. Louis

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers. Newly approved by the Food and Drug Administration (FDA) for types of advanced non-Hodgkin lymphoma in adults, the CAR-T cell therapy harnesses a patient’s own immune system to fight cancer.

Released: 19-Oct-2017 10:55 AM EDT
Insulin Signaling Molecule in Liver Controls Levels of Triglyceride in Blood
Perelman School of Medicine at the University of Pennsylvania

A new animal study shows how insulin controls the movement and storage of fat molecules in the liver and how a breakdown in this system could lead to non-alcoholic fatty liver disease and changes in circulating lipid levels associated with cardiovascular disease.

Released: 18-Oct-2017 7:05 PM EDT
UChicago Medicine First Site in Illinois Offering Pioneering CAR T-Cell Therapy for Cancer
University of Chicago Medical Center

The U.S. Food and Drug Administration today approved the use of a breakthrough cancer treatment — Yescarta (axicabtagene ciloleucel) — for adult patients with relapsed or refractory diffuse large B-cell lymphoma. Approval came just weeks after making the therapy available for young patients with leukemia. The University of Chicago Medicine is the first site in Illinois to be certified by both Kite Pharma Inc. and Novartis.

Released: 16-Oct-2017 2:00 PM EDT
Researchers Discover New Blood Test That May Diagnose Breast Cancer
Christiana Care Health System

In a potential major breakthrough in breast cancer research, scientists at the Center for Translational Cancer Research (CTCR) at the Helen F. Graham Cancer Center & Research Institute of Christiana Care Health System have developed a revolutionary new blood test to diagnose breast cancer.

12-Oct-2017 10:00 AM EDT
Bolstering Fat Cells Offers Potential New Leukemia Treatment
McMaster University

Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, according to a study from McMaster University's Stem Cell and Cancer Research Institute and published in Nature Cell Biology.

13-Oct-2017 4:05 PM EDT
Flu Vaccine Failed to Protect Young Leukemia Patients During Cancer Treatment
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital investigators said the results reinforce the importance of hand washing and other measures to help protect vulnerable patients from influenza infections.

Released: 13-Oct-2017 11:05 AM EDT
Worms Reveal Secrets of Aging
Case Western Reserve University

Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals. In a Nature Communications study published today, researchers showed that worms with excess levels of certain proteins lived longer and healthier than normal worms. In addition, mice with excess levels of these proteins demonstrated a delay in blood vessel dysfunction associated with aging. The study has major implications for our understanding of aging and age-associated disorders.

Released: 12-Oct-2017 5:05 PM EDT
Lawmakers Participate in Bleeding Control Training Hosted by American College of Surgeons on Capitol Hill
American College of Surgeons (ACS)

Nearly 40 members of Congress received training today from surgeon members of the American College of Surgeons (ACS) in how to stop potentially life-threatening bleeding.

Released: 12-Oct-2017 11:05 AM EDT
UAB Hosts Blood Equality Medical Advisory Board to Discuss Changes in Current Blood Donation Policy Regarding Gay Men
University of Alabama at Birmingham

Leaders in HIV research and treatment gather at UAB to address laws that prohibit gay men from donating blood.

9-Oct-2017 3:05 PM EDT
Fred Hutch Studies Advance Methods to Avert Toxicity That Can Accompany Immunotherapy
Fred Hutchinson Cancer Center

Two new papers from researchers at Fred Hutchinson Cancer Research Center provide the most comprehensive data yet reported on side effects of the emerging cancer immunotherapy strategy known as CAR T-cell therapy.

6-Oct-2017 1:05 PM EDT
Study: Risk Factors on Rise Among People with Stroke
American Academy of Neurology (AAN)

Despite prevention efforts, researchers have found a significant increase over a 10-year period in the percentage of people with stroke who have high blood pressure, diabetes, smoking and other risk factors for stroke. The study is published in the October 11, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 11-Oct-2017 5:00 AM EDT
Intermountain Healthcare Researchers Launch Major Three-Year Genomics Breast Cancer Study
Intermountain Medical Center

Goal of new Intermountain Healthcare genomics study is to show whether screening patients for the presence of circulating tumor DNA, known as ctDNA, can successfully detect breast cancer using a blood draw.

Released: 11-Oct-2017 12:05 AM EDT
World's "Better" Countries Have Higher Rates of Cancer
University of Adelaide

The world's "better" countries, with greater access to healthcare, experience much higher rates of cancer incidence than the world's "worse off" countries, according to new research from the University of Adelaide.

Released: 9-Oct-2017 4:05 PM EDT
Cells That Die with a Bang Contribute to High Death Rate in Bloodstream Infections
University of Illinois Chicago

Cells lining blood vessels in the lungs that are exposed to bacterial toxins don’t die easy, according to a new study led by researchers at the University of Illinois at Chicago College of Medicine.

9-Oct-2017 11:00 AM EDT
Novel Treatment Causes Cancer to Self-Destruct Without Affecting Healthy Cells
Albert Einstein College of Medicine

Scientists at Albert Einstein College of Medicine have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue of Cancer Cell, was directed against acute myeloid leukemia (AML) cells but may also have potential for attacking other types of cancers.

Released: 5-Oct-2017 12:00 PM EDT
Researchers Identify Genetic Drivers of Most Common Form of Lymphoma
Duke Health

An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer -- diffuse large B cell lymphoma – and how those genes might play a role in patients’ responses to therapies.

Released: 5-Oct-2017 10:05 AM EDT
Scientists Find New RNA Class in Kidneys Is Linked to Hypertension
American Physiological Society (APS)

Researchers from the University of Toledo (Ohio) College of Medicine and Life Sciences have discovered more than 12,000 different types of noncoding RNA (circRNAs) in the kidney tissue of rats. This type of genetic material, previously thought to have no function, may play a significant role in regulating blood pressure in heart and kidney disease.

4-Oct-2017 11:05 AM EDT
Fight Against Top Killer, Clogged Arteries, Garners Acclaimed NIH Award
Georgia Institute of Technology

No disorder appears to kill more people than atherosclerosis, and hopeful experimental treatments with "good cholesterols" have failed. New research reapproaches them with carefully designed cholesterols in an organ-on-a-chip in highly reproducible experiments.

2-Oct-2017 5:00 PM EDT
A Need for Bananas? Dietary Potassium Regulates Calcification of Arteries
University of Alabama at Birmingham

Researchers have shown, for the first time, that reduced dietary potassium promotes elevated aortic stiffness in a mouse model. Such arterial stiffness in humans is predictive of heart disease and death from heart disease, and it represents an important health problem for the nation.

2-Oct-2017 9:00 AM EDT
For Women, High Blood Pressure in Your 40s May Be Tied to Increased Risk of Dementia
American Academy of Neurology (AAN)

Women who develop high blood pressure in their 40s may be more likely to develop dementia years later, according to a study published in the October 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 3-Oct-2017 12:05 PM EDT
New Portable Blood Analyzer Could Improve Anemia Detection Worldwide
American Institute of Physics (AIP)

To reduce the burden of anemia, health officials need a better picture of the disease's global impact, an understanding made viable by a portable and affordable way to analyze blood. Researchers at the University of Washington developed a device smaller than a toaster that can detect the level of hemoglobin in whole blood samples using optical absorbance. The work is published this week in AIP Advances.

   
Released: 3-Oct-2017 12:05 PM EDT
IBD Patients May Stay Healthier When Doctors Monitor Medications Before They Lose Efficacy
Beth Israel Lahey Health

Proactive monitoring of blood levels of the therapeutic drug infliximab was associated with improved outcomes including lower risk of surgery and hospitalization.

Released: 2-Oct-2017 2:05 PM EDT
What a Rare Blood Disease Can Teach Us About Blood Clotting
American Society for Biochemistry and Molecular Biology (ASBMB)

New insight into how the protein antithrombin works could lead to treatments not only for patients with antithrombin deficiency, but also to better-designed drugs for other blood disorders.

Released: 2-Oct-2017 10:00 AM EDT
Shlomo Melmed, MB, ChB, Dean of Cedars-Sinai Medical Faculty, Honored by Endocrine Society
Cedars-Sinai

Shlomo Melmed, MB, ChB, executive vice president, Academic Affairs, and dean of the medical faculty at Cedars-Sinai, has won the 2018 Outstanding Scholarly Physician Award from the Endocrine Society, the largest global membership organization representing professionals in endocrinology. The annual award recognizes outstanding contributions to the practice of clinical endocrinology in academic settings.

Released: 2-Oct-2017 9:05 AM EDT
Illinois Medical Universities to Study Factors Affecting Rural Opioid Epidemic
University of Chicago Medical Center

Southern Illinois University School of Medicine and the University of Chicago Medicine will use a $1.13 million federal grant to study the opioid epidemic affecting the state’s 16 southernmost counties.

28-Sep-2017 9:05 AM EDT
Researchers Review Risks, Recommendations for Weight Gain Management in Midlife Women
Mayo Clinic

A review of the weight gain risks and challenges faced by women in midlife has led Mayo Clinic researchers to a series of recommendations for this patient population. The findings are published in this month's edition of Mayo Clinic Proceedings.

Released: 29-Sep-2017 1:05 PM EDT
Promising Drug Combination Silences the Rage of Graft-Versus-Host Disease
Seattle Children's Hospital

To pass the nearly 180 days she was a patient in Seattle Children’s Cancer Unit with graft-versus-host disease (GVHD), London Bowater took orders from her doctors, nurses and other patients and families for friendship bracelets that she would braid from her hospital bed.

Released: 29-Sep-2017 6:00 AM EDT
Study Shows MRIs Are Safe for Patients with Wide Variety of Pacemakers and Defibrillators
Intermountain Medical Center

Magnetic resonance imaging appears to be safe for patients with cardiac implantable electronic devices, even for chest imaging, according to a new study by researchers from the Intermountain Medical Center Heart Institute.

29-Sep-2017 1:05 PM EDT
Bristol-Myers Squibb Foundation Provides $1.7 million grant to UNC School of Medicine to fund program streamlining Afib care & education for underserved populations
University of North Carolina Health Care System

UNC School of Medicine cardiologist Anil Gehi, MD, will use a $1.7 million grant from the Bristol-Myers Squibb Foundation to further innovate a care model, launched in 2015, that reduced hospitalizations for patients with atrial fibrillation (Afib) presenting in the emergency room by more than 30 percentage points in its first year.



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